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Hepatitis A -- Costa RicaAs many as 22 people suffered from hepatitis A infection in San Ramón de Alajuela, and consequently the Health authorities closed a pizzeria in the area.A source close to this media confirmed the existence of the cases which were detected since 13 Jan 2020. The cases were thought to be related to food consumption in that establishment 4 of patients were employees of the pizzeria.In statements to the media La Nación, Azalea Espinoza of the Directorate of Surveillance of the Ministry
Hepatitis A -- United StatesState / Case total / Hospitalizations n (%) / Deaths / Outbreak start date / Current through date / Av. weekly cases since last postTotal / 29 804 / 18 143 (61%) / 302 / -- / 6 Jan 2020 / 202 States with an ongoing outbreak -------------------------------------------Alabama / 203 / 116 (57%) / NR / 1 Sep 2018 / 10 Dec 2019 / 8Arizona / 599 / 479 (80%) / 8 / 1 Nov 2018 / 2 Jan 2020 / 0 Arkansas / 447 / 234 (52%) / 3 / 7 Feb 2018 / 3 Jan 2020 / 1Colorado / 322 / 232 (72%) / 2 /
Hepatitis E -- PakistanHepatitis E is spreading rapidly in the Almas area of Ashiri Darra in Upper Dir, and over 60 patients have been diagnosed with the disease during the last one month. Those diagnosed with hepatitis E also include women and children. The local people have expressed grave concern over the outbreak of the epidemic and called upon the government to send health teams to the area to stop the disease from further spreading.The area people said hepatitis E has affected almost every home in the
Tuberculosis, Antimicrobial resistance, Other Human Disease, Pneumonia, Respiratory Syncytial Virus, Q Fever, HIV/AIDS, Measles, Influenza, Dengue, Hepatitis B, Hantavirus, Gastroenteritis, Schistosomiasis, Leishmaniasis, Chikungunya, Rickettsia -- SyriaFrequent testicular involvement in multibacillary leprosyHendra Gunawan, Pati Aji Achdiat, Rachel Marsella Rahardjo, Reti Hindritiani, Oki SuwarsaInternational Journal of Infectious Diseases, Volume 90, January 2020, pp. 60-64Antibiotic use among hospitalized adult patients in a setting with limited laboratory infrastructure in Freetown Sierra Leone, 2017-2018Sulaiman Lakoh, Olukemi Adekanmbi, Darlinda F. Jiba, Gibrilla F. Deen, Wadzani Gashau, Stephen Sevalie, Eili Y.
Hepatitis A -- United StatesWhen hearing about hepatitis A, many people think about contaminated food and water. However, in the United States, hepatitis A is more commonly spread from person to person. Since March 2017, CDC's Division of Viral Hepatitis (DVH) has been assisting multiple state and local health departments with hepatitis A outbreaks, spread through person-to-person contact.The hepatitis A vaccine is the best way to prevent HAV [hepatitis A virus] infection.The following groups are at highest risk
Hepatitis A -- United StatesThe Food and Drug Administration (FDA) has reported that 16 people have now been sickened from a hepatitis A outbreak linked to blackberries. The FDA and CDC are investigating illnesses in Indiana, Michigan, Minnesota, Missouri, Nebraska, and Wisconsin. These are potentially linked to fresh conventional blackberries from the grocery store Fresh Thyme Farmers Market. The company says that there is no evidence any of the product was contaminated via handling in its stores.Of the 16 people
Hepatitis E -- NamibiaThe Ministry of Health and Social Services and other stakeholders at Gobabis are working around the clock to curb the spread of hepatitis E in the region. Since the 1st case in the Omaheke region was reported in December 2017, about 137 other cases have been confirmed between March and November 2019. Out of the notified cases, one death has been recorded.Most of the reported cases in the region are from Gobabis, mainly from the Kanaan C informal settlement, where 123 cases were reported.
Hepatitis A -- IndonesiaThe local administration of Depok has finally elevated the status of its hepatitis A outbreak and considers it to be a full-blown extraordinary occurrence (KLB), compared to its previous partial KLB.The head of Depok Health Agency, Novarita, said the increased health warning was mainly attributed to the fact that hepatitis A still loomed over SMPN-20 junior-high students in the City of Depok."Based on our data, the spread is not limited to SMPN-20 students but has also spread further.
Hepatitis A -- United StatesThe [Nebraska] Central District Health Department [CDHD] reported [Wed 20 Nov 2019], a multi-state outbreak of hepatitis A that has been linked to eating blackberries and potentially to strawberries purchased at Fresh Thyme grocery stores. The berries were distributed in 3 states [I believe they mean cases have occurred in these states - Mod.LL], including Nebraska as well as Indiana and Wisconsin. The department noted that these same berries were also distributed in Iowa, Illinois, Kentucky,
Pierre Gallian, Valérie Barlet, Lina Mouna, Sylvie Gross, Pascal Morel, Sophie Le Cam, Céline Ricard, Claude Maugard, Elodie Pouchol, Benoit Flan, Catherine Visse, Rachid Djoudi, Julie Figoni, Henriette De Valk, Pierre Tiberghien and Anne-Marie Roque-Afonso
Tuberculosis, Whooping Cough, Yellow Fever, Hand, Foot and Mouth Disease, Antimicrobial resistance, Influenza, Chagas, Hepatitis B, HIV/AIDS, Other Human Disease, Rabies -- Worldwide/UnknownPertussis in the Association of Southeast Asian Nations: epidemiology and challengesUsa Thisyakorn, Terapong Tantawichien, Chule Thisyakorn, Philippe BuchyInternational Journal of Infectious Diseases, Volume 86, September 2019, pp. 75-83Anti-PcrV titers in non-cystic fibrosis patients with _Pseudomonas aeruginosa_ respiratory tract infectionKentaro Nagaoka, Yu Yamashita, Hirokazu Kimura, Hiroki Kimura, Masaru Suzuki, Tatsuya Fukumoto, Kasumi Hayasaka, Mari Yoshida, Takafumi Hara,
Opioid use disorder and hepatitis C virus infection rates significantly increased during 2000-2015 among women delivering in hospitals in the United States.
This report analyzes drinking water-associated hepatitis A outbreaks reported to the Waterborne Disease and Outbreak Surveillance System during 1971-2017.
In April 2015, the country of Georgia, with a high prevalence of hepatitis C virus (HCV) infection (5.4% of the adult population, approximately 150,000 persons), embarked on the world's first national elimination program.
World Hepatitis Day, observed each year on July 28, was established to raise awareness and promote understanding of viral hepatitis around the world.
During 2016-2018, reports of hepatitis A infections in the United States increased by 294% compared with 2013-2015.
May is Hepatitis Awareness Month, and May 19 is Hepatitis Testing Day. Many people with hepatitis B and hepatitis C remain unaware of their infection until serious complications occur.
Investigation identified an outbreak of at least 12 hepatitis C virus infections in patients who had received opioid injections from a nurse who admitted to diverting injectable narcotic drugs.
As of August 28, 2018, 664 outbreak-associated hepatitis A cases were identified by the Kanawha-Charleston Health Department.
Among 249 confirmed cases of hepatitis A virus infection, 4% occurred among persons with human immunodeficiency virus infection.
In the report "Update: Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Postexposure Prophylaxis and for Preexposure Prophylaxis for International Travel," errors occurred in Table 1.
During 2005-2017, regional hepatitis B vaccine birth dose (HepB-BD) and third dose (HepB3) coverage increased from 63% to 85% and from 76% to 93%, respectively. In 2017, 15 (42%) and 18 (50%) of 36 Western Pacific Region countries/areas achieved ≥95% HepB-BD and HepB3 coverage, respectively. Chronic hepatitis infection in children declined to
All persons aged 1 year and older experiencing homelessness should be routinely immunized against hepatitis A virus infection. Vaccination of homeless persons facilitates integration of hepatitis A vaccine into routine preventive services.
The number and proportion of increased risk donors have increased since 2010, likely because of the epidemic of opioid overdose deaths. Compared with standard risk donors, increased risk donors were significantly more likely to have hepatitis B virus and hepatitis C virus infection.
Postexposure prophylaxis with hepatitis A vaccine or immune globulin effectively prevents infection with hepatitis A virus when administered within 2 weeks of exposure.
The 2017 hepatitis A outbreaks among persons reporting drug use or experiencing homelessness reinforce the need to vaccinate people at risk for hepatitis A.
G Ireland, R Simmons, M Hickman, M Ramsay, C Sabin and S Mandal
Liver transplantation is an important measure of burden from hepatitis C virus (HCV)-associated liver disease.
To describe transplant rates and survival in individuals with HCV infection from 2008 to 2017 in England through data linkage.
This is a retrospective observational cohort study. Laboratory reports of HCV infection were linked to the Liver Transplant Registry for individuals aged 15 years and over, first diagnosed between 1998 and 2017. We estimated age-sex standardised incidence rates and used Poisson regression to investigate predictors of liver transplantation and test for a change in incidence after introduction of direct-acting antivirals (DAAs) in 2014. Kaplan-Meier survival analysis was used to calculate post-transplant survival rates.
Of 124,238 individuals diagnosed with HCV infection, 1,480 were registered and 1,217 received a liver transplant. Of individuals registered, 1,395 had post-HCV cirrhosis and 636 had hepatocellular carcinoma (618 also had post-HCV cirrhosis). Median time from HCV diagnosis to transplant was 3.4 years (interquartile range: 1.3–6.8 years). Liver transplant rates were lower 2014–17 compared with 2011–13 (incidence rate ratio: 0.64; 95% confidence interval: 0.55–0.76). Survival rates were 93.4%, 79.9% and 67.9% at 1, 5 and 10 years, respectively. Data linkage showed minimal under-reporting of HCV in the transplant registry.
In the post-DAA era, liver transplant rates have fallen in individuals with HCV infection, showing early impact of HCV treatment scale-up; but the short time from HCV diagnosis to liver transplant suggests late diagnosis is a problem.
The US Food and Drug Agency has warned that three direct-acting antiviral drugs have been associated with rare cases of severe liver injury in patients being treated for hepatitis C virus infection.
Hepatitis A -- United StatesA Missouri county has imposed mandatory hepatitis A vaccinations for food handlers. Franklin County, Missouri, joins a handful of jurisdictions across the country with mandatory hepatitis A vaccine programs aimed at preventing further cases. This development is part of a larger trend aimed at expanding vaccinations for hepatitis A and addressing future outbreaks of the disease.Hepatitis A is a contagious liver disease that can cause symptoms ranging from fever to jaundice and, in extreme
Hepatitis A -- United StatesHealth officials in Las Vegas are using the word "outbreak" to describe a sharp spike in hepatitis A cases reported mostly among homeless people and drug users. The Southern Nevada Health District reported on Wednesday [14 Aug 2019] that from November  to June  it tallied 83 cases of the virus that causes liver damage and can lead to death.That's far more than the 58 cases reported in 2016, 2017, and 2018, combined. The district says more than 80% of reported patients were
Hepatitis A -- AustraliaAustralian Capital Territory (ACT) health officials are investigating a cluster of hepatitis A cases in Canberra's South Korean community. There have been 8 cases of the virus in the ACT and Sydney since June 2019. The cluster of cases comes as South Korea experiences a large outbreak of the virus, with more than 11 000 cases reported in the country in 2019.ACT Health said it was working with its counterparts in New South Wales to investigate the cause of the outbreak. An ACT Health
Hepatitis A -- United StatesSince March 2017, CDC's Division of Viral Hepatitis (DVH) has been assisting multiple state and local health departments with hepatitis A outbreaks, spread through person-to-person contact.The hepatitis A vaccine is the best way to prevent HAV infection.The following groups are at highest risk for acquiring HAV infection or developing serious complications from HAV infection in these outbreaks and should be offered the hepatitis A vaccine in order to prevent or control an outbreak:-
Hepatitis E -- United States
Hepatitis A -- United StatesAn outbreak of hepatitis A with 23 confirmed cases has been traced to a food handler who worked in the kitchen of a private Morris County country club, state officials said on Thu 15 Aug 2019. One infected individual remained "seriously ill" on Thu 15 Aug 2019, according to New Jersey Department of Health spokeswoman Donna Leusner.Patrons of the Mendham Golf and Tennis Club are anxiously awaiting a Mon 19 Aug 2019 deadline for the incubation period to pass for the infectious liver disease,
The virus continues its march across the nation, with Florida and Philadelphia the latest areas to declare public health emergencies.
Hepatitis E -- China"Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan and the United States with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat hepatitis E virus with a considerably divergent genomic sequence compared to other rat HEV strains. It is
Hepatitis A -- United StatesSince March 2017, CDC's Division of Viral Hepatitis (DVH) has been assisting multiple state and local health departments with hepatitis A outbreaks, spread through person-to-person contact.The hepatitis A vaccine is the best way to prevent HAV infectionThe following groups are at highest risk for acquiring HAV infection or developing serious complications from HAV infection in these outbreaks and should be offered the hepatitis A vaccine in order to prevent or control an outbreak:-
Hepatitis A -- United StatesCommunity leaders in Kensington say 2 residents have contracted hepatitis A within the last month and are encouraging neighbors to get vaccinated as soon as possible. Free vaccinations are currently being provided by the city for anyone worried about exposure.Philadelphia health officials sounded the alarm this month [July 2019] about an upsurge in reports of the infectious disease. The number of cases citywide, about 30 annually, has quintupled in the last 2 years. Most at risk are people
Özgür Koc, Pierre Van Damme, Dana Busschots, Rob Bielen, Anmarie Forier, Frederik Nevens and Geert Robaeys
Belgium is a low-endemic country for hepatitis B. Universal hepatitis B vaccination in infants with catch-up in the age cohort of 10–13 year-olds began in 1999.
Our objective was to evaluate the effect of prevention and control strategies on acute hepatitis B notification rates in Flanders (Belgium) from 2009 to 2017.
This observational study collected demographic data and risk factors for acute hepatitis B from mandatory notifications to the Agency for Care and Health.
In Flanders, acute hepatitis B notification rates per 100,000 population decreased from 1.6 in 2009 to 0.7 in 2017. These rates declined in all age groups: 0–4-year-olds: 0.6 to 0.0, 5–14-year-olds: 0.2 to 0.0, 15–24-year-olds: 0.8 to 0.7, 25–34-year-olds: 3.4 to 1.1 and ≥ 35-year-olds: 1.59 to 0.7. There was also a downward trend in acute hepatitis B notification rates in native Belgians and first-generation migrants. Among 15–24-year-olds and 25–34-year-olds, a possible reversal of the decreasing trend was observed in 2016 and 2015, respectively. Among 548 acute hepatitis B cases, the main route of transmission was sexual activity (30.7%), and the pattern of transmission routes over time showed an increasing proportion of sexual transmission in men who have sex with men (MSM) after 2014. During the period from 2009 to 2017, five mother-to-child transmissions were reported.
Prevention and control strategies were effective in reducing the acute hepatitis B notification rate. However, stronger prevention and control measures are needed in adult risk groups, particularly MSM.
Lauren MK Mason, Erika Duffell, Irene K Veldhuijzen, Uarda Petriti, Eveline M Bunge and Lara Tavoschi
People living with HIV (PLHIV) and people in prison are population groups with a potentially high risk and/or prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection.
We conducted a systematic review in order to find prevalence and incidence estimates in these populations in the European Union/European Economic Area (EU/EEA).
Original research articles published between January 2005 and February 2017 were retrieved from PubMed and Embase in February 2017.
Fifty-two articles were included, providing 97 estimates of HBV/HCV infection prevalence or incidence. Estimates of HBV infection prevalence ranged between 2.9% and43.4% in PLHIV and 0.0% and 25.2% in people in prison. Estimates of HCV infection prevalence ranged from 2.9% to 43.4% in PLHIV and 0.0% to 25.2% in people in prison. Incidence estimates ranged between 0.0 and 2.5 cases per 100 person-years for HBV infection in PLHIV. No such data was available for people in prison. HCV infection incidence ranged between 0.3 and 0.9 cases per 100 person-years in PLHIV and between 1 and 1.2 cases per 100 person-years in people in prison. Prevalence estimates were generally higher than in the general population, especially for HCV infection and among groups with multiple risk factors.
PLHIV, people in prison and groups with multiple risk factors, have a high prevalence of HBV and HCV and may be at ongoing risk of infection. These groups should be among the populations prioritised and targeted for active case finding and prevention programmes in the EU/EEA.
Georgina Ireland, Sema Mandal, Matthew Hickman, Mary Ramsay, Ross Harris and Ruth Simmons
Monitoring trends in mortality for individuals diagnosed with hepatitis C virus (HCV) infection are important as we expand treatment and move towards World Health Organization elimination targets.
To estimate mortality rates for individuals aged ≥ 15 years diagnosed with HCV infection in England 2008–16.
An observational cohort study whereby death certificate information was linked to the Sentinel Surveillance of Blood Borne Virus Testing in England. Age-sex standardised mortality rates (ASMR) for individuals diagnosed with HCV infection (2008–16) were calculated and compared to the general population.
Of 43,895 individuals with HCV infection, 2,656 (6.3%) died. All-cause ASMRs were 2,834.2 per 100,000 person years (PY), 2.3 times higher than in the general population. In individuals aged 30–69 years, all-cause mortality rates were 1,768.9 per 100,000 PY among individuals with HCV, 4.7 times higher than in the general population. ASMRs had not decreased between 2010 (2,992) and 2016 (2,340; p=0.10), with no change from 2014 (p = 0.058). ASMRs were 441.0 times higher for hepatitis, 34.4 times higher for liver cancer, 8.1 times higher for end stage liver disease and 6.4 times higher for external causes than in the general population.
Mortality was higher in individuals with diagnosed HCV infection compared to the general population, highlighting health inequalities. There is a need to improve HCV diagnosis, engagement in care and treatment rates. The high mortality from external causes highlights the importance of integrated health and social care strategies and addressing the needs of this vulnerable population.
Hepatitis -- PhilippinesInformation received on [and dated] 22 Jul 2019 from Dr. Enrico Garzon, assistant secretary for livestock, Bureau of Animal Industry, Department of Agriculture, Quezon City, PhilippinesSummaryReport type: immediate notification (final report)Date of start of the event: 14 Mar 2018Date of confirmation of the event: 14 Mar 2018Date event resolved: 1 Oct 2018Reason for notification: emerging diseaseMorbidity: 1 (scale 0 to 5)Mortality: 0 (scale 0 to 5)Zoonotic impact:
Hepatitis A -- United StatesSince March 2017, CDC's Division of Viral Hepatitis (DVH) has been assisting multiple state and local health departments with hepatitis A outbreaks, spread through person-to-person contact.The hepatitis A vaccine is the best way to prevent HAV infection. The following groups are at highest risk for acquiring HAV infection or developing serious complications from HAV infection in these outbreaks and should be offered the hepatitis A vaccine in order to prevent or control an outbreak: -
Chronic/Non-Infectious Disease -- RussiaAs many as 150 child cancer patients have been infected with hepatitis C in Russia's Far East in an outbreak that parents and officials say is the result of unhygienic medical practices, BBC Russia has reported. Officials in the Amur region said parents had been ringing the alarm about a hepatitis С outbreak in the Blagoveshchensk children's cancer hospital since 2012. Local officials suspected that the reuse of gloves and catheters has infected dozens of children as young as 6 months old in
Theresa Enkirch, Ettore Severi, Harry Vennema, Lelia Thornton, Jonathan Dean, Maria-Louise Borg, Anna Rita Ciccaglione, Roberto Bruni, Iva Christova, Siew Lin Ngui, Koye Balogun, Vratislav Němeček, Mia Kontio, Mária Takács, Andrea Hettmann, Rita Korotinska, Arthur Löve, Ana Avellón, Milagros Muñoz-Chimeno, Rita de Sousa, Denisa Janta, Jevgenia Epštein, Sofieke Klamer, Vanessa Suin, Stephan W Aberle, Heidemarie Holzmann, Kassiani Mellou, Josefine Lundberg Ederth, Lena Sundqvist, Anne-Marie Roque-Afonso, Sanj
Sequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.
The objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.
In 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases’ samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.
Of 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.
While HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.
Specialespecifikt kursus om immundefekt og feber af ukendt årsag
28.01.2020 - 29.01.2020
International Congress on Infectious Diseases (ICID) 2020
Kuala Lumpur, Malaysia
20.02.2020 - 23.02.2020
Dansk Selskab for Intern Medicin (DSIM) årsmøde og overrækkelse af Hagedorn prisen 2020
Novo Nordisk Fonden, Tuborg Havnevej 19, 2900 Hellerup
Conference on Retroviruses and Opportunistic Infections (CROI) 2020
Boston, Massachusetts, USA
8.03.2020 - 11.03.2020
Når CROI går i fisk - med transmissioner fra CROI 2020
10.03.2020 - 11.03.2020
Retningslinjer til sundhedsprofessionelle vedr. håndtering af infektion med zikavirus (2019)
Antiviral behandling af hiv smittede personer (2019)
Lumbalpunktur af patienter i blodfortyndende behandling (2019)
Widening the lens to ensure children who are HIV exposed are alive, HIV-free and thriving
24.01.2020Clinical Infectious Diseases Advance Access
Mortality, HIV transmission and growth in children exposed to HIV in rural Zimbabwe
24.01.2020Clinical Infectious Diseases Advance Access
RSV Antivirals: Problems and Progress
24.01.2020The Journal of Infectious Diseases Advance Access
Efficacy and safety of ceftolozane/tazobactam as therapeutic option for complicated skin and soft tissue infections by MDR/XDR Pseudomonas aeruginosa in patients with impaired renal function: a case series from a single-center experience
24.01.2020Latest Results for Infection
How to Choose Target Facilities in a Region to Implement Carbapenem-Resistant Enterobacteriaceae (CRE) Control Measures
23.01.2020Clinical Infectious Diseases Advance Access
Hvorfor synes Professor Jens Lundgren, at du bør læse"Dolutegravir plus Two Different Prodrugs of Tenofovir to Treat HIV."?
Hvad mener Professor Troels Lillebæk om artiklen"The global prevalence of latent tuberculosis: a systematic review and meta-analysis."?
Hvad tænker Professor Lars Østergaard om"Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial."?
Hvad tænker Professor Thomas Benfield om"Oral versus Intravenous Antibiotics for Bone and Joint Infection."?
Hvad mener Professor Niels Obel om artiklen"Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis."?
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