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Andreas Kerschbaumer, Daniel Aletaha
Pharmacological management of chronic immune-mediated inflammatory conditions has experienced many advances in the past decade. Psoriatic arthritis has for a long time almost exclusively had therapeutic strategies that were originally developed for rheumatoid arthritis, on which most arthritis research has focused. The complexity of psoriatic arthritis, with its different disease manifestations besides the arthritis (enthesitis, dactylitis, involvement of the axial skeleton, and skin and nail disease), poses a challenge to comprehensive assessment of disease activity and to manifestation-oriented management of the disease.
When the UK National Institute for Health and Care Excellence (NICE) released draft guidelines on the diagnosis and management of abdominal aortic aneurysms in May, 2018, it caused outcry. By recommending that endovascular aneurysm repair (EVAR) of unruptured aneurysms should not be offered—even in patients for whom open surgical repair was contraindicated—critics said that many patients would be denied life-saving treatment and that the guidelines were unworkable.
Never has the “leave no one behind” pledge felt more urgent. As nations around the world implement measures to control the spread of SARS-CoV-2, including lockdowns and restrictions on individuals’ movements, they must heed their global commitments. When member states adopted the UN 2030 Agenda for Sustainable Development, they promised to ensure no one will be left behind. Chief among the world's most vulnerable people are refugees and migrants. The COVID-19 crisis puts these groups at enormous risk.
What does it mean to be vulnerable? Vulnerable groups of people are those that are disproportionally exposed to risk, but who is included in these groups can change dynamically. A person not considered vulnerable at the outset of a pandemic can become vulnerable depending on the policy response. The risks of sudden loss of income or access to social support have consequences that are difficult to estimate and constitute a challenge in identifying all those who might become vulnerable. Certainly, amid the COVID-19 pandemic, vulnerable groups are not only elderly people, those with ill health and comorbidities, or homeless or underhoused people, but also people from a gradient of socioeconomic groups that might struggle to cope financially, mentally, or physically with the crisis.
Gerardo Chowell, Kenji Mizumoto
As of March 19, 2020, 191 127 cases of, including 7807 deaths attributed to, coronavirus disease 2019 (COVID-19) have been reported worldwide.1 The incidence of reported cases in China has dramatically reduced to tens per day as a result of strict social distancing measures; however, the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now generating sustained transmission in many countries including the USA. In The Lancet, Isaac Ghinai, Tristan D McPherson, and colleagues2 report details of the first known human-to-human transmission of SARS-CoV-2 in the USA, which was identified in late January, 2020.
Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yingke He, Ayôla A Adegnika, Peter G Kremsner, Selidji T Agnandji, Amadou A Sall, Zhen Liang, Chen Qiu, Fu Long Liao, Tingliang Jiang, Sanjeev Krishna, Youyou Tu
The coronavirus disease 2019 (COVID-19) pandemic that first emerged in Wuhan in China's Hubei province1 has quickly spread to the rest of China and many other countries. Within 3 months, more than 125 000 people have been infected and the death toll had reached over 4600 worldwide on March 12, 2020.2 In an attempt to contain the virus, the Chinese Government has made unprecedented efforts and invested enormous resources and these containment efforts have stemmed the spread of the disease.3 As of March 12, 2020, malaria-endemic regions in Africa have reported a few imported COVID-19 cases including in Nigeria, Senegal, and the Democratic Republic of the Congo.
Brian McCloskey, Alimuddin Zumla, Giuseppe Ippolito, Lucille Blumberg, Paul Arbon, Anita Cicero, Tina Endericks, Poh Lian Lim, Maya Borodina, WHO Novel Coronavirus-19 Mass Gatherings Expert Group
The coronavirus disease 2019 (COVID-19) pandemic1 presents countries with major political, scientific, and public health challenges. Pandemic preparedness and reducing risk of global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are key concerns. Mass gathering (MG) events2 pose considerable public health challenges to health authorities and governments. Historically, sporting, religious, music, and other MGs have been the source of infectious diseases that have spread globally.
Alastair Brown, Richard Horton
It is natural during the unfolding coronavirus disease 2019 (COVID-19) pandemic to focus on emergency response planning, including containment, treatment procedures, and vaccine development, and nobody would doubt the need for these measures. However, an emergency can also open a window of opportunity for reflection and learning. We live in increasingly global, interdependent, and environmentally constrained societies and the COVID-19 pandemic exemplifies these aspects of our world. We would therefore be wise to take a broad integrated perspective on this disease, the impacts of which are already spilling over into the realms of economics, international trade, politics, and inequality.
How should countries plan for the approaching health crisis caused by coronavirus disease 2019 (COVID-19)? In the UK, Prime Minister Boris Johnson, himself struck down with infection, has written to every household warning that, “we know things will get worse before they get better”. The UK Government is right to prepare the public for the coming human catastrophe. All governments have a responsibility to do the same. But this advice does not go far enough. Here are five critical actions that need to be considered immediately.
Laboratories and diagnostic companies are racing to produce antibody tests, a key part of the response to the COVID-19 pandemic. Anna Petherick reports.
On March 31, the Gairdner Foundation announced the winners of its annual prizes in biomedical science and global health. Talha Burki spoke with the laureates.
Masculinities: Liberation through Photography explores half a century of photographic representations of men—their bodies, their identities, and their social roles. Contemporary politics is full of powerful men—Donald Trump, Boris Johnson, Vladimir Putin, and Recep Tayyip Erdoğan—behaving in stereotypically dominant ways. You could be forgiven for thinking that the more things change, the more things remain the same. But #MeToo is here to say it can't go on like this, in the wake of the conviction of Harvey Weinstein.
Fay Bound Alberti
In 2017 the face of Katie Stubblefield made headlines. Not the face she was born with or the face that emerged after 22 reconstructive surgeries. This was another face altogether: a transplant that Stubblefield would receive from Adrea Schneider. There have been 46 recorded face transplants in history. Katie's was the 40th—only the third to have taken place at the Cleveland Clinic in Ohio, which also undertook the first face transplant in the USA, on Connie Culp, in 2008. According to the Cleveland Clinic, it took 11 surgeons and staff from 15 specialties more than 31 hours to transplant Stubblefield's new face, including her jaw, teeth, facial nerves, muscles, and skin.
Molecular geneticist and genetic code breaker. He was born in Washington, DC, USA, on Nov 19, 1934, and died from complications of Parkinson's disease in Chestnut Hill, MA, USA, on Feb 2, 2020, aged 85 years.
Dale Fisher, Annelies Wilder-Smith
“Much of the global community is not yet ready for COVID-19 [coronavirus disease 2019]”.1 This is arguably one of the most resonating phrases in the Report of the WHO-China Joint Mission on Coronavirus Disease 2019,1 released publicly on Feb 28, 2020. Major transmission hotspots were brought under control in China, but subsequently others sprouted across the globe. Since late February, 2020, the daily number of new cases has been higher in other parts of the world. New major epicentres have established in South Korea, Japan, Iran, and Italy.
Andrea Saglietto, Fabrizio D’Ascenzo, Giuseppe Biondi Zoccai, Gaetano Maria De Ferrari
Severe acute respiratory syndrome coronavirus 2 is rapidly spreading worldwide,1 and WHO declared the coronavirus disease 2019 (COVID-19) outbreak a pandemic on March 11, 2020.2
Andrew I Ritchie, Aran Singanayagam
Mehta and colleagues1 postulate that hyperinflammation in coronavirus disease 2019 (COVID-19) could be a driver of severity that is amenable to therapeutic targeting since retro-spective data have shown that systemic inflammation is associated with adverse outcome. However, correlation does not equal causation, and it is equally plausible that increased virus burden (secondary to failure of the immune response to control infection) drives inflammation and consequent severity (as shown for other viruses2) rather than augmented inflammation being an inappropriate host response that requires correction.
Juan M Pericàs
Punitive social policy, encompassing the dismantling of the welfare state with the expansion of the penal state and its associated institutions, as nicely stated by Elias Nosrati and Michael Marmot in their Perspective,1 might indeed be considered an upstream social determinant of health. Nosrati and Marmot's analysis relates to the findings described by Navarro and colleagues,2 linking political ideology with policies aimed at reducing social inequalities such as welfare state and labour market policies.
Gorka Orive, Unax Lertxundi
Mass drug administration is the strategy recommended by WHO to control or eliminate many neglected tropical diseases that cause devastating consequences worldwide. This strategic approach, which has produced unquestionable benefits, consists of treating every person, infected or not, living in a defined geographical area at approximately the same time.1 In 2017, more than 1·7 billion treatments (mainly albendazole, mebendazole, ivermectin, azithromycin, and praziquantel) were delivered to 1·04 billion individuals.
Genichi Sugihara, Nori Takei
Japan has achieved one of the most successful health-care systems in the world.1 Under the nation's insurance scheme, Japanese citizens have taken for granted that anyone can choose any health-care facility and receive the most advanced medical care across the nation. However, little attention has been paid to the fact that such a health system is supported by dedicated and self-sacrificing medical professionals. Such overloaded expectation is especially high in rural areas where the number of doctors remains low.
Renato D Lopes, Claudio Gimpelewicz, John J V McMurray
10 years after highlighting the health consequences for millions of people infected with Trypanosoma cruzi, a 2019 report from the Pan American Health Organization concluded that there has been little progress in the prevention and treatment of Chagas disease, a problem that now extends beyond Latin America.1
Fathiah Zakham, Olli Vapalahti, Hilal A Lashual
Yemen, known to many as the land of Sheba, and Manhattan of the desert, is now referred to only as one of the poorest countries on Earth. The name Yemen has become synonymous with cholera, famine, death, instability, and war. The war continues to erase the lives, history, and the future of Yemenis, and meaningful aid and peace have yet to reach Yemen.
Journal of Medical Virology, Accepted Article.
Northern European Conference on Travel Medicine (NECTM) 2020
Mødet udskudt på grund af COVID-19
3.06.2020 - 5.06.2020
ASM Microbe 2020
Aflyst på grund af COVID-19
18.06.2020 - 22.06.2020
Ph.d. forsvar ved Kristina Langholz Kristensen
International AIDS Conference (AIDS) 2020
6.07.2020 - 10.07.2020
International Liver Congress (ILC) 2020
27.08.2020 - 29.08.2020
COVID-19 retningslinje (2020)
National handlingsplan for antibiotika til mennesker (2017)
Retningslinjer til sundhedsprofessionelle vedr. håndtering af infektion med zikavirus (2019)
Antiviral behandling af hiv smittede personer (2019)
Ratio, rate, or risk?
28.05.2020The Lancet Infectious Diseases
Reducing transmission of SARS-CoV-2
27.05.2020Science Express TOC RSS Feed
Device-Associated Menstrual Toxic Shock Syndrome [Reviews]
27.05.2020CMR Current Issue
Taenia solium Cysticercosis and Its Impact in Neurological Disease [Reviews]
27.05.2020CMR Current Issue
Evaluation of World Health Organization–Recommended Hand Hygiene Formulations
27.05.2020Emerging Infectious Diseases Journal
Hvorfor anbefaler Professor Jens Lundgren artiklen"Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV."?
Hvad tænker Professor Troels Lillebæk om"The global prevalence of latent tuberculosis: a systematic review and meta-analysis."?
Hvad mener Professor Lars Østergaard om artiklen"Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial."?
Hvorfor synes Professor Thomas Benfield, at du bør læse"Oral versus Intravenous Antibiotics for Bone and Joint Infection."?
Hvorfor synes Professor Niels Obel, at du bør læse"Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis."?
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