De nyeste tal fra Statens Serum Institut viser, at der blev fundet færre med klamydia i 2017 end i 2016, selv om flere blev testet. Men tallene skal tages med forbehold, mener forskerne.

Pifeltro contains doravirine, a new nonnucleoside reverse transcriptase inhibitor, and Delstrigo is a fixed-dose combination of doravirine, lamivudine, and tenofovir disoproxil fumarate.

What is the best choice of antibiotic therapy for uncomplicated appendicitis in children? Dr Lowenfels comments on a study published in Annals of Surgery.

The FDA has proposed a subscription-based drug payment model to encourage pharmaceutical companies to develop new antimicrobials, as part of a four-pronged plan to combat antibiotic resistance.

Den seneste opdatering fra ECDC, Det Europæiske Center for Sygdomsforebyggelse og –kontrol, viser en kraftig yderligere stigning og geografisk spredning af tilfælde af vestnilfeber i Central- og Sydeuropa i løbet af den seneste måned. Rejsende til de berørte områder bør beskytte sig imod myggestik og behandlende læger skal være opmærksomme på sygdommen hos hjemvendte rejsende.

Candida auris infections resistant to fluconazole (and sometimes to amphotericin) were identified in 20 hospitals and nursing homes, according to the CDC.

Lamprini Veneti, Katrine Borgen, Kaja Sverdrup Borge, Kostas Danis, Margrethe Greve-Isdahl, Kirsten Konsmo, Gro Njølstad, Svein Arne Nordbø, Kari Stidal Øystese, Rikard Rykkvin, Eli Sagvik and Øystein Rolandsen Riise

From 6 September 2015–May 2016, a large mumps outbreak occurred among vaccinated students in Norway. A case was defined as a person presenting with a clinical mumps infection, notified between 1 September 2015 and 30 June 2016. Confirmed cases had positive laboratory confirmation and probable cases had an epidemiological link; PCR-positive specimens were genotyped. A total of 232 cases were notified (230 confirmed) with median age of 23 years (range 4–81) and 61% were male. Of 68 (30%) confirmed cases that were genotyped, 66 were genotype G and associated with the outbreak. Cases that had received two doses of the measles-mumps-rubella (MMR) vaccine had reduced risk of hospitalisation (adjusted relative risk (aRR): 0.14; 95%CI: 0.03–0.57), mumps-related orchitis (aRR: 0.21; 95% CI: 0.08–0.55) and severe outcome (aRR: 0.25; 95% CI: 0.10–0.62) compared with those unvaccinated. A third dose of the vaccine was offered to approximately 1,300 fully vaccinated close contacts and subsequently reported cases decreased. This large outbreak, occurring among predominately vaccinated students, suggests the current genotype A vaccine offers suboptimal protection against mumps genotype G. We recommend maintaining high vaccination coverage and offering the vaccine to all unvaccinated individuals.

Forskere fra Bartholin Instituttet på Rigshospitalet har i samarbejde med Statens Serum Institut fundet en mulig sammenhæng mellem gluten, graviditet og type 1 diabetes hos barnet. Der er dog brug for flere studier for at bekræfte konklusionerne og undersøge de mekanismer, der ligger bagved, understreger forskerne.

Vabomere combines meropenem and vaborbactam for treatment of complicated UTIs and other infections; Xerava (eravacycline) is for complicated intra-abdominal infections.

Få to års uddannelse til felt-epidemiolog eller public health mikrobiolog i et andet europæisk land.

Yuval Dadon, Eric J. Haas, Ehud Kaliner, Emilia Anis, Shepherd Roee Singer, Yafit Atiya-Nasagi, Michal Cohen-Dar, Eva Avramovich, Roni King, Oded Sued, Tamir Goshen, Sharon Amit, Ian Miskin, Efrat Gino, Ruth Yishai, Rivka Sheffer, Itamar Grotto and Jacob Moran-Gilad

We report preliminary findings of a large outbreak of human leptospirosis with 36 confirmed/probable and 583 suspected cases from June–August 2018, linked to contaminated water bodies in Northern Israel. There was a travel-associated case in Germany; additional cases are being investigated in other countries. The presumed chain of transmission, implicating wild boar and cattle, raises multiple challenges for risk assessment, risk management and risk communication currently being addressed by a public health response team.

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Ebola -- DR CongoThe investigation team sent to Komanda [North Kivu] began the work of contact identification and vaccination this Mon 17 Sep 2018. Upon arrival, the team was faced with resistance from the population. After a sensitization session by the community leader, tensions eased slightly and several contacts volunteered. So far 25 contacts have already been registered.Vaccination-----------Since the beginning of vaccination on 8 Aug 2018, 9721 people have been vaccinated, including 3826 in…

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African Swine Fever -- RomaniaThe southern County of Dambovita has recorded its 1st African swine fever [ASF] outbreak, and authorities have summoned the Local Centre for Combating Disease, AGERPRES Dambovita DSVSA (Sanitary Veterinary and Food Safety Directorate) director Sandu Tolea said on Sun 16 Sep 2018.When asked about this outbreak, Tolea answered: "I cannot give you any further information since we are at a meeting of the Local Centre for Combating Disease."The authorities were initially alerted after a…

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African Swine Fever -- RomaniaInformation received on [and dated] 17 Sep 2018 from Dr Geronimo Raducu Branescu, President Secretary of State Chief Veterinary Officer, National Sanitary Veterinary and Food Safety, National Sanitary Veterinary and Food Safety Authority, Bucharest, RomaniaSummaryReport type: immediate notificationDate of start of the event: 17 Sep 2018Date of confirmation of the event: 17 Sep 2018Reason for notification: recurrence of a listed diseaseDtae of previous occurrence: 20 Nov…

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African Swine Fever -- BelgiumAccording to the Belgian Federal Agency for the Safety of the Food Chain (Afsca), 13 countries have now officially announced the suspension of Belgian pork imports, following the discovery of 10 dead wild boars infected with African swine fever [ASF] in [Luxembourg province of Wallonia].Afsca specifies that the trade restrictions vary with respect to different pork product imports, some only affecting gelatine products, while others target the exportation of living animals.The list of…

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Poisoning -- MalaysiaPolice in Malaysia are investigating a case of alcohol poisoning that killed at least 21 people, with dozens more hospitalized, most of them citizens of Asian nations, officials said on Wednesday [19 Sep 2018].Cheap, homemade liquor is popular among poor, migrant workers in Muslim-majority Malaysia, which has high taxes on alcohol.A total of 57 cases of methanol poisoning had been reported in Kuala Lumpur, the capital, and its surrounding state of Selangor, Health Minister Dzulkefly…

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Influenza -- BulgariaA primary outbreak of bird flu has been identified by the Bulgarian Food Safety Agency (BSAF) in the village of Trilistnik in Plovdiv. The disease was established in an industrial breeding establishment for laying hens and was confirmed by a laboratory test report, the agency said.For the control and eradication of the disease, NVS [National Veterinary Service] has implemented all measures in accordance with current legislation. Humane killing and destruction of all birds kept on the…

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Campylobacter -- United States_Campylobacter_ causes an estimated 1.3 million diarrheal illnesses in the USA annually (1). In August 2017, the Florida Department of Health notified CDC of 6 _Campylobacter jejuni_ infections linked to company A, a national pet store chain based in Ohio. CDC examined whole-genome sequencing (WGS) data and identified 6 isolates from company A puppies in Florida that were highly related to an isolate from a company A customer in Ohio. This information prompted a multistate investigation by…

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Classical Swine Fever -- JapanThe [classical] swine fever [CSF] virus recently detected at a pig farm in the city of Gifu is a type that had not been found before in the country, the National Agriculture and Food Research Organization has said.The virus type, seen in other parts of Asia and in Europe, was confirmed through genetic analysis, the institute said Friday [14 Sep 2018], adding that it is highly likely that the virus came from abroad.Also, on Friday [14 Sep 2018], the Gifu prefectural government said the…

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Classical Swine Fever -- JapanInformation received on [and dated] 18 Sep 2018 from Dr Norio Kumagai, Director, Chief Veterinary Officer, Animal Health Division, Food Safety and Consumer Affairs Bureau, Ministry of Agriculture, Forestry and Fisheries, Tokyo, JapanSummaryReport type: follow-up report no. 1Date of start of the event: 3 Sep 2018Date of confirmation of the event: 9 Sep 2018Report date: 18 Sep 2018Date submitted to OIE: 18 Sep 2018Reason for notification: recurrence of a listed diseaseDate of…

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Classical Swine Fever -- Japan1. The gene sequences of the virus were different from those that previously caused swine fever outbreaks in Japan, according to the Agriculture, Forestry and Fisheries Ministry.The report on genotype from National Institute of Animal Health (in Japanese, with figure) is available at [for an updated version, see comment]2. A total of 5 wild boars were found around the farm to be dead and positive for classical swine fever. (TBS News, 20 Sep 2018)For a map with the locations of the…

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Crimean-Congo Hemorrhagic Fever -- PakistanAuthorities at Jinnah Postgraduate Medical Centre (JPMC) have confirmed another patient with Congo-Crimean hemorrhagic fever (CCHF) has been admitted to their hospital. "[MA], a factory worker, was brought to JPMC emergency with symptoms similar to CCHF infection and today [Thu 20 Sep 2018] he was confirmed having the viral disease after lab results," Executive Director JPMC Dr. Seemin Jamali told The News on [Thu 20 Sep 2018]. She said the patient had been moved to an isolation ward in the…

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Eastern Equine Encephalitis -- CanadaThe Ontario Ministry of Agriculture, Food and Rural Affairs confirmed 2 cases of eastern equine encephalitis [EEE] from the Regional Municipality of Niagara on 12 Sep 2018. Both horses were unvaccinated and had no travel history. One horse is recovering from depression and ataxia with supportive treatment. The other horse was euthanized following the development of sudden and severe neurological signs. The total number of EEE cases for 2018 is 10.EEE is a mosquito-transmitted disease that…

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Eastern Equine Encephalitis -- United StatesHealth officials say a resident of western Michigan has been infected with eastern equine encephalitis [EEE virus].The Michigan Department of Health and Human Services and the Allegan County Health Department announced [Mon 17 Sep 2018] that the person was hospitalized in late August [2018].Eastern equine encephalitis is one of the most dangerous mosquito-borne diseases in the US. It can be fatal and often leaves survivors with brain damage.Southwestern Michigan has experienced…

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Ebola -- DR Congo- A joint investigation team was sent to the Komanda health zone, north of Beni city [North Kivu], after an Ebola confirmed case died at the Ebola treatment center in Beni. The purpose of the mission is to identify contacts and define vaccination belts.- To date, 4 038 431 travelers have been checked at the various entry points set up.Vaccination------------ Immunization activities continue in the 48 vaccination belts spread over the 7 affected health zones. A data consolidation and…

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Ebola -- DR Congo…

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Ebola -- DR CongoThe World Health Organization (WHO) said Fri [21 Sep 2018] that the latest Ebola outbreak in the Democratic Republic of the Congo (DRC) remains active, with the cities of Beni and Butembo becoming the new hotspots.Substantial progress has been made to limit the spread of the disease to new areas, and the situation at Mabalako Health Zone in Mangina, North Kivu province, is stabilizing, WHO said in a statement.In the meantime, response teams continue to enhance activities to mitigate…

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Epizootic Hemorrhagic Disease -- United StatesA disease affecting some mule deer in the Yavapai Hills community and surrounding areas near Prescott [Yavapai county] has been confirmed by the Arizona Game and Fish Department.After receiving reports in recent weeks from residents who observed deer that appeared to be lethargic, blind, walking in circles, and unaware of their surroundings, Game and Fish biologists collected tissue samples from 3 animals and sent them to a laboratory for testing, according to a news release.The…

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Epizootic Hemorrhagic Disease -- United States…

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Foot and Mouth -- Guinea-BissauInformation received on Wed 19 Sep 2018 from Dr Bernardo Cassama, Dr, Direccao Geral da Pecuaria, Ministerio da Agricultura, Floresta e Pecuaria, Bissau, Guinea-BissauSummaryReport type: immediate notificationDate of start of the event: 2 Aug 2018Date of confirmation of the event: 27 Aug 2018Report date: 19 Sep 2018Date submitted to OIE: 19 Sep 2018Reason for notification: recurrence of a listed diseaseDate of previous occurrence: 31 Mar 2017Manifestation of disease:…

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Tick-borne disease -- United StatesThe 1st case of Heartland virus, a tickborne illness, has been reported in Illinois, according to a press release from the Illinois Department of Public Health (IDPH). A Kankakee resident recently tested positive for Heartland virus. Reported cases of Heartland virus disease are relatively rare. Likely spread by the Lone Star tick, more than 30 cases of Heartland virus disease have been reported in the midwestern and southern USA.Heartland virus was first identified in 2009 when 2 Missouri…

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Other Animal Disease -- MalaysiaInformation received on [and dated] 14 Sep 2018 from Dr Quaza Nizamuddin Bin Hassan Nizam, Deputy Director General (Veterinary Health), Department of veterinary services, Division of livestock resources and technology development, Putrajaya, MalaysiaSummaryReport type: immediate notification (final report)Date of start of the event: 4 Jun 2018Date of confirmation of the event: 7 Jun 2018Report date: 14 Sep 2018Date submitted to OIE: 14 Sep 2018Date event resolved: 30 Jun…

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Leishmaniasis -- BrazilAbstract:BackgroundThe study presents estimates for the burden of visceral leishmaniasis (VL) and cutaneous and mucocutaneous leishmaniasis (CML) in Brazil and its 27 federated units using data from the Global Burden of Disease Study (GBD) 2016.MethodologyWe report the incidence, years of life lost (YLL), years lived with disability (YLD), and disability-adjusted life years (DALY) for leishmaniasis in Brazil from 1990 to 2016. The metrics are presented as age-standardized rates per…

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Leptospirosis -- Austria…

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Leptospirosis -- PhilippinesMost cases of leptospirosis in Iloilo province involve farmworkers, according to the Provincial Health Office [PHO]. They may have been infected because they waded in contaminated water in farms.The Provincial Health Office (PHO) recorded 88 leptospirosis cases with 9 deaths since January [2018], 283 percent higher than the cases recorded in the same period last year [2017]. There were 23 recorded leptospirosis cases from 1 Jan to 18 Aug 2017, PHO records showed.The 5 municipalities…

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MERS -- Saudi ArabiaNew Case No. 18 - 1749MERS in Riyadh city: 38-year-old male in Rumah city, Riyadh regionContact with camels: NoCase classification: Primary, community acquiredCurrent status: HospitalizedNew Case No. 18 - 1750MERS in Buraidah city: 62-year-old male in Buraidah city, Qaseem [Al Qasim] regionContact with camels: NoCase classification: Secondary, household contactCurrent status: HospitalizedNew Case No. 18 - 1751MERS in Riyadh city: 34-year-old male in Riyadh city,…

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Monkeypox -- United KingdomThe 2nd patient is a UK man of unknown age who returned to the country from a 22-day vacation in Nigeria on [4 Sep 2018] via a flight from Paris. He sought care at the Accident and Emergency Department at Blackpool Teaching Hospitals on the northwest coast on [6 Sep 2018] for fever, swollen lymph nodes, a scrotal lump, and an itchy maculopapular rash, which is a flat, typically red area covered with small, connected bumps.The man said the rash first appeared in Nigeria before his trip back…

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Psittacosis -- United StatesThe Virginia and Georgia departments of health are investigating a multistate outbreak of psittacosis occurring at 2 poultry slaughter plants owned by a single corporation. CDC and the U.S. Department of Agriculture (USDA) are assisting with the investigation.Recommendations---------------- Contact a healthcare professional if you have fever, cough, headache, or muscle aches after working at a poultry slaughter plant involved in the outbreak. Tell your healthcare professional that you…

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Other Animal Disease -- United KingdomA veterinary practice has warned animal lovers of a deadly virus suspected of killing a number of rabbits.Elwood, Briggs and Turner Vets in Kirton, near Boston, has issued warnings on its Facebook page after a number of pet rabbit deaths.The Facebook post states: We have, unfortunately, seen a few cases lately that we suspect were the newest strain of viral haemorrhagic disease, VHD2/RHDV2. This viral infection usually leads to the death of pet rabbits. We now have a vaccine available…

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Sheep/Goat Pox -- RussiaInformation received on [and dated] 18 Sep 2018 from Dr Nikolay Vlasov, Deputy Head of the Rosselkhoznadzor [Federal Service for Veterinary and Phytosanitary Surveillance], Ministry of Agriculture, Ministry of Agriculture, Moscow, RussiaSummaryReport type: immediate notificationDate of start of the event: 12 Sep 2018Date of confirmation of the event: 14 Sep 2018Reason for notification: recurrence of a listed diseaseDate of previous occurrence: 3 Dec 2010Manifestation of…

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Sheep/Goat Pox -- RussiaAn outbreak of smallpox was recorded in a private subsidiary farm located in the village of Kuznetsy, Aleksinsky district, Tula region.According to the press service of the Rosselkhoznadzor Administration in Moscow, the Moscow and Tula oblasts, the owner of a backyard holding contacted the Yasnogorsk Inter-District Veterinary Association on [Thu 13 Sep 2018] to report the disease in sheep. At the time of the outbreak, the farm housed 20 goats and sheep. Based on the results of laboratory…

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Tick-borne Encephalitis -- Switzerland1. Foppa IM. The basic reproductive number of tick-borne encephalitis virus. An empirical approach. J Math Biol. 2005; 51(6): 616-28; .2. Mansfield KL, Johnson N, Phipps LP, et al. Tick-borne encephalitis virus - a review of an emerging zoonosis. J Gen Virol. 2009; 90(Pt 8): 1781-94. doi: 10.1099/vir.0.011437-0; .3. Randolph SE, 2001. The shifting landscape of tick-borne zoonoses: tick-borne encephalitis and Lyme borreliosis in Europe. Philos Trans R Soc Lond B Biol Sci. 2001; 356(1411):…

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West Nile Virus -- Worldwide/UnknownHealth authorities say mosquito-borne viruses have killed 4 people in Romania this week, bringing the total deaths from West Nile virus to 21.The National Public Health Institute [Fri 14 Sep 2018] reported 30 new cases of people getting sick after being bitten by mosquitoes carrying the virus. It said all the deaths involved people with other health complications.The 1st deaths were recorded in August [2018] and the virus has made 200 people ill all over Romania. The health ministry…

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West Nile Virus -- CanadaHundreds of cases of the West Nile virus have been reported [worldwide] so far this year and 22 people have already died as a result of the mosquito-borne infection. In the most recent case, one person is reportedly dead due to West Nile virus (WNV) in Canada, blackburnnews.com wrote. This is the 1st death of the season attributed to the virus in Canada, the Windsor-Essex County Health Unit [in Ontario] said in a news release on [Fri 14 Sep 2018].It also warned that WNV continues to be a…

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West Nile Virus -- SloveniaInformation received on [and dated] 17 Sep 2018 from Dr Janez Posedi, Director General, Administration of the Republic of Slovenia for Food Safety, Veterinary Sector and Plant Protection (AFSVSPP), Ministry of Agriculture, Forestry and Food, Ljubljana, SloveniaSummaryReport type: immediate notificationDate of start of the event: 13 Sep 2018Date of confirmation of the event: 13 Sep 2018Report date: 17 Sep 2018Date submitted to OIE: 17 Sep 2018Reason for notification: 1st…

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Amoeba -- United KingdomAbstractBackground: _Acanthamoeba_ keratitis (AK) is a chronic debilitating corneal infection principally affecting contact lens (CL) users. Studies were designed to test claims that the UK incidence may have increased in 2012 to 2014 and to evaluate potential causes.Methods: Annualised incidence data were collected from January 1984 to December 2016. Case-control study subjects were recruited between 14 Apr 2011 and 5 Jun 2017. Reusable CL users with AK were recruited retrospectively…

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Cholera -- Saudi ArabiaOn 23 Aug 2018, the Algerian Ministry of Health (MoH) announced an outbreak of cholera in northern parts of the country, in and around the capital province Algiers. From 7 Aug 2018 to 6 Sep 2018, 217 cases with cholera-like symptoms have been hospitalized, 2 of the patients died (CFR: 0.9%). Cases have been reported from 7 provinces (wilayas). Of these, 83 have been confirmed as _Vibrio cholerae_ serogroup O1 Ogawa at the Institut Pasteur Algiers. More than half of the confirmed cases have…

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Cholera -- ZimbabweOn 6 Sep 2018, a cholera outbreak in Harare was declared by the Ministry of Health and Child Care (MoHCC) of Zimbabwe and notified to WHO on the same day. 25 patients were admitted to a hospital in Harare presenting with diarrhea and vomiting on 5 Sep 2018. The 1st case, a 25-year-old woman, presented to a hospital and died on 5 Sep 2018. A sample from the woman tested positive for _Vibrio cholerae_ serotype O1 Ogawa. All 25 patients had typical cholera symptoms including excessive vomiting…

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Cholera -- Chile1. Bhattacharya MK, Dutta D, Bhattacharya SK, et al. Association of disease approximating cholera caused by _Vibrio cholerae_ of serogroups other than O1 and O139. Epidemiol Infect. 1998; 120(1): 1-5; .2. Sharma C, Thungapathra M, Ghosh A, et al. Molecular analysis of non-O1, non-O139 _Vibrio cholerae_ associated with an unusual upsurge in the incidence of cholera-like disease in Calcutta, India. J Clin Microbiol. 1998; 36: 756-63; .3. Bidinost C, Saka HA, Aliendro O, et al. Virulence…

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Other Human Disease -- United States[On 18 Sep 2018], the FDA [Food and Drug Administration] a statement from Commissioner Scott Gottlieb on the prevalence of cyclosporiasis cases in the US this year [2018]. The US Centers for Disease Control and Prevention reported there have been 2173 cases this spring and summer as of [12 Sep 2018].The rise in cases, in part, can be attributed to new FDA testing methods applied in routine tests on "appropriate commodities." That includes cilantro, which along with basil, parsley, and…