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Eric J. Rubin, Lindsey R. Baden, Stephen Morrissey
New England Journal of Medicine, 14.09.2022
Tilføjet 15.09.2022
New England Journal of Medicine, 14.09.2022
Tilføjet 15.09.2022
New England Journal of Medicine, Volume 387, Issue 11, Page 1050-1051, September 2022.
Læs mere Tjek på PubMedAsma Khalil, Athina Samara, Pat O'Brien, Conrado Milani Coutinho, Geraldo Duarte, Silvana Maria Quintana, Shamez N Ladhani
Lancet Infectious Diseases, 15.09.2022
Tilføjet 15.09.2022
The monkeypox case count in the current global outbreak surpassed 52 000 on Sept 1, 2022. Community transmission is affecting people considered to be at high risk of severe disease, including pregnant women and neonates, albeit in small numbers so far. As of Sept 2, 2022, ten cases of monkeypox in pregnant women have been reported worldwide, mostly via local news media rather than medical or public health publications, with the first case reported in the USA on July 23, 2022.1 Based on available information, vertical transmission did not occur; the neonate received prophylactic vaccinia immunoglobulin and did not develop monkeypox disease.
Læs mere Tjek på PubMedLiangxia Ning, Bin Wang
PLoS One Infectious Diseases, 14.09.2022
Tilføjet 14.09.2022
by Liangxia Ning, Bin Wang
Background Neurofilament light chain (NfL) in cerebrospinal fluid (CSF) is a biomarker of multiple sclerosis (MS). However, CSF sampling is invasive and has limited the clinical application. With the development of highly sensitive single-molecule assay, the accurate quantification of the very low NfL levels in blood become feasible. As evidence being accumulated, we performed a meta-analysis to evaluate the diagnostic and predictive value of blood NfL in MS patients. Methods We performed literature search on PubMed, EMBASE, Web of Science and Cochrane Library from inception to May 31, 2022. The blood NfL differences between MS vs. controls, MS vs. clinically isolated syndrome (CIS), progressive MS (PMS) vs. relapsing-remitting MS (RRMS), and MS in relapse vs. MS in remission were estimated by standard mean difference (SMD) and corresponding 95% confidence interval (CI). Pooled hazard ratio (HR) and 95%CI were calculated to predict time to reach Expanded Disability Status Scale (EDSS) score≥4.0 and to relapse. Results A total of 28 studies comprising 6545 MS patients and 2477 controls were eligible for meta-analysis of diagnosis value, and 5 studies with 4444 patients were synthesized in analysis of predictive value. Blood NfL levels were significantly higher in MS patients vs. age-matched controls (SMD = 0.64, 95%CI 0.44–0.85, p<0.001), vs. non-matched controls (SMD = 0.76, 95%CI 0.56–0.96, p<0.001) and vs. CIS patients (SMD = 0.30, 95%CI 0.18–0.42, p<0.001), in PMS vs. RRMS (SMD = 0.56, 95%CI 0.27–0.85, p<0.001), and in relapsed patients vs. remitted patients (SMD = 0.54, 95%CI 0.16–0.92, P = 0.005). Patients with high blood NfL levels had shorter time to reach EDSS score≥4.0 (HR = 2.36, 95%CI 1.32–4.21, P = 0.004) but similar time to relapse (HR = 1.32, 95%CI 0.90–1.93, P = 0.155) compared to those with low NfL levels. Conclusion As far as we know, this is the first meta-analysis evaluating the diagnosis and predictive value of blood NfL in MS. The present study indicates blood NfL may be a useful biomarker in diagnosing MS, distinguishing MS subtypes and predicting disease worsening in the future.
Læs mere Tjek på PubMedQing Hong, Hongmin Sun, Meng Chen, Shaoping Zhang, Qingsong Yu
PLoS One Infectious Diseases, 14.09.2022
Tilføjet 14.09.2022
by Qing Hong, Hongmin Sun, Meng Chen, Shaoping Zhang, Qingsong Yu
The objective of this study was to investigate the treatment effects of non-thermal atmospheric gas plasmas (NTAP) on destruction and the recovery (or re-colonization) of Porphyromonas gingivalis (P. gingivalis) in biofilms. P. gingivalis is a well-known keystone periodontal pathogen strongly associated with periodontal diseases, especially periodontitis. P. gingivalis biofilms were formed on stainless steel coupons and treated for 1, 2, and 5 minutes by NTAP of pure argon gas and argon+oxygen gas mixture. MTT assay, colony forming unit (CFU) counting assay and confocal laser scanning microscopy (CLSM) were used to assess the destruction efficiency. In addition, the plasma treated biofilms were re-cultured in the medium supplemented with antibiotics and oxidative stress sources to determine the synergy of the NTAP with other antimicrobial agents. The results showed the plasma treatment could result in 2.7 log unit reduction in bacterial load. The recovered biofilm CFU with NTAP treatment combined with sub minimal inhibition concentration of amoxicillin was 0.33 log units less than the biofilm treated with amoxicillin alone. The recovered biofilm CFU in NTAP groups was about 2.0 log units less than that in the untreated controls under H2O2 treatment. There was approximately 1.0 log unit reduction of biofilm CFU in plasma treated biofilm compared with untreated control under paraquat treatment. The plasma treated biofilms exhibited less resistance to amoxicillin and greater susceptibility to hydrogen peroxide (H2O2) and paraquat, suggesting that NTAP may enhance biofilm susceptibility to host defense. These in vitro findings suggested that NTAP could be a novel and effective treatment method of oral biofilms that cause periodontal diseases.
Læs mere Tjek på PubMedPaul Kwok-ming Poon, Ngai-sze Wong, Wai-shing Leung, Bonnie Chun-kwan Wong, Tsz-shan Kwong, Tsz-ho Kwan, Grace Chung-yan Lui, Owen Tak-yin Tsang, Man-po Lee, Ka-hing Wong, Shui-shan Lee
PLoS One Infectious Diseases, 14.09.2022
Tilføjet 14.09.2022
by Paul Kwok-ming Poon, Ngai-sze Wong, Wai-shing Leung, Bonnie Chun-kwan Wong, Tsz-shan Kwong, Tsz-ho Kwan, Grace Chung-yan Lui, Owen Tak-yin Tsang, Man-po Lee, Ka-hing Wong, Shui-shan Lee
Objectives To assess impacts of early detection and prompt antiretroviral therapy (ART) on the latest epidemiologic situation to inform intervention strategy. Methods We analysed data from two clinical cohorts in Hong Kong where sexual transmission accounted for the majority of HIV infections. The two cohorts comprised patients newly diagnosed in 2007–2008 and 2016–2018 respectively. Secular trend and differences between men who have sex with men (MSM) and heterosexual patients were examined. Predictors of late presentation (defined as CD4 ≤350 or AIDS-defining illness within 3 months of diagnosis) and prolonged interval between diagnosis and ART initiation were assessed by multivariable regressions. Results There were 1,136 newly diagnosed HIV patients with 644 in the first and 492 in the second cohort, a majority (91.7%) presented with sexually acquired infection. There were less MSM in the first than the second cohort (50.3%% vs 87.8%, χ2 = 117.05, p<0.001). The mean (SD) number of days between diagnosis and ART initiation decreased from 514.3 (516.1) to 61.8 (94.2) days across the two cohorts. Younger age, non-Chinese, outpatient-based service and lower CD4 count were predictors of faster ART initiation in the first but not in the second cohort. Interval between diagnosis and ART initiation became highly uniform among groups in the second cohort. Nearly 60% were classified as late presenters in both cohorts. Heterosexuals (aOR 1.58, 95% CI 1.13–2.19) had a higher risk of late presentation. Conclusions There was remarkable improvement in acceleration of ART initiation. Clinical implementation of accelerated ART recommendations has been effective for both MSM and heterosexuals. Late presentation was more marked among heterosexuals and remained a problem. The continued phenomenon of late presentation could offset the epidemiologic gains from accelerated ART initiation.
Læs mere Tjek på PubMedPatrick Ristau, Jan Wnent, Jan-Thorsten Gräsner, Matthias Fischer, Andreas Bohn, Berthold Bein, Sigrid Brenner, Stephan Seewald
PLoS One Infectious Diseases, 14.09.2022
Tilføjet 14.09.2022
by Patrick Ristau, Jan Wnent, Jan-Thorsten Gräsner, Matthias Fischer, Andreas Bohn, Berthold Bein, Sigrid Brenner, Stephan Seewald
Introduction The global COVID-19 pandemic effects people and the health system. Some international studies reported an increasing number of out-of-hospital cardiac arrest (OHCA). Comparable studies regarding the impact of COVID-19 on incidence and outcome of OHCA are not yet available for Germany. Materials and methods This epidemiological study from the German Resuscitation Registry (GRR) compared a non-pandemic period (01.03.2018–28.02.2019) and a pandemic period (01.03.2020–28.02.2021) regarding the pandemic-related impact on OHCA care. Results A total of 18,799 cases were included. The incidence of OHCA (non-pandemic 117.9 vs. pandemic period 128.0/100,000 inhabitants) and of OHCA with resuscitation attempted increased (66.0 vs. 69.1/100,000). OHCA occurred predominantly and more often at home (62.8% vs. 66.5%, p<0.001). The first ECG rhythm was less often shockable (22.2% vs. 20.3%, p = 0.03). Fewer cases of OHCA were observed (58.6% vs. 55.6% p = 0.02). Both the bystander resuscitation rate and the proportion of telephone guided CPR remained stable (38.6% vs. 39.8%, p = 0.23; and 22.3% vs. 22.5%, p = 0.77). EMS arrival times increased (08:39 min vs. 09:08 min, p<0.001). Fewer patients reached a return of spontaneous circulation (ROSC) (45.4% vs. 40.9%, p<0.001), were admitted to hospital (50.2% vs. 45.0%, p<0.001), and discharged alive (13.9% vs. 10.2%, p<0.001). Discussion Survival after OHCA significantly decreased while the bystander resuscitation rate remained stable. However, longer EMS arrival times and fewer cases of witnessed OHCA may have contributed to poorer survival. Any change to EMS systems in the care of OHCA should be critically evaluated as it may mean a real loss of life—regardless of the pandemic situation.
Læs mere Tjek på PubMedPaula de Michelena, Ignacio Torres, Enric-Cuevas Ferrando, Beatriz Olea, Fernando González-Candelas, Gloria Sánchez, David Navarro
Clinical Microbiology and Infection, 14.09.2022
Tilføjet 14.09.2022
To compare SARS-CoV-2 RNA load in nasopharyngeal specimens from patients with breakthrough COVID-19 caused by the Delta or Omicron variants.
Læs mere Tjek på PubMedLetícia de Almeida, Alexandre L. N. da Silva, Tamara S. Rodrigues, Samuel Oliveira, Adriene Y. Ishimoto, Amanda A. Seribelli, Amanda Becerra, Warrison A. Andrade, Marco A. Ataide, Camila C. S. Caetano, Keyla S. G. de Sá, Natália Pelisson, Ronaldo B. Martins, Juliano de Paula Souza, Eurico Arruda, Sabrina S. Batah, Ricardo Castro, Fabiani G. Frantz, Fernando Q. Cunha, Thiago M. Cunha, Alexandre T. Fabro, Larissa D. Cunha, Paulo Louzada-Junior, Rene D. R. de Oliveira, Dario S. Zamboni
Science Advances, 14.09.2022
Tilføjet 14.09.2022
Thayne H. Dickey, Wai Kwan Tang, Brandi Butler, Tarik Ouahes, Sachy Orr-Gonzalez, Nichole D. Salinas, Lynn E. Lambert, Niraj H. Tolia
Science Advances, 14.09.2022
Tilføjet 14.09.2022
Yamato Sajiki, Satoru Konnai, Kei Watari, Tomohiro Okagawa, Akina Tanaka, Satoko Kawaji, Reiko Nagata, Naoya Maekawa, Yasuhiko Suzuki, Yukinari Kato, Shiro Murata, Yasuyuki Mori, Kazuhiko Ohashi aDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido Universitygrid.39158.36, Sapporo, Japan bDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido Universitygrid.39158.36, Sapporo, Japan cBacterial and Parasitic Disease Research Division, National Institute of Animal Health, Tsukuba, Japan dDivision of Bioresources, International Institute for Zoonosis Control, Hokkaido Universitygrid.39158.36, Sapporo, Japan eDepartment of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan fDepartment of Molecular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan, Sabine Ehrt
Infection and Immunity, 14.09.2022
Tilføjet 14.09.2022
Monica R. Cesinger, Oluwasegun I. Daramola, Lucy M. Kwiatkowski, Michelle L. Reniere aDepartment of Microbiology, University of Washington School of Medicinegrid.471394.c, Seattle, Washington, USA bDepartment of Biomedical Laboratory Science, University of Ibadan College of Medicine, Ibadan, Nigeria, Victor J. Torres
Infection and Immunity, 14.09.2022
Tilføjet 14.09.2022
Andrew C. Camire, Nathaniel S. O’Bier, Dhara T. Patel, Nicholas A. Cramer, Reinhard K. Straubinger, Edward B. Breitschwerdt, Rebecca A. Funk, Richard T. Marconi aDepartment of Microbiology and Immunology, Virginia Commonwealth University Medical Centergrid.417264.2, Richmond, Virginia, USA bInstitute of Infectious Diseases and Zoonoses, Department of Veterinary Sciences, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany cDepartment of Clinical Sciences, The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA dDepartment of Large Animal Clinical Sciences, VA-MD College of Veterinary Medicine, Blacksburg, Virginia, USA eDepartment of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, School of Dentistry, Virginia Commonwealth University, Richmond, Virginia, USA, Andreas J. Bäumler
Infection and Immunity, 14.09.2022
Tilføjet 14.09.2022
Yamamoto, K., Hosogaya, N., Inoue, T., Jounai, K., Tsuji, R., Fujiwara, D., Yanagihara, K., Izumikawa, K., Mukae, H.
BMJ Open, 14.09.2022
Tilføjet 14.09.2022
Introduction
The COVID-19 pandemic has been a major concern worldwide; however, easily accessible treatment options for patients with mild COVID-19 remain limited. Since the oral intake of Lactococcus lactis strain plasma (LC-Plasma) enhances both the innate and acquired immune systems through the activation of plasmacytoid dendritic cells (pDCs), we hypothesised that the oral intake of LC-Plasma could aid the relief or prevention of symptoms in patients with asymptomatic or mild COVID-19.
Methods and analysis
This is an exploratory, multicentre, double-blinded, randomised, placebo-controlled trial. This study was initiated in December 2021 and concludes in April 2023. The planned number of enrolled subjects is 100 (50 subjectsx2 groups); subject enrolment will be conducted until October 2022. Patients with asymptomatic or mild COVID-19 will be enrolled and randomly assigned in a 1:1 ratio to group A (oral intake of LC-Plasma-containing capsule, 200 mg/day, for 14 days) or group B (oral intake of placebo capsule, for 14 days). The primary endpoint is the change in subjective symptoms measured by the severity score. Secondary endpoints include SARS-CoV-2 viral loads, biomarkers for pDC activation, serum SARS-CoV-2-specific antibodies, serum cytokines, interferon and interferon-inducible antiviral effectors and the proportion of subjects with emergency room visits to medical institutions or who are hospitalised.
Ethics and dissemination
The study protocol was approved by the Clinical Research Review Board of Nagasaki University, in accordance with the Clinical Trials Act of Japan. The study will be conducted in accordance with the Declaration of Helsinki, the Clinical Trials Act, and other current legal regulations in Japan. Written informed consent will be obtained from all the participants. The results of this study will be reported in journal publications.
Trial registration number
Japan Registry of Clinical Trials (registration number: jRCTs071210097).
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Azia, I. N., Carelse, S., Nyembezi, A., Mukumbang, F. C.
BMJ Open, 14.09.2022
Tilføjet 14.09.2022
Introduction
There are presently over four million people living with HIV (PLHIV) in the South African national antiretroviral therapy (ART) programme. However, some ART programmes are battling poor ART adherence emanating from patient-related factors, including their religious beliefs. In this paper, we outline a study protocol to understand the adherence behaviours of Pentecostal Christians living with HIV to ART and to develop guidelines that can be used to strengthen ART adherence.
Methods and analysis
We propose an exploratory multimethod research design. In phase 1, a scoping review will be conducted. The data captured in this phase will be put into charting forms, analysed qualitatively, and then collated and summarised to hypothesise the relationship between religious beliefs and ART adherence. In phase 2, an explanatory qualitative approach will be used. Semistructured interviews will be conducted with purposefully selected religious leaders, Pentecostal Christians living with HIV who are not adhering to ART and healthcare workers delivering ART at selected healthcare facilities in the Milnerton subhealth district. The qualitative data obtained in this phase will be transcribed verbatim and analysed thematically using the ATLAS.ti V.8 software program towards strengthening the hypothesised relationship between religious beliefs and ART adherence. In phase 3, intervention mapping and nominal group techniques will be applied with purposefully selected stakeholders to develop guidelines to strengthen ART adherence among PLHIV.
Ethics and dissemination
Phase 1 of the study will not require ethics approval. Ethics approval for phases 2 and 3 has been received from the University of the Western Cape Biomedical Research and Ethics Committee and the Western Cape Department of Health. Informed consent forms will be obtained from all participants at the different phases of the study. The study findings will be disseminated through publications in scientific journals, presentations at conferences and workshops aimed at improving ART adherence.
Læs mere Tjek på PubMed
Patterson, B. E., Donaldson, A., Cowan, S. M., King, M. G., Barton, C. G., McPhail, S. M., Hagglund, M., White, N. M., Lannin, N. A., Ackerman, I. N., Dowsey, M. M., Hemming, K., Makdissi, M., Culvenor, A. G., Mosler, A. B., Bruder, A. M., Choong, J., Livingstone, N., Elliott, R. K., Nikolic, A., Fitzpatrick, J., Crain, J., Haberfield, M. J., Roughead, E. A., Birch, E., Lampard, S. J., Bonello, C., Chilman, K. L., Crossley, K. M.
BMJ Open, 14.09.2022
Tilføjet 14.09.2022
Introduction
Due to the increase in participation and risk of anterior cruciate ligament (ACL) injuries and concussion in women’s Australian Football, an injury prevention programme (Prep-to-Play) was codesigned with consumers (eg, coaches, players) and stakeholders (eg, the Australian Football League). The impact of supported and unsupported interventions on the use of Prep-to-Play (primary aim) and injury rates (secondary aim) will be evaluated in women and girls playing community Australian Football.
Methods and analysis
This stepped-wedge, cluster randomised controlled trial will include ≥140 teams from U16, U18 or senior women’s competitions. All 10 geographically separated clusters (each containing ≥14 teams) will start in the control (unsupported) phase and be randomised to one of five dates (or ‘wedges’) during the 2021 or 2022 season to sequentially transition to the intervention (supported Prep-to-Play), until all teams receive the intervention. Prep-to-Play includes four elements: a neuromuscular training warm-up, contact-focussed football skills (eg, tackling), strength exercises and education (eg, technique cues). When transitioning to supported interventions, study physiotherapists will deliver a workshop to coaches and player leaders on how to use Prep-to-Play, attend team training at least two times and provide ongoing support. In the unsupported phase, team will continue usual routines and may freely access available Prep-to-Play resources online (eg, posters and videos about the four elements), but without additional face-to-face support. Outcomes will be evaluated throughout the 2021 and 2022 seasons (~14 weeks per season). Primary outcome: use of Prep-to-Play will be reported via a team designate (weekly) and an independent observer (five visits over the two seasons) and defined as the team completing 75% of the programme, two-thirds (67%) of the time. Secondary outcomes: injuries will be reported by the team sports trainer and/or players. Injury definition: any injury occurring during a football match or training that results in: (1) being unable to return to the field of play for that match or (2) missing ≥ one match. Outcomes in the supported and unsupported phases will be compared using a generalised linear mixed model adjusting for clustering and time. Due to the type III hybrid implementation-effectiveness design, the study is powered to detect a improvement in use of Prep-to-Play and a reduction in ACL injuries.
Ethics and dissemination
La Trobe University Ethics Committee (HREC 20488) approved. Coaches provided informed consent to receive the supported intervention and players provided consent to be contacted if they sustained a head or knee injury. Results will be disseminated through partner organisations, peer-reviewed publications and scientific conferences.
Trial registration number
NCT04856241.
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Werter, D. E., Kazemier, B. M., van Leeuwen, E., de Rotte, M. C. F. J., Kuil, S. D., Pajkrt, E., Schneeberger, C.
BMJ Open, 14.09.2022
Tilføjet 14.09.2022
Introduction
Symptoms of urinary tract infections in pregnant women are often less specific, in contrast to non-pregnant women where typical clinical symptoms of a urinary tract infection are sufficient to diagnose urinary tract infections. Moreover, symptoms of a urinary tract infection can mimic pregnancy-related symptoms, or symptoms of a threatened preterm birth, such as contractions. In order to diagnose or rule out a urinary tract infection, additional diagnostic testing is required.
The diagnostic accuracy of urine dipstick analysis and urine sediment in the diagnosis of urinary tract infections in pregnant women has not been ascertained nor validated.
Methods and analysis
In this single-centre prospective cohort study, pregnant women (≥16 years old) with a suspected urinary tract infection will be included. The women will be asked to complete a short questionnaire regarding complaints, risk factors for urinary tract infections and baseline characteristics. Their urine will be tested with a urine dipstick, urine sediment and urine culture. The different sensitivities and specificities per test will be assessed. Our aim is to evaluate and compare the diagnostic accuracy of urine dipstick analysis and urine sediment in comparison with urine culture (reference test) in pregnant women. In addition, we will compare these tests to a predefined ‘true urinary tract infection’, to distinguish between a urinary tract infection and asymptomatic bacteriuria.
Ethics and dissemination
Approval was requested from the Medical Ethics Review Committee of the Academic Medical Centre; an official approval of this study by the committee was not required. The outcomes of this study will be published in a peer-reviewed journal.
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Filbay, S., Bennell, K. L., Morello, R., Smith, L., Hinman, R. S., Lawford, B. J.
BMJ Open, 14.09.2022
Tilføjet 14.09.2022
Objectives
In people with a disability, or their caregivers, who reported suboptimal experiences, the objectives were to explore: (1) challenges with telehealth-delivered allied health services during the COVID-19 pandemic and (2) suggestions to improve such services.
Design
Qualitative study based on an interpretivist paradigm and a phenomenological approach.
Setting
Participants who accessed allied healthcare via telehealth during the pandemic.
Participants
Data saturation was achieved after 12 interviews. The sample comprised three people with permanent or significant disabilities, and nine carers/partners/family members of people with permanent or significant disabilities, who were funded by the Australian National Disability Insurance Scheme and had suboptimal experiences with telehealth. Semistructured one-on-one interviews explored experiences with telehealth and suggestions on how such services could be improved. An inductive thematic analysis was performed.
Results
Six themes relating to the first study objective (challenges with telehealth) were developed: (1) evoked behavioural issues in children; (2) reliant on caregiver facilitation; (3) inhibits clinician feedback; (4) difficulty building rapport and trust; (5) lack of access to resources and (6) children disengaged/distracted. Five themes relating to the second study objective (suggestions to improve telehealth services) were developed: (1) establish expectations; (2) increase exposure to telehealth; (3) assess suitability of specific services; (4) access to support workers and (5) prepare for telehealth sessions.
Conclusions
Some people with permanent and significant disabilities who accessed allied healthcare via telehealth during the pandemic experienced challenges, particularly children. These unique barriers to telehealth need customised solutions so that people with disabilities are not left behind when telehealth services become more mainstream. Increasing experience with telehealth, setting expectations before consultations, supplying resources for therapy and assessing the suitability of clients for telehealth may help overcome some of the challenges experienced.
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Zhong, Y., Zhao, H., Lee, T.-Y., Yu, T., Liu, M. F., Ji, J.
BMJ Open, 14.09.2022
Tilføjet 14.09.2022
Objectives
This study aimed to examine COVID-19 patients’ experiences in a Fangcang shelter hospital in China, to provide insights into the effectiveness of this centralised isolation strategy as a novel solution to patient management during emerging infectious disease outbreaks.
Design
This study adopted a qualitative descriptive design. Data were collected by individual semistructured interviews and analysed using thematic analysis.
Setting
This study was undertaken in 1 of the 16 Fangcang shelter hospitals in Wuhan, China between 28 February 2020 and 7 March 2020. Fangcang shelter hospitals were temporary healthcare facilities intended for large-scale centralised isolation, treatment and disease monitoring of mild-to-moderate COVID-19 cases. These hospitals were an essential component of China’s response to the first wave of the COVID-19 pandemic.
Participants
A total of 27 COVID-19 patients were recruited by purposive sampling. Eligible participants were (1) COVID-19 patients; (2) above 18 years of age and (3) able to communicate effectively. Exclusion criteria were (1) being clinically or emotionally unstable and (2) experiencing communication difficulties.
Results
Three themes and nine subthemes were identified. First, COVID-19 patients experienced a range of psychological reactions during hospitalisation, including fear, uncertainty, helplessness and concerns. Second, there were positive and negative experiences associated with communal living. While COVID-19 patients’ evaluation of essential services in the hospital was overall positive, privacy and hygiene issues were highlighted as stressors during their hospital stay. Third, positive peer support and a trusting patient–healthcare professional relationship served as a birthplace for resilience, trust and gratitude in COVID-19 patients.
Conclusions
Our findings suggest that, while sacrificing privacy, centralised isolation has the potential to mitigate negative psychological impacts of social isolation in COVID-19 patients by promoting meaningful peer connections, companionship and support within the shared living space. To our knowledge, this is the first study bringing patients’ perspectives into healthcare service appraisal in emergency shelter hospitals.
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Dongxu Sun, Ruslan Tsivkovski, Joe Pogliano, Hannah Tsunemoto, Kirk Nelson, Debora Rubio-Aparicio, Olga Lomovskaya aQpex Biopharma, Inc., San Diego, California, USA bLinnaeus Biosciences, Inc., San Diego, California, USA cUniversity of California, San Diegogrid.266100.3, San Diego, California, USA
Antimicrobial Agents And Chemotherapy, 14.09.2022
Tilføjet 14.09.2022
Abiu Sempere, Belén Viñado, Ibai Los-Arcos, David Campany, Nieves Larrosa, Nuria Fernández-Hidalgo, Dolors Rodríguez-Pardo, Juan José González-López, Xavier Nuvials, Benito Almirante, Laura Escolà-Vergé aInfectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain bDepartment of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain cMicrobiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain dSpanish Network for the Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, Madrid, Spain ePharmacy Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain fCIBERINFEC, ISCIII—CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain gCritical Care Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain hSepsis Organ Dysfunction and Resuscitation (SODIR) Research Group, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Antimicrobial Agents And Chemotherapy, 14.09.2022
Tilføjet 14.09.2022
Carolyn Chu, Daniele Armenia, Charles Walworth, Maria M. Santoro, Robert W. Shafer aDepartment of Family and Community Medicine, University of California San Francisco, San Francisco, California, USA bUniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy cLabCorp-Monogram Biosciences, South San Francisco, California, USA dDepartment of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy eDivision of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California, USA
Clinical Microbiology Reviews, 14.09.2022
Tilføjet 14.09.2022
Millet, Guillaume Y.; Kennouche, Djahid; Foschia, Clément; Brownstein, Callum G.; Gondin, Julien; Lapole, Thomas; Rimaud, Diana; Royer, Nicolas; Thiery, Guillaume; Gauthier, Vincent; Oujamaa, Lydia; Sorg, Marine; Vergès, Samuel; Doutreleau, Stéphane; Marillier, Mathieu; Prudent, Mélanie; Bitker, Laurent; Féasson, Léonard; Gergelé, Laurent; Stauffer, Emeric; Guichon, Céline; Morel, Jérôme
Critical Care Medicine, 26.10.2022
Tilføjet 14.09.2022
Objectives:
The aim of the present study was to investigate the level of cardiorespiratory fitness and neuromuscular function of ICU survivors after COVID-19 and to examine whether these outcomes are related to ICU stay/mechanical ventilation duration.
Design:
Prospective nonrandomized study.
Setting:
Patients hospitalized in ICU for COVID-19 infection.
Patients:
Sixty patients hospitalized in ICU (mean duration: 31.9 ± 18.2 d) were recruited 4–8 weeks post discharge from ICU.
Interventions:
None.
Measurements and Main Results:
Patients visited the laboratory on two separate occasions. The first visit was dedicated to quality of life questionnaire, cardiopulmonary exercise testing, whereas measurements of the knee extensors neuromuscular function were performed in the second visit. Maximal oxygen uptake (Vo2max) was 18.3 ± 4.5 mL·min–1·kg-1, representing 49% ± 12% of predicted value, and was significantly correlated with ICU stay/mechanical ventilation (MV) duration (R = –0.337 to –0.446; p < 0.01 to 0.001), as were maximal voluntary contraction and electrically evoked peak twitch. Vo2max (either predicted or in mL· min–1·kg-1) was also significantly correlated with key indices of pulmonary function such as predicted forced vital capacity or predicted forced expiratory volume in 1 second (R = 0.430–0.465; p ≤ 0.001) and neuromuscular function. Both cardiorespiratory fitness and neuromuscular function were correlated with self-reported physical functioning and general health status.
Conclusions:
Vo2max was on average only slightly above the 18 mL·min–1·kg-1, that is, the cut-off value known to induce difficulty in performing daily tasks. Overall, although low physical capacities at admission in ICU COVID-19 patients cannot be ruled out to explain the association between Vo2max or neuromuscular function and ICU stay/MV duration, altered cardiorespiratory fitness and neuromuscular function observed in the present study may not be specific to COVID-19 disease but seem applicable to all ICU/MV patients of similar duration.
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 14.09.2022
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Journal Name: The American Journal of Tropical Medicine and HygieneVolume: 107Issue: 3Pages: 689-700
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American Journal of Tropical Medicine and Hygiene, 14.09.2022
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American Journal of Tropical Medicine and Hygiene, 14.09.2022
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American Journal of Tropical Medicine and Hygiene, 14.09.2022
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Journal Name: The American Journal of Tropical Medicine and HygieneVolume: 107Issue: 3Pages: 709-719
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American Journal of Tropical Medicine and Hygiene, 14.09.2022
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Journal Name: The American Journal of Tropical Medicine and HygieneVolume: 107Issue: 3Pages: 720-723
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American Journal of Tropical Medicine and Hygiene, 14.09.2022
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American Journal of Tropical Medicine and Hygiene, 14.09.2022
Tilføjet 14.09.2022
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