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Eurosurveillance: Most Recent Articles, 15.08.2019
Tilføjet 16.08.2019 18:43
Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018
In October 2018, two Atelerix algirus hedgehogs were admitted to the Wildlife Rehabilitation Hospital in Mallorca (Balearic Islands, Spain) with signs of acute neurological disease. Necropsy detected immature, fully developed nematodes in the subarachnoid space of both hedgehogs, including a gravid female worm. DNA-based molecular tools confirmed the nematode as Angiostrongylus cantonensis, an important aetiological agent of eosinophilic meningitis in humans. So far this zoonotic parasite in has not been reported in western European wildlife.
Eurosurveillance: Most Recent Articles, 11.07.2019
Tilføjet 12.07.2019 08:09
Extraordinary increase in West Nile virus cases and first confirmed human Usutu virus infection in Hungary, 2018
During the 2018 WNV transmission season, similarly to other endemic areas in Europe, a large number of human West Nile virus (WNV) infections were reported in Hungary.
We summarise the epidemiological and laboratory findings of the 2018 transmission season and expand experiences in flavivirus differential diagnostics.
Every patient with clinical suspicion of acute WNV infection was in parallel tested for WNV, tick-borne encephalitis virus and Usutu virus (USUV) by serological methods. Sera, whole blood and urine samples were also tested for the presence of viral nucleic acid.
Until the end of December 2018, 215 locally acquired and 10 imported human WNV infections were notified in Hungary. All reported cases were symptomatic; most of them exhibited neurological symptoms. In a large proportion of tested individuals, whole blood was the most appropriate sample type for viral nucleic acid detection, but because whole blood samples were not always available, testing of urine samples also extended diagnostic possibilities. In addition, the first human USUV infection was confirmed in 2018 in a patient with aseptic meningitis. Serological cross-reactions with WNV in different serological assays were experienced, but subsequent molecular biological testing and sequence analysis identified Europe lineage 2 USUV infection.
Careful interpretation and simultaneous application of different laboratory methods are necessary to avoid misdiagnosis of human USUV cases. Expansion of the laboratory-confirmed case definition criteria for detection of viral RNA in any clinical specimens to include urine samples could increase diagnostic sensitivity.
Eurosurveillance: Most Recent Articles, 26.09.2019
Tilføjet 16.10.2019 14:57
Increased detection of enterovirus A71 infections, Germany, 2019
We report on the increased circulation of enterovirus A71 in Germany in 2019. Strains were mainly identified in hospitalised patients with suspected aseptic meningitis/encephalitis. Molecular analysis showed co-circulation of EV-A71 sub-genogroups C1 and C4, a signal for physicians and public health authorities to include/intensify EV diagnostic in patients showing signs of aseptic meningitis, encephalitis or acute flaccid paralysis/myelitis.
Eurosurveillance: Most Recent Articles, 16.05.2019
Tilføjet 19.05.2019 19:48
Lyme neuroborreliosis epidemiology in Sweden 2010 to 2014: clinical microbiology laboratories are a better data source than the hospital discharge diagnosis register
In a study from 2013 that prioritised communicable diseases for surveillance in Sweden, we identified Lyme borreliosis as one of the diseases with highest priority. In 2014, when the present study was designed, there were also plans to make neuroborreliosis notifiable within the European Union.
We compared possibilities of surveillance of neuroborreliosis in Sweden through two different sources: the hospital discharge register and reporting from the clinical microbiology laboratories.
We examined the validity of ICD-10 codes in the hospital discharge register by extracting personal identification numbers for all cases of neuroborreliosis, defined by a positive cerebrospinal fluid–serum anti-Borrelia antibody index, who were diagnosed at the largest clinical microbiology laboratory in Sweden during 2014. We conducted a retrospective observational study with a questionnaire sent to all clinical microbiology laboratories in Sweden requesting information on yearly number of cases, age group and sex for the period 2010 to 2014.
Among 150 neuroborreliosis cases, 67 (45%) had received the ICD-10 code A69.2 (Lyme borreliosis) in combination with G01.9 (meningitis in bacterial diseases classified elsewhere), the combination that the Swedish National Board of Health and Welfare recommends for neuroborreliosis. All 22 clinical laboratories replied to our questionnaire. Based on laboratory reporting, the annual incidence of neuroborreliosis in Sweden was 6.3 cases per 100,000 in 2014.
The hospital discharge register was unsuitable for surveillance of neuroborreliosis, whereas laboratory-based reporting was a feasible alternative. In 2018, the European Commission included Lyme neuroborreliosis on the list of diseases under epidemiological surveillance.
Morbidity and Mortality Weekly Report (MMWR), 8.11.2018
Tilføjet 10.11.2019 18:59
Notes from the Field: Cronobacter sakazakii Meningitis in a Full-Term Neonate Fed Exclusively with Breast Milk --- Indiana, 2018
In January 2018, the Indiana State Department of Health was notified of a case of Cronobacter sakazakii meningitis in an infant who had been fed exclusively maternal milk.
HealthMap Global Disease Alerts, 13.08.2019
Tilføjet 13.08.2019 08:54
PRO/AH/EDR> Arboviral meningitis - Bulgaria: RFI
HealthMap Global Disease Alerts, 5.08.2019
Tilføjet 05.08.2019 08:57
PRO/AH/EDR> West Nile virus (23): Europe (Greece)
HealthMap Global Disease Alerts, 23.05.2019
Tilføjet 23.05.2019 18:13
PRO/EDR> Amebic meningoencephalitis, primary - India: (KL) fatal
Amoeba -- India1. Sood A, Chauhan S, Chandel L, Jaryal SC. Prompt diagnosis and extraordinary survival from _Naegleria fowleri_ meningitis: A rare case report. Indian J Med Microbiol 2014; 32(2):193-6; .2. Jain R, Prabhakar S, Modi M, Bhatia R, Sehgal R. _Naegleria_ meningitis: a rare survival. Neurol India 2002; 50(4): 470-2; .There have been 5 well-documented survivors in North America: one in the US in 1978, one in Mexico in 2003, 2 additional survivors from the US in 2013, and one from the US in
Amebic meningoencephalitis, primary - India: (KL) fatal" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Finfmed.dk%2Fudbrud%3Frss_filter%3Dmeningitis%26setpoint%3D105447%23115921">
HealthMap Global Disease Alerts, 21.03.2019
Tilføjet 21.03.2019 18:32
PRO/EDR> Meningitis, meningococcal - Africa Mn belt: emergence of new sg post-mass vaccn.
HealthMap Global Disease Alerts, 26.07.2019
Tilføjet 26.07.2019 19:06
PRO/EDR> Meningitis, meningococcal - Australia: (WA) sg W
HealthMap Global Disease Alerts, 19.02.2019
Tilføjet 19.02.2019 03:13
PRO/EDR> Meningitis, meningococcal - Ireland: emergence of serogroups W & Y
HealthMap Global Disease Alerts, 17.03.2019
Tilføjet 18.03.2019 20:16
PRO/EDR> Meningitis, meningococcal - Niger: counterfeit vaccine
HealthMap Global Disease Alerts, 31.12.2018
Tilføjet 01.01.2019 00:21
PRO/EDR> Meningitis, meningococcal - Nigeria (04): fatal, serogroup C
HealthMap Global Disease Alerts, 19.02.2019
Tilføjet 20.02.2019 01:14
PRO/EDR> Meningitis, meningococcal - Nigeria: fatal, serogroup C, 2018-2019
HealthMap Global Disease Alerts, 25.08.2019
Tilføjet 26.08.2019 15:15
PRO/EDR> Meningitis, meningococcal - UK: non-group, cipro-resist, ex Saudi Arabia
HealthMap Global Disease Alerts, 23.04.2019
Tilføjet 23.04.2019 17:53
PRO/EDR> Meningitis, meningococcal vaccine, limited availability for Hajj, 2019 - India
Eurosurveillance: Most Recent Articles, 3.01.2019
Tilføjet 04.01.2019 07:45
Serogroup C Neisseria meningitidis disease epidemiology, seroprevalence, vaccine effectiveness and waning immunity, England, 1998/99 to 2015/16
In 1999, the United Kingdom (UK) was the first country to introduce meningococcal group C (MenC) conjugate vaccination. This vaccination programme has evolved with further understanding, new vaccines and changing disease epidemiology.
To characterise MenC disease and population protection against MenC disease in England.
Between 1998/99–2015/16, surveillance data from England for laboratory-confirmed MenC cases were collated; using the screening method, we updated vaccine effectiveness (VE) estimates. Typing data and genomes were obtained from the Meningitis Research Foundation Meningococcus Genome Library and PubMLST Neisseria database. Phylogenetic network analysis of MenC cc11 isolates was undertaken. We compared bactericidal antibody assay results using anonymised sera from 2014 to similar data from 1996–1999, 2000–2004 and 2009.
MenC cases fell from 883 in 1998/99 (1.81/100,000 population) to 42 cases (0.08/100,000 population) in 2015/16. Lower VE over time since vaccination was observed after infant immunisation (p = 0.009) and a single dose at 1–4 years (p = 0.03). After vaccination at 5–18 years, high VE was sustained for ≥ 8 years; 95.0% (95% CI: 76.0– 99.5%). Only 25% (75/299) children aged 1–14 years were seroprotected against MenC disease in 2014. Recent case isolates mostly represented two cc11 strains.
High quality surveillance has furthered understanding of MenC vaccines and improved schedules, maximising population benefit. The UK programme provides high direct and indirect protection despite low levels of seroprotection in some age groups. High-resolution characterisation supports ongoing surveillance of distinct MenC cc11 lineages.
Medscape Infectious Diseases Headlines, 8.08.2019
Tilføjet 09.08.2019 04:37
West Nile Virus Neuroinvasive Disease On the Rise
Healthcare providers should consider arboviral infections in patients with aseptic meningitis or encephalitis and perform appropriate diagnostic tests, the CDC cautions.