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1
Earworms—A Narrative Review of Infectious Music
Journal of the American Medical Association, 2.04.2024
Tilføjet 2.04.2024
This Arts and Medicine feature reviews the clinical and neurophysiologic features of earworms, music fragments heard in the mind that repeat over and over as if jammed in playback mode.
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2
CDC Eases Isolation Guidance for Respiratory Viruses
Journal of the American Medical Association, 2.04.2024
Tilføjet 2.04.2024
New guidance from the US Centers for Disease Control and Prevention (CDC) provides updated measures to combat respiratory viruses such as SARS-CoV-2, influenza, and respiratory syncytial virus. The recommendations come at a time when deaths and hospitalizations from COVID-19 have decreased from the peak of the pandemic and the availability of tools to fight respiratory viruses is greater than ever, the agency noted.
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3
Drug-Resistant E coli in Pet Dogs Could Pose Risk to People
Journal of the American Medical Association, 2.04.2024
Tilføjet 2.04.2024
In a recent study of pet dogs in China, researchers detected the presence of multidrug-resistant (MDR) Escherichia coli in more than half of the bacteria sampled. Because dogs’ fecal matter sheds bacteria, these MDR E coli pose a health risk to their owners, the study authors noted in PLOS One.
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4
CDC Recommends Additional COVID-19 Booster for Older Adults
Journal of the American Medical Association, 2.04.2024
Tilføjet 2.04.2024
From October 2023 to December 2023, older adults made up more than half of COVID-19 hospitalizations in the US. The Centers for Disease Control and Prevention (CDC) now recommends an additional updated 2023-2024 COVID-19 vaccine dose for adults aged 65 years or older.
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5
Cover
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: i-i
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6
Contents
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: ii-ii
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7
Acknowledgments
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: iii-iii
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8
Systematic Reviews and Meta-Analyses to Inform Recommendations for the Final Phase of Elimination and Prevention of Re-Establishment of Malaria
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 1-2
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9
Development of WHO Recommendations for the Final Phase of Elimination and Prevention of Re-Establishment of Malaria
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 3-10
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10
Development of Systematic Reviews to Inform WHO’s Recommendations for Elimination and Prevention of Re-Establishment of Malaria: Methodology
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 11-16
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11
Mass Drug Administration to Reduce Malaria Transmission: A Systematic Review and Meta-Analysis
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 17-29
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12
Mass Drug Administration: Contextual Factor Considerations
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 30-37
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13
Mass Relapse Prevention to Reduce Transmission of Plasmodium vivax— A Systematic Review
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 38-43
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14
Mass Testing and Treatment to Accelerate Malaria Elimination: A Systematic Review and Meta-Analysis
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 44-53
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15
Targeted Testing and Treatment To Reduce Human Malaria Transmission in High-Risk Populations: A Systematic Review
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 54-64
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16
Targeted Drug Administration to Reduce Malaria Transmission: A Systematic Review and Meta-Analysis
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 65-72
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17
Targeted Test and Treat at Point of Entry to Reduce Importation of Malaria Parasites: A Systematic Review
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 73-81
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18
Reactive Case Detection and Treatment and Reactive Drug Administration for Reducing Malaria Transmission: A Systematic Review and Meta-Analysis
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 82-93
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19
Reducing Malaria Transmission through Reactive Indoor Residual Spraying: A Systematic Review
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 94-100
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20
Full Issue PDF
American Journal of Tropical Medicine and Hygiene, 2.04.2024
Tilføjet 2.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4_Suppl Pages: 1-100
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21
Issue Information
Tropical Medicine & International Health, 2.04.2024
Tilføjet 2.04.2024
22
Optimization of Mother-to-Child Hepatitis B Virus Prevention Program: Integration of Maternal Screening and Infant Post-vaccination Serologic Testing
Clinical Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
Abstract Background Evaluation of the impact on mother-to-child transmission (MTCT) of a HBV-prevention program that incorporates maternal antiviral prophylaxis is hindered by the limited availability of real-world data.Methods This study analyzed data on maternal HBV screening, neonatal immunization, and post-vaccination serologic testing (PVST) for HBsAg among at-risk infants born to HBV carrier mothers from the National Immunization Information System during 01/01/2008–31/12/2022. Through linkage with the National Health Insurance Database, information of maternal antiviral therapy was obtained. Multivariate logistic regression was performed to explore MTCT risk in relation to infant-mother characteristics and prevention strategies.Results Totally, 2,460,218 deliveries with maternal HBV status were screened. Between 2008 and 2022, the annual HBsAg and HBeAg seropositivity rates among native pregnant women aged 15–49 years decreased from 12.2% to 2.6% and from 2.7% to 0.4%, respectively (p for both trends < 0.0001). Among the 22,859 at-risk infants undergoing PVST, the MTCT rates differed between infants born to HBsAg-positive/HBeAg-negative and HBeAg-positive mothers (0.75% and 6.33%, respectively; p < 0.001). The MTCT rate was 1.72% (11/641) for infants born to HBeAg-positive mothers with antiviral prophylaxis. MTCT risk increased with maternal HBeAg-positivity (OR 9.29, 6.79–12.73) and decreased with maternal antiviral prophylaxis (OR 0.28, 0.16–0.49). For infants with maternal HBeAg-positivity, MTCT risk was associated with mothers born in the immunization era (OR 1.40, 1.17–1.67).Conclusions MTCT was related to maternal HBeAg-positivity and effectively prevented by maternal prophylaxis in the immunized population. At-risk infants born to maternal vaccinated cohorts might possibly pose further risk.
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23
Revolutionizing Daptomycin Dosing: A Single 7-11 Hour Sample for Pragmatic Application
Clinical Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
Abstract Precision daptomycin dosing faces clinical implementation barriers despite known exposure-safety concerns with the use of twice the regulatory-approved doses. We propose achieving a single 7-11 hour post-dose plasma target concentration of 30 mg/L to 43 mg/L to be a practical starting point to facilitate precision daptomycin dosing.
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24
True DisCoVeRy of COVID-19 Disease Burden Versus Speculated Antiviral Cardiovascular Risk Requires a Control Group
Clinical Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
25
Cardiac Adverse Events and Remdesivir in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19): A Post Hoc Safety Analysis of the Randomized DisCoVeRy Trial
Clinical Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
Abstract Background We aimed to evaluate the cardiac adverse events (AEs) in hospitalized patients with Coronavirus Disease 2019 (COVID-19) receiving remdesivir plus standard of care (SoC) compared to SoC alone (control), as an association was noted in some cohort studies and disproportionality analyses of safety databases.Methods This post-hoc safety analysis is based on data from the multicenter, randomized, open-label, controlled DisCoVeRy trial in hospitalized patients with COVID-19 (NCT04315948). Any first AE occurring between randomization and day 29 in the modified intention-to-treat (mITT) population randomized to either remdesivir or control group was considered. Analysis was performed using Kaplan-Meier survival curves and Kaplan-Meier estimates were calculated for event rates.Results Cardiac AEs were reported in 46 (11.2%) of 410 and 48 (11.3%) of 423 patients in the mITT population (n = 833) enrolled in the remdesivir and control groups, respectively. The difference between both groups was not significant (HR 1.0, 95% CI 0.7-1.5, p = 0.98), even when evaluating serious and non-serious cardiac AEs separately. The majority of reports in both groups were of arrhythmic nature (remdesivir, 84.8%; control, 83.3%) and were associated with a favorable outcome. There was no significant difference between remdesivir and control groups in the occurrence of different cardiac AE subclasses, including arrhythmic events (HR 1.1, 95% CI: 0.7-1.7, p = 0.68).Conclusions Remdesivir treatment was not associated with an increased risk of cardiac AEs, whether serious or not, and regardless of AE severity, compared to control, in patients hospitalized with moderate or severe COVID-19. This is consistent with the results of other randomized controlled trials and meta-analyses.
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26
Exploring the impact of epidemiological and clinical factors on the progression of canine leishmaniosis by statistical and whole genome analyses: from breed predisposition to comorbidities
International Journal for Parasitology, 2.04.2024
Tilføjet 2.04.2024
Publication date: Available online 2 April 2024 Source: International Journal for Parasitology Author(s): Carolina R. Sanz, Juliana Sarquis, María Ángeles Daza, Guadalupe Miró
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27
TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH‐SY5Y cells
Chengcheng Jiang, Yixuan Huang, Hongya Gui, Xiaojie Liu, Haiwen Li, Maozhen Han, Shenghai Huang
Journal of Medical Virology, 2.04.2024
Tilføjet 2.04.2024
28
Influenza vaccination on SARS‐CoV‐2 infection risk: A subgroup analysis on geographic factor
Kuo‐Chuan Hung, Ting‐Sian Yu, Kuei‐Fen Wang, I‐Wen Chen
Journal of Medical Virology, 2.04.2024
Tilføjet 2.04.2024
29
Human transmission and outbreaks of feline‐like G6 rotavirus revealed with whole‐genome analysis of G6P[9] feline rotavirus
Yuya Fukuda, Hajime Kusuhara, Reiko Takai‐Todaka, Kei Haga, Kazuhiko Katayama, Takeshi Tsugawa
Journal of Medical Virology, 2.04.2024
Tilføjet 2.04.2024
30
Correction: Opportunistic gill infection is associated with TiO2 nanoparticle-induced mortality in zebrafish
The PLOS One Staff
PLoS One Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
31
Our perception may not be reality: A longitudinal study of the relationship between perceived and actual change in smoking behavior
Astrid Juhl Andersen, Solène Wallez, Maria Melchior, Murielle Mary-Krause
PLoS One Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
by Astrid Juhl Andersen, Solène Wallez, Maria Melchior, Murielle Mary-Krause Introduction Results of the impact of lockdowns and stay-at-home orders during the COVID-19 pandemic on changes in cigarette smoking are mixed. Previous studies examining smoking changes during the early stages of the pandemic in 2020 have mainly focused on smoker’s perception of changes in cigarette consumption. Such measure has not been widely used in other contexts, and therefore we aim to compare the discrepancy between smokers’ perceived changes in cigarette smoking and the actual change in the number of cigarettes smoked, using repeated measurements. Methods We included 134 smokers from the French TEMPO cohort with repeated measurements of their perceived changes in smoking habits during the first phase of the COVID-19 pandemic and the number of cigarettes smoked repeatedly from March to May 2020. We used generalized estimation equations (GEE) to examine the association between changes in the number of cigarettes smoked and the odds of mismatched answers. Results The results suggest that at each study wave, 27–45% of participants provided mismatching answers between their perceived change in smoking habits and the actual change in the number of cigarettes smoked daily, measured repeatedly. Results from GEE analysis demonstrated that a mismatching assessment of smoking behavior was elevated among those who had an increase (OR = 2.52 [1.37;4.65]) or a decrease (OR = 5.73 [3.27;10.03]) in number of cigarettes smoked. Discussion Our findings highlight the possibility of obtaining different results depending on how changes in tobacco smoking are measured. This highlights the risk of underestimating the actual changes in cigarette smoking during the COVID-19 pandemic, but also more generally when validating public health interventions or smoking cessation programs. Therefore, objective measures such as the actual consumption of psychoactive substances should be utilized, preferably on a longitudinal basis, to mitigate recall bias.
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32
The retinoid X receptor has a critical role in synthetic rexinoid-induced increase in cellular all-trans-retinoic acid
Olga V. Belyaeva, Alla V. Klyuyeva, Ansh Vyas, Wilhelm K. Berger, Laszlo Halasz, Jianshi Yu, Venkatram R. Atigadda, Aja Slay, Kelli R. Goggans, Matthew B. Renfrow, Maureen A. Kane, Laszlo Nagy, Natalia Y. Kedishvili
PLoS One Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
by Olga V. Belyaeva, Alla V. Klyuyeva, Ansh Vyas, Wilhelm K. Berger, Laszlo Halasz, Jianshi Yu, Venkatram R. Atigadda, Aja Slay, Kelli R. Goggans, Matthew B. Renfrow, Maureen A. Kane, Laszlo Nagy, Natalia Y. Kedishvili Rexinoids are agonists of nuclear rexinoid X receptors (RXR) that heterodimerize with other nuclear receptors to regulate gene transcription. A number of selective RXR agonists have been developed for clinical use but their application has been hampered by the unwanted side effects associated with the use of rexinoids and a limited understanding of their mechanisms of action across different cell types. Our previous studies showed that treatment of organotypic human epidermis with the low toxicity UAB30 and UAB110 rexinoids resulted in increased steady-state levels of all-trans-retinoic acid (ATRA), the obligatory ligand of the RXR-RAR heterodimers. Here, we investigated the molecular mechanism underlying the increase in ATRA levels using a dominant negative RXRα that lacks the activation function 2 (AF-2) domain. The results demonstrated that overexpression of dnRXRα in human organotypic epidermis markedly reduced signaling by resident ATRA, suggesting the existence of endogenous RXR ligand, diminished the biological effects of UAB30 and UAB110 on epidermis morphology and gene expression, and nearly abolished the rexinoid-induced increase in ATRA levels. Global transcriptome analysis of dnRXRα-rafts in comparison to empty vector-transduced rafts showed that over 95% of the differentially expressed genes in rexinoid-treated rafts constitute direct or indirect ATRA-regulated genes. Thus, the biological effects of UAB30 and UAB110 are mediated through the AF-2 domain of RXRα with minimal side effects in human epidermis. As ATRA levels are known to be reduced in certain epithelial pathologies, treatment with UAB30 and UAB110 may represent a promising therapy for normalizing the endogenous ATRA concentration and signaling in epithelial tissues.
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33
Distribution of pathogens and risk factors for post-replantation wound infection in patients with traumatic major limb mutilation
Chang Gao, Haiyan Wang, Jihui Ju, Keran Zhang, Ye Gao, Shiqi Guo, Di Yin, Ruixing Hou, Qiang Guo
PLoS One Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
by Chang Gao, Haiyan Wang, Jihui Ju, Keran Zhang, Ye Gao, Shiqi Guo, Di Yin, Ruixing Hou, Qiang Guo Purpose Even though replantation of limb mutilation is increasing, postoperative wound infection can result in increasing the financial and psychological burden of patients. Here, we sought to explore the distribution of pathogens and identify risk factors for postoperative wound infection to help early identification and managements of high-risk patients. Methods Adult inpatients with severed traumatic major limb mutilation who underwent replantation from Suzhou Ruixing Medical Group between November 09, 2014, and September 6, 2022 were included in this retrospective study. Demographic, and clinical characteristics, treatments, and outcomes were collected. Data were used to analyze risk factors for postoperative wound infection. Results Among the 249 patients, 185 (74.3%) were males, the median age was 47.0 years old. Postoperative wound infection in 74 (29.7%) patients, of whom 51 (20.5%) had infection with multi-drug resistant bacteria. Ischemia time (OR 1.31, 95% CI 1.13–1.53, P = 0.001), wound contamination (OR 6.01, 95% CI 2.38–15.19, P
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34
Assessing equity in the uptake of remote foot temperature monitoring in a large integrated US healthcare system
Alyson J. Littman, Andrew K. Timmons, Kenneth T. Jones, Suzanne Shirley, Jeffrey Robbins, Ernest Moy
PLoS One Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
by Alyson J. Littman, Andrew K. Timmons, Kenneth T. Jones, Suzanne Shirley, Jeffrey Robbins, Ernest Moy Objective We assessed equity in the uptake of remote foot temperature monitoring (RTM) for amputation prevention throughout a large, integrated US healthcare system between 2019 and 2021, including comparisons across facilities and between patients enrolled and eligible patients not enrolled in RTM focusing on the Reach and Adoption dimensions of the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. Material and methods To assess whether there was equitable use of RTM across facilities, we examined distributions of patient demographic, geographic, and facility characteristics across facility RTM use categories (e.g., no RTM use, and low, moderate, and high RTM use) among all eligible patients (n = 46,294). Second, to understand whether, among facilities using RTM, there was equitable enrollment of patients in RTM, we compared characteristics of patients enrolled in RTM (n = 1066) relative to a group of eligible patients not enrolled in RTM (n = 27,166) using logistic regression and including all covariates. Results RTM use increased substantially from an average of 11 patients per month to over 40 patients per month between 2019 and 2021. High-use RTM facilities had higher complexity and a lower ratio of patients per podiatrist but did not have consistent evidence of better footcare process measures. Among facilities offering RTM, enrollment varied by age, was inversely associated with Black race (vs. white), low income, living far from specialty care, and being in the highest quartiles of telehealth use prior to enrollment. Enrollment was positively associated with having osteomyelitis, Charcot foot, a partial foot amputation, BMI≥30 kg/m2, and high outpatient utilization. Conclusions RTM growth was concentrated in a small number of higher-resourced facilities, with evidence of lower enrollment among those who were Black and lived farther from specialty care. Future studies are needed to identify and address barriers to uptake of new interventions like RTM to prevent exacerbating existing ulceration and amputation disparities.
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35
Short-stay urgent hospital admissions of children with convulsions: A mixed methods exploratory study to inform out of hospital care pathways
Cari Malcolm, Pat Hoddinott, Emma King, Smita Dick, Richard Kyle, Philip Wilson, Emma France, Lorna Aucott, Stephen W. Turner
PLoS One Infectious Diseases, 2.04.2024
Tilføjet 2.04.2024
by Cari Malcolm, Pat Hoddinott, Emma King, Smita Dick, Richard Kyle, Philip Wilson, Emma France, Lorna Aucott, Stephen W. Turner Objective To inform interventions focused on safely reducing urgent paediatric short stay admissions (SSAs) for convulsions. Methods Routinely acquired administrative data from hospital admissions in Scotland between 2015–2017 investigated characteristics of unscheduled SSAs (an urgent admission where admission and discharge occur on the same day) for a diagnosis of febrile and/or afebrile convulsions. Semi-structured interviews to explore perspectives of health professionals (n = 19) making referral or admission decisions about convulsions were undertaken. Interpretation of mixed methods findings was complemented by interviews with four parents with experience of unscheduled SSAs of children with convulsion. Results Most SSAs for convulsions present initially at hospital emergency departments (ED). In a subset of 10,588 (11%) of all cause SSAs with linked general practice data available, 72 (37%) children with a convulsion contacted both the GP and ED pre-admission. Within 30 days of discharge, 10% (n = 141) of children admitted with afebrile convulsions had been readmitted to hospital with a further convulsion. Interview data suggest that panic and anxiety, through fear that the situation is life threatening, was a primary factor driving hospital attendance and admission. Lengthy waits to speak to appropriate professionals exacerbate parental anxiety and can trigger direct attendance at ED, whereas some children with complex needs had direct access to convulsion professionals. Conclusions SSAs for convulsions are different to SSAs for other conditions and our findings could inform new efficient convulsion-specific pre and post hospital pathways designed to improve family experiences and reduce admissions and readmissions.
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36
IL-22-dependent responses and their role during Citrobacter rodentium infection
Karine MelchiorRomana R. GernerSuzana HossainSean-Paul NuccioCristiano Gallina MoreiraManuela Raffatellu1Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA2School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil3School of Life Sciences, ZIEL – Institute for Food and Health, Freising-Weihenstephan, Technical University of Munich, Munich, Germany4Department of Internal Medicine III, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany5Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA6Center for Microbiome Innovation, University of California San Diego, La Jolla, California, USA7Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, California, USA, Andreas J. Bäumler
Infection and Immunity, 2.04.2024
Tilføjet 2.04.2024
37
First imported case of Candida auris infection in Milan, Italy: genomic characterisation
Infection, 2.04.2024
Tilføjet 2.04.2024
Abstract Purpose Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance. Case presentation On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C. auris. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain. Conclusion Importation of C. auris from abroad has been previously described. We report the first case of C. auris imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.
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38
In vitro activity of cefoxitin, imipenem, meropenem, and ceftaroline in combination with vaborbactam against Mycobacterium abscessus
Liang ChenElena ShashkinaNatalia KurepinaVinicius Calado Nogueira de MouraCharles L. DaleyBarry N. Kreiswirth1Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA2Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA3Department of Medicine, National Jewish Health, Denver, Colorado, USA4The University of Colorado, Aurora, Colorado, USA, Jared A. Silverman
Antimicrobial Agents And Chemotherapy, 2.04.2024
Tilføjet 2.04.2024
39
Treatment Mechanism and Inflammatory Subphenotyping in Acute Respiratory Distress Syndrome
Alexis L. Serra, Nuala J. Meyer, Jeremy R. Beitler
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 774-776, April 1, 2024.
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40
Lessons Are Still Being Learned about Intrapulmonary Antibiotic Concentrations
Keith A. Rodvold, Andrew F. Shorr
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 777-778, April 1, 2024.
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41
SARS-CoV-2 Lurking and Lingering in the Depths of Lungs
Rohit Gaurav
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 779-780, April 1, 2024.
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42
Beyond Septic Shock: Who Else Requires Immediate Antibiotics?
Michael Klompas, Greg S. Martin
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 781-782, April 1, 2024.
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43
Antimicrobial Drug Penetration Is Enhanced by Lung Tissue Inflammation and Injury
Johannes Geilen, Matthias Kainz, Bernhard Zapletal, Asami Naka, Johanna Tichy, Walter Jäger, Michaela Böhmdorfer, Markus Zeitlinger, Marcus J. Schultz, Tanja Stamm, Valentin Ritschl, Silvana Geleff, Edda Tschernko
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 829-839, April 1, 2024.
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44
SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset
Michele Tomasicchio, Shameem Jaumdally, Lindsay Wilson, Andrea Kotze, Lynn Semple, Stuart Meier, Anil Pooran, Aliasgar Esmail, Komala Pillay, Riyaadh Roberts, Raymond Kriel, Richard Meldau, Suzette Oelofse, Carley Mandviwala, Jessica Burns, Rolanda Londt, Malika Davids, Charnay van der Merwe, Aqeedah Roomaney, Louié Kühn, Tahlia Perumal, Alex J. Scott, Martin J. Hale, Vicky Baillie, Sana Mahtab, Carolyn Williamson, Rageema Joseph, Alex Sigal, Ivan Joubert, Jenna Piercy, David Thomson, David L. Fredericks, Malcolm G. A. Miller, Marta C. Nunes, Shabir A. Madhi, Keertan Dheda
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 840-851, April 1, 2024.
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45
Heterogeneity of Benefit from Earlier Time-to-Antibiotics for Sepsis
Rachel K. Hechtman, Patricia Kipnis, Jennifer Cano, Sarah Seelye, Vincent X. Liu, Hallie C. Prescott
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 852-860, April 1, 2024.
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46
Differences in the Response to High-Dose Inhaled Nitric Oxide in Self-identified Black and White Individuals: A Post Hoc Analysis of the NOSARSCOVID Randomized Clinical Trial
Naman S. Shetty, Valentina Giammatteo, Mokshad Gaonkar, Peng Li, Oluwaseun Akeju, Garima Arora, Lorenzo Berra, Pankaj Arora
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 887-890, April 1, 2024.
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Low-Dose Anticoagulation to Prevent Intracranial Hemorrhage in COVID-19 Patients under Extracorporeal Membrane Oxygenation Support
Pedro David Wendel-Garcia, Benjamin Seeliger, Daniel Hofmaenner, Christian Bode, Klaus Stahl, Sascha David
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 894-895, April 1, 2024.
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48
Reply to Wendel-Garcia et al.: Low-Dose Anticoagulation to Prevent Intracranial Hemorrhage in COVID-19 Patients under Extracorporeal Membrane Oxygenation Support
Marco Giani, Matthieu Schmidt, Daniel Brodie, Roberto Lorusso, Antonio Arcadipane, Gennaro Martucci
American Journal of Respiratory and Critical Care Medicine , 1.04.2024
Tilføjet 1.04.2024
American Journal of Respiratory and Critical Care Medicine, Volume 209, Issue 7, Page 895-896, April 1, 2024.
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49
The clinical profile and outcomes of drug resistant tuberculosis in Central Province of Zambia
BMC Infectious Diseases, 1.04.2024
Tilføjet 1.04.2024
Abstract Background The emergence of Drug Resistant Tuberculosis (DR-TB) is one of the main public health and economic problems facing the world today. DR-TB affects mostly those in economically productive years and prevents them from being part of the workforce needed for economic growth. The aim of this study was to determine the Clinical Profile and Outcomes of DR-TB in Central Province of Zambia. Methods This was a retrospective cross sectional study that involved a review of records of patients with confirmed DR-TB who were managed at Kabwe Central Hospital’s Multi-Drug Resistant TB (MDR-TB) Ward from the year 2017 to 2021. 183 patients were managed during this period and all were recruited in the study. Data was collected from DR-TB registers and patient files and then entered in SPSS version 22 where all statistical analyses were performed. Results The study revealed that the prevalence of DR-TB among registered TB patients in Central Province was 1.4%. Majority of those affected were adults between the ages of 26 and 45 years (63.9%). The study also found that more than half of the patients were from Kabwe District (60.7%). Other districts with significant number of cases included Kapiri Mposhi 19 (10.4%), Chibombo 12 (6.6%), Chisamba 10 (5.5%), Mumbwa 7 (3.8%) and Mkushi 7 (3.8%). Furthermore, the analysis established that most of the patients had RR-TB (89.6%). 9.3% had MDR-TB, 0.5% had IR-TB and 0.5% had XDR-TB. RR-TB was present in 93.8% of new cases and 88.9% of relapse cases. MDR-TB was present in 6.2% of new cases and 10% of relapse cases. With regard to outcomes of DR-TB, the investigation revealed that 16.9% of the patients had been declared cured, 45.9% had completed treatment, 6% were lost to follow up and 21.3% had died. Risk factors for mortality on multivariate analysis included age 36–45 years (adjusted odds ratio [aOR] 0.253, 95% CI [0.70–0.908] p = 0.035) and male gender (aOR 0.261, 95% CI [0.107–0.638] p = 0.003). Conclusion The research has shown beyond doubt that the burden of DR-TB in Central Province is high. The study recommends putting measures in place that will help improve surveillance, early detection, early initiation of treatment and proper follow up of patients.
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