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Søgeord (influenza) valgt.
26 emner vises.
BMC Infectious Diseases, 23.04.2024
Tilføjet 23.04.2024
Abstract Background Severe acute respiratory infection (SARI), a significant global health concern, imposes a substantial disease burden. In China, there is inadequate data concerning the monitoring of respiratory pathogens, particularly bacteria, among patients with SARI. Therefore, this study aims to delineate the demographic, epidemiological, and aetiological characteristics of hospitalised SARI patients in Central China between 2018 and 2020. Methods Eligible patients with SARI admitted to the First Affiliated Hospital of Zhengzhou University between 1 January 2018 and 31 December 2020 were included in this retrospective study. Within the first 24 h of admission, respiratory (including sputum, nasal/throat swabs, bronchoalveolar lavage fluid, thoracocentesis fluid, etc.), urine, and peripheral blood specimens were collected for viral and bacterial testing. A multiplex real-time polymerase chain reaction (PCR) diagnostic approach was used to identify human influenza virus, respiratory syncytial virus, parainfluenza virus, adenovirus, human bocavirus, human coronavirus, human metapneumovirus, and rhinovirus. Bacterial cultures of respiratory specimens were performed with a particular focus on pathogenic microorganisms, including S. pneumoniae, S. aureus, K. pneumoniae, P. aeruginosa, Strep A, H. influenzae, A. baumannii, and E. coli. In cases where bacterial culture results were negative, nucleic acid extraction was performed for PCR to assay for the above-mentioned eight bacteria, as well as L. pneumophila and M. pneumoniae. Additionally, urine specimens were exclusively used to detect Legionella antigens. Furthermore, epidemiological, demographic, and clinical data were obtained from electronic medical records. Results The study encompassed 1266 patients, with a mean age of 54 years, among whom 61.6% (780/1266) were males, 61.4% (778/1266) were farmers, and 88.8% (1124/1266) sought medical treatment in 2020. Moreover, 80.3% (1017/1266) were housed in general wards. The most common respiratory symptoms included fever (86.8%, 1122/1266) and cough (77.8%, 986/1266). Chest imaging anomalies were detected in 62.6% (792/1266) of cases, and 58.1% (736/1266) exhibited at least one respiratory pathogen, with 28.5% (361/1266) having multiple infections. Additionally, 95.7% (1212/1266) of the patients were from Henan Province, with the highest proportion (38.3%, 486/1266) falling in the 61–80 years age bracket, predominantly (79.8%, 1010/1266) seeking medical aid in summer and autumn. Bacterial detection rate (39.0%, 495/1266) was higher than viral detection rate (36.9%, 468/1266), with the primary pathogens being influenza virus (13.8%, 175/1266), K. pneumoniae (10.0%, 127/1266), S. pneumoniae (10.0%, 127/1266), adenovirus (8.2%, 105/1266), P. aeruginosa (8.2%, 105/1266), M. pneumoniae (7.8%, 100/1266), and respiratory syncytial virus (7.7%, 98/1266). During spring and winter, there was a significant prevalence of influenza virus and human coronavirus, contrasting with the dominance of parainfluenza viruses in summer and autumn. Respiratory syncytial virus and rhinovirus exhibited higher prevalence across spring, summer, and winter. P. aeruginosa, K. pneumoniae, and M. pneumoniae were identified at similar rates throughout all seasons without distinct spikes in prevalence. However, S. pneumoniae showed a distinctive pattern with a prevalence that doubled during summer and winter. Moreover, the positive detection rates of various other viruses and bacteria were lower, displaying a comparatively erratic prevalence trend. Among patients admitted to the intensive care unit, the predominant nosocomial bacteria were K. pneumoniae (17.2%, 43/249), A. baumannii (13.6%, 34/249), and P. aeruginosa (12.4%, 31/249). Conversely, in patients from general wards, predominant pathogens included influenza virus (14.8%, 151/1017), S. pneumoniae (10.4%, 106/1017), and adenovirus (9.3%, 95/1017). Additionally, paediatric patients exhibited significantly higher positive detection rates for influenza virus (23.9%, 11/46) and M. pneumoniae (32.6%, 15/46) compared to adults and the elderly. Furthermore, adenovirus (10.0%, 67/669) and rhinovirus (6.4%, 43/669) were the primary pathogens in adults, while K. pneumoniae (11.8%, 65/551) and A. baumannii (7.1%, 39/551) prevailed among the elderly, indicating significant differences among the three age groups. Discussion In Central China, among patients with SARI, the prevailing viruses included influenza virus, adenovirus, and respiratory syncytial virus. Among bacteria, K. pneumoniae, S. pneumoniae, P. aeruginosa, and M. pneumoniae were frequently identified, with multiple infections being very common. Additionally, there were substantial variations in the pathogen spectrum compositions concerning wards and age groups among patients. Consequently, this study holds promise in offering insights to the government for developing strategies aimed at preventing and managing respiratory infectious diseases effectively.
Læs mere Tjek på PubMedJournal of the American Medical Association, 21.04.2024
Tilføjet 21.04.2024
People who were infected with SARS-CoV-2 had a 25% higher risk of later being diagnosed with an autoimmune inflammatory rheumatic disease (AIRD) after infection than those who weren’t infected, according to a large cohort study that included more than 22 million participants in Japan and South Korea. They also had a 30% greater risk of developing AIRD, such as systemic lupus erythematosus or rheumatoid arthritis, compared with people who had influenza, the researchers reported in the Annals of Internal Medicine.
Læs mere Tjek på PubMedJimin Yoon, Yu Meng Zhang, Cheenou Her, Robert A. Grant, Anna I. Ponomarenko, Bryce E. Ackermann, Tiffani Hui, Yu-Shan Lin, Galia T. Debelouchina, Matthew D. Shoulders
Science Advances, 20.04.2024
Tilføjet 20.04.2024
Sabrina L Jin, Jessica Kolis, Jessica Parker, Dylan A Proctor, Dimitri Prybylski, Claire Wardle, Neetu Abad, Kathryn A Brookmeyer, Christopher Voegeli, Howard Chiou
Lancet Infectious Diseases, 20.04.2024
Tilføjet 20.04.2024
Recognition of misinformation as a public health threat and interest in infodemics, defined as an inundation of information accompanying an epidemic or acute health event, have increased worldwide. However, scientists have no consensus on how to best define and identify misinformation and other essential characteristics of infodemics. We conducted a narrative review of secondary historical sources to examine previous infodemics in relation to four infectious diseases associated with pandemics (ie, smallpox, cholera, 1918 influenza, and HIV) and challenge the assumption that misinformation is a new phenomenon associated with increased use of social media or with the COVID-19 pandemic.
Læs mere Tjek på PubMedDong‐Hwi Kim, Jae‐Hyeong Kim, Kyu‐Beom Lim, Joong‐Bok Lee, Seung‐Yong Park, Chang‐Seon Song, Sang‐Won Lee, Dong‐Hun Lee, In‐Soo Choi
Journal of Medical Virology, 19.04.2024
Tilføjet 19.04.2024
Clinical Infectious Diseases, 18.04.2024
Tilføjet 18.04.2024
Abstract Background Outbreaks of vaccine preventable diseases (VPDs) in health care workers (HCWs) can result in morbidity and mortality and cause significant disruptions to health care services, patients and visitors as well as an added burden on the health system. This scoping review is aimed to describe the epidemiology of VPD outbreaks in HCW, caused by diseases which are prevented by the ten vaccines recommended by World Health Organization (WHO) for HCWs.Methods In April 2022 CINAHL, MEDLINE, Global Health and EMBASE were searched for all articles reporting on VPD outbreaks in HCWs since the year 2000. Articles were included regardless of language and study type. Clinical and epidemiological characteristics of VPD outbreaks were described.Results Our search found 9363 articles, of which 216 met inclusion criteria. Studies describing six of the ten VPDs were found: influenza, measles, varicella, tuberculosis, pertussis and rubella. Most articles (93%) were from high- and upper middle-income countries. While most outbreaks occurred in hospitals, several influenza outbreaks were reported in long term care facilities. Based on available data, vaccination rates amongst HCWs were rarely reported.Conclusion We describe several VPD outbreaks in HCWs from 2000 to April 2022. The review emphasises the need to understand the factors influencing outbreaks in HCWs and highlight importance of vaccination amongst HCWs.
Læs mere Tjek på PubMedJurre Y. SiegersMichelle WilleSokhoun YannSongha TokSarath SinSokha CheaAlice PorcoSreyem SoursVutha ChimSamban CheaKimtuo ChhelSothyra TumSan SornMakara HakPeter ThielenVijaykrishna DhanasekaranErik A. Karlssona Virology Unit, Institute Pasteur du Cambodge, Phnom Penh, Cambodiab Centre for Pathogen Genomics, Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australiac WHO Collaborating Centre for Reference and Research on Influenza, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australiad Wildlife Conservation Society, Phnom Penh, Cambodiae National Animal Health and Production Research Institute, Phnom Penh, Cambodiaf Food and Agriculture Organization of the United Nations Country Office, Phnom Penh, Cambodiag Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USAh School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of Chinai HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China
Emerg Microbes Infect, 18.04.2024
Tilføjet 18.04.2024
Hinh LyDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA
Virulence, 18.04.2024
Tilføjet 18.04.2024
Marco Del Riccio, Saverio Caini, Guglielmo Bonaccorsi, Chiara Lorini, John Paget, Koos van der Velden, Adam Meijer, Mendel Haag, Ian McGovern, Patrizio Zanobini
International Journal of Infectious Diseases, 17.04.2024
Tilføjet 17.04.2024
The emergence of the COVID-19 pandemic, caused by SARS-CoV-2, has undeniably reshaped life on a global scale. As infection rates and fatalities surged to historic proportions, initial strategies to combat the crisis revolved around non-pharmaceutical interventions (NPIs) such as the use of facemasks, physical distancing, travel bans, and lockdowns, considering the absence of available vaccines or targeted therapeutics. Characterized by a spectrum of actions spanning individual precautions to broader societal measures, NPIs aimed to curtail the rapid dissemination of the virus [1].
Læs mere Tjek på PubMedEskild Petersen, Ziad A Memish, David S Hui, Alessandra Scagliarini, Lone Simonsen, Edgar Simulundu, Jennifer Bloodgood, Lucille Blumberg, Shui- Shan Lee, Alimuddin Zumla
International Journal of Infectious Diseases, 16.04.2024
Tilføjet 16.04.2024
GBD 2021 Lower Respiratory Infections and Antimicrobial Resistance Collaborators
Lancet Infectious Diseases, 16.04.2024
Tilføjet 16.04.2024
Substantial progress has been made in reducing LRI mortality, but the burden remains high, especially in low-income and middle-income countries. During the COVID-19 pandemic, with its associated non-pharmaceutical interventions, global incident LRI cases and mortality attributable to influenza and RSV declined substantially. Expanding access to health-care services and vaccines, including S pneumoniae, H influenzae type B, and novel RSV vaccines, along with new low-cost interventions against S aureus, could mitigate the LRI burden and prevent transmission of LRI-causing pathogens.
Læs mere Tjek på PubMedYaqin BaiHui LeiWenjun SongSang-Chul ShinJiaqi WangBiying XiaoZeynep A. KoçerMin-Suk SongRobert WebsterRichard J. WebbySook-San WongMark Zanina HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of Chinab Guangzhou Medical University, Guangzhou, People’s Republic of Chinac State Key Laboratory of Respiratory Diseases, Guangzhou, People’s Republic of Chinad School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of Chinae Centre for Immunology & Infection, Hong Kong SAR, People's Republic of Chinaf Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, People’s Republic of Chinag Korea Institute of Science and Technology, Seoul, Koreah Emerging Viral Diseases Laboratory, Izmir Biomedicine and Genome Center, Izmir, Türkiyei Department of Biomedicine and Health Technologies, Izmir International Biomedicine and Genome Institute, Izmir, Türkiyej Department of Microbiology, Chungbuk National University Medical School, Chungbuk, Koreak Department of Host-Microbe Interactions, St. Jude Children’s Research Hospital, Memphis, TN, USA
Emerg Microbes Infect, 15.04.2024
Tilføjet 15.04.2024
Xie, W., Xiao, J., Chen, J., Huang, H., Huang, X., He, S., Xu, L.
BMJ Open, 13.04.2024
Tilføjet 13.04.2024
IntroductionInfluenza is a major public health threat, and vaccination is the most effective prevention method. However, vaccination coverage remains suboptimal. Low health literacy regarding influenza vaccination may contribute to vaccine hesitancy. This study aims to evaluate the effect of health education interventions on influenza vaccination rates and health literacy. Methods and analysisThis cluster randomised controlled trial will enrol 3036 students in grades 4–5 from 20 primary schools in Dongguan City, China. Schools will be randomised to an intervention group receiving influenza vaccination health education or a control group receiving routine health education. The primary outcome is the influenza vaccination rate. Secondary outcomes include health literacy levels, influenza diagnosis rate, influenza-like illness incidence and vaccine protection rate. Data will be collected through questionnaires, influenza surveillance and self-reports at baseline and study conclusion. Ethics and disseminationEthical approval has been sought from the Ethics Committee of the School of Public Health, Sun Yat-sen University. Findings from the study will be made accessible to both peer-reviewed journals and key stakeholders. Trial registration numberNCT06048406.
Læs mere Tjek på PubMedKatherine R. LandwehrCaitlyn M. GranlandKelly M. MartinovichNaomi M. ScottElke J. SeppanenLuke BerryDeborah StricklandAlma FulurijaPeter C. RichmondLea-Ann S. Kirkham1Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, Australia2School of Population Health, Curtin University, Perth, Australia3Wal-yan Respiratory Research Centre, Telethon Kids Institute, Perth, Australia4Centre for Child Health Research, University of Western Australia, Perth, Australia5Department of Paediatrics, School of Medicine, University of Western Australia, Perth, Australia6Department of Immunology, Perth Children’s Hospital, Child and Adolescent Health Service, Perth, Australia, Igor E. Brodsky
Infection and Immunity, 11.04.2024
Tilføjet 11.04.2024
Chongqiang HuangLiangzheng YuYi XuJiamo HuangYibin QinXuan GuoYongfang ZengYifeng QinKang OuyangZuzhang WeiWeijian HuangAdolfo García-SastreYing Chena Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People’s Republic of Chinab Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People’s Republic of Chinac Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Nanning, People’s Republic of Chinad Guangxi Institute of Veterinary Medicine, Nanning, People’s Republic of Chinae Guangxi Nongken Yongxin Animal Husbandry Group Co. Ltd., Nanning, People’s Republic of Chinaf Nanning Zhufulai Animal Health Management Co. Ltd., Nanning, People’s Republic of Chinag Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USAh Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAi Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Emerg Microbes Infect, 10.04.2024
Tilføjet 10.04.2024
Journal of Infectious Diseases, 10.04.2024
Tilføjet 10.04.2024
To the Editor—We read with great interest the results of the analysis by Harteloh et al [1], who concluded that the death rate in The Netherlands from the 1918–1920 Spanish flu was more than twice as high as the death rate for coronavirus disease 2019 (COVID-19) in 2020–2022 (ie, 214 vs 98 per 100 000 per year exposure). This is not surprising as the pathogen responsible for the Spanish flu pandemic (ie, influenza virus A/H1N1) was very aggressive, hit a nearly naive population with no prior immunity, and evolved at a time when healthcare and economic resources were extremely limited compared to recent times. To determine whether similar evidence could be replicated in other countries, we used statistics on the total resident population and the number of deaths from the Spanish flu in 1918–1920 [2] and from COVID-19 in 2020 [3] (ie, before the introduction of COVID-19 vaccination at the end of December 2020) in Italy.
Læs mere Tjek på PubMedAnton ChesnokovAndrei A. IvashchenkoYoko MatsuzakiEmi TakashitaVasiliy P. MishinAlexandre V. IvachtchenkoLarisa V. Gubareva1Influenza Division, NCIRD, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA2ChemDiv, San Diego, California, USA3Department of Infectious Diseases, Yamagata University Faculty of Medicine, Yamagata, Japan4Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan5AVISA LLC, Hallandale Beach, Florida, USA, Miguel Angel Martinez
Antimicrobial Agents And Chemotherapy, 9.04.2024
Tilføjet 9.04.2024
Journal of Infectious Diseases, 5.04.2024
Tilføjet 5.04.2024
Abstract Background Respiratory syncytial virus (RSV) infection is gaining interest due to the recent development of vaccines, but it is still misdiagnosed in the elderly. The primary objective was to compare all-cause mortality at day 30. Secondary objectives were to compare clinical presentation, and rates of consolidative pneumonia, hospitalization, and intensive care unit (ICU) admission.Methods Single-centre retrospective study conducted in a French university hospital during 7 epidemic seasons. All patients aged ≥75 years were included.Results 558 patients were included: 125 with RSV and 433 with Influenza. Median age was 84.8 years. RSV patients had more respiratory symptoms (wheezing, dyspnea), whereas Influenza patients had more general symptoms (fever, asthenia, myalgia). Consolidative pneumonia (28.8% vs. 17.2%; p = 0.004), hospitalization rates (83.2% vs. 70%; p = 0.003), ICU admissions (7.2% vs. 3.0%; p = 0.034) and length of stay (9 days [2-16] vs. 5 days [0-12]; p = 0.002), were higher in the RSV group. Mortality rates at day 30 were comparable (RSV 9.6%, Influenza 9.7%; p = 0.973).Conclusions This study included the largest cohort of RSV-infected patients aged over 75, documented in-depth thus far. RSV shares a comparable mortality rate with Influenza but is associated with higher rates of consolidative pneumonia, hospitalization, ICU admissions, and extended hospital stays.
Læs mere Tjek på PubMedKosuke Tamura, Reiko Shimbashi, Ayu Kasamatsu, Bin Chang, Kenji Gotoh, Yoshinari Tanabe, Koji Kuronuma, Kengo Oshima, Takaya Maruyama, Masashi Nakamatsu, Shuichi Abe, Kei Kasahara, Junichiro Nishi, Yu Arakawa, Yuki Kinjo, Motoi Suzuki, Yukihiro Akeda, Kazunori Oishi, Adult IPD Study Group
International Journal of Infectious Diseases, 5.04.2024
Tilføjet 5.04.2024
Streptococcus pneumoniae asymptomatically colonizes the nasopharynx, often causes pneumococcal disease in children and adults, and can enter the bloodstream to cause invasive pneumococcal disease (IPD). The most common presentation is bacteremic pneumonia, which accounts for approximately 60% of all adult IPD cases [1]. Adult patients with bacteremic pneumococcal pneumonia have a higher in-hospital mortality rate than those without bacteremia [2]. Therefore, understanding the diverse clinical aspects of pneumococcal infection is crucial for effective management and prevention strategies especially in adult population.
Læs mere Tjek på PubMedClinical Infectious Diseases, 3.04.2024
Tilføjet 3.04.2024
Abstract Background Research on influenza burden in adults has focused on crude subgroups with cut-points at 65-years, limiting insight into how burden varies with increasing age. This study describes the incidence of influenza-related outpatient visits, emergency room (ER) visits, and hospitalizations, along with healthcare resource use and complications in the aging adult population.Methods Individuals ≥18 years of age in the United States were evaluated retrospectively in five seasonal cohorts (2015–2020 seasons) in strata of age with 5-year increments. Person-level electronic medical records linked to pharmacy and medical claims were used to ascertain patient characteristics and outcomes. Influenza-related medical encounters were identified based on diagnostic codes (ICD-10 codes J09*–J11*).Results Incidence of influenza-related outpatient visits was highest among people aged 18–34 years and declined with increasing age. For ER visits, incidence tended to be elevated for people aged 18–34 years, relatively stable from 35 through 60, and increased rapidly after 60. Hospitalization incidence remained relatively stable until about 50 years of age and then increased with age. One in three patients was diagnosed with pneumonia after hospitalization, regardless of age. Across seasons, age groups, and clinical settings, on average, 40.8% of individuals were prescribed antivirals and 17.2% antibiotics.Conclusions Incidence of influenza-related hospitalizations begins to increase around age 50 rather than the more common cut-point of 65, whereas incidence of outpatient visits was highest among younger adults. Influenza infections frequently led to antiviral and antibiotic prescriptions, underscoring the role influenza vaccination can play in combating antimicrobial resistance.
Læs mere Tjek på PubMedXin WangFeiyang PuXuanye YangXili FengJiayou ZhangKai DuanXuanxuan NianZhongren MaXiao-Xia MaXiao-Ming Yanga Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou, Chinab School of Stomatology, Lanzhou University, Lanzhou, Chinac National Engineering Technology Research Center for Combined Vaccines, Wuhan, Chinad Wuhan Institute of Biological Products Co, Ltd, Wuhan, Chinae China National Biotech Group Company Limited, Beijing, China
Virulence, 3.04.2024
Tilføjet 3.04.2024
Hinh LyDepartment of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA
Virulence, 3.04.2024
Tilføjet 3.04.2024
Journal of the American Medical Association, 2.04.2024
Tilføjet 2.04.2024
New guidance from the US Centers for Disease Control and Prevention (CDC) provides updated measures to combat respiratory viruses such as SARS-CoV-2, influenza, and respiratory syncytial virus. The recommendations come at a time when deaths and hospitalizations from COVID-19 have decreased from the peak of the pandemic and the availability of tools to fight respiratory viruses is greater than ever, the agency noted.
Læs mere Tjek på PubMedKuo‐Chuan Hung, Ting‐Sian Yu, Kuei‐Fen Wang, I‐Wen Chen
Journal of Medical Virology, 2.04.2024
Tilføjet 2.04.2024
Gianella, Sara; Anderson, Christy; Chaillon, Antoine; Wells, Alan; Porrachia, Magali; Caballero, Gemma; Vargas, Milenka; Lonergan, Joseph; Woodworth, Brendon; Gaitan, Noah; Rawlings, Stephen A.; Muttera, Leticia; Harkness, Liliana; Little, Susan J.; May, Susanne; Smith, Davey
AIDS, 30.03.2024
Tilføjet 30.03.2024
Objective: :We sought to determine if standard influenza and pneumococcal vaccines can be used to stimulate HIV reservoirs during antiretroviral therapy (ART). Design: :Prospective, randomized, double-blinded, placebo-controlled, crossover trial of two clinically recommended vaccines (influenza and pneumococcal). Methods: :Persons with HIV on ART (N = 54) were enrolled in the clinical trial. Blood was collected at baseline and days 2,4,7,14 and 30 postimmunizations. Levels of cellular HIV RNA and HIV DNA were measured by ddPCR. Expression of immunological markers on T cell subsets were measured by flow cytometry. Changes in unspliced cellular HIV RNA from baseline to day 7 postinjection between each vaccine and placebo was the primary outcome. Results: :Forty-seven participants completed at least one cycle and there were no serious adverse events related to the intervention. We observed no significant differences in the change in cellular HIV RNA after either vaccine compared to placebo at any timepoint. In secondary analyses we observed a transient increase in total HIV DNA levels after influenza vaccine, as well as increased T cell activation and exhaustion on CD4+ T cells after pneumococcal vaccine. Conclusions: :Clinically recommended vaccines were safe but did not appear to stimulate the immune system strongly enough to elicit significantly noticeable HIV RNA transcription during ART. Clinicaltrials.gov identifier: NCT02707692. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Læs mere Tjek på PubMedIván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Irene Arroyo-Hernantes, Marta Domínguez-Gil, Silvia Rojo-Rello, Marta Hernández, José M Eiros
International Journal of Infectious Diseases, 30.03.2024
Tilføjet 30.03.2024
Since the precise significance of viral load (VL) test for the management and treatment of patients with respiratory viruses remains unknown, it is not a commonly used tool. However, since the COVID-19 pandemic, VL evaluation has gained popularity in the scientific community and healthcare providers due to the possible application in daily clinical practice and research [1–3]. During the worst part of the pandemic, when hospitalization was overcrowded and a huge need for resources was the most important issue, the Ct value (Cycle threshold), a subrogate of the VL, was used as a criterion for discharging patients.
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