47 ud af 47 tidsskrifter valgt, søgeord (hepatitis) valgt, emner højest 180 dage gamle, sorteret efter nyeste først.
168 emner vises.
151
Histomolecular characterisation of hepatitis B virus induced liver cancer
Adane Adugna;
Reviews in Medical Virology, 11.11.2023
Tilføjet 11.11.2023
Hepatitis B virus (HBV)‐associated liver cancer is the third most prevalent cancer‐related cause of death worldwide. Different studies have been done on the histomolecular analysis of HBV induced‐liver cancer including epigenetics which are dynamic molecular mechanisms to control gene expression without altering the host deoxyribonucleic acid, genomics characterise the integration of the viral genome with host genome, proteomics characterise how gene modifies and results overexpression of proteins, glycoproteomics discover different glyco‐biomarker candidates and show glycosylation in malignant hepatocytes, metabolomics characterise how HBV impairs a variety of metabolic functions during hepatocyte immortalisation, exosomes characterise immortalised liver cells in terms of their differentiation and proliferation, and autophagy plays a role in the development of hepatocarcinogenesis linked to HBV infection.
Læs mere
Tjek på PubMed
152
A monoclonal antibody activating AdipoR for type 2 diabetes and nonalcoholic steatohepatitis
Naomi Asahara, Miki Okada-Iwabu, Masato Iwabu, Kouichi Wada, Kozo Oka, Toshimasa Yamauchi, Takashi Kadowaki
Science Advances, 11.11.2023
Tilføjet 11.11.2023
153
Noninvasive diagnosis of significant liver inflammation in patients with chronic hepatitis B in the indeterminate phase
Jie ZhanJian WangZhiyi ZhangRuifei XueSuling JiangJiacheng LiuYilin LiuLi ZhuJuan XiaXiaomin YanWeimao DingChuanwu ZhuYuanwang QiuJie LiRui HuangChao Wua Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, Chinab Department of General Practice, Jiangpu Street Community Health Service Center, Nanjing, Jiangsu, Chinac Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, Chinad Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, Chinae Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, Chinaf Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, Jiangsu, Chinag Department of Hepatology, Huai’an No. 4 People’s Hospital, Huai’an, Jiangsu, Chinah Department of Infectious Diseases, The Fifth People’s Hospital of Wuxi, Wuxi, Jiangsu, China
Virulence, 9.11.2023
Tilføjet 9.11.2023
154
Impact of voluntary testing on infectious disease epidemiology: A game theoretic approach
Amandine Pepiot, Virginie Supervie, Romulus Breban
PLoS One Infectious Diseases, 8.11.2023
Tilføjet 8.11.2023
by Amandine Pepiot, Virginie Supervie, Romulus Breban The World Health Organization recommends test-and-treat interventions to curb and even eliminate epidemics of HIV, viral hepatitis, and sexually transmitted infections (e.g., chlamydia, gonorrhea, syphilis and trichomoniasis). Epidemic models show these goals are achievable, provided the participation of individuals in test-and-treat interventions is sufficiently high. We combine epidemic models and game theoretic models to describe individual’s decisions to get tested for infectious diseases within certain epidemiological contexts, and, implicitly, their voluntary participation to test-and-treat interventions. We develop three hybrid models, to discuss interventions against HIV, HCV, and sexually transmitted infections, and the potential behavioral response from the target population. Our findings are similar across diseases. Particularly, individuals use three distinct behavioral patterns relative to testing, based on their perceived costs for testing, besides the payoff for discovering their disease status. Firstly, if the cost of testing is too high, then individuals refrain from voluntary testing and get tested only if they are symptomatic. Secondly, if the cost is moderate, some individuals will test voluntarily, starting treatment if needed. Hence, the spread of the disease declines and the disease epidemiology is mitigated. Thirdly, the most beneficial testing behavior takes place as individuals perceive a per-test payoff that surpasses a certain threshold, every time they get tested. Consequently, individuals achieve high voluntary testing rates, which may result in the elimination of the epidemic, albeit on temporary basis. Trials and studies have attained different levels of participation and testing rates. To increase testing rates, they should provide each eligible individual with a payoff, above a given threshold, each time the individual tests voluntarily.
Læs mere
Tjek på PubMed
155
Prevalence of HDV infection in Central Italy has remained stable across the last two decades with dominance of sub-genotypes 1 and characterized by elevated viral replication
Romina Salpini, Lorenzo Piermatteo, Giulia Torre, Stefano D'Anna, Sohaib Khan, Leonardo Duca, Ada Bertoli, Simone La Frazia, Vincenzo Malagnino, Elisabetta Teti, Marco Iannetta, Pierpaolo Paba, Marco Ciotti, Ilaria Lenci, Simona Francioso, Caterina Paquazzi, Miriam Lichtner, Claudio Mastroianni, Francesco Santopaolo, Giuseppe De Sanctis, Adriano Pellicelli, Giovanni Galati, Alessandra Moretti, Katia Casinelli, Luciano Caterini, Nerio Iapadre, Giustino Parruti, Iacopo Vecchiet, Maurizio Paoloni, Massimo Marignani, Francesca Ceccherini-Silberstein, Leonardo Baiocchi, Sandro Grelli, Loredana Sarmati, Valentina Svicher
International Journal of Infectious Diseases, 7.11.2023
Tilføjet 7.11.2023
Hepatitis D virus (HDV) is the smallest known human virus with a genome of ∼1.7 kb single-stranded circular RNA. HDV is a satellite virus that can infect only in presence of hepatitis B virus (HBV), its helper virus [1]. Indeed, HDV exploits the HBV surface proteins (collectively defined as HBsAg) for the release of its progeny and de novo entry into hepatocytes[1]. HBV+HDV infection causes the most severe form of viral hepatitis, leading to the development of cirrhosis in 15% of cases within 1–2 years and in 70–80% of cases within 5–10 years[2].
Læs mere
Tjek på PubMed
156
Hepatitis B vaccination status and knowledge, attitude, and practice towards Hepatitis B virus among medical sciences students: A cross-sectional study
Ibrahim A. Naqid, Ahmed A. Mosa, Shah Vahel Ibrahim, Nizar Hussein Ibrahim, Nawfal R. Hussein
PLoS One Infectious Diseases, 6.11.2023
Tilføjet 6.11.2023
by Ibrahim A. Naqid, Ahmed A. Mosa, Shah Vahel Ibrahim, Nizar Hussein Ibrahim, Nawfal R. Hussein Background and aims Healthcare staff are at high risk of occupational exposure to Hepatitis B and other blood-borne diseases. Lack of education about the knowledge of Hepatitis B virus contributes to an increase in cases. This study aims to determine the knowledge of the Hepatitis B virus among the medical professionals in Duhok province, Kurdistan Region of Iraq, and to determine their knowledge of the importance of vaccination. Materials and methods This cross-sectional study was conducted in Duhok province, Kurdistan Region of Iraq, among medical science students from November 2022 to February 2023 and a total of 511 students participated in the study. A Self-administered questionnaire comprising 22 items categorized into five sections was distributed to the students either electronically or by paper and pen method. The survey utilized a Five-point Likert scale when assessing respondents’ opinions on knowledge, attitude, and practice (KAP). Microsoft Excel and GraphPad Prism 9 were used for statistical analysis. Results A total of 511 responses were collected from medical, dental, pharmacy, and laboratory students. The average age of the participants was 20.74 ±1.43 years. Among the respondents, only 96 (18.8%) were fully vaccinated against the Hepatitis B virus (received 3 or more doses of the vaccine), while 294 (57.5%) were not vaccinated. Lack of vaccination programs was the major reason for not receiving a vaccination (n = 182, 62%). About 286 (55.96%) of the participants had good knowledge, attitude, and practice on Hepatitis B, manifesting median scores of 26, 18, and 20, respectively. Conclusion In our study, half of the students were found to be unvaccinated, mainly due to the absence of vaccination programs. Vaccinated students exhibited better knowledge, attitude, and practice toward the infection than non-vaccinated students. Therefore, we recommend the implementation of a vaccination program as well as training on infection prevention guidelines to increase awareness and encourage vaccination.
Læs mere
Tjek på PubMed
157
Hepatitis A outbreak in a refugee shelter in Kiel, northern Germany
Andi Krumbholz, Anne Marcic, Malte Valentin, Mathias Schemmerer, Jürgen J. Wenzel
Journal of Medical Virology, 3.11.2023
Tilføjet 3.11.2023
158
Serum wisteria floribunda agglutinin-positive human Mac-2 binding protein is unsuitable as a diagnostic marker of occult hepatocellular carcinoma in end-stage liver cirrhosis
Kantoku Nagakawa, Masaaki Hidaka, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Takayuki Tanaka, Tomohiko Adachi, Akihiko Soyama, Kengo Kanetaka, Susumu Eguchi
PLoS One Infectious Diseases, 2.11.2023
Tilføjet 2.11.2023
by Kantoku Nagakawa, Masaaki Hidaka, Takanobu Hara, Hajime Matsushima, Hajime Imamura, Takayuki Tanaka, Tomohiko Adachi, Akihiko Soyama, Kengo Kanetaka, Susumu Eguchi Background and purpose Serum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) is a marker of liver fibrosis and hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the diagnostic ability of WFA+-M2BP for occult HCC, which current diagnostic imaging tests fail to detect. Methods Patients who underwent hepatectomy for liver transplantation (LT) and whose whole liver could be sliced and subjected to histological examination between 2010 and 2018 were eligible for this study (n = 89). WFA+-M2BP levels were measured in samples collected before the LT. Comparison of the postoperative histological test results with the preoperative imaging data grouped the patients into histologically no group (N), histologically detected group (D), histologically increased group (I), and histologically decreased or same group (DS), and the results were compared with the WFA+-M2BP values. In addition, comparisons were made between each data with and without HCC, including occult HCC, and total tumor diameter. Results Irrespective of underlying hepatic disease conditions, there were 6 patients in the N group, 10 in the D group, 41 in the I group, and 32 in the DS group. The median of the serum WFA+-M2BP level for each group was as follows: N group, 8.05 (1.25–11.9); D group, 11.025 (1.01–18.21); I group, 9.67 (0.29–17.83); and DS group, 9.56 (0.28–19.44) confidence of interval. We found no significant differences between the pairings. Comparison of underlying hepatic diseases revealed that liver cirrhosis due to hepatitis B and C and non-B and -C liver cirrhosis had no significant differences. AFP levels, on the other hand, had significant relationships in comparison between the presence or absence of histological HCC, in correlation between total tumor diameter, and in the ROC analysis for the diagnosis of HCC including occult HCC. Conclusion Serum WFA+-M2BP cannot help diagnose occult HCC that is already undetected using imaging tests in decompensated liver cirrhosis patients requiring LT.
Læs mere
Tjek på PubMed
159
Clinical, Gender, Socioeconomic Characteristics and Outcomes of Individuals Receiving Hepatitis B Treatment in Ethiopia: 18-Month Follow-Up
American Journal of Tropical Medicine and Hygiene, 1.11.2023
Tilføjet 1.11.2023
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 109 Issue: 5 Pages: 1161-1165
Læs mere
Tjek på PubMed
160
‘Prevalence of human immunodeficiency virus, syphilis, and hepatitis B and C virus infections in pregnant women: a systematic review and meta-analysis’ – Author’s reply
Shouyuan Wu, Jianjian Wang, Yaolong Chen
Clinical Microbiology and Infection, 31.10.2023
Tilføjet 31.10.2023
We would like to thank Dr Zhou and his colleague for their interest in our paper and for taking the time to express their concerns. In his letter to the editor, Dr Zhou raised valid concerns regarding the pooled Human immunodeficiency virus (HIV) prevalence of this analysis1,2. We would like to address these concerns and provide our response.
Læs mere
Tjek på PubMed
161
Trends in sexually transmitted and blood-borne infections in China from 2005 to 2021: a joinpoint regression model
BMC Infectious Diseases, 30.10.2023
Tilføjet 30.10.2023
Abstract Background Sexually transmitted and blood-borne infections (STBBIs) is a major public health concern in China. This study assessed the overall trends in STBBIs to improve the comprehensive understanding of the burden of STBBIs and provide evidence for their prevention and control. Methods Data for the period from 2005 to 2021 were analyzed across China on infections with hepatitis B or C; syphilis; gonorrhea; and HIV infection. Trends, annual percent change (APC), and average annual percent change (AAPC) in diagnosis rate was analyzed using joinpoint regression models for the five STBBIs together or individually. Results From 2005 to 2021, the overall diagnosis rate of all five STBBIs increased, with an AAPC of 1.3% [95% confidence interval (CI) -0.5% to 3.1%]. Diagnosis rates of HIV, syphilis and hepatitis C increased individually, but it decreased for infections of hepatitis B and gonorrhea. Joinpoint analysis identified four phases in diagnosis rate of hepatitis C; three phases in diagnosis rate of hepatitis B, HIV infection, and syphilis; two in diagnosis rate of gonorrhea infection. Conclusion Despite national efforts to prevent and control STBBIs, their overall diagnosis rate has continued to rise in China, and they remain an important public health challenge. Further efforts should be made to educate the general population about STBBIs, particularly HIV. Interventions targeting vulnerable groups should be adopted and their efficacy monitored through regular analysis of trends.
Læs mere
Tjek på PubMed
162
Molecular point of care testing for hepatitis C: available technologies, pipeline and promising future directions
Journal of Infectious Diseases, 29.10.2023
Tilføjet 29.10.2023
AbstractHepatitis C (HCV) remains a major public health problem, despite the availability of effective treatments. In many areas, the ability to diagnose HCV infection at the point of care is key to scaling up access to care and treatment. To achieve this, an accurate, easy-to-use and affordable diagnostic tool is required – this would enable decentralized testing and the creation of one-stop centers to eliminate gaps in the care cascade, which would help reach the millions of people with undiagnosed HCV in low- and middle-income countries and high-risk populations in high income countries. In this review, we examine the current state of point-of-care molecular technologies, the advantages and limitations of currently available devices (both near- and true-point-of-care), the potential of molecular testing to transform diagnostic medicine in the future, and the challenges that need to be addressed for broader adoption of this technology in routine clinical practice.
Læs mere
Tjek på PubMed
163
Virus infection participates in the occurrence and development of human diseases through monoamine oxidase
Yujie Sun; Wen Liu; Bing Luo;
Reviews in Medical Virology, 8.09.2023
Tilføjet 8.09.2023
Monoamine oxidase (MAO) is a membrane‐bound mitochondrial enzyme that maintains the steady state of neurotransmitters and other biogenic amines in biological systems through catalytic oxidation and deamination. MAO dysfunction is closely related to human neurological and psychiatric diseases and cancers. However, little is known about the relationship between MAO and viral infections in humans. This review summarises current research on how viral infections participate in the occurrence and development of human diseases through MAO. The viruses discussed in this review include hepatitis C virus, dengue virus, severe acute respiratory syndrome coronavirus 2, human immunodeficiency virus, Japanese encephalitis virus, Epstein‐Barr virus, and human papillomavirus. This review also describes the effects of MAO inhibitors such as phenelzine, clorgyline, selegiline, M‐30, and isatin on viral infectious diseases. This information will not only help us to better understand the role of MAO in the pathogenesis of viruses but will also provide new insights into the treatment and diagnosis of these viral diseases.
Læs mere
Tjek på PubMed
164
Prospects for developing an Hepatitis C virus E1E2‐based nanoparticle vaccine
Eric A. Toth; Alexander K. Andrianov; Thomas R. Fuerst;
Reviews in Medical Virology, 8.09.2023
Tilføjet 8.09.2023
Globally, more than 58 million people are chronically infected with Hepatitis C virus (HCV) with 1.5 million new infections occurring each year. An effective vaccine for HCV is therefore a major unmet medical and public health need. Since HCV rapidly accumulates mutations, vaccines must elicit the production of broadly neutralising antibodies (bnAbs) in a reproducible fashion. Decades of research have generated a number of HCV vaccine candidates. Based on the available data and research through clinical development, a vaccine antigen based on the E1E2 glycoprotein complex appears to be the best choice, but robust induction of humoral and cellular responses leading to virus neutralisation has not yet been achieved. One issue that has arisen in developing an HCV vaccine (and many other vaccines as well) is the platform used for antigen delivery. The majority of viral vaccine trials have employed subunit vaccines. However, subunit vaccines often have limited immunogenicity, as seen for HCV, and thus multiple formats must be examined in order to elicit a robust anti‐HCV immune response. Nanoparticle vaccines are gaining prominence in the field due to their ability to facilitate a controlled multivalent presentation and trafficking to lymph nodes, where they can interact with both arms of the immune system. This review discusses the potential for development of a nanoparticle‐based HCV E1E2 vaccine, with an emphasis on the potential benefits of such an approach along with the major challenges facing the incorporation of E1E2 into nanoparticulate delivery systems and how those challenges can be addressed.
Læs mere
Tjek på PubMed
165
Trends in disease burden of hepatitis B infection in Jiangsu Province, China, 1990–2021
Infectious Disease Modelling, 11.07.2023
Tilføjet 11.07.2023
Publication date: Available online 10 July 2023 Source: Infectious Disease Modelling Author(s): Kang Fang, Yingying Shi, Zeyu zhao, Yunkang Zhao, Yichao Guo, Buasivamu Abudunaibi, Huimin Qu, Qiao Liu, Guodong Kang, Zhiguo Wang, Jianli Hu, Tianmu Chen
Læs mere
Tjek på PubMed
166
Canonical fibroblast growth factors in viral infection
Giulia Lottini; Erika Plicanti; Michele Lai; Paola Quaranta; Mauro Pistello; Giulia Freer;
Reviews in Medical Virology, 10.07.2023
Tilføjet 10.07.2023
Fibroblast growth factors (FGFs) are a family of proteins that play a crucial role in the development and maintenance of various tissues in the body. There are three function‐al groups of FGFs: canonical FGFs (cFGFs), intracellularly retained FGFs, and metabolic (also called endocrine) FGFs. cFGFs are secreted and act in an autocrine/paracrine fashion to regulate differentiation during foetal development, as well as tissue repair in adults. Recent studies have also begun to unravel the role of cFGFs during viral infections, suggesting that FGF‐2 and other canonical FGFs may have an important virus‐specific role, also by the regulation of the immune response. Because dysregulation in the FGF pathways is pivotal in cancer development, FGFs are the target of many anticancer drugs. These drugs may be repurposed to treat viral infection, since dysregulation of FGF signalling has been implicated in the pathogenesis of viral infections, such as hepatitis C. Overall, the role of cFGFs during viral infection is an underrepresented area of current research. This review focuses on overviewing the effects of canonical FGFs during infection by different viruses. Many studies highlight that the effects of FGFs during viral infection may be complex and context‐dependent. While there is evidence to suggest that FGFs may have a beneficial impact on the immune response and tissue repair during viral infection, further studies are needed to fully understand the mechanisms underlying these effects and to determine in what cases FGFs could be targeted as a therapeutic approach for viral infection.
Læs mere
Tjek på PubMed
167
Diagnostic performance of hepatitis C core antigen assay to identify active infections: A systematic review and meta‐analysis
Daniel Sepúlveda‐Crespo; Ana Treviño‐Nakoura; José M. Bellón; Amanda Fernández‐Rodríguez; Pablo Ryan; Isidoro Martínez; María A. Jiménez‐Sousa; Salvador Resino;
Reviews in Medical Virology, 10.05.2023
Tilføjet 10.05.2023
Hepatitis C virus (HCV) core antigen (HCVcAg) assay is an alternative for diagnosing HCV infection in a single step. This meta‐analysis aimed to evaluate the Abbott ARCHITECT HCV Ag assay\'s diagnostic performance (validity and utility) for diagnosing active hepatitis C. PubMed, EMBASE, Scopus, Web of Science, and Cochrane Library were searched until 10 January 2023. The protocol was registered at the prospective international register of systematic reviews (PROSPERO: CRD42022337191). Abbott ARCHITECT HCV Ag assay was the test for evaluation, and nucleic acid amplification tests with a cut‐off ≤50 IU/mL were the gold standard. Statistical analysis was performed using STATA with the MIDAS module and random‐effects models. The bivariate analysis was conducted on 46 studies (18,116 samples). The pooled sensitivity was 0.96 (95% CI = 0.94–0.97), specificity 0.99 (95% CI = 0.99–1.00), positive likelihood ratio 141.81 (95% CI = 72.39–277.79), and negative likelihood ratio 0.04 (95% CI = 0.03–0.06). The area under the summary receiver operating characteristic curve was 1.00 (95% CI = 0.34–1.00). For active hepatitis C prevalence values of 0.1%–15%, the probability that a positive test was a true positive was 12%–96%, respectively, indicating that a confirmatory test should be necessary, particularly with a prevalence ≤5%. However, the probability that a negative test was a false negative was close to zero, indicating the absence of HCV infection. The validity (accuracy) of the Abbott ARCHITECT HCV Ag assay for screening active HCV infection in serum/plasma samples was excellent. Although the HCVcAg assay showed limited diagnostic utility in low prevalence settings (≤1%), it might help diagnose hepatitis C in high prevalence scenarios (≥5%).
Læs mere
Tjek på PubMed
168
Sphingosine‐1‐phosphate related signalling pathways manipulating virus replication
Lu Zhang; Juan Liu; Erya Xiao; Qingzhen Han; Lin Wang;
Reviews in Medical Virology, 24.04.2023
Tilføjet 24.04.2023
Viruses can create a unique cellular environment that facilitates replication and transmission. Sphingosine kinases (SphKs) produce sphingosine‐1‐phosphate (S1P), a bioactive sphingolipid molecule that performs both physiological and pathological effects primarily by activating a subgroup of the endothelial differentiation gene family of G‐protein coupled cell surface receptors known as S1P receptors (S1PR1‐5). A growing body of evidence indicates that the SphK/S1P axis is crucial for regulating cellular activities in virus infections like respiratory viruses, enteroviruses, hepatitis viruses, herpes viruses, and arboviruses replicate. Depending on the type of virus, pro‐ or anti‐viral activities of the SphK/S1P axis sometimes rely on the host immune system and sometimes directly through intracellular signalling pathways or cell proliferation. Recent research has shown novel roles of S1P and SphK in viral replication. Sphingosine kinase isoforms (SphK1 and SphK2) levels can be manipulated by several viruses to promote the effects that are expected. Regulation of cellular signalling pathways plays a significant role in the mechanism. The purpose of this review is to provide insight of the characters played by the SphK/S1P axis throughout diverse viral infection processes. We then assess potential therapeutic methods that are based on S1P signalling and metabolism during viral infections.
Læs mere
Tjek på PubMed