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Søgning på udtrykket 'tnf' giver 25 resultater
Dokumenter [2] Sider [2] Nyt fra tidsskrifterne [+20] Aktuelle smitsomme sygdomme [1]
Dokumenter [2]
[…] vejledning omhandler vurdering og behandling af tuberkuloseinfektion hos voksne, som skal behandles med immunsupprimerende medicin i form af f.eks TNF-α hæmmere eller andre immunsupprimerende biologiske lægemidler, hvor der er øget risiko for tuberkulosereaktivering. Guideline dækker ikke børn, personer med medfødt immundefekt, HIV positive, patienter i dialyse, patienter med dysreguleret diabetes, silicose, erhvervede immundefekter eller patienter i konventionel kortvarig kemoterapi. Denne guideline […]
[…] biologiske og målrettede syntetiske lægemidler (BMSL) til patienter i forhold til risiko for tuberkulose (TB), Humant Papillom Virus (HPV), Hepatitis B og C (HBV og HCV), Varicella Zoster Virus (VZV), Herpes Simplex Virus (HSV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV) og Humant Immundefekt Virus (HIV) og øvrige infektioner. Vejledningen er udarbejdet af repræsentanter fra Dansk Selskab for Gastroenterologi og Hepatologi (DSGH), Dansk Reumatologisk Selskab (DRS), Dansk Dermatologisk […]
Sider [2]
[…] Fischer, Marie Helleberg, Jannik Helweg-Larsen, Lykke Larsen, Daria Podlekareva, Line Dahlerup Rasmussen, Pernille Ravn Aspleni Vaccination af voksne kandidater og recipienter til solid organtransplantation TNF-alfa screening Pernille Ravn (tovholder) og Jan Gerstoft Screening, profylakse og information før behandling med anti-TNF-alfa Tjekliste ved screening før behandling med anti-TNF-alpha Indvandrermedicin Chalotte Stecher (tovholder), Hanne Nødgaard Christensen, Christian Wejse, Jane Agergaard, […]
[…] Patienter i kronisk hæmodialysebehandling Patienter forud for behandling med biologiske lægemidler (fx monoklonale antistoffer, TNF-alfa– og interleukin 1 blokerende behandling) Patienter forud for immunterapi Patienter forud for kemoterapi Patienter med forhøjet ALAT (>50 IU/l mænd og >35 IU/l kvinder) Patienter med hepatitis C Patienter med HIV Patienter med cirrose Patienter med primær lever cancer Normalområdet for ALAT ved kronisk viral hepatitis Der er i Skandinavien indført et normalområde […]
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JAMA Network Open New Online
11. september 2025
This systematic review and meta-analysis of head-to-head comparative effectiveness studies examines safety outcomes in patients with immune-mediated inflammatory diseases (IMIDs) treated with Janus kinase (JAK) inhibitors vs tumor necrosis factor (TNF) antagonists.
Proceedings of the National Academy of Sciences
29. august 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025. SignificanceThe mechanism of how tumor necrosis factor (TNF) triggers extrinsic apoptosis is key to understanding both physiological homeostasis and inflammatory ailments. Upon TNF receptor ligation, it is believed that merely one or three molecules of ...
Journal of Medical Virology
9. august 2025
Journal of Medical Virology, Volume 97, Issue 8, August 2025.
Clinical & Experimental Immunology
29. juli 2025
[…] Introduction Heterozygous loss-of-function mutations in the TNFAIP3 gene lead to A20 haploinsufficiency (HA20). A20 protein is a negative feedback regulator of NF-κB signaling. Traditionally, HA20 is associated with Behçet\'s disease-like symptoms, however, recent findings suggest it may also manifest with a broader array of autoimmune diseases. This study introduces a novel TNFAIP3 variant within a Dutch family, predominantly exhibiting polyautoimmunity rather than autoinflammatory […]
PLoS One Infectious Diseases
6. juni 2025
[…] Ying Chen, Yanqiu Li, Deyu Zhang Tumor necrosis factor alpha-induced protein 9 (TNFAIP9) is a crucial effector molecule that protects cells from inflammatory and metabolic damage. This study focuses on investigating the role and regulatory mechanisms of TNFAIP9 in the progression of chronic kidney disease (CKD). By analyzing CKD-related datasets from the GEO database, we discovered that TNFAIP9 was upregulated in CKD patients and CKD mice compared to their normal controls. To elucidate the functional […]
PLoS One Infectious Diseases
5. februar 2025
by Lavanya Joshi, Meenakshi Ponnana, Ramya Sivangala, Lakshmi Kiran Chelluri, Prathiba Nallari, Sitaramaraju Penmetsa, Vijayalakshmi Valluri, Sumanlatha Gaddam
PLoS One Infectious Diseases
10. januar 2025
by The PLOS ONE Editors
Journal of Medical Virology
1. januar 2025
Journal of Medical Virology, Volume 97, Issue 1, January 2025.
PLoS One Infectious Diseases
7. november 2025
[…] due to increased levels of TNF-α and IL-1ß, feeding with hazelnut did not change it. In heart, inflammatory cytokines were similar between groups. In histopathological analysis, inflammation was observed both in livers, hearts of HFCS group. In hazelnut group, a significant decrease in damage was observed compared to HFCS, HFCS+H groups. According to our results, hazelnut supplementation reduced liquid intake and showed limited cardiac protection, but did not reverse HFCS-induced hepatic or cardiac […]
PLoS One Infectious Diseases
1. november 2025
[…] contribution. Mediation analysis confirmed that inflammation and oxidative stress exert mediating effects. GO and KEGG enrichment analyses indicated that its effects are exerted through the TNF and PI3K–Akt signaling pathways, and that DHBMA binds stably to AKT1. Conclusion This nationally representative cross-sectional study revealed a positive correlation between exposure to mVOCs and sarcopenia via TNF and PI3K–Akt signaling pathways. DHBMA plays a potentially pivotal role in this […]
PLoS One Infectious Diseases
25. oktober 2025
[…] oligodendrocytes by regulating oxidative stress levels. in vivo experiments further confirmed the neurorestorative effects of TRIM37. In an experimental autoimmune encephalomyelitis (EAE) model, overexpression TRIM37 significantly suppressed neuroinflammation mediated by microglia, reduced the expression of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), and alleviated demyelination lesions (as evidenced by reduced myelin damage shown by Luxol fast blue (LFB) staining, P […]
Journal of Acquired Immune Deficiency Syndromes
24. oktober 2025
[…] dysfunction, neurogenesis, and inflammatory responses were assessed by multiplex profiling and ELISA. Results: The majority of inflammatory biomarkers either decreased or remained unchanged over the evaluated time frame. Notable exceptions were IL-9, TNF-α, and CCL-4, which increased at t=2 compared to earlier time points. The BBB disruption and vascular dysfunction biomarkers (S100β and soluble ICAM1, respectively) increased at t=1 and then returned to basal levels, suggesting transient loss of BBB […]
BMC Infectious Diseases
24. oktober 2025
[…] no differences in expression were observed between the treatment success and failure groups for most activation, co-stimulatory, and co-inhibitory molecules and transcription factors. Furthermore, no difference in effector cytokine production (IL-2, TNF, and IFN-γ) in CD4+ and CD8+ T cells was observed between the groups. However, patients with MAC-PD with low IL-2-producing CD8⁺ T cells had a significantly longer disease duration than those with moderate and high IL-2-producing status (138.3 vs. 42.7 […]
BMJ Open
22. oktober 2025
[…] a combination of PFAD–RRT will be employed. The primary endpoint of this study is all-cause mortality at 90 days after enrolment. Secondary endpoints of the study include the declining proportion of serum cytokines such as tumour necrosis factor-α (TNF-α), IL-4, IL-6, IL-8, IL-10 and high-mobility group box 1 within 24 hours after enrolment. Additionally, the study will evaluate the improvement of the Sequential Organ Failure Assessment score on day 7 postenrolment, as well as the 30-day mortality […]
PLoS One Infectious Diseases
13. oktober 2025
[…] by biomarkers in blood serum. Clarifying methodological aspects of biomarkers may provide insights into their predictive role in the pathway of developing WMSDs. This study will primarily assess reliability of systemic inflammatory biomarkers (CRP, TNF-α, IL-6, IL-1β) and immune cell reactivity by repeated measures in workers with constant workloads over time. Methods This observational cross-sectional study will include two groups of workers: exposed group including workers exposed to higher […]
Journal of Infectious Diseases
11. oktober 2025
[…] and signaling pathways of immune cells, and flow cytometry analysis further confirmed the scRNA-seq data. An in-depth analysis with macrophages, the main target cell for Brucella, demonstrated activation of type I IFN and type II IFN signaling, TNF production, diverse cell deaths, etc. Specifically, Vir-2308 Brucella infection induced IFN-β expression, primarily originating from macrophages. In vitro, a significantly lower level of intracellular Brucella survival was observed in ifnar1-/- […]
PLoS One Infectious Diseases
10. oktober 2025
[…] poor adherence to ART (missing two or more doses in 2 weeks) (adjusted OR (AOR) = 14.96; 95% CI: 2.39–93.49, p = 0.004) and lower CD4 count (AOR; 0.99, 0.99–1.00, p = 0.026). Proinflammatory markers tumor necrosis factor-alpha (TNF-α) (p = 0.196) and D-dimer (p = 0.709) did not differ between the suppressed and unsuppressed CPHIV. Conclusion One in six children with perinatally acquired HIV in Ndola, Zambia, had unsuppressed viral load, which was associated with poor ART adherence and lower CD4 counts. […]
Journal of Infectious Diseases
7. oktober 2025
[…] using flow cytometry and quantitated cytokines on an expanded cohort (n=29) to confirm FLEX-CITE-Seq findings.Results Cell types with statistically significantly differential levels of expression for more than 40 genes all had over-representation of a TNF-mediated pathway. In an expanded cohort of 29 people with HIV, we found a larger percentage of plasmacytoid dendritic cells by flow cytometry and increased plasma IL-6, IL-12p70, IL-15, IL-2, IFN-alpha, and TNF in the TB history group (n=18) compared […]
BMJ Open
6. oktober 2025
[…] irradiation. Primary and secondary outcome measuresThe primary outcome was degree of pain rating (VAS). Secondary outcomes included forearm disability (Patient-Rated Tennis Elbow Evaluation, PRTEE), grip strength, serum tumour necrosis factor-alpha (TNF-α) levels and treatment satisfaction. Assessments were conducted at baseline, post-treatment (3 weeks) and at 4-week follow-up. ResultsPBMT-sMF yielded a higher responder rate (defined as the proportion of participants achieving at least a 30% reduction […]
PLoS One Infectious Diseases
4. oktober 2025
[…] (TNF-α), interleukin-1β (IL-1β), and intestinal fatty acid binding protein (iFABP) levels using enzyme-linked immunosorbent assays (ELISA). The thiobarbituric acid test was used to measure the concentration of serum malondialdehyde (MDA). Dietary intake data were collected using structured questionnaires. Logistic regression models were used to evaluate associations with CRC risk. Results CRC patients showed significantly higher levels of TNF-α, IL-1β, MDA and iFABP compared to the control group (p […]
Aktuelle smitsomme sygdomme [1]
Aktuelle smitsomme sygdomme [1]
Medscape Infectious Diseases
29. oktober 2025
Several factors — but not older age — increased infection risk with the use of non-TNF biologics following first-line anti-TNF use. Medscape Medical News