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Enrico Ricchizzi, Katrien Latour, Tommi Kärki, Rossella Buttazzi, Béatrice Jans, Maria Luisa Moro, Olivia Aya Nakitanda, Diamantis Plachouras, Dominique L Monnet, Carl Suetens, Pete Kinross and the HALT Study Group
Antimicrobials are commonly prescribed and contribute to the development of antimicrobial resistance in long-term care facilities (LTCFs). In 2010, the European Centre for Disease Prevention and Control initiated point prevalence surveys (PPS) of healthcare-associated infections and antimicrobial use in European LTCFs, performed by external contractors as the Healthcare-Associated infections in Long-Term care facilities (HALT) projects. Here, we investigated prevalence and characteristics of antimicrobial use and antimicrobial stewardship indicators in European LTCFs in 2016–17. Twenty-four European Union/European Economic Area (EU/EEA) countries, the former Yugoslav Republic of Macedonia and Serbia participated in the third PPS in European LTCFs. Overall, 4.9% (95% confidence interval: 4.8–5.1) of LTCF residents in the EU/EEA participating countries received at least one antimicrobial. The most commonly reported Anatomical Therapeutic Chemical (ATC) groups were beta-lactam antibacterials/penicillins (J01C), other antibacterials (J01X) (e.g. glycopeptide antibacterials, polymyxins), quinolones (J01M), sulfonamides and trimethoprim (J01E), and other beta-lactams (J01D). Urinary tract infections and respiratory tract infections were the main indications for antimicrobial prescription. This PPS provides updated and detailed information on antimicrobial use in LTCFs across the EU/EEA that can be used to identify targets for future interventions, follow-up of these interventions and promote prudent use of antimicrobials in European LTCFs.
Sebastian Thole, Daniela Kalhoefer, Maria an der Heiden, Doris Nordmann, Inka Daniels-Haardt and Annette Jurke
When a person with contagious measles has travelled by aircraft, European guidelines recommend contact tracing of passengers and crew within 5 days of exposure for post-exposure prophylaxis (PEP), and within 12 days of exposure for informing passengers and crew, in order to prevent further transmissions. To be effective, contact tracing requires prompt diagnosis, immediate notification of public health authorities and rapid availability of passenger contact data. We report two events of contact tracing initiated in Germany after two individuals with measles travelled on three international flights. In one event, contact tracing was initiated late because laboratory confirmation of a clinically diagnosed measles case was awaited unnecessarily. Accessing passenger contact data was difficult in both events because of data protection issues with the airline which was not based in Germany. In both events, passengers were not reached in time to provide PEP, and one event resulted in at least two secondary measles cases. As all passengers were reached before the incubation period ended, tertiary cases were most probably prevented. Public health authorities and the transport sector must collaborate to resolve competing legal regulations for infection prevention and data protection, to simplify and accelerate identification of air travellers exposed to communicable diseases.
WHO har 1/12-2017 i en rapport fra Strategic Advisory Group of Experts on Immunization, SAGE, udgivet nye retningslinjer på baggrund af ny evidens om brugen af rabiesvacciner og rabies-immunglobulin (RIG).
Chronic Wasting Disease -- United StatesThe Virginia Department of Game and Inland Fisheries (DGIF) has confirmed chronic wasting disease (CWD) in a male deer (buck) legally harvested in Culpeper county in November 2018.A cooperating taxidermist submitted the sample to DGIF in late January . At the time this deer was harvested, the hunter did not notice any outward signs of disease and the buck appeared to be in good condition.While CWD has been documented in northwest Virginia for over 9 years, this deer was harvested
Other Animal Disease -- RussiaThe crops that bring us most of our food provide for 35 per cent of calorie intake, as well as most minerals, vitamins, and antioxidants. Nuts, melons, and berries will not grow without pollinating insects. Bees also pollinate citrus fruits, apples, onions, broccoli cabbage, zucchini, beans, peppers, eggplants, cucumbers, tomatoes, beans, coffee, cocoa, avocados, and coconuts. The production of these crops belongs to most valuable segments of the global food industry. Thus, the disappearance
Rabies -- MalaysiaRef: Parize P, Dacheux L, Larrous F, Bourhy H. The shift in rabies epidemiology in France: Time to adjust rabies post-exposure risk assessment. Euro Surveill. 2018; 23(39): pii=1700548. Received: 2 Aug 2017; Accepted: 11 Feb 2018Abstract. The epidemiology of rabies in France and western Europe has changed during the past 22 years. In France, rabies in non-flying terrestrial mammals was declared to be eliminated in 2001, and the risk of rabies is now limited to contact with bats, rabid
Rift Valley Fever -- Région d'outre-mer de Mayotte, France1. Ministry of Agriculture and Food, France. Presentation: Rift Valley fever (RVF) situation in Mayotte, a French department in the Indian Ocean. EU - Standing Committee on Plants, Animals, Food and Feed (SCPAFF), 21 Mar 2019 committee meeting; .2. Chevalier V, Pepin M, Plee L, Lancelot R. Rift Valley fever -- a threat for Europe? Euro Surveill. 2010; 15(10): pii=19506; .3. European Centre for Disease Prevention and Control. Rift Valley fever outbreak in Mayotte, France. Stockholm: ECDC;
Salmonella -- FranceFrench health authorities on [Sat 2 Dec 2017], ordered the recall of infant formula products that were possibly contaminated by _Salmonella_, while 20 babies aged less than 6 months have been infected by salmonella in 8 different regions of France.The Public Health Agency of France and the General Direction for Competition, Consumer Affairs and Fraud Control (DGCCRF) in an urgent press release have asked parents not to use 12 batches of Lait Picot SL lactose free (1st age 350 g), Pepti
Botulism -- CanadaYummy Market is recalling "Yummy Market brand Smoked Lake Trout w/Pepper with Cracked Black Pepper" for possible _Clostridium botulinum_ contamination. It was sold from Yummy Market at 1390 Major Mackenize Drive West in Maple, Ontario. The recall was triggered by a consumer complaint.There has been one illness reported that may be associated with the consumption of this product. If you purchased it, do not eat it. Throw it away in a sealed package, or take it back to the place of purchase
Other Plant Disease -- Worldwide/UnknownThe whole of the Balkan region is facing big problems with virus infection. CMV (cucumber mosaic virus) is the primary problem, and the secondary being TSWV [tomato spotted wilt virus] on peppers [capsicum]. The problems are especially big in unheated greenhouses.Due to excessive virus damage, the  season is turning out to be very bad. Middle of May  symptoms appeared first on the top of the plants, then on the fruits, which stay small and deformed with brown-red stripes. All
Other Plant Disease -- United States_Impatiens necrotic spot virus_ (INSV) was confirmed by the [University of Massachusetts] on pepper [capsicum] seedlings grown in a greenhouse. Symptoms of INSV on pepper include leaf distortion and tan or brown lesions that may or may not be circular. Wilting and necrosis of meristems may also occur.Management starts with discarding infected plants. Monitor and manage thrips populations in the greenhouse. Carefully inspect all incoming plant material for disease symptoms and thrips.
-- United KingdomThe statement [in the source media report ProMED-mail post http://promedmail.org/post/20190523.6483054] that "The virus displays symptoms akin to _Tomato brown rugose fruit virus_ or _Pepino mosaic virus_" is inaccurate. STV [_Southern tomato virus_] was initially reported from symptomatic tomatoes in the US, but its link to the symptoms never proven. In several cases where it has been described since that initial report, it was in symptomless plants. As far as I know, there is to date no good
Perrine Parize, Laurent Dacheux, Florence Larrous, Hervé Bourhy and the French network of antirabies clinics
The epidemiology of rabies in France and western Europe has changed during the past 22 years. In France, rabies in non-flying terrestrial mammals was declared to be eliminated in 2001, and the risk of rabies is now limited to contact with bats, rabid animals illegally imported from rabies-enzootic countries and traveller exposure in enzootic areas. We analysed the epidemiology of rabies in France from 1995 to 2016, describing and analysing data on human rabies surveillance as well as data on post-exposure prophylaxis (PEP) collected from the network of French antirabies clinics. Over the study period, seven individuals were diagnosed with rabies in France, all of whom were infected outside mainland France. PEP data analysis revealed an expected overall decrease in PEP administration for individuals exposed in mainland France, but there was still overuse of anti-rabies drugs, given the very low epidemiological risk. On the other hand, a significant increase in PEP delivered to individuals exposed abroad was evidenced. These epidemiological trends indicate that clear guidelines should be provided to support physicians’ efforts to adjust rabies risk assessment to the evolution of the epidemiological situation.
Retningslinjer til sundhedsprofessionelle vedr. håndtering af infektion med zikavirus (2019)
Antiviral behandling af hiv smittede personer (2019)
Lumbalpunktur af patienter i blodfortyndende behandling (2019)
Reply to Barner and Bruno-Murtha
23.09.2019Clinical Infectious Diseases Advance Access
False-negative Results of Human Immunodeficiency Virus (HIV) Rapid Testing in HIV Controllers
21.09.2019Clinical Infectious Diseases Advance Access
Resistance of Influenza Virus to Antiviral Medications
20.09.2019Clinical Infectious Diseases Advance Access
Oseltamivir resistance in severe influenza A(H1N1)pdm09 pneumonia and acute respiratory distress syndrome: a French multicenter observational cohort study
20.09.2019Clinical Infectious Diseases Advance Access
Baloxavir marboxil in Japanese pediatric patients with influenza: safety and clinical and virologic outcomes
20.09.2019Clinical Infectious Diseases Advance Access
Hvad tænker Professor Thomas Benfield om"Oral versus Intravenous Antibiotics for Bone and Joint Infection."?
Hvad mener Professor Niels Obel om artiklen"Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis."?
Hvad tænker Professor Thomas Benfield om"Duration of Antibiotic Treatment in Community-Acquired Pneumonia: A Multicenter Randomized Clinical Trial."?
Hvad synes Professor Morten Sodemann om"Evidence-based clinical guidelines for immigrants and refugees."?
Hvad tænker Professor Niels Obel om"Use of statins and risk of AIDS-defining and non-AIDS-defining malignancies among HIV-1 infected patients on antiretroviral therapy."?
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