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47 ud af 47 tidsskrifter valgt, søgeord (covid) valgt, emner højest 180 dage gamle, sorteret efter nyeste først.
1288 emner vises.
Ranjeet S. Mahla
Journal of Medical Virology, 3.11.2023
Tilføjet 3.11.2023
Valerie Percival, Oskar T Thoms, Ben Oppenheim, Dane Rowlands, Carolyn Chisadza, Sara Fewer, Gavin Yamey, Amy C Alexander, Chloe L Allaham, Sara Causevic, François Daudelin, Siri Gloppen, Debarati Guha-Sapir, Maseh Hadaf, Samuel Henderson, Steven J Hoffman, Ana Langer, Toni Joe Lebbos, Luiz Leomil, Minna Lyytikäinen, Anju Malhotra, Paul Mkandawire, Holly A Norris, Ole Petter Ottersen, Jason Phillips, Sigrún Rawet, Alexa Salikova, Idil Shekh Mohamed, Ghazal Zazai, Tarja Halonen, Catherine Kyobutungi, Zulfiqar A Bhutta, Peter Friberg
Lancet, 3.11.2023
Tilføjet 3.11.2023
The multiple and overlapping crises faced by countries, regions, and the world appear unprecedented in their magnitude and complexity. Protracted conflicts continue and new ones emerge, fuelled by geopolitics and social, political, and economic pressures. The legacy of the COVID-19 pandemic, economic uncertainty, climatic events ranging from droughts to fires to cyclones, and rising food insecurity add to these pressures. These crises have exposed the inadequacy of national and global leadership and governance structures.
Læs mere Tjek på PubMedMariana M. S. Santos, Isabel J. Pereira, Nelson Cuboia, Joana Reis-Pardal, Diana Adrião, Teresa Cardoso, Irene Aragão, Lurdes Santos, António Sarmento, Regis G. Rosa, Cristina Granja, Cassiano Teixeira, Luís Azevedo
PLoS One Infectious Diseases, 3.11.2023
Tilføjet 3.11.2023
by Mariana M. S. Santos, Isabel J. Pereira, Nelson Cuboia, Joana Reis-Pardal, Diana Adrião, Teresa Cardoso, Irene Aragão, Lurdes Santos, António Sarmento, Regis G. Rosa, Cristina Granja, Cassiano Teixeira, Luís Azevedo Background To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy. Methods In this multicentre, prospective cohort study, we included 586 critically ill COVID-19 patients. Results We observed an overall ICU mortality of 20.1% [95%CI: 17.1% to 23.6%] (118/586) and an overall hospital mortality of 25.4% [95%CI: 22.1% to 29.1%] (149/586). For ICU survivors, 30 days (early) post-ICU mortality was 5.3% [95%CI: 3.6% to 7.8%] (25/468) and one-year (late) post-ICU mortality was 7.9% [95%CI: 5.8% to 10.8%] (37/468). Pre-existing conditions/comorbidities were identified as the main independent predictors of mortality after ICU discharge: hypertension and heart failure were independent predictors of early mortality; and hypertension, chronic kidney disease, chronic obstructive pulmonary disease and cancer were independent predictors of late mortality. Conclusion Early and late post-ICU mortality exhibited an initial surge (in the first 30 days post-ICU) followed by a subsequent decline over time. Close monitoring of critically ill COVID-19 post-ICU survivors, especially those with pre-existing conditions, is crucial to prevent adverse outcomes, reduce mortality and to establish an appropriate follow-up strategy.
Læs mere Tjek på PubMedJae-Mahn Shim
PLoS One Infectious Diseases, 3.11.2023
Tilføjet 3.11.2023
by Jae-Mahn Shim South Koreans are susceptible to the medical face mask against the COVID-19 pandemic. Meanwhile, their mask practices are intriguingly laden with contradictions and inconsistencies. This study accounts for this puzzle by expanding two sociological frontiers: the sociology of action (i.e., action theory of agency and individuality) and the sociology of the mask. Drawing on action theory, it stresses that contradictions and inconsistencies reveal the nature of individuals as social individuals and develops a typology of social individuals during the current pandemic (i.e., atomists, collectivists, and dualists). For mask sociology, it amplifies that any mask practices are conceptualized as a masquerade involving multiple elements for individuality and proposes a theory of mask multivocality that appreciates the ways in which masquerade the social drama becomes concretized. With this two-pronged conceptual innovation, it first demonstrates a patterned relationship between social individuals and mask multivocality. Dualists take more voices from the mask than atomists or collectivists. Dualists take the most contradictory voices as well. Second, it shows that Koreans who take more meanings from the mask reveal not only more vulnerability but more transformative power amid the current pandemic. Demonstrating the promise of mask sociology for the action theory of individuality, it ultimately argues that individuals as social performers often reveal themselves as mask-wearers who become as transformative as they are vulnerable. While this model is founded upon the recent pandemic, it ramifies in political and cultural events that various face coverings accompany.
Læs mere Tjek på PubMedde Miranda, K. G., Rodrigues da Silva, I. C., Fonseca, R. M. A. M., Gallassi, A. D.
BMJ Open, 2.11.2023
Tilføjet 2.11.2023
ObjectiveThe objective of this study is to analyse the relationship and psychosocial issues between working during the COVID-19 pandemic in primary healthcare (PHC) facilities located in the most vulnerable health region (HR) of the Federal District of Brazil (FDB) compared with a lesser region. DesignMixed-method study data. The questionnaire was based on the World Health Survey and the Convid Behavioural Survey. Quantitative data were described in absolute and relative frequency. Pearson’s 2 test verified differences according to the region (significance level
Læs mere Tjek på PubMedBMC Infectious Diseases, 2.11.2023
Tilføjet 2.11.2023
Abstract Background Understanding community transmission of SARS-CoV-2 variants of concern (VOCs) is critical for disease control in the post pandemic era. The Delta variant (B.1.617.2) emerged in late 2020 and became the dominant VOC globally in the summer of 2021. While the epidemiological features of the Delta variant have been extensively studied, how those characteristics shaped community transmission in urban settings remains poorly understood. Methods Using high-resolution contact tracing data and testing records, we analyze the transmission of SARS-CoV-2 during the Delta wave within New York City (NYC) from May 2021 to October 2021. We reconstruct transmission networks at the individual level and across 177 ZIP code areas, examine network structure and spatial spread patterns, and use statistical analysis to estimate the effects of factors associated with COVID-19 spread. Results We find considerable individual variations in reported contacts and secondary infections, consistent with the pre-Delta period. Compared with earlier waves, Delta-period has more frequent long-range transmission events across ZIP codes. Using socioeconomic, mobility and COVID-19 surveillance data at the ZIP code level, we find that a larger number of cumulative cases in a ZIP code area is associated with reduced within- and cross-ZIP code transmission and the number of visitors to each ZIP code is positively associated with the number of non-household infections identified through contact tracing and testing. Conclusions The Delta variant produced greater long-range spatial transmission across NYC ZIP code areas, likely caused by its increased transmissibility and elevated human mobility during the study period. Our findings highlight the potential role of population immunity in reducing transmission of VOCs. Quantifying variability of immunity is critical for identifying subpopulations susceptible to future VOCs. In addition, non-pharmaceutical interventions limiting human mobility likely reduced SARS-CoV-2 spread over successive pandemic waves and should be encouraged for reducing transmission of future VOCs.
Læs mere Tjek på PubMedMallhi Tauqeer, Khan Yusra Habib, Salman Muhammad, Butt Muhammad Hammad
Clinical Microbiology and Infection, 2.11.2023
Tilføjet 2.11.2023
Prior to the COVID-19 pandemic, the term Coronavirus referred primarily to the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the Arab world. The MERS-CoV was first identified in a 60-year-old male who died of respiratory distress and renal failure in June 2012, in Jeddah, Saudi Arabia [1]. Recent estimates by the World Health Organization (WHO) indicate that the infection has spread to 27 countries, including all six WHO regions. As of 29 August 2023, WHO had received reports of 2605 cases, the majority of which (n=2196; 84%) were from Saudi Arabia.
Læs mere Tjek på PubMedCornelisse, Vincent J.; Murphy, Dean; Lee, Sue J.; Stoove, Mark; Traeger, Michael W.; Wright, Edwina J.
AIDS, 2.11.2023
Tilføjet 2.11.2023
Introduction: HIV pre-exposure prophylaxis (PrEP) is highly effective at preventing HIV. We aimed to assess mental and physical health among long-term PrEP users in Australia\'s X-PLORE cohort. Methods: In early 2021, 1,485 X-PLORE participants were emailed a survey covering demographics, sexual practices, ongoing PrEP use, physical and psychological diagnoses received since commencing PrEP, substance use, and impacts of the COVID-19 pandemic. Current anxiety and depression were assessed using GAD-7 and PHQ-9 questionnaires. Results: Of 476 participants (completion rate 32.1%), 99.8% were cis-gender men. Median PrEP use duration was 48 months (2,002 person-years), with 81.7% currently using PrEP. PrEP-related toxicity was uncommon: 2.9% reported bone fractures, 1.3% low bone density, and 4.0% reported kidney problems, largely not necessitating PrEP cessation. Most (92.0%) rated their health as “good” to “excellent”, and 22.6% reported improved health since starting PrEP, often due to improved mental health. Only 6.2% reported deterioration in health since starting PrEP, largely unrelated to PrEP. The most common diagnoses were hypertension (9.9%), depression (13.2%) and anxiety (14.9%); 17.0% had PHQ-9 scores indicating current moderate-to-severe depression, which was associated with unemployment (aOR 3.90), regular cannabis use (aOR 2.49), and having ceased PrEP (aOR 2.13). Conclusions: Among long-term PrEP users, of which over 80% were currently using PrEP, self-reported PrEP toxicity was uncommon. With almost one in five PrEP users categorised as having depression, and with higher risk among those having ceased PrEP, we recommend routine screening for depression and anxiety in PrEP users and corresponding follow-up of patients no longer attending for PrEP. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Læs mere Tjek på PubMedPaul Adepoju
The Lancet Microbe, 2.11.2023
Tilføjet 2.11.2023
While announcing that COVID-19 was no longer a public health emergency of international concern (PHEIC), WHO Director-General Tedros Adhanom Ghebreyesus said the virus is “still killing, and it\'s still changing”. He urged countries to transition from emergency mode to managing COVID-19 alongside other infectious diseases. But at the frontline and in global health boardrooms, there are concerns that the end of the PHEIC could negatively affect COVID-19 vaccination efforts in Africa.
Læs mere Tjek på PubMedMaheshi N Ramasamy, Elizabeth J Kelly, Seth Seegobin, Paul I Dargan, Ruth Payne, Vincenzo Libri, Matthew Adam, Parvinder K Aley, Nuria Martinez-Alier, Alison Church, Brett Jepson, Mark Khan, Sam Matthews, G Todd Townsend, Johan Vekemans, Sagida Bibi, Phillip A Swanson, Teresa Lambe, Menelas N Pangalos, Tonya Villafana, Andrew J Pollard, Justin A Green, AZD2816 Study Group
The Lancet Microbe, 2.11.2023
Tilføjet 2.11.2023
Both boosters were well tolerated, with immunogenicity against ancestral SARS-CoV-2 similar to AZD1222 primary-series vaccination. AZD2816 gave greater immune responses against beta versus AZD1222.
Læs mere Tjek på PubMedEva Stadler, Khai Li Chai, Timothy E Schlub, Deborah Cromer, Shanchita R Khan, Mark N Polizzotto, Stephen J Kent, Claire Beecher, Heath White, Tari Turner, Nicole Skoetz, Lise Estcourt, Zoe K McQuilten, Erica M Wood, David S Khoury, Miles P Davenport
The Lancet Microbe, 2.11.2023
Tilføjet 2.11.2023
Early administration before hospitalisation and sufficient doses of passive antibody therapy are crucial to achieving high efficacy in preventing clinical progression. The relationship between dose and efficacy provides a framework for the rational assessment of future passive antibody prophylaxis and treatment strategies for COVID-19.
Læs mere Tjek på PubMedMitima Jean-Marie Limenyande, Joyce Owens Kobusingye, Tonny Tindyebwa, Dorothy Akongo, John Bosco Isunju, David Musoke
PLoS One Infectious Diseases, 2.11.2023
Tilføjet 2.11.2023
by Mitima Jean-Marie Limenyande, Joyce Owens Kobusingye, Tonny Tindyebwa, Dorothy Akongo, John Bosco Isunju, David Musoke Background In the context of the COVID-19 pandemic that originated from China in December 2019 and spread around the world, Kampala City witnessed a high number of infections and deaths among healthcare workers (HCWs). This study assessed the level of compliance with Infection Prevention and Control (IPC) measures and its associated factors among HCWs during the COVID-19 pandemic, in Kampala City, Uganda. Methodology A cross-sectional study was conducted in Nakawa Division, Kampala City, among 240 HCWs and used multistage sampling in government and private not-for-profit (PNFP) healthcare facilities. The outcome variable was self-reported IPC compliance which was composed of the use of masks, gloves, and hand hygiene. These were assessed using a 4-scale tool: always as recommended, most of the time, occasionally, and rarely. Only HCWs who responded “always as recommended” were considered compliant while the rest were considered non-compliant. Data was analyzed in STATA 14.0 using Modified Poisson regression to obtain factors associated with IPC compliance at 95% confidence interval (CI). Results Forty-six (19.2%) respondents were compliant with all the three IPC measures, and this was associated with the presence of a COVID-19 patients’ ward in the healthcare facility (Adjusted Prevalence Ratio, APR: 2.51, 95%CI: 1.24–5.07). Factors associated with the use of masks were being of the Muslim religion (APR: 1.31, CI: 1.05–1.65), and working in a healthcare facility that has COVID-19 patients’ ward (APR: 1.29, CI: 1.06–1.59). Factors associated with the use of gloves were the age of the HCW, those above 40 years old being less complaint (APR: 0.47, CI: 0.24–0.93), working in the diagnosis department (APR: 2.08, CI: 1.17–3.70), and working in a healthcare facility that has COVID-19 patients’ ward (APR: 1.73, CI: 1.13–2.64). Factors associated with hand hygiene were working in a health center (HC) IV (PR: 1.7, CI: 1.26–2.30) or a HC II (PR: 1.68, CI: 1.28–2.21). Conclusion Considering the elevated risk of disease transmission in health settings, IPC compliance was low; indicating an increased risk of COVID-19 infection among health care workers in Kampala City.
Læs mere Tjek på PubMedDirghayu K. C., Namuna Shrestha, Rachana Shrestha, Dev Ram Sunuwar, Anil Poudyal
PLoS One Infectious Diseases, 2.11.2023
Tilføjet 2.11.2023
by Dirghayu K. C., Namuna Shrestha, Rachana Shrestha, Dev Ram Sunuwar, Anil Poudyal Background The COVID-19 pandemic led to surging concerns about food insecurity status throughout the world. In response to global and national concerns on food and nutrition security, this study aimed to examine the prevalence and determining factors of household food insecurity and dietary diversity among people from selected rural municipalities of Lalitpur district, Nepal. Methods A community-based cross-sectional study was conducted among 432 households. Pretested structured questionnaires were used to collect socio-demographic characteristics of the participants, household income; influence of COVID-19 on their income and livelihood, household’s access to food and dietary diversity. Food insecurity was measured using the Household Food Insecurity Access Scale (HFIAS) and the Household Dietary Diversity Score (HDDS). A multivariable analysis was done using binary logistic regression model following a bivariate analysis to assess the association between the dependent and independent variables. Results More than one-third (36%) of the households reported some form of food insecurity. The overall mean score for Household Dietary Diversity Score (HDDS) was 6.0 (±1.1). Multivariable logistic regression analysis showed that participants aged 41–64 years (aOR = 0.35, 95% CI: 0.21–0.59), those over 64 years (aOR = 0.22, 95% CI: 0.07–0.66), as well as those in service occupation (aOR = 0.22, 95% CI: 0.06–0.77) were associated with lower odds of HFIAS. Conversely, Participants belonging to a disadvantaged ethnic group (aOR = 2.73, 95% CI: 1.23–6.07), having no education (aOR = 3.70, 95% CI: 1.16–11.71) or primary education (aOR = 3.67, 95% CI: 1.23–9.89), and those suffering from chronic illness (aOR = 3.12, 95% CI: 1.53–6.35) were associated with higher odds of HFIAS. As for HDDS, participants aged 41–64 years (aOR = 0.48, 95% CI: 0.28–0.83) were associated with lower odds of HDDS, while participants having no education (aOR = 10.05, 95% CI: 4.05–24.01) were associated with significantly higher odds of HDDS. Conclusion Owing to the pandemic, our study showed a substantial prevalence of food insecurity among diverse community residing in rural outskirts of Kathmandu Valley, particularly among disadvantaged ethnic group and people with lower level of education. Interventions targeting these particular groups may help in improving HFIAS and HDDS among them during emergencies.
Læs mere Tjek på PubMedUkai, T., Tabuchi, T.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
ObjectivesWe examined the association between social isolation and loneliness, increasingly recognised but neglected social determinants of health, with being unvaccinated against COVID-19. DesignThis was a cross-sectional study. Setting and participantsA representative cohort of 22 756 individuals (aged 15–81 years) from the general Japanese population who responded to both the Japan COVID-19 and Society Internet Survey 2021 and Japan Society and New Tobacco Internet Survey 2022. Primary and secondary outcome measuresWe calculated the ORs of remaining unvaccinated against COVID-19 in 2022, attributable to social isolation as assessed by the Lubben Social Network Scale, or loneliness as evaluated by the University of California, Los Angeles Loneliness Scale version 3. Reasons for abstaining from vaccination were solicited from the unvaccinated respondents. A multivariable logistic regression model was conducted with adjustments for demographic variables. Propensity score-matched comparisons were conducted as part of the sensitivity analysis. ResultsIndividuals with social isolation were more likely to be unvaccinated (OR 1.48, 95% CI 1.37 to 1.60), while individuals with loneliness were not (OR 0.96, 95% CI 0.88 to 1.05). Socially isolated individuals were significantly less likely to receive information from people who had been vaccinated (11% vs 15%) and less likely not to trust the vaccine approval process (19% vs 27%) compared with those who were not socially isolated. ConclusionsDespite not harbouring negative perceptions of the vaccine, socially isolated individuals exhibited lower rates of COVID-19 vaccination. Socially isolated individuals are important targets to reach to increase the number of vaccinated individuals.
Læs mere Tjek på PubMedMoin, J. S., Vigod, S. N., Plumptre, L., Troke, N., Asaria, M., Papanicolas, I., Wodchis, W. P., Brail, S., Anderson, G.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
ObjectivesThe pandemic and public health response to contain the virus had impacts on many aspects of young people’s lives including disruptions to daily routines, opportunities for social, academic, recreational engagement and early employment. Consequently, children, adolescents and young adults may have experienced mental health challenges that required use of mental health services. This study compared rates of use for inpatient and outpatient mental health services during the pandemic to pre-pandemic rates. DesignPopulation-based repeated cross-sectional study. SettingPublicly delivered mental healthcare in primary and secondary settings within the province of Ontario, Canada. ParticipantsAll children 6–12 years of age (n=2 043 977), adolescents 13–17 years (n=1 708 754) and young adults 18–24 years (n=2 286 544), living in Ontario and eligible for provincial health insurance between March 2016 and November 2021. Primary outcome measuresOutpatient mental health visits to family physicians and psychiatrists for: mood and anxiety disorders, alcohol and substance abuse disorders, other non-psychotic mental health disorders and social problems. Inpatient mental health visits to emergency departments and hospitalisations for: substance-related and addictive disorders, anxiety disorders, assault-related injuries, deliberate self-harm and eating disorders. All outcomes were analysed by cohort and sex. ResultsDuring the pandemic, observed outpatient visit rates were higher among young adults by 19.01% (95% CI: 15.56% to 22.37%; 209 vs 175 per 1000) and adolescent women 24.17% (95% CI: 18.93% to 29.15%; 131 vs 105 per 1000) for mood and anxiety disorders and remained higher than expected. Female adolescents had higher than expected usage of inpatient care for deliberate self-harm, eating disorders and assault-related injuries. ConclusionsStudy results raise concerns over prolonged high rates of mental health use during the pandemic, particularly in female adolescents and young women, and highlights the need to better monitor and identify mental health outcomes associated with COVID-19 containment measures and to develop policies to address these concerns.
Læs mere Tjek på PubMedJoncic, G., Jain, M., Chattu, V. K., Gohar, B., Nowrouzi-Kia, B.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
ObjectivesThis study aims to explore the overall and specific aspects of the functioning of medical laboratory professionals (MLPs) in Ontario, Canada during the COVID-19 pandemic. DesignA cross-sectional analysis where a questionnaire was used to assess the mental status of MLPs. SettingAn online questionnaire administered in Ontario, Canada. Participants632 MLPs (medical laboratory technologists, technicians and assistants) were included. Main outcome measuresWe employed the WHO Disability Assessment Schedule V.2.0 (WHODAS V.2.0) Questionnaire to assess functioning/disability and Copenhagen Psychosocial Questionnaire, third edition for psychosocial workplace factors. Multiple regression analysis examined the relationship between overall and specific domain functioning scores and psychosocial workplace factors. ResultsOf the total 632 participants, the majority were female gender and Caucasian. It was found that health (β=2.25, p
Læs mere Tjek på PubMedCherry, N., Adisesh, A., Burstyn, I., Durand-Moreau, Q., Galarneau, J.-M., Labreche, F., Ruzycki, S. M., Zadunayski, T.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
PurposeHealthcare workers were recruited early in 2020 to chart effects on their health as the COVID-19 pandemic evolved. The aim was to identify modifiable workplace risk factors for infection and mental ill health. ParticipantsParticipants were recruited from four Canadian provinces, physicians (medical doctors, MDs) in Alberta, British Columbia, Ontario and Quebec, registered nurses (RNs), licensed practical nurses (LPNs) and healthcare aides (HCAs) in Alberta and personal support workers (PSWs) in Ontario. Volunteers gave blood for serology testing before and after vaccination. Cases with COVID-19 were matched with up to four referents in a nested case-referent study. Findings to dateOverall, 4964/5130 (97%) of those recruited joined the longitudinal cohort: 1442 MDs, 3136 RNs, 71 LPNs, 235 PSWs, 80 HCAs. Overall, 3812 (77%) were from Alberta. Prepandemic risk factors for mental ill health and respiratory illness differed markedly by occupation. Participants completed questionnaires at recruitment, fall 2020, spring 2021, spring 2022. By 2022, 4837 remained in the cohort (127 had retired, moved away or died), for a response rate of 89% (4299/4837). 4567/4964 (92%) received at least one vaccine shot: 2752/4567 (60%) gave postvaccine blood samples. Ease of accessing blood collection sites was a strong determinant of participation. Among 533 cases and 1697 referents recruited to the nested case-referent study, risk of infection at work decreased with widespread vaccination. Future plansSerology results (concentration of IgG) together with demographic data will be entered into the publicly accessible database compiled by the Canadian Immunology Task Force. Linkage with provincial administrative health databases will permit case validation, investigation of longer-term sequelae of infection and comparison with community controls. Analysis of the existing dataset will concentrate on effects on IgG of medical condition, medications and stage of pregnancy, and the role of occupational exposures and supports on mental health during the pandemic.
Læs mere Tjek på PubMedZhang, X., Guan, C., He, J., Wang, J.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
IntroductionLong-term care needs for people with dementia are predicted to increase due to increased life expectancy and dementia diagnoses. Most published meta- syntheses of dementia care focus on hospitals or home settings. When focusing on long-term care facilities, most reviews about dementia care only focus on a single outcome, such as feeding, behavioural symptoms management, palliative care and others, which is limited. The present study aims to synthesise qualitative data and examine barriers and facilitators to caring for people with dementia in long-term care facilities. Methods and analysisThis is the protocol for our systematic review and meta-synthesis, which describes the design of this study, and we plan to complete the study from October 2023 to November 2024. The systematic review and meta-synthesis will follow the Joanna Briggs Institute (JBI) guidance for systematic reviews of qualitative evidence. Nine databases (five English and four Chinese) were searched, including Embase, Web of Science, Medline, CINAHL, PsycINFO and Wan Fang Data, China National Knowledge Infrastructure, VIP and Chinese Biomedical Medicine, from inception to August 2023. Qualitative and mixed-approach research about barriers and facilitators to caring for people with dementia in long-term care facilities, which are reported in English or Chinese, will be included. Covidence software will help with study selection, assessment and data extraction. The JBI Critical Appraisal Checklist for Qualitative Research (2020) will be used for included studies’ quality assessment. Data extraction will be based on the JBI Qualitative Assessment and Review Instrument Data Extraction Tool for Qualitative Research. The JBI aggregation approach will be used to synthesise data. We will use the JBI ConQual tool to assess the credibility and dependability of each synthesised finding to establish confidence in the synthesised findings. All review steps will be managed by two reviewers independently, and disparities will be discussed. If consensus cannot reach a resolution, a third reviewer will be consulted. Ethics and disseminationThe present study is a secondary analysis of published qualitative data. So ethical approval is not required. The findings may be disseminated through peer-reviewed publications, conference papers or elsewhere. PROSPERO registration numberThe protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) in May 2022, and the registration number is CRD42022326178.
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 1.11.2023
Tilføjet 1.11.2023
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 109 Issue: 5 Pages: 1205-1206
Læs mere Tjek på PubMedBMC Infectious Diseases, 1.11.2023
Tilføjet 1.11.2023
Abstract Background Variation in immune response to COVID-19 vaccines is observed among different ethnicities. We aimed to describe the reinfection rates, change in antibody titers, and adverse events among Filipinos. Methods This is a secondary analysis of a cohort study of 307 participants within one year of having COVID-19 infection. We measured COVID-19 antibody levels at pre-determined timepoints (Days 21, 90, 180, 270, and 360 from initial infection). We monitored for COVID-19 symptoms and obtained details on COVID-19 vaccination. An adjudication committee classified the participants as probable, possible, or unlikely COVID-19 reinfection. We determined the probable reinfection rate, adverse events, and the geometric mean titer (GMT) ratio of pre- and post-vaccination antibody levels according to type and brand of COVID-19 vaccine. Results At the end of the follow-up period, 287 (93.5%) out of 307 study participants were fully vaccinated, 1 was partially vaccinated (0.3%), and 19 were unvaccinated (6.2%). Among the fully vaccinated participants, those given mRNA vaccines had the lowest reinfection rate (19.2 cases/100 person-years, 95% CI 9.6, 38.4), followed by viral vector vaccines (29.8 cases/100 person-years, 95% CI 16.9, 52.4). We observed the highest reinfection rate among those given inactivated virus vaccines (32.7 cases/100 person-years, 95% CI 23.6, 45.3). The reinfection rate was 8.6 cases/100 person-years (95% CI 4.1, 17.9) for unvaccinated participants and 3.6 cases/100 person-years (95% CI 0.5, 25.3) for partially vaccinated participants. We observed the largest rise in antibody titers among those given mRNA vaccines (GMT ratio 288.5), and the smallest rise among those given inactivated virus vaccines (GMT ratio 16.7). We observed the highest percentage of adverse events following immunization with viral vector vaccines (63.8%), followed by mRNA vaccines (62.7%), and the lowest for inactivated virus vaccines (34.7%). No serious adverse events were reported. Conclusion Vaccinees given the mRNA vaccines had the lowest reinfection rate and the highest rise in antibody titers. Vaccinees given inactivated virus vaccines had the highest reinfection rate, smallest rise in antibody titers, and lowest percentage of adverse events. The small sample size and imbalanced distribution of the type of vaccines received limits the external generalizability of our results. Study Registration The cohort study was registered at the Philippine Health Research Registry on December 14, 2020 (PHRR201214-003199).
Læs mere Tjek på PubMedBMC Infectious Diseases, 1.11.2023
Tilføjet 1.11.2023
Abstract Background Many countries, including high-income nations, struggled to control epidemic waves caused by the Omicron variant (B.1.1.529), which had an antigenically distinct evolution. Evaluating the direct and indirect effects of vaccination during the Omicron waves is essential to assess virus control policies. The present study assessed the population impacts of a vaccination program during the sixth wave caused by BA.1 and BA.2 from January to May 2022, in Tokyo. Methods We analyzed the primary series and booster vaccination coverages and the confirmed cases stratified by vaccination history. We estimated the number of COVID-19 cases that were directly and indirectly prevented by vaccination. To estimate the direct impact, we used a statistical model that compared risks between unvaccinated and vaccinated individuals. A transmission model employing the renewal process was devised to quantify the total effect, given as the sum of the direct and indirect effects. Results Assuming that the reporting coverage of cases was 25%, mass vaccination programs, including primary and booster immunizations, directly averted 640,000 COVID-19 cases (95% confidence interval: 624–655). Furthermore, these programs directly and indirectly prevented 8.5 million infections (95% confidence interval: 8.4–8.6). Hypothetical scenarios indicated that we could have expected a 19% or 7% relative reduction in the number of infections, respectively, compared with the observed number of infections, if the booster coverage had been equivalent to that of the second dose or if coverage among people aged 10–49 years had been 10% higher. If the third dose coverage was smaller and comparable to that of the fourth dose, the total number of infections would have increased by 52% compared with the observed number of infections. Conclusions The population benefit of vaccination via direct and indirect effects was substantial, with an estimated 65% reduction in the number of SARS-CoV-2 infections compared with counterfactual (without vaccination) in Tokyo during the sixth wave caused by BA.1 and BA.2.
Læs mere Tjek på PubMedBMC Infectious Diseases, 1.11.2023
Tilføjet 1.11.2023
Abstract Background Variation in immune response to COVID-19 vaccines is observed among different ethnicities. We aimed to describe the reinfection rates, change in antibody titers, and adverse events among Filipinos. Methods This is a secondary analysis of a cohort study of 307 participants within one year of having COVID-19 infection. We measured COVID-19 antibody levels at pre-determined timepoints (Days 21, 90, 180, 270, and 360 from initial infection). We monitored for COVID-19 symptoms and obtained details on COVID-19 vaccination. An adjudication committee classified the participants as probable, possible, or unlikely COVID-19 reinfection. We determined the probable reinfection rate, adverse events, and the geometric mean titer (GMT) ratio of pre- and post-vaccination antibody levels according to type and brand of COVID-19 vaccine. Results At the end of the follow-up period, 287 (93.5%) out of 307 study participants were fully vaccinated, 1 was partially vaccinated (0.3%), and 19 were unvaccinated (6.2%). Among the fully vaccinated participants, those given mRNA vaccines had the lowest reinfection rate (19.2 cases/100 person-years, 95% CI 9.6, 38.4), followed by viral vector vaccines (29.8 cases/100 person-years, 95% CI 16.9, 52.4). We observed the highest reinfection rate among those given inactivated virus vaccines (32.7 cases/100 person-years, 95% CI 23.6, 45.3). The reinfection rate was 8.6 cases/100 person-years (95% CI 4.1, 17.9) for unvaccinated participants and 3.6 cases/100 person-years (95% CI 0.5, 25.3) for partially vaccinated participants. We observed the largest rise in antibody titers among those given mRNA vaccines (GMT ratio 288.5), and the smallest rise among those given inactivated virus vaccines (GMT ratio 16.7). We observed the highest percentage of adverse events following immunization with viral vector vaccines (63.8%), followed by mRNA vaccines (62.7%), and the lowest for inactivated virus vaccines (34.7%). No serious adverse events were reported. Conclusion Vaccinees given the mRNA vaccines had the lowest reinfection rate and the highest rise in antibody titers. Vaccinees given inactivated virus vaccines had the highest reinfection rate, smallest rise in antibody titers, and lowest percentage of adverse events. The small sample size and imbalanced distribution of the type of vaccines received limits the external generalizability of our results. Study Registration The cohort study was registered at the Philippine Health Research Registry on December 14, 2020 (PHRR201214-003199).
Læs mere Tjek på PubMedBMC Infectious Diseases, 1.11.2023
Tilføjet 1.11.2023
Abstract Background Many countries, including high-income nations, struggled to control epidemic waves caused by the Omicron variant (B.1.1.529), which had an antigenically distinct evolution. Evaluating the direct and indirect effects of vaccination during the Omicron waves is essential to assess virus control policies. The present study assessed the population impacts of a vaccination program during the sixth wave caused by BA.1 and BA.2 from January to May 2022, in Tokyo. Methods We analyzed the primary series and booster vaccination coverages and the confirmed cases stratified by vaccination history. We estimated the number of COVID-19 cases that were directly and indirectly prevented by vaccination. To estimate the direct impact, we used a statistical model that compared risks between unvaccinated and vaccinated individuals. A transmission model employing the renewal process was devised to quantify the total effect, given as the sum of the direct and indirect effects. Results Assuming that the reporting coverage of cases was 25%, mass vaccination programs, including primary and booster immunizations, directly averted 640,000 COVID-19 cases (95% confidence interval: 624–655). Furthermore, these programs directly and indirectly prevented 8.5 million infections (95% confidence interval: 8.4–8.6). Hypothetical scenarios indicated that we could have expected a 19% or 7% relative reduction in the number of infections, respectively, compared with the observed number of infections, if the booster coverage had been equivalent to that of the second dose or if coverage among people aged 10–49 years had been 10% higher. If the third dose coverage was smaller and comparable to that of the fourth dose, the total number of infections would have increased by 52% compared with the observed number of infections. Conclusions The population benefit of vaccination via direct and indirect effects was substantial, with an estimated 65% reduction in the number of SARS-CoV-2 infections compared with counterfactual (without vaccination) in Tokyo during the sixth wave caused by BA.1 and BA.2.
Læs mere Tjek på PubMedInfectious Disease Modelling, 1.11.2023
Tilføjet 1.11.2023
Publication date: Available online 31 October 2023 Source: Infectious Disease Modelling Author(s): Dustin T. Hill, Mohammed A. Alazawi, E. Joe Moran, Lydia J. Bennett, Ian Bradley, Mary B. Collins, Christopher J. Gobler, Hyatt Green, Tabassum Z. Insaf, Brittany Kmush, Dana Neigel, Shailla Raymond, Mian Wang, Yinyin Ye, David A. Larsen
Læs mere Tjek på PubMedRhys, G. H., Wakeling, T., Moore, J. P., Subbe, C. P.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
ObjectivesWe aimed to identify exercise tests that have been validated to support a safe discharge to home in patients with or without COVID-19. Study designScoping review, using PRISMA-ScR reporting standards. Medline, PubMed, AMED, Embase, CINAHL and LitCovid databases were searched between 16 and 22 February 2021, with studies included from any publication date up to and including the search date. InterventionShort exercise tests. Primary outcome measuresSafe discharge from hospital, readmission rate, length of hospital stay, mortality. Secondary outcomes measures: safety, feasibility and reliability. ResultsOf 1612 original records screened, 19 studies were included in the analysis. These used a variety of exercise tests in patients with chronic obstructive pulmonary disease, suspected pulmonary embolism and pneumocystis carinii pneumonia, heart failure or critical illness. Only six studies had examined patients with COVID-19, of these two were still recruiting to evaluate the 1 min sit-to-stand test and the 40-steps test. There was heterogeneity in patient populations, tests used and outcome measures. Few exercise tests have been validated to support discharge decisions. There is currently no support for short exercise tests for triage of care in patients with COVID-19. ConclusionsFurther research is needed to aid clinical decision-making at discharge from hospital.
Læs mere Tjek på PubMedFan, X., Du, J., Yu, H., Xu, Q., Weng, X., Gou, Y., Si, Y.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
BackgroundDue to the COVID-19 epidemic, Chinese hospitals are forced to impose stringent regulations, which unavoidably affect patients with stroke who need continued rehabilitation and long-term disease treatment. However, there is a lack of qualitative studies in the literature on female relative caregivers of hospitalised patients who had a stroke with dysphagia during the COVID-19 pandemic. ObjectiveIn this study, we aimed to explore the experiences of female Chinese caregivers living in the hospital with patients with post-stroke dysphagia during the pandemic. DesignWe conducted a qualitative study using semi-structured interviews. Setting(s)From May 2022 to July 2022, patients were selected from the Acupuncture and Moxibustion Ward and the Encephalopathy Ward of Shenzhen Chinese Medicine Hospital, which receives patients from across the country. Participants10 Chinese women who were caregivers of patients with post-stroke dysphagia were finally interviewed. MethodsInterviews were transcribed verbatim and analysed using Colaizzi’s approach. ResultsThe primary theme was determined to be ‘kidnapped’ lives. Other sub-themes evolved to depict the lives of female relative caregivers, including inevitable tasks and challenges, precise care, a special dietary pattern, solitary and forgotten, and an elusive future. Due to the trivial nature of caring for patients who had a stroke with dysphagia, the caregivers’ lives were tightly organised and entirely dictated by the patient’s caring needs. Consequently, the caregivers felt that their lives had been kidnapped. ConclusionsIt is imperative that healthcare workers identify and understand the living conditions of female relative caregivers in the hospital, so as to determine their difficulties and needs. Finally, caregivers deserve adequate and effective support, such as technical support, financial support and nutritional guidance.
Læs mere Tjek på PubMedBhattacharya, P., John, D., Mukherjee, N., MS, N., Menon, J., Banerjee, A.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
ObjectivesThe state of West Bengal witnessed a significant surge of COVID-19 in all three waves. However, there is a gap in understanding the economic loss associated with COVID-19. This study estimates future non-health gross domestic product (NHGDP) losses associated with COVID-19 deaths in West Bengal, India. SettingVarious open domains were used to gather data on COVID-19 deaths in West Bengal and the aforementioned estimates. Primary and secondary outcome measuresThe NHGDP losses were evaluated using the cost-of-illness approach. Future NHGDP losses were discounted at 3%. Excess death estimates by the WHO and Global Burden of Disease (GBD) were used. Sensitivity analysis was carried out by varying discount rates and average age of death (AAD). Results21 532 deaths in West Bengal from 17 March 2020 to 31 December 2022 decreased the future NHGDP by $0.92 billion. Nearly 90% of loss was due to deaths occurring in the age group of 30 years and above. Majority of the NHGDP loss was borne by the 46–60 years age group. NHGDP loss/death was $55,171; however, the average loss/death declined with rise in age. Based on the GBD and WHO excess death estimates, the NHGDP loss increased to $9.38 billion and $9.42 billion, respectively. When the lower age interval is considered as AAD, the NHGDP loss increased to $1.3 billion. At 5% and 10% discount rates, the losses reduced to $0.767 billion and $0.549 billion, respectively. ConclusionsResults from the study suggest that COVID-19 contributed to a major economic loss in West Bengal. The mortality and morbidity caused by COVID-19, the substantial economic costs at individual and population levels in West Bengal, and probably across India and other countries, is another economic argument for better infection control strategies across the globe to minimise the impact of COVID-19.
Læs mere Tjek på PubMedVardavas, C., Zisis, K., Nikitara, K., Lagou, I., Marou, V., Aslanoglou, K., Athanasakis, K., Phalkey, R., Leonardi-Bee, J., Fernandez, E., Condell, O., Lamb, F., Sandmann, F., Pharris, A., Deogan, C., Suk, J. E.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
ObjectivesThe economic burden of COVID-19 pandemic is substantial, with both direct and indirect costs playing a significant role. DesignA systematic literature review was conducted to estimate the cost of the COVID-19 pandemic and the cost-effectiveness of pharmaceutical or non-pharmaceutical interventions. All cost data were adjusted to the 2021 Euro, and interventions compared with null. Data sourcesOvid MEDLINE and EMBASE were searched from January 2020 through 22 April 2021. Eligibility criteriaStudies regarding COVID-19 outbreak or public health preparedness measures or interventions with outcome measures related to the direct and indirect costs for disease and preparedness and/or response in countries of the European Union (EU), the European Economic Area (EEA), the UK and the Organisation for Economic Co-operation and Development (OECD) of all relevant epidemiological designs which estimate cost within the selected time frame were considered eligible. Data extraction and synthesisStudies were searched, screened and coded independently by two reviewers with high measure of inter-rater agreement. Data were extracted to a predefined data extraction sheet. The risk of bias was assessed using the Consensus on Health Economic Criteria checklist. ResultsWe included data from 41 economic studies. Ten studies evaluated the cost of the COVID-19 pandemic, while 31 assessed the cost-benefit of public health surveillance, preparedness and response measures. Overall, the economic burden of the COVID-19 pandemic was found to be substantial. Community screening, bed provision policies, investing in personal-protective-equipment and vaccination strategies were cost-effective. Physical distancing measures were associated with health benefits; however, their cost-effectiveness was dependent on the duration, compliance and the phase of the epidemic in which it was implemented. ConclusionsCOVID-19 pandemic is associated with substantial short-term and long-term economic costs to healthcare systems, payers and societies, while interventions including testing and screening policies, vaccination and physical distancing policies were identified as those presenting cost-effective options to deal with the pandemic, dependent on population vaccination and the Re at the stage of the pandemic.
Læs mere Tjek på PubMedKeeshan, A., Galipeau, Y., Heiskanen, A., Collins, E., McCluskie, P. S., Arnold, C., Saginur, R., Booth, R., Little, J., McGuinty, M., Buchan, C. A., Crawley, A., Langlois, M.-A., Cooper, C.
BMJ Open, 1.11.2023
Tilføjet 1.11.2023
BackgroundPredictors of COVID-19 vaccine immunogenicity and the influence of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection require elucidation. MethodsStop the Spread Ottawa is a prospective cohort of individuals at-risk for or who have been infected with SARS-CoV-2, initially enrolled for 10 months beginning October 2020. This cohort was enriched for public-facing workers. This analysis focuses on safety and immunogenicity of the initial two doses of COVID-19 vaccine. ResultsPost-vaccination data with blood specimens were available for 930 participants. 22.8% were SARS-CoV2 infected prior to the first vaccine dose. Cohort characteristics include: median age 44 (IQR: 22–56), 66.6% women, 89.0% white, 83.2% employed. 38.1% reported two or more comorbidities and 30.8% reported immune compromising condition(s). Over 95% had detectable IgG levels against the spike and receptor binding domain (RBD) 3 months post second vaccine dose. By multivariable analysis, increasing age and high-level immune compromise predicted diminishing IgG spike and RBD titres at month 3 post second dose. IgG spike and RBD titres were higher immediately post vaccination in those with SARS-CoV-2 infection prior to first vaccination and spike titres were higher at 6 months in those with wider time intervals between dose 1 and 2. IgG spike and RBD titres and neutralisation were generally similar by sex, weight and whether receiving homogeneous or heterogeneous combinations of vaccines. Common symptoms post dose 1 vaccine included fatigue (64.7%), injection site pain (47.5%), headache (27.2%), fever/chills (26.2%) and body aches (25.3%). These symptoms were similar with subsequent doses. ConclusionThe initial two COVID-19 vaccine doses are safe, well-tolerated and highly immunogenic across a broad spectrum of vaccine recipients including those working in public facing environments.
Læs mere Tjek på PubMedBMC Infectious Diseases, 1.11.2023
Tilføjet 1.11.2023
Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused significant economic damage and forced a slew of limitations to be placed by regulatory bodies worldwide. As the SARS-CoV-2 virus continuously mutates over time, it’s crucial to understand how well the vaccines are effective against a new variant. Objectives To measure COVID-19 vaccine effectiveness against ICU admission with the Omicron variant in Saudi Arabia regions. Methods and materials A retrospective cohort study was conducted of vaccinated and non-vaccinated individuals who tested positive during Omicron dominant period (Jan 1, 2020- Jun 11, 2022). We used a Cox proportional hazards model based on calendar time to assess the vaccine’s effectiveness while controlling for age and gender. Results A total of 14103 individuals who were divided into fully vaccinated included 8388 (59.5%) individuals, partially vaccinated included 1851 (13.5%) individuals, and un-vaccinated included 3864 (27.4%) individuals. Higher age was associated with a higher risk of ICU admission (HR = 1.03, 95% CI: 1.02, 1.04). Three doses are associated with a lower risk of ICU admission compared to the single dose (HR = 0.09, 95% CI: 0.04, 0.20). By studying the distribution of Omicron infection among different regions, Al-Madinah Al-Monawarah had the highest proportion at 60.23 per 100,000 population (95% CI: 57.05, 63.53). In contrast, Al-jouf had the lowest proportion at 4.51 per 100,000 population (95%CI: 2.891, 6.713). The vaccination status was significantly different in different regions, as the highest proportion of fully vaccinated participants inhabited in Tabouk region, with 71.8% of its cases. Out of all regions, Najran had the highest proportion of ICU admission among Omicron cases with 20% (95% CI: 9.94%, 34.22%). While the lowest rates existed in Riyadh with 0.86% (95%CI: 0.61%, 1.17%). Conclusion We found that a booster significantly enhanced protection against severe COVID-19. The partially vaccinated and unvaccinated participants were at significantly higher risk of ICU admission when compared to the fully vaccinated participants. Furthermore, in future, it is worth investigating the effectiveness of a booster when other potential factors (e.g., region, comorbidities, etc.) are included, particularly among future variants of COVID-19.
Læs mere Tjek på PubMedMisganu Endriyas, Belete Woldemariam, Endashaw Shibru, Mamush Hussen, Bersabeh Bedru, Mathewos Moges, Mintesinot Melka, Fiseha Lemango, Male Mate, Tesfaye Lejiso, Biruk Gebremedhin, Alemu Tolcha, Biniam Shiferaw, Girma Wondimu, Tesfatsion Terefe, Sinafikish Ayele, Tebeje Misganaw, Teka Samuel, Temesgen Kelaye, Agegnehu Gebru, Amare Assefa, Wogene Getachew, Bereket Yalew, Dereje Geleta
PLoS One Infectious Diseases, 31.10.2023
Tilføjet 31.10.2023
by Misganu Endriyas, Belete Woldemariam, Endashaw Shibru, Mamush Hussen, Bersabeh Bedru, Mathewos Moges, Mintesinot Melka, Fiseha Lemango, Male Mate, Tesfaye Lejiso, Biruk Gebremedhin, Alemu Tolcha, Biniam Shiferaw, Girma Wondimu, Tesfatsion Terefe, Sinafikish Ayele, Tebeje Misganaw, Teka Samuel, Temesgen Kelaye, Agegnehu Gebru, Amare Assefa, Wogene Getachew, Bereket Yalew, Dereje Geleta Background School closures in response to the COVID-19 impacted children’s education, protection, and wellbeing. After understanding these impacts and that children were not super spreaders, countries including Ethiopia decided to reopen schools with specified preconditions. But when deciding to reopen schools, the benefits and risks across education, public health and socio-economic factors have to be evaluated. However, there was information gap on status of schools as per preconditions. Hence, this study was designed to investigate status of schools in Southern Ethiopia. Methods School based cross-sectional study was conducted in October 2020 in Southern Ethiopia. Sample of 430 schools were included. National school reopening guideline was used to develop checklist for assessment. Data was collected by public health experts at regional emergency operation center. Descriptive analysis was performed to summarize data. Results A total of 430 schools were included. More than two thirds, 298 (69.3%), of schools were from rural areas while 132 (30.7%) were from urban settings. The general infection prevention and water, sanitation and hygiene (IPC-WASH) status of schools were poor and COVID-19 specific preparations were inadequate to meet national preconditions to reopen schools during the pandemic. Total score from 24 items observed ranged from 3 to 22 points with mean score of 11.75 (SD±4.02). No school scored 100% and only 41 (9.5%) scored above 75% while 216 (50.2%%) scored below half point that is 12 items. Conclusion Both the basic and COVID-19 specific IPC-WASH status of schools were inadequate to implement national school reopening preconditions and general standards. Some of strategies planned to accommodate teaching process and preconditions maximized inequalities in education. Although COVID-19 impact lessened due to vaccination and other factors, it is rational to consider fulfilling water and basic sanitation facilities to schools to prevent communicable diseases of public health importance.
Læs mere Tjek på PubMedChristophe Bonaldi, Anne Fouillet, Cécile Sommen, Daniel Lévy-Bruhl, Juliette Paireau
PLoS One Infectious Diseases, 31.10.2023
Tilføjet 31.10.2023
by Christophe Bonaldi, Anne Fouillet, Cécile Sommen, Daniel Lévy-Bruhl, Juliette Paireau Background The effective reproduction number (Rt) quantifies the average number of secondary cases caused by one person with an infectious disease. Near-real-time monitoring of Rt during an outbreak is a major indicator used to monitor changes in disease transmission and assess the effectiveness of interventions. The estimation of Rt usually requires the identification of infected cases in the population, which can prove challenging with the available data, especially when asymptomatic people or with mild symptoms are not usually screened. The purpose of this study was to perform sensitivity analysis of Rt estimates for COVID-19 surveillance in France based on three data sources with different sensitivities and specificities for identifying infected cases. Methods We applied a statistical method developed by Cori et al. to estimate Rt using (1) confirmed cases identified from positive virological tests in the population, (2) suspected cases recorded by a national network of emergency departments, and (3) COVID-19 hospital admissions recorded by a national administrative system to manage hospital organization. Results Rt estimates in France from May 27, 2020, to August 12, 2022, showed similar temporal trends regardless of the dataset. Estimates based on the daily number of confirmed cases provided an earlier signal than the two other sources, with an average lag of 3 and 6 days for estimates based on emergency department visits and hospital admissions, respectively. Conclusion The COVID-19 experience confirmed that monitoring temporal changes in Rt was a key indicator to help the public health authorities control the outbreak in real time. However, gaining access to data on all infected people in the population in order to estimate Rt is not straightforward in practice. As this analysis has shown, the opportunity to use more readily available data to estimate Rt trends, provided that it is highly correlated with the spread of infection, provides a practical solution for monitoring the COVID-19 pandemic and indeed any other epidemic.
Læs mere Tjek på PubMedAhmed M. Alzahrani, Ahmed Hakami, Ahmad AlHadi, Nassr Al-maflehi, Mohammed H. Aljawadi, Rawan M. Alotaibi, Muhannad M. Alzahrani, Salem Ali Alammari, Mohammed A. Batais, Turky H. Almigbal
PLoS One Infectious Diseases, 31.10.2023
Tilføjet 31.10.2023
by Ahmed M. Alzahrani, Ahmed Hakami, Ahmad AlHadi, Nassr Al-maflehi, Mohammed H. Aljawadi, Rawan M. Alotaibi, Muhannad M. Alzahrani, Salem Ali Alammari, Mohammed A. Batais, Turky H. Almigbal Introduction There is growing interest in Mindfulness-based Stress Reduction (MBSR) program to combat mental distress in medical students. In Saudi Arabia, literature is insufficient about MBSR and its effectiveness. This study aims to measure the effectiveness of MBSR in improving mindful state, stress, anxiety, and depression in medical students. Also, the study explores the association between the attendance rate of MBSR sessions and its effectiveness. Lastly, the study examines gender differences in response to MBSR. Methods This is a stratified randomized controlled study of 84 medical students from two medical schools in Riyadh, Saudi Arabia. They were recruited voluntarily from November 2018 to April 2021, and allocated to MBSR and waitlist groups using a stratified randomization method based on gender. MBSR group received eight weeks of sessions through audiovisual materials. An online survey utilizing validated questionnaires assessing stress, mindfulness, anxiety, and depression was used to evaluate both groups pre-program (time 0), post-program (time 1), and three months later (time 2). Results Seventy-one participants completed the post-test (time 1). There were no differences between study groups at time 0 and 1. However, in 41 subjects who completed the follow-up test (time 2), the anxiety dropped significantly in MBSR group (mean difference (MD), -3.935; 95% CI, -7.580 to -0.290). Furthermore, attending more MBSR sessions was inversely correlated with depression (r, -0.556; P, 0.002), and anxiety (r, -0.630; P, 0.000). Compared to their baseline, males in MBSR group improved in stress (MD, 3.08; 95% CI, 0.30 to 5.86), anxiety (MD, 4.91; 95% CI, 3.32 to 6.50), and mindfulness (MD, -0.58; 95% CI, -1.01 to -0.15), while females improved in stress (MD, 2.64; 95% CI, 0.02 to 5.26). Conclusion Despite the study being interrupted by the stressful COVID-19 outbreak, the findings suggest that MBSR improved psychological outcomes when participants commit to the program.
Læs mere Tjek på PubMedKatarina Hedin
Clinical Microbiology and Infection, 31.10.2023
Tilføjet 31.10.2023
Sore throat is a common condition, and approximately 30 per 1000 inhabitants are diagnosed with tonsillitis in Swedish primary care each year. A minor proportion of these cases are admitted to the hospital due to suspicion of peritonsillar abscesses (PTA). The incidence of purulent complications from tonsillitis is less than one percent [1].
Læs mere Tjek på PubMedThe Lancet Respiratory Medicine
Lancet Respiratory Medicine, 31.10.2023
Tilføjet 31.10.2023
On Sept 22, 2023, the UN General Assembly held the second high-level meeting on the fight against tuberculosis. In the political declaration submitted by the President of the General Assembly, member states reaffirmed their collective commitment to end tuberculosis by 2030. Although previous pledges—including those made at the first UN high-level meeting in 2018—were followed by declining incidence and mortality, progress was unacceptably slow and was abruptly reversed by the COVID-19 pandemic. A plethora of tools and interventions is available to take important steps towards tuberculosis elimination, and possible paths to a tuberculosis-free world have been mapped out many times, yet 1·6 million people worldwide are estimated to have died from the disease in 2021.
Læs mere Tjek på PubMedJean-Christophe Richard, Nicolas Terzi, Hodane Yonis, Fatima Chorfa, Florent Wallet, Claire Dupuis, Laurent Argaud, Bertrand Delannoy, Guillaume Thiery, Christian Pommier, Paul Abraham, Michel Muller, Florian Sigaud, Guillaume Rigault, Emilie Joffredo, Mehdi Mezidi, Bertrand Souweine, Loredana Baboi, Hassan Serrier, Muriel Rabilloud, Laurent Bitker, VT4COVID collaborators
Lancet Respiratory Medicine, 31.10.2023
Tilføjet 31.10.2023
In patients with moderate-to-severe COVID-19-related ARDS, there was no significant difference with ULTV compared with LTV in the composite score based on mortality and ventilator-free days among patients alive at day 60. These findings do not support the systematic use of ULTV in patients with COVID-19-related ARDS.
Læs mere Tjek på PubMedThe C-MORE/PHOSP-COVID Collaborative Group
Lancet Respiratory Medicine, 31.10.2023
Tilføjet 31.10.2023
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification.
Læs mere Tjek på PubMedJoseph Hickey, Denis G. Rancourt
PLoS One Infectious Diseases, 30.10.2023
Tilføjet 30.10.2023
by Joseph Hickey, Denis G. Rancourt Objectives Since the declaration of the COVID-19 pandemic, many governments have imposed policies to reduce contacts between people who are presumed to be particularly vulnerable to dying from respiratory illnesses and the rest of the population. These policies typically address vulnerable individuals concentrated in centralized care facilities and entail limiting social contacts with visitors, staff members, and other care home residents. We use a standard epidemiological model to investigate the impact of such circumstances on the predicted infectious disease attack rates, for interacting robust and vulnerable populations. Methods We implement a general susceptible-infectious-recovered (SIR) compartmental model with two populations: robust and vulnerable. The key model parameters are the per-individual frequencies of within-group (robust-robust and vulnerable-vulnerable) and between-group (robust-vulnerable and vulnerable-robust) infectious-susceptible contacts and the recovery times of individuals in the two groups, which can be significantly longer for vulnerable people. Results Across a large range of possible model parameters including degrees of segregation versus intermingling of vulnerable and robust individuals, we find that concentrating the most vulnerable into centralized care facilities virtually always increases the infectious disease attack rate in the vulnerable group, without significant benefit to the robust group. Conclusions Isolated care homes of vulnerable residents are predicted to be the worst possible mixing circumstances for reducing harm in epidemic or pandemic conditions.
Læs mere Tjek på PubMedAngela Nuzzi, Valeria Latorre, Domenico Semisa, Barbara Scozzi
PLoS One Infectious Diseases, 30.10.2023
Tilføjet 30.10.2023
by Angela Nuzzi, Valeria Latorre, Domenico Semisa, Barbara Scozzi Covid-19 outbreak led all organizations to reorganize their processes to prevent infection and contagion risk. All healthcare facilities, included penitentiary mental health services, had to redesign their processes to safely deliver care services. In this paper, the case of a Penitentiary Mental Health Division located in southern Italy is presented. Soft System Methodology and Business process management principles and techniques are adopted to analyse and redesign the detainees’ mental health care process. The process, characterized by direct, close and prolonged contact with patients, exposes detainees and healthcare staff to a high Covid-19 infection risk. Through document analysis, interviews with the actors involved in the process and direct observation, the process’s inefficiencies and criticalities are identified. The process is redesigned to make it compliant with Covid-19 prevention provisions and national penitentiary regulations and address the other criticalities. The proposed methodological approach–which innovatively combines Soft System Methodology and Business Process Management–constitutes a human-centered process-based redesign approach that can be used both in healthcare and other organizational settings.
Læs mere Tjek på PubMedYingji Chen, Pingyang Han, Yunjie Gao, Ruifeng Jiang, Mei Tao, Ximin Li
PLoS One Infectious Diseases, 30.10.2023
Tilføjet 30.10.2023
by Yingji Chen, Pingyang Han, Yunjie Gao, Ruifeng Jiang, Mei Tao, Ximin Li Background COVID-19 and influenza A can cause severe respiratory illness. Differentiating between the two diseases and identifying critically ill patients in times of epidemics become a challenge for frontline medical staff. We sought to investigate whether both diseases and their severity could be recognized by routine blood parameters. Methods Our retrospective study analysed the clinical data and first-time routine blood parameters of 80 influenza A patients and 123 COVID-19 patients. COVID-19 patients were divided into three groups according to treatment modalities and outcomes: outpatient group, inpatient without invasive mechanical ventilation (IMV) group, and inpatient with IMV group. We used the Mann-Whitney and Kruskal-Wallis tests to analyze the differences in routine blood parameters between the two or three groups. Receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) were used to assess the diagnostic accuracy. Results Compared with outpatient influenza A patients, outpatient COVID-19 patients had a higher neutrophil to lymphocyte ratio (NLR) (6.63 vs 3.55). ROC analysis showed that the NLR had a high diagnostic value for differentiating COVID-19 from influenza A (AUC = 0.739). The best cut-off point of the NLR was 6.48, the diagnostic sensitivity was 0.523, and the specificity was 0.925. The median platelet (PLT) count in the different COVID-19 groups was as follows: outpatient group (189×109/L), inpatient without IMV group (161×109/L), and inpatient with IMV group (94×109/L). Multivariate logistic regression analysis found a significant association between PLT and treatment modality and outcome in COVID-19 patients (p
Læs mere Tjek på PubMedJane Agergaard, Jesper Damsgaard Gunst, Berit Schiøttz-Christensen, Lars Østergaard, Christian Wejse
International Journal of Infectious Diseases, 30.10.2023
Tilføjet 30.10.2023
More than three years after the first COVID-19 cases, several patients suffer from post-infectious health effects called long COVID [1, 2]. These sequelae have been defined as symptoms persisting more than 3 months after initial COVID-19 [3]. Fatigue, concentration difficulties, shortness of breath, and myalgia are among the numerous symptoms associated with long COVID [1, 4, 5]. It was early documented, that Omicron infection resulted in a milder acute course compared to previous variants [6], and understanding the risk and the characteristics of long COVID symptoms following changing variants has been of great interest for planning prevention and rehabilitation strategies.
Læs mere Tjek på PubMedBishop, J., Quilliam, C., Wong Shee, A.
BMJ Open, 30.10.2023
Tilføjet 30.10.2023
ObjectivesThe aim of this study was to explore the intention of health professionals to use evidence generated through an integrated knowledge translation (iKT) activity undertaken during the COVID-19 pandemic to answer a time-critical research question about the delivery of community-based group programmes to rural clients via virtual technology, and describe the participating health professionals and researchers’ perceptions of the iKT partnership. DesignMultimethod study incorporating qualitative and quantitative approaches. SettingTwo regional health services in Victoria (Australia). Participants26 allied health professionals (knowledge-partners) from eight disciplines across two regional health services and eight researchers from five Victorian universities. InterventionAn iKT approach was used to facilitate problem identification, evidence synthesis and adaption of evidence to the local context. Data collection and analysisParticipants were invited to complete a survey (knowledge-partners) and undertake a semistructured interview (knowledge-partners and researchers) on their experiences. A process log of collaborative activities tracked the type of engagement activities, who attended and the outcomes. The survey and process log results were analysed descriptively, the interviews using thematic analysis and a comparison of results approach applied to evaluate similarities and differences in the perception of the partnership from separate data collection and analysis processes. ResultsThe survey indicated strong positive attitudes towards using research evidence in practice as well as strong intentions to use it in the future by knowledge-partners. Knowledge-partners indicated that their expertise was used in the research process, although there was greater collaboration in some steps of iKT. The context of COVID-19 facilitated collaboration between knowledge-partners and researchers through a sense of urgency and shared purpose. Rapid team development was a key mechanism that enabled iKT. Team participation was necessarily pragmatic and flexible in nature to facilitate knowledge-partner involvement. Participants suggested the iKT process was likely to result in greater end-user buy in and a powerful example of how to upskill health professionals without a significant impact on their day-to-day workload. This project was considered by knowledge-partners to be more likely to have an impact compared with other projects without a research partner. ConclusionsThis study highlights how researchers and knowledge-partners can work effectively and rapidly to address a time-sensitive problem of mutual interest. Establishing and nurturing rural-based researcher and knowledge-partner networks is key to enabling agile and timely responses to the changing evidence needs of the health system.
Læs mere Tjek på PubMedLovett, R., Filec, S., Bonham, M., Yoshino Benavente, J., O'Conor, R., Russell, A., Zheng, P., Wismer, G., Yoon, E., Weiner-Light, S., Vogeley, A., Morrissey Kwasny, M., Lowe, S., Curtis, L. M., Federman, A., Bailey, S. C., Wolf, M.
BMJ Open, 30.10.2023
Tilføjet 30.10.2023
IntroductionCOVID-19 is an unprecedented public health threat in modern times, especially for older adults or those with chronic illness. Beyond the threat of infection, the pandemic may also have longer-term impacts on mental and physical health. The COVID-19 & Chronic Conditions (‘C3’) study offers a unique opportunity to assess psychosocial and health/healthcare trajectories over 5 years among a diverse cohort of adults with comorbidities well-characterised from before the pandemic, at its onset, through multiple surges, vaccine rollouts and through the gradual easing of restrictions as society slowly returns to ‘normal’. Methods and analysisThe C3 study is an extension of an ongoing longitudinal cohort study of ‘high-risk’ adults (aged 23–88 at baseline) with one or more chronic medical conditions during the COVID-19 pandemic. Five active studies with uniform data collection prior to COVID-19 were leveraged to establish the C3 cohort; 673 adults in Chicago were interviewed during the first week of the outbreak. The C3 cohort has since expanded to include 1044 participants across eight survey waves (T1–T8). Four additional survey waves (T9–T12) will be conducted via telephone interviews spaced 1 year apart and supplemented by electronic health record and pharmacy fill data, for a total of 5 years of data post pandemic onset. Measurement will include COVID-19-related attitudes/behaviours, mental health, social behaviour, lifestyle/health behaviours, healthcare use, chronic disease self-management and health outcomes. Mental health trajectories and associations with health behaviours/outcomes will be examined in a series of latent group and mixed effects modelling, while also examining mediating and moderating factors. Ethics and disseminationThis study was approved by Northwestern University’s Feinberg School of Medicine Institutional Review Board (STU00215360). Results will be published in international peer-reviewed journals and summaries will be provided to the funders of the study.
Læs mere Tjek på PubMedRamesh, R. M., Oswald, W. E., Israel, G. J., Aruldas, K., Galagan, S., Legge, H., Puthupalayam Kaliappan, S., Walson, J., Halliday, K. E., Ajjampur, S. S. R.
BMJ Open, 30.10.2023
Tilføjet 30.10.2023
ObjectivesWith increasing mobile phone subscriptions, phone-based surveys are gaining popularity with public health programmes. Despite advantages, systematic exclusion of participants may limit representativeness. Similar to control programmes for neglected tropical diseases (NTDs), the DeWorm3 trial of biannual community-wide mass drug administration (MDA) for elimination of soil-transmitted helminth infection used in-person coverage evaluation surveys to measure the proportion of the at-risk population treated during MDA. Due to lockdown during the COVID-19 pandemic, a phone-based coverage evaluation survey was necessary, providing an opportunity for the current study to compare representativeness and implementation (including non-response) of these two survey modes. DesignComparison of two cross-sectional surveys. SettingThe DeWorm3 trial site in Tamil Nadu, India, includes Timiri, a rural subsite, and Jawadhu Hills, a hilly, hard-to-reach subsite inhabited predominantly by a tribal population. ParticipantsIn the phone-based and in-person coverage evaluation surveys, all individuals residing in 2000 randomly selected households (50 in each of the 40 trial clusters) were eligible to participate. Here, we characterise household participation. ResultsOf 2000 households, 1780 (89.0%) participated during the in-person survey. Of 2000 households selected for the phone survey, 346 (17.3%) could not be contacted as they had not provided a telephone number during the census and 1144 (57.2%) participated. Smaller households, households with lower socioeconomic status and those with older, women or less educated household-heads were under-represented in the phone-based survey compared with censused households. Regression analysis revealed non-response in the phone-based survey was higher among households from the poorest socioeconomic quintile (prevalence ratio (PR) 2.3, 95% CI 2.0 to 2.7) and lower when heads of households had completed secondary school or higher education (PR 0.7, 95% CI 0.6 to 0.8). ConclusionsOur findings suggest phone-based surveys under-represent households likely to be at higher risk of NTDs and in-person surveys are more appropriate for measuring MDA coverage within programmatic settings. Trial registration numberNCT03014167.
Læs mere Tjek på PubMedFortuna, D., Caselli, L., Berti, E., Moro, M. L.
BMJ Open, 30.10.2023
Tilføjet 30.10.2023
ObjectivesWe aimed to provide a region-wide comprehensive account of the direct effects of COVID-19 on chronic disease patients, in terms of disease incidence, severity and mortality, over a 2-year pandemic period (2020–2021). DesignPopulation-based retrospective study. Setting/participantsAdult patients, affected by at least 1 of 32 prevalent chronic conditions, residing in the Emilia-Romagna Region in Italy, during the years 2020 (N=1 791 189, 47.7% of the overall adult regional population) and 2021 (N=1 801 071, 47.8%). ResultsCOVID-19 incidence among chronic disease patients was 4.1% (74 067 cases) in 2020 and 7.3% (126 556 cases) in 2021, varying across pathologies, with obesity and dementia showing the highest incidence. Hospitalisation rate for pneumonia or acute respiratory distress syndrome among SARS-CoV-2-positive patients was 15.4%. COVID-19-related excess mortality, that is, deaths from COVID-19 as either main or contributing (1.5% of the total) cause of death, was observed during the three pandemic waves, with observed/expected death ratios ranging from +38% (March 2020) to +11% (December 2021). Increased risks of both COVID-19-related hospitalisation and death were associated with male gender, elderly age and many pre-existing pathologies, including cardiovascular, cerebrovascular and respiratory diseases, neurological and psychiatric disorders, and metabolic dysfunctions. The higher the number of concomitant pathologies, the greater the risk of COVID-19-related adverse outcomes: the likelihood of hospitalisation and death more than doubled for people with more than two comorbidities, compared with those with one underlying condition. ConclusionsThis study presents a thorough and up-to-date quantification of the direct impact of COVID-19 on chronic disease patients. The results obtained are particularly relevant considering that people with pre-existing chronic conditions accounted for almost all cases of COVID-19-related hospitalisation (82.6%) and death (91.5%) in a vast region of Italy, among the hardest hit by the pandemic.
Læs mere Tjek på PubMedInfection, 29.10.2023
Tilføjet 29.10.2023
Abstract Purpose We aimed to assess IgG antibodies against the SARS-CoV-2 spike protein (anti-SARS-CoV-2 S IgG) in vaccinated mothers and their infants at delivery and 2–3 months of age. Methods We conducted a prospective study on mothers who received at least one dose of the COVID-19 vaccine (Pfizer-BNT162b2, Moderna mRNA-1273, or Oxford-AstraZeneca ChAdOx1-S) during pregnancy and on their infants. The baseline was at the time of delivery (n = 93), and the end of follow-up was 2 to 3 months post-partum (n = 53). Serum anti-SARS-CoV-2 S IgG titers and ACE2 binding inhibition levels were quantified by immunoassays. Results Mothers and infants had high anti-SARS-CoV-2 S IgG titers against the B.1 lineage at birth. However, while antibody titers were maintained at 2–3 months post-partum in mothers, they decreased significantly in infants (p 0.8, p
Læs mere Tjek på PubMedAmnuay Kleebayoon; Viroj Wiwanitkit;
Reviews in Medical Virology, 8.09.2023
Tilføjet 8.09.2023
Konstantinos Karampatsas; Asma Khalil; Paul T. Heath; Kirsty Le Doare; Shamez N. Ladhani;
Reviews in Medical Virology, 8.09.2023
Tilføjet 8.09.2023
Haokun Tian; Changsen Yang; Tiangang Song; Kechen Zhou; Lequan Wen; Ye Tian; Lirui Tang; Weikai Xu; Xinyuan Zhang;
Reviews in Medical Virology, 8.09.2023
Tilføjet 8.09.2023
Our study is aimed to access the efficacy and safety outcomes for coronavirus disease 2019 (COVID‐19) patients treated with Paxlovid. According to inclusion and exclusion criteria, databases were used to retrieve articles from 1 January 2020 to 1 January 2023. Article screening, quality evaluation and data extraction were completed and cross‐checked. The meta‐analysis and trial sequential analysis (TSA) were conducted using RevMan, StataMP, and TSA software. A total of 42 original articles were included. Overall meta‐analysis results showed that for death, hospitalisation, death or hospitalisation, emergency department (ED) visit, intensive care unit (ICU) admission, and extra oxygen requirement outcomes, every odds ratio (OR) was 0.05. For adverse events (AEs) outcome, the OR was >1 and
Læs mere Tjek på PubMedSana Zulfiqar; Robin B. Gasser; Sahar Ghodsian; Mustafa Almukhtar; Celia Holland; Ali Rostami;
Reviews in Medical Virology, 8.09.2023
Tilføjet 8.09.2023
The COVID‐19 pandemic linked to the virus SARS‐CoV‐2, which began in China, affected ∼765 million people as of 30 April 2023. The widespread use of corticosteroids for the symptomatic treatment of COVID‐19 could lead to the reactivation of infections of opportunistic pathogens, including . We sought to determine the clinical symptoms and demographic characteristics of SARS‐CoV‐2– co‐infection, particularly in patients with severe disease and being treated with immunosuppressive drugs. To do this, we undertook a systematic review of the literature, and searched public accessible scientific databases—the Web of Science, Scopus, PubMed/Medline and Embase –for eligible studies (1 December 2019 to 30 August 2022). The review protocol is registered in PROSPERO (CRD42022377062). Descriptive statistical analyses were used to present the clinical and laboratory parameters of the co‐infection; for this, we calculated prevalence using the following formula: positive cases/total number of cases × 100. Of a total of 593 studies identified, 17 studies reporting 26 co‐infected patients met the criteria for inclusion in this review. The median age of these patients was 55.14 years. Most of cases (53.8%) were treated with dexamethasone, followed by methylprednisolone (26.9%). Eighteen of 26 patients were immigrants living in European countries or the USA; most of these immigrants originated from Latin America (58%) and South‐East Asia (11%). The commonest symptoms of co‐infection were abdominal pain (50%), fever (46.1%), dyspnoea (30.7%) and cough (30.7%), and frequently reported laboratory findings were high absolute eosinophil count (38.4%), high white blood cell count (30.7%), high C‐reactive protein (23.0%) and high neutrophil count (19.2%). Two of the 26 patients (7.7%) had fatal outcomes. Most of the SARS‐CoV‐2– coinfected cases were immigrants living in developed countries, emphasising the need for clinicians in these countries to be aware of clinical and laboratory parameters associated with such co‐infections, as well as the key importance of rapid and accurate diagnostic tests for timely and effective diagnosis and patient management.
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