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Morbidity and Mortality Weekly Report (MMWR), 3.07.2019
Tilføjet 10.11.2019 18:59
Bacterial and Fungal Infections in Persons Who Inject Drugs --- Western New York, 2017
During 2014--2017, CDC Emerging Infections Program surveillance data reported that the occurrence of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections associated with injection drug use doubled among persons aged 18--49 years residing in Monroe County in western New York.
Eurosurveillance: Most Recent Articles, 11.04.2019
Tilføjet 19.04.2019 21:56
Changing epidemiology of meticillin-resistant Staphylococcus aureus in 42 hospitals in the Dutch–German border region, 2012 to 2016: results of the search-and-follow-policy
Meticillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections.
We describe MRSA colonisation/infection and bacteraemia rate trends in Dutch–German border region hospitals (NL–DE-BRH) in 2012–16.
All 42 NL–DE BRH (8 NL-BRH, 34 DE-BRH) within the cross-border network EurSafety Health-net provided surveillance data (on average ca 620,000 annual hospital admissions, of these 68.0% in Germany). Guidelines defining risk for MRSA colonisation/infection were reviewed. MRSA-related parameters and healthcare utilisation indicators were derived. Medians over the study period were compared between NL- and DE-BRH.
Measures for MRSA cases were similar in both countries, however defining patients at risk for MRSA differed. The rate of nasopharyngeal MRSA screening swabs was 14 times higher in DE-BRH than in NL-BRH (42.3 vs 3.0/100 inpatients; p
Eurosurveillance: Most Recent Articles, 28.03.2019
Tilføjet 29.03.2019 21:04
Clonal expansion of community-associated meticillin-resistant Staphylococcus aureus (MRSA) in people who inject drugs (PWID): prevalence, risk factors and molecular epidemiology, Bristol, United Kingdom, 2012 to 2017
Background: In 2015, Bristol (South West England) experienced a large increase in cases of meticillin-resistant Staphylococcus aureus (MRSA) infection in people who inject drugs (PWID).
Aim: We aimed to characterise and estimate the prevalence of MRSA colonisation among PWID in Bristol and test evidence of a clonal outbreak.
Methods: PWID recruited through an unlinked-anonymous community survey during 2016 completed behavioural questionnaires and were screened for MRSA. Univariable logistic regression examined associations with MRSA colonisation. Whole-genome sequencing used lineage-matched MRSA isolates, comparing PWID (screening and retrospective bacteraemia samples from 2012-2017) with non-PWID (Bristol screening) in Bristol and national reference laboratory database samples.
Results: The MRSA colonisation prevalence was 8.7% (13/149) and was associated with frequently injecting in public places (odds ratio (OR): 5.5; 95% confidence interval (CI):1.34–22.70), recent healthcare contact (OR: 4.3; 95% CI: 1.34–13.80) and injecting in groups of three or more (OR: 15.8; 95% CI: 2.51–99.28). People reporting any one of: injecting in public places, injection site skin and soft tissue infection or hospital contact accounted for 12/13 MRSA positive cases (sensitivity 92.3%; specificity 51.5%). Phylogenetic analysis identified a dominant clade associated with infection and colonisation among PWID in Bristol belonging to ST5-SCCmecIVg.
Conclusions: MRSA colonisation in Bristol PWID is substantially elevated compared with general population estimates and there is evidence of clonal expansion, community-based transmission and increased infection risk related to the colonising strain. Targeted interventions, including community screening and suppression therapy, education and basic infection control are needed to reduce MRSA infections in PWID.
Medscape Infectious Diseases Headlines, 5.12.2019
Tilføjet 06.12.2019 01:34
FDA Clears Faster Diagnostic Test for MRSA
The cobas vivoDx MRSA test uses a new bacteriophage technology based on bioluminescence to detect MRSA from nasal swab samples in 5 hours or less compared with 24 to 48 hours for conventional cultures.
Eurosurveillance: Most Recent Articles, 17.10.2019
Tilføjet 18.10.2019 07:13
International travel as source of a hospital outbreak with an unusual meticillin-resistant Staphylococcus aureus clonal complex 398, Denmark, 2016
In May 2016, an unusual outbreak with the Panton-Valentine leukocidin-positive human variant of meticillin-resistant Staphylococcus aureus (MRSA) clonal complex 398 occurred among mothers and infants in the maternity unit of a Danish hospital. MRSA sharing genotypic and phenotypic characteristics was confirmed in 36 cases, including 26 patients, nine household members and a healthcare worker (HCW) who had contact with all the patients. The national MRSA database contained 37 seemingly unlinked MRSA cases whose isolates shared the same genotypic and phenotypic characteristics as the outbreak strain. Whole genome sequencing showed that three of these isolates clustered together with the 36 outbreak isolates, suggesting spread outside the hospital. The HCW and 21 of 37 cases from the national MRSA database had links to south-eastern Asia, where the outbreak strain is endemic. These findings suggest that the HCW acquired the outbreak strain while travelling in south-eastern Asia and then introduced it into the hospital; from there, it spread within the patients’ households and into the community. Screening of travellers returning from countries with high levels of MRSA could be an important intervention to prevent spread of these bacteria into hospitals via patients or HCWs.
Medscape Infectious Diseases Headlines, 14.02.2019
Tilføjet 15.02.2019 06:44
MRSA Decolonization Reduces Postdischarge Infection Risk
A new study finds that decolonization of MRSA carriers following discharge from the hospital can reduce the risk of developing an infection in the subsequent year.
HealthMap Global Disease Alerts, 28.02.2019
Tilføjet 01.03.2019 05:04
PRO/AH/EDR> Antibiotic Resistance - Europe: (salm, campyl, E. coli, MRSA) ECDC, EFSA, 2017
MRSA, Antimicrobial resistance -- Worldwide/UnknownAn analysis of human isolates from 19 EU nations, plus Iceland and Norway, found that 57.7% of _Campylobacter jejuni_ -- the commonest _Campylobacter_ species identified -- were resistant to ciprofloxacin, and 45.4% were resistant to tetracyclines. Resistance to erythromycin was low (2%).In Cyprus, Portugal, Spain, Lithuania, and Estonia, resistance to ciprofloxacin was from 80% to 96.5%. In addition, 8 of 17 countries saw a statistically significant increase in ciprofloxacin resistance
Antibiotic Resistance - Europe: (salm, campyl, E. coli, MRSA) ECDC, EFSA, 2017" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Finfmed.dk%2Fudbrud%3Frss_filter%3Dmrsa%26setpoint%3D105791%23110852">
HealthMap Global Disease Alerts, 4.01.2019
Tilføjet 05.01.2019 01:47
PRO/ALL> New in IJID (01): January 2019
Monkeypox, Hepatitis B, Other Human Disease, Tuberculosis, Zika virus, HIV/AIDS, Rubella, Measles, MRSA, Crimean-Congo Hemorrhagic Fever, Chagas -- NigeriaEditorials and perspectivesMonkeypox -- Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication eraEskild Petersen, Ibrahim Abubakar, Chikwe Ihekweazu, David Heymann, Francine Ntoumi, Lucille Blumberg, Danny Asogun, Victor Mukonka, Swaib Abubaker Lule, Matthew Bates, Isobella Honeyborne, Sayoki Mfinanga, Peter Mwaba, Osman Dar, Francesco Vairo, Maowia Mukhtar, Richard Kock, Timothy D. McHugh, Giuseppe Ippolito,
New in IJID (01): January 2019" som kan hentes fra Dansk Selskab for Infektionsmedicin's hjemmeside via linket vist nedenfor:%0D%0A%0D%0Ahttp%3A%2F%2Finfmed.dk%2Fudbrud%3Frss_filter%3Dmrsa%26setpoint%3D105791%23105791">
Eurosurveillance: Most Recent Articles, 24.01.2019
Tilføjet 25.01.2019 08:43
Prospective genomic surveillance of methicillin-resistant Staphylococcus aureus (MRSA) associated with bloodstream infection, England, 1 October 2012 to 30 September 2013
Mandatory reporting of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) has occurred in England for over 15years. Epidemiological information is recorded, but routine collection of isolates for characterisation has not been routinely undertaken. Ongoing developments in whole-genome sequencing (WGS) have demonstrated its value in outbreak investigations and for determining the spread of antimicrobial resistance and bacterial population structure. Benefits of adding genomics to routine epidemiological MRSA surveillance are unknown.
To determine feasibility and potential utility of adding genomics to epidemiological surveillance of MRSA.
We conducted an epidemiological and genomic survey of MRSA BSI in England over a 1-year period (1 October 2012–30 September 2013).
During the study period, 903 cases of MRSA BSI were reported; 425 isolates were available for sequencing of which, 276 (65%) were clonal complex (CC) 22. Addition of 64 MRSA genomes from published outbreak investigations showed that the study genomes could provide context for outbreak isolates and supported cluster identification. Comparison to other MRSA genome collections demonstrated variation in clonal diversity achieved through different sampling strategies and identified potentially high-risk clones e.g. USA300 and local expansion of CC5 MRSA in South West England.
We demonstrate the potential utility of combined epidemiological and genomic MRSA BSI surveillance to determine the national population structure of MRSA, contextualise previous MRSA outbreaks, and detect potentially high-risk lineages. These findings support the integration of epidemiological and genomic surveillance for MRSA BSI as a step towards a comprehensive surveillance programme in England.
Morbidity and Mortality Weekly Report (MMWR), 7.03.2019
Tilføjet 10.11.2019 18:59
Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections --- United States
Staphylococcus aureus is a major cause of community- and health care-associated infections, ranging from superficial skin and soft tissue infections (SSTI) to invasive infections, sepsis, and death. Methicillin-resistant S. aureus (MRSA) has long been recognized as a pathogen associated with health care settings; however, in the 1990s, community-associated MRSA infections, causing mostly SSTI, emerged in the United States.
Morbidity and Mortality Weekly Report (MMWR), 7.03.2019
Tilføjet 10.11.2019 18:59
Vital Signs: Trends in Staphylococcus aureus Infections in Veterans Affairs Medical Centers - United States, 2005-2017
Staphylococcus aureus is among the most common causes of health care-associated infections and accounts for significant morbidity and mortality. Beginning in 2005, in response to high rates of methicillin-resistant S. aureus (MRSA) infections, the U.S. Department of Veterans Affairs (VA) piloted an MRSA prevention program in 18 VA medical centers (VAMCs).