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30 emner vises.
Suchun Wang, Nan Jiang, Lijian Jiang, Qingye Zhuang, Qiong Chen, Guangyu Hou, Zhiyu Xiao, Ran Zhao, Yang Li, Chenglong Zhao, Fuyou Zhang, Jianmin Yu, Jinping Li, Hualei Liu, Fuliang Sun, Kaicheng Wang
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Suchun Wang, Nan Jiang, Lijian Jiang, Qingye Zhuang, Qiong Chen, Guangyu Hou, Zhiyu Xiao, Ran Zhao, Yang Li, Chenglong Zhao, Fuyou Zhang, Jianmin Yu, Jinping Li, Hualei Liu, Fuliang Sun, Kaicheng Wang
In order to develop an appropriate method for high-throughput detection of avian metapneumovirus, a quadruple real-time reverse-transcription polymerase chain reaction assay was established with four pairs of specific primers and four specific probes based on the G or M gene of aMPV-A, aMPV-B, aMPV-C and aMPV-D. Its specificity and sensitivity were evaluated, and clinical samples were tested by the method. The results showed that all the four subgroups of avian metapneumovirus can be detected in the quadruple real-time RT-PCR assay simultaneously, with a detection limit of 100–1000 cRNA copies/reaction. The other common poultry viruses were negative. In the avian clinical sample detection, 39 out of 1920 clinical samples collected from 8 provinces were positive. Compared with published RT-PCR assays, the κ value of the quadruple real-time RT-PCR assay in 1920 avian clinical samples was 1.000 (P < 0.001). The established method could be used for the rapid detection of the four subgroups of avian metapneumovirus with high specificity and high sensitivity.
Læs mere Tjek på PubMedPei-Che Chung, Hung-Yi Wu, Yi-Chia Chen, Ting-Hsuan Hung, Chia-Lin Chung
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Pei-Che Chung, Hung-Yi Wu, Yi-Chia Chen, Ting-Hsuan Hung, Chia-Lin Chung
Anthracnose is a major disease of strawberry that seriously impacts the strawberry industry. To prevent the spread of anthracnose through symptomless plants, it is important to detect pathogenic Colletotrichum spp. at the latent infection stage in the nursery. Previous PCR-based methods developed for the diagnosis or detection of Colletotrichum acutatum and Colletotrichum gloeosporioides have used primers targeting the internal transcribed spacer region of ribosomal DNA, β-tubulin gene, or mating type gene. In this study, to specifically detect Colletotrichum siamense and Colletotrichum fructicola, the most predominant and virulent Colletotrichum species causing strawberry anthracnose in Taiwan, we conducted a comparative genomics analysis of 29 Colletotrichum spp. and identified a non-conserved 1157-bp intergenic region suitable for designing specific primers for a nested PCR assay. In silico analysis and actual tests suggested that the new nested PCR assay could detect pathogenic C. siamense and C. fructicola, but not other strawberry pathogens (Botrytis sp., Fusarium spp., Neopestalotiopsis rosae, and Phytophthora sp.) or ubiquitous saprophytes (Fusarium spp. and Trichoderma spp.). The inner to outer primer ratio was optimized to 1:10 to eliminate unexpected bands and enhance the signal. The assay could detect as little as 1 pg of C. siamense genomic DNA, which corresponds to ~15 cells. Application of the new detection assay on 747 leaf samples collected from 18 strawberry nurseries in 2019 and 2020 showed that an average of 20% of strawberry mother plants in Taiwan were latently infected by C. siamense or C. fructicola. The newly developed assay is being applied to facilitate the production of healthy strawberry runner plants in Taiwan.
Læs mere Tjek på PubMedMaximilian Nicolaus Burger, Matthias Mayer, Ivo Steimanis
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Maximilian Nicolaus Burger, Matthias Mayer, Ivo Steimanis
Background Many countries, such as Germany, struggle to vaccinate enough people against COVID-19 despite the availability of safe and efficient vaccines. With new variants emerging and the need for booster vaccinations, overcoming vaccination hesitancy gains importance. The research to date has revealed some promising, albeit contentious, interventions to increase vaccination intention. However, these have yet to be tested for their effectiveness in increasing vaccination rates. Methods & results We conducted a preregistered survey experiment with N = 1,324 participants in Germany in May/June 2021. This was followed by a series of emails reminding participants to get vaccinated in August and concluded with a follow-up survey in September. We experimentally assess whether debunking vaccination myths, highlighting the benefits of being vaccinated, or sending vaccination reminders decreases hesitancy. In the survey experiment, we find no increase in the intention to vaccinate regardless of the information provided. However, communicating vaccination benefits over several weeks reduced the likelihood of not being vaccinated by 9 percentage points, which translates into a 27% reduction compared to the control group. Debunking vaccination myths and reminders alone also decreased the likelihood, yet not significantly. Discussion Our findings suggest that if soft governmental interventions such as information campaigns are employed, highlighting benefits should be given preference over debunking vaccination myths. Furthermore, it seems that repeated messages affect vaccination action while one-time messages might be insufficient, even for increasing vaccination intentions. Our study highlights the importance of testing interventions outside of survey experiments that are limited to measuring vaccination intentions—not actions—and immediate changes in attitudes and intentions—not long-term changes.
Læs mere Tjek på PubMedIveta Herichová, Soňa Jendrisková, Paulína Pidíková, Lucia Kršková, Lucia Olexová, Martina Morová, Katarína Stebelová, Peter Štefánik
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Iveta Herichová, Soňa Jendrisková, Paulína Pidíková, Lucia Kršková, Lucia Olexová, Martina Morová, Katarína Stebelová, Peter Štefánik
Covid-19 progression shows sex-dependent features. It is hypothesized that a better Covid-19 survival rate in females can be attributed to the presence of higher 17β-estradiol (E2) levels in women than in men. Virus SARS-CoV-2 is enabled to enter the cell with the use of angiotensin converting enzyme 2 (ACE2). The expression of several renin-angiotensin system components has been shown to exert a rhythmic pattern, and a role of the circadian system in their regulation has been implicated. Therefore, the aim of the study is to elucidate possible interference between E2 signalling and the circadian system in the regulation of the expression of ACE2 mRNA and functionally related molecules. E2 was administered at a dosage of 40 μg/kg/day for 7 days to male Wistar rats, and sampling of the lungs and colon was performed during a 24-h cycle. The daily pattern of expression of molecules facilitating SARS-CoV-2 entry into the cell, clock genes and E2 receptors was analysed. As a consequence of E2 administration, a rhythm in ACE2 and TMPRSS2 mRNA expression was observed in the lungs but not in the colon. ADAM17 mRNA expression showed a pronounced rhythmic pattern in both tissues that was not influenced by E2 treatment. ESR1 mRNA expression exerted a rhythmic pattern, which was diminished by E2 treatment. The influence of E2 administration on ESR2 and GPER1 mRNA expression was greater in the lungs than in the colon as a significant rhythm in ESR2 and GPER1 mRNA expression appeared only in the lungs after E2 treatment. E2 administration also increased the amplitude of bmal1 expression in the lungs, which implicates altered functioning of peripheral oscillators in response to E2 treatment. The daily pattern of components of the SARS-CoV-2 entrance pathway and their responsiveness to E2 should be considered in the timing of pharmacological therapy for Covid-19.
Læs mere Tjek på PubMedJeanette J. Rainey, Casey Siesel, Xiafang Guo, Lina Yi, Yuzhi Zhang, Shuyu Wu, Adam L. Cohen, Jie Liu, Eric Houpt, Barry Fields, Zhonghua Yang, Changwen Ke
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Jeanette J. Rainey, Casey Siesel, Xiafang Guo, Lina Yi, Yuzhi Zhang, Shuyu Wu, Adam L. Cohen, Jie Liu, Eric Houpt, Barry Fields, Zhonghua Yang, Changwen Ke
Background Southern China is at risk for arborvirus disease transmission, including Zika virus and dengue. Patients often present to clinical care with non-specific acute febrile illnesses (AFI). To better describe the etiology of AFI, we implemented a two-year AFI surveillance project at five sentinel hospitals in Yunnan and Guangdong Provinces. Methods Between June 2017 and August 2019, we enrolled patients between 2 and 65 years of age presenting at one sentinel hospital in Mengla County, Yunnan, and four in Jiangmen City, Guangdong, with symptoms of AFI (acute onset of fever ≥ 37.5°C within the past 7 days) without respiratory symptoms or diarrhea. Demographic, epidemiologic, and clinical information was obtained and entered into a web-based AFI surveillance database. A custom TaqMan Array card (TAC) was used to test patients’ whole blood specimens for 27 different pathogens using real-time polymerase chain reaction assays. Results During the two-year project period, 836 patients were enrolled; 443 patients from Mengla County and 393 patients from Jiangmen City. The median age was 33 years [range: 2–65], and most were hospitalized [641, 77%]. Of 796 patients with valid TAC results, 341 (43%) were positive for at least one of the 10 unique pathogens detected. This included 205 (26%) patients positive for dengue virus, 60 (8%) for Orientia tsutsugamushi, and 42 (5%) for Coxiella burnetii. Ten patients (1%) in Jiangmen City tested positive for malaria, 8 of whom reported recent travel outside of China. TAC results were negative for 455 (57%) patients. None of the patients had a positive TAC detection for Zika virus. Conclusions The project detected variability in the etiology of AFI in Southern China and highlighted the importance of differential diagnosis. Dengue, O. tsutsugamushi, and C. burnetii were the most frequently identified pathogens among enrolled AFI patients. As a non-notifiable disease, the frequent detection of C. burnetii is noteworthy and warrants additional investigation. The project provided a framework for routine surveillance for persons presenting with AFI.
Læs mere Tjek på PubMedCarolyn M. Audet, Mariah Pettapiece-Phillips, Yuqi Tian, Bryan E. Shepherd, Sten H. Vermund, Jose Salato
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Carolyn M. Audet, Mariah Pettapiece-Phillips, Yuqi Tian, Bryan E. Shepherd, Sten H. Vermund, Jose Salato
Across rural sub-Saharan Africa, people living with HIV (PLHIV) commonly seek out treatment from traditional healers. We report on the clinical outcomes of a community health worker intervention adapted for traditional healers with insight into our results from qualitative interviews. We employed a pre-post intervention study design and used sequential mixed methods to assess the impact of a traditional healer support worker intervention in Zambézia province, Mozambique. After receiving a positive test result, 276 participants who were newly enrolled in HIV treatment and were interested in receiving home-based support from a traditional healer were recruited into the study. Those who enrolled from February 2016 to August 2016 received standard of care services, while those who enrolled from June 2017 to May 2018 received support from a traditional healer. We conducted interviews among healers and participants to gain insight into fidelity of study activities, barriers to support, and program improvement. Medication possession ratio at home (based on pharmacy pick-up dates) was not significantly different between pre- and post-intervention participants (0.80 in the pre-intervention group compared to 0.79 in the post-intervention group; p = 0.96). Participants reported receiving educational and psychosocial support from healers. Healers adapted their support protocol to initiate directly observed therapy among participants with poor adherence. Traditional healers can provide community-based psychosocial support, education, directly observed therapy, and disclosure assistance for PLHIV. Multiple factors may hinder patients’ desire and ability to remain adherent to treatment, including poverty, confusion about medication side effects, and frustration with wait times at the health facility.
Læs mere Tjek på PubMedAnmar Abdul-Rahman, William Morgan, Ying Jo Khoo, Christopher Lind, Allan Kermode, William Carroll, Dao-Yi Yu
PLoS One Infectious Diseases, 28.06.2022
Tilføjet 28.06.2022
by Anmar Abdul-Rahman, William Morgan, Ying Jo Khoo, Christopher Lind, Allan Kermode, William Carroll, Dao-Yi Yu
Purpose To compare the retinal vascular pulsatile characteristics in subjects with normal (ICPn) and high (ICPh) intracranial pressure and quantify the interactions between intraocular pressure, intracranial pressure, and retinal vascular pulse amplitude in the Fourier domain. Materials and methods Twenty-one subjects were examined using modified photoplethysmography with simultaneous ophthalmodynamometry. A harmonic regression model was fitted to each pixel in the time-series, and used to quantify the retinal vascular pulse wave parameters including the harmonic regression wave amplitude (HRWa). The pulse wave attenuation was measured under different ranges of induced intraocular pressure (IOPi), as a function of distance along the vessel (VDist). Intracranial pressure (ICP) was measured using lumbar puncture. A linear mixed-effects model was used to estimate the correlations between the Yeo-Johnson transformed harmonic regression wave amplitude (HRWa-YJt) with the predictors (IOPi, VDist and ICP). A comparison of the model coefficients was done by calculating the weighted Beta (βx) coefficients. Results The median HRWa in the ICPn group was higher in the retinal veins (4.563, interquartile range (IQR) = 3.656) compared to the retinal arteries (3.475, IQR = 2.458), p<0.0001. In contrast, the ICPh group demonstrated a reduction in the median venous HRWa (3.655, IQR = 3.223) and an elevation in the median arterial HRWa (3.616, IQR = 2.715), p<0.0001. Interactions of the pulsation amplitude with ICP showed a significant disordinal interaction and the loss of a main effect of the Fourier sine coefficient (bn1) in the ICPh group, suggesting that this coefficient reflects the retinal vascular response to ICP wave. The linear mixed-effects model (LME) showed the decay in the venous (HRWa-YJt) was almost twice that in the retinal arteries (−0.067±0.002 compared to −0.028±0.0021 respectively, p<0.00001). The overall interaction models had a total explanatory power of (conditional R2) 38.7%, and 42% of which the fixed effects explained 8.8%, and 5.8% of the variance (marginal R2) for the venous and arterial models respectively. A comparison of the damping effect of VDist and ICP showed that ICP had less influence on pulse decay than distance in the retinal arteries (βICP = -0.21, se = ±0.017 compared to βVDist=-0.26, se = ±0.019), whereas the mean value was equal for the retinal veins (venous βVDist=-0.42, se = ±0.015, βICP = -0.42, se = ±0.019). Conclusion The retinal vascular pulsation characteristics in the ICPh group showed high retinal arterial and low venous pulsation amplitudes. Interactions between retinal vascular pulsation amplitude and ICP suggest that the Fourier sine coefficient bn1 reflects the retinal vascular response to the ICP wave. Although a matrix of regression lines showed high linear characteristics, the low model explanatory power precludes its use as a predictor of ICP. These results may guide future predictive modelling in non-invasive estimation of ICP using modified photoplethysmography.
Læs mere Tjek på PubMedMartin Belan, Tiffany Charmet, Laura Schaeffer, Sarah Tubiana, Xavier Duval, Jean-Christophe Lucet, Arnaud Fontanet, Gabriel Birgand, Solen Kernéis
Clinical Microbiology and Infection, 28.06.2022
Tilføjet 28.06.2022
This study assessed the roles of various exposures and personal protective equipment (PPE) use on healthcare workers’risk (HCWs) of COVID-19 working in primary care, long-term-care facilities or hospitals.
Læs mere Tjek på PubMedMalaria Journal, 28.06.2022
Tilføjet 28.06.2022
Abstract
Background
Malaria chemoprophylaxis using chloroquine (CQ) and primaquine (PQ) has been administered to resident soldiers in the 3rd Army of Republic of Korea (ROK) to prevent malaria infection since the year 1997. Due to mass chemoprophylaxis against malaria, concern exists about the occurrence of chloroquine resistance (CQR). This study aimed to investigate the single nucleotide polymorphisms (SNPs) of the Plasmodium vivax multi-drug resistance protein-1 (pvmdr-1) gene to monitor the risk of CQR.
Methods
SNPs of the pvmdr-1 gene were analysed in 73 soldiers of the 3rd Army of ROK diagnosed with infection by P. vivax.
Results
Quintuple mutations (G698S, L845F, M908L, T958M, and F1076L) were detected in 73 soldiers. A newly identified non-synonymous mutation in the Y541C position had been introduced into P. vivax malaria-endemic areas in ROK, at a frequency of 1.3% (1/73). In addition, synonymous mutations were detected at positions K44 (38.4%, 28/73), L493 (26%, 19/73), T529 (61.6%, 45/73), and E1233 (52.1%, 38/73). Based on these SNPs, pvmdr-1 sequences of ROK were classified into 6 haplotypes. The phylogenetic analysis closed to the type of North Korean showed that P. vivax malaria of ROK could be a reason of influx from North Korea.
Conclusions
This study showed that synonymous and non-synonymous mutations of pvmdr-1 were observed in the malaria chemoprophylaxis-executed regions of ROK from 2016 to 2017. Based on the rapid transition of pvmdr-1 SNPs, continuous surveillance for SNPs of pvmdr-1 related to CQR in the malaria-endemic regions of ROK is essential.
Læs mere Tjek på PubMed
Gabriel Cavalcante Lima Chagas, Amanda Ribeiro Rangel, Luísa Macambira Noronha, Felipe Camilo Santiago Veloso, Samir Buainain Kassar, Michelle Jacintha Cavalcante Oliveira, Gdayllon Cavalcante Meneses, Geraldo Bezerra da Silva Junior, Elizabeth De Francesco Daher
Tropical Medicine & International Health, 28.06.2022
Tilføjet 28.06.2022
Gdayllon Cavalcante Meneses, Pedro Eduardo Andrade de Carvalho Gomes, Gabriela Studart Galdino, Gabriela Freire Bezerra, Ranieri Sales de Souza Santos, Alice Maria Costa Martins, Geraldo Bezerra da Silva Junior, Alexandre Braga Libório, Roberto da Justa Pires Neto, Elizabeth De Francesco Daher
Tropical Medicine & International Health, 28.06.2022
Tilføjet 28.06.2022
Daniella Pontes Matos, Mateus Dantas Torres, Liniker Scolfild Rodrigues da Silva, Carlos Alberto Andrade Serra dos Santos, Francisca Jacinta Feitoza de Oliveira, Márcio Flávio Moura de Araújo, Maria Aparecida Alves de Oliveira Serra
Tropical Medicine & International Health, 28.06.2022
Tilføjet 28.06.2022
Caitlyn L. Holmes, Sara N. Smith, Stephen J. Gurczynski, Geoffrey B. Severin, Lavinia V. Unverdorben, Jay Vornhagen, Harry L. T. Mobley, Michael A. Bachman aDepartment of Pathology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA bDepartment of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Ann Arbor, Michigan, USA, Nancy E. Freitag
Infection and Immunity, 28.06.2022
Tilføjet 28.06.2022
Rudym D, Chang SH, Angel LF.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
To the Editor A recent study reported impressive outcomes in 30 patients who underwent lung transplant for COVID-19–associated acute respiratory distress syndrome (ARDS). However, we wonder whether some patients in this cohort may not have needed a lung transplant if given more time to recover.
Læs mere Tjek på PubMedManerikar A, Budinger G, Bharat A.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
In Reply Institutional and national cohort studies have reported the success of lung transplant for COVID-19–associated ARDS. However, given the unpredictable trajectory of patients with COVID-19–associated ARDS and the lack of clinically available biomarkers of permanent lung injury, referral for lung transplant requires careful evaluation of pulmonary physiology, radiographic and histologic changes, medical course, and treatment response. Furthermore, lung transplant referral should only be considered after sufficient time has passed from the onset of ARDS and after longitudinal multidisciplinary evaluation indicates that lung recovery or successful liberation from life support is unlikely.
Læs mere Tjek på PubMedSlomski A.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
A single dose of vaginal clindamycin gel successfully treated most women with bacterial vaginosis, including those with recurrent disease, a recent trial reported. The US Food and Drug Administration approved the bioadhesive extended-release gel, marketed as Xaciato, in 2021 to treat bacterial vaginosis. The recent study, published in Obstetrics & Gynecology, assessed efficacy based on the percentage of participants who were considered clinically cured.
Læs mere Tjek på PubMedPearlman BL.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
A woman with a history of intravenous heroin use and chronic inactive hepatitis B virus infection had sudden onset of painless jaundice and malaise. Vital signs, mentation, and physical examination were normal except for scleral icterus; she reported no history of travel outside the US and no raw meat ingestion; aminotransferase and bilirubin levels were newly elevated, but she had no acute hepatitis A or C virus infection. What is the diagnosis and what would you do next?
Læs mere Tjek på PubMedRubin R.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
This Medical News feature examines the unexpected phenomenon of symptoms and positive test results recurring in Paxlovid users who’d a few days earlier felt fine and tested negative.
Læs mere Tjek på PubMeddel Rio C, Malani PN.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
This Viewpoint discusses how variants and subvariants of SARS-CoV-2 will affect the continually changing COVID-19 pandemic and the ways in which the spread of COVID-19 can be controlled.
Læs mere Tjek på PubMedLevy N, Koppel JH, Kaplan O, et al.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
This study examines outcomes of multisystem inflammatory syndrome in children during the Alpha, Delta, and Omicron variant waves of the COVID-19 pandemic in Israel.
Læs mere Tjek på PubMedPetty LA, Malani PN.
Journal of the American Medical Association, 28.06.2022
Tilføjet 28.06.2022
This JAMA Patient Page describes 2 new oral antiviral medications that are available for patients with mild to moderate COVID-19 who are not hospitalized but are at high risk of developing severe disease.
Læs mere Tjek på PubMedYu Nakagama, Maria-Virginia Rodriguez-Funes, Rhina Dominguez, Katherine-Sofia Candray-Medina, Naoto Uemura, Evariste Tshibangu-Kabamba, Yuko Nitahara, Natsuko Kaku, Akira Kaneko, Yasutoshi Kido
Clinical Microbiology and Infection, 28.06.2022
Tilføjet 28.06.2022
The novel coronavirus disease 2019 (COVID-19) pandemic has threatened the public health systems worldwide. Its impact, however, has been under-evaluated in most low- and middle-income countries, including regions in Central America [1]. We launched a seroepidemiological survey, extending from end-January to mid-February 2021, at a tertiary care referral hospital located in the capital city of El Salvador, where a large number of confirmed and far more suspected cases of SARS-CoV-2 affected healthcare workers (HCWs) had been documented during the first wave of the pandemic.
Læs mere Tjek på PubMedSeongman Bae, Eun Sil Kim, Hee Seung Kim, Eunmi Yang, Hyemin Chung, Yun Woo Lee, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim aDivision of Infectious Diseases, Department of Internal Medicine, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea bCenter for Antimicrobial Resistance and Microbial Genetics, University of Ulsan College of Medicine, Seoul, Republic of Korea
Antimicrobial Agents And Chemotherapy, 28.06.2022
Tilføjet 28.06.2022
Tom Jefferson, Elizabeth A. Spencer, Igho J. Onakpoya, Annette Plu¨ddemann, John M. Conly, Carl J. Heneghan
Clinical Microbiology and Infection, 28.06.2022
Tilføjet 28.06.2022
SARS-CoV-2 transmission is still incompletely understood, and the relative contribution and importance of transmission from individuals without COVID-19 symptoms remains unclear.
Læs mere Tjek på PubMedInfection, 27.06.2022
Tilføjet 28.06.2022
Abstract
Purpose
School closures have been used as part of lockdown strategies to contain the spread of SARS-CoV-2, adversely affecting children’s health and education. To ensure the accessibility of educational institutions without exposing society to the risk of increased transmissions, it is essential to establish SARS-CoV-2 testing strategies that are child-friendly, scalable and implementable in a daily school routine. Self-sampling using non-invasive saliva swabs combined with pooled RT-qPCR testing (Lolli-Method) has been proven to be a sensitive method for the detection of SARS-CoV-2.
Methods
We conducted a pilot project in Cologne, Germany, designed to determine the feasibility of a large-scale rollout of the Lolli-Method for testing without any additional on-site medical staff in schools. Over a period of three weeks, students from 22 schools were sampled using the Lolli-Method. At the end of the project, teachers were asked to evaluate the overall acceptance of the project.
Results
We analyzed a total of 757 pooled RT-qPCRs obtained from 8,287 individual swabs and detected 7 SARS-CoV-2 infected individuals. The Lolli-Method was shown to be a feasible and accepted testing strategy whose application is only slightly disruptive to the daily school routine.
Conclusion
Our observations suggest that the Lolli-Method in combination with pooled RT-qPCR can be implemented for SARS-CoV-2 surveillance in daily school routine, applicable on a large scale.
Læs mere Tjek på PubMed
Linda Schönborn, Sabrina E. Seck, Thomas Thiele, Theodore E. Warkentin, Andreas Greinacher
New England Journal of Medicine, 27.06.2022
Tilføjet 28.06.2022
Maxime Danjean, Claire Amaris Hobson, Maud Gits-Muselli, C. Courroux, A. Monjault, S. Bonacorsi, A. Birgy
Clinical Microbiology and Infection, 27.06.2022
Tilføjet 28.06.2022
New antibiotics have been developed to treat multidrug-resistant Enterobacterales. We evaluated the impact of the inoculum size on MICs of recently commercialized antibiotics.
Læs mere Tjek på PubMedZe Xiang, Bin Jiang, Wei Li, Guanghua Zhai, Hao Zhou, Ying Wang, Jian Wu
Journal of Medical Virology, 28.06.2022
Tilføjet 28.06.2022
Nader Tavakoli, Nahid Nafissi, Sima Shokri, Morteza Fallahpour, Sanaz Soleimani, Taghi Riahi, Saeed Kalantari, Alireza Javan, Azadeh Goodarzi, Rohollah Valizadeh
Journal of Medical Virology, 27.06.2022
Tilføjet 28.06.2022
Nevio Cimolai
Journal of Medical Virology, 27.06.2022
Tilføjet 28.06.2022