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BMC Infectious Diseases, 10.10.2024
Tilføjet 10.10.2024
Abstract Background Identifying risk factors for respiratory syncytial virus (RSV)–associated severe acute respiratory illness (SARI) will assist with targeting vaccine interventions. Methods Using surveillance data from South Africa (2012–2018), we compared the characteristics of individuals with RSV-associated influenza-like illness (ILI) (reference group) to those with RSV-associated SARI to describe factors associated with SARI using a multivariable analysis. Results RSV was detected in 6% (483/7792) of ILI cases and 15% (844/5672) of SARI cases. Factors associated with SARI in children included age
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.10.2024
Tilføjet 10.10.2024
Abstract Background Cutaneous infections caused by non-tuberculous mycobacteria (NTM) are extremely rare, particularly when they are localized to the facial area. This condition presents significant diagnostic challenges due to its unusual presentation and the need for precise microbiological identification. Case Presentation A two-year-old male patient presented with a progressively enlarging reddish-brown mass on the left side of his face. Despite the absence of systemic symptoms, the lesion’s growth warranted investigation due to its growth. Ultrasonography showed a hypoechoic mass in the dermis, indicating an underlying abscess. The subsequent aspiration resulted in pale yellow pus, which upon testing and culture, confirmed the presence of Mycobacterium avium complex infection, a species of NTM. This case exemplifies the synergy between imaging modalities and microbiological analysis, highlighting the crucial role of both in achieving favorable clinical outcomes in patients with suspected cutaneous NTM infections. Ultrasound can expedite diagnosis, improve treatment planning, and enhance patient care by enabling targeted interventions and monitoring response to therapy in these scenarios. However, it is the combination of pathogen-specific diagnostics that ensures accurate etiological attribution and appropriate antimicrobial stewardship. Conclusion Although rare, facial cutaneous infections caused by NTM still deserve thorough investigation to determine the exact cause. Ultrasound is used to identify cutaneous lesions, measure their extent, and guide surgical procedures. The ultimate diagnosis is based on microbiological confirmation.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.10.2024
Tilføjet 10.10.2024
Abstract Background Post-viral symptoms have long been known in the medical community but have received more public attention during the COVID-19 pandemic. Many post-viral symptoms were reported as particularly frequent after SARS-CoV-2 infection. However, there is still a lack of evidence regarding the specificity, frequency and persistence of these symptoms in comparison to other viral infectious diseases such as influenza. Methods We investigated a large population-based cohort based on German routine healthcare data. We matched 573,791 individuals with a PCR-test confirmed SARS-CoV-2 infection from the year 2020 to contemporary controls without SARS-CoV-2 infection and controls from the last influenza outbreak in 2018 and followed them up to 18 months. Results We found that post-viral symptoms as defined for COVID-19 by the WHO as well as tissue damage were more frequent among the COVID-19 cohort than the influenza or contemporary control cohort. The persistence of post-viral symptoms was similar between COVID-19 and influenza. Conclusion Post-viral symptoms following SARS-CoV-2 infection constitute a substantial disease burden as they are frequent and often persist for many months. As COVID-19 is becoming endemic, the disease must not be trivialized. Research should focus on the development of effective treatments for post-viral symptoms.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.10.2024
Tilføjet 10.10.2024
Abstract Background The COVID-19 disease requires accurate diagnosis to effectively manage infection rates and disease progression. The study aims to assess the relationship between vaccination status and RT-PCR cycle threshold (Ct) values by comparing clinical, RDT and RT-PCR results. Methods A total of 453 suspected COVID-19 cases were included in this study. Nasopharyngeal swabs were collected for both RDT and RT-PCR testing, with RDTs conducted on-site and RT-PCR at the Ethiopian Public Health Institute (EPHI) genomics laboratory. Detailed clinical, RDT, and RT-PCR results were analyzed. Data analysis included descriptive statistics, cross-tabulation, and Chi-Square tests to investigate the connections between diagnostic outcomes and vaccination status, with a focusing on Ct values. Results RDT results showed 34.0% negative and 65.8% positive, while RT-PCR results indicated 35.8% negative and 64.2% positive cases. The discrepancies between RDT and RT-PCR results emphasize the importance of thorough testing. No significant association was found between vaccination status and viral load, as indicated by Ct values. Among RT-PCR positive cases, 49.8% had been vaccinated, suggesting challenges in interpreting results among vaccinated individuals. Further analysis revealed that vaccination (first or second dose) had minimal impact on Ct values, indicating limited influence of vaccination status on viral load dynamics in infected individuals. Conclusions The study highlights the significant differences between RDT and RT-PCR outcomes, underscoring the need for a comprehensive testing approach. Additionally, the findings suggest that vaccination status does not significantly impact RT-PCR Ct values, complicating the interpretation of diagnostic results in vaccinated individuals, especially in breakthrough infections and potential false positives.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.10.2024
Tilføjet 10.10.2024
Abstract Background Nontuberculous mycobacterial pulmonary disease (NTM-PD), a chronic respiratory condition, presents a growing challenge globally. Uncertainties exist regarding the impact of concurrent bacterial co-isolation on treatment initiation and long-term prognosis. Methods This study analysed data from participants enrolled in an ongoing prospective observational cohort study on NTM-PD (NCT01616745) between 1 July 2011, and 31 December 2022, who provided sputum samples for bacterial culture at enrolment. Identification of potential pathogenic microorganisms (PPMs) was defined as a positive bacterial culture. Clinical characteristics were compared between NTM-PD patients with Pseudomonas, non-pseudomonal PPMs, and those without PPM co-isolation. Cox proportional hazard regression models were employed to assess the association of bacterial co-isolation with rates of NTM-PD treatment initiation and all-cause mortality. Results Overall, 453 patients (median age, 62 years; 30% male) were included in the analysis. PPMs were co-isolated in 77 patients (17%), including 13 with Pseudomonas species. Co-isolation of Pseudomonas was associated with a significantly higher erythrocyte sedimentation rate (P = 0.02) and St. George’s Respiratory Questionnaire score (P = 0.01). Non-pseudomonal PPM co-isolation was significantly associated with a higher likelihood of NTM-PD treatment initiation (adjusted hazards ratio [aHR], 1.56, 95% confidence interval [CI], 1.03–2.36, P = 0.036), whereas co-isolation of Pseudomonas was independently correlated with increased all-cause mortality (aHR, 3.25, 95% CI, 1.08–9.84, P = 0.037). Conclusions Our findings emphasize the importance of microbial surveillance, as bacterial co-isolation affects treatment initiation and prognosis in patients with NTM-PD.
Læs mere Tjek på PubMedGrunwell, Jocelyn R.; Huang, Min; Stephenson, Susan T.; Tidwell, Mallory; Ripple, Michael J.; Fitzpatrick, Anne M.; Kamaleswaran, Rishikesan
Critical Care Explorations, 10.10.2024
Tilføjet 10.10.2024
OBJECTIVES: Monocytes are plastic cells that assume different polarization states that can either promote inflammation or tissue repair and inflammation resolution. Polarized monocytes are partially defined by their transcriptional profiles that are influenced by environmental stimuli. The airway monocyte response in pediatric acute respiratory distress syndrome (PARDS) is undefined. To identify differentially expressed genes and networks using a novel transcriptomic reporter assay with donor monocytes exposed to the airway fluid of intubated children with and at-risk for PARDS. To determine differences in gene expression at two time points using the donor monocyte assay exposed to airway fluid from intubated children with PARDS obtained 48–96 hours following initial tracheal aspirate sampling. DESIGN: In vitro pilot study carried out using airway fluid supernatant. SETTING: Academic 40-bed PICU. PARTICIPANTS: Fifty-seven children: 44 children with PARDS and 13 children at-risk for PARDS. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We performed bulk RNA sequencing using a transcriptomic reporter assay of monocytes exposed to airway fluid from intubated children to discover gene networks differentiating PARDS from at-risk for PARDS and those differentiating mild/moderate from severe PARDS. We also report differences in gene expression in children with PARDS 48–96 hours following initial tracheal aspirate sampling. We found that interleukin (IL)-10, IL-4, and IL-13, cytokine/chemokine signaling, and the senescence-associated secretory phenotype are upregulated in monocytes exposed to airway fluid from intubated children with PARDS compared with those at-risk for PARDS. Signaling by NOTCH, histone deacetylation/acetylation, DNA methylation, chromatin modifications (B-WICH complex), and RNA polymerase I transcription and its associated regulatory apparatus were upregulated in children with PARDS 48–96 hours following initial tracheal aspirate sampling. CONCLUSIONS: We identified gene networks important to the PARDS airway immune response using bulk RNA sequencing from a monocyte reporter assay that exposed monocytes to airway fluid from intubated children with and at-risk for PARDS. Mechanistic investigations are needed to validate our findings.
Læs mere Tjek på PubMedMurray, Brian; Athale, Janhavi; Balk, Robert A.; Behal, Michael L.; Brown, Judah E.; Chanas, Tyler; Dumitru, Roxana; Gifford, Dalton C.; Hohlfelder, Benjamin; Jones, Honey M.; Makic, Mary Beth F.; Rausen, Michelle S.; Sacco, Alicia J.; Sines, Benjamin J.; Gurnani, Payal K.
Critical Care Explorations, 10.10.2024
Tilføjet 10.10.2024
OBJECTIVES: We aimed to summarize the most significant and impactful publications describing the pharmacotherapeutic care of critically ill patients in 2023. DATA SOURCES: PubMed/MEDLINE and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. STUDY SELECTION: Randomized controlled trials and prospective studies of adult critically ill patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints published between January 1, 2023, and December 31, 2023, were eligible for inclusion in this article. DATA EXTRACTION: Articles from a systematic search and the Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update were included. An a priori defined three-round modified Delphi process was employed to achieve consensus on the most impactful publications based on the following considerations: 1) overall contribution to scientific knowledge and 2) novelty to the literature. DATA SYNTHESIS: The systematic search and Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update returned a total of 1202 articles, of which 1164 were excluded. The remaining 38 articles underwent a three-round modified Delphi process. In each round, articles were independently scored based on overall contribution to scientific knowledge and novelty to the literature. Included articles are summarized and their impact discussed. Article topics included hydrocortisone for severe community-acquired pneumonia, inhaled amikacin for prevention of ventilator-associated pneumonia, methylene blue for septic shock, restrictive vs. liberal fluid management for sepsis-induced hypotension, andexanet alfa for major bleeding associated with factor Xa inhibitors, and early administration of four-factor prothrombin complex concentrate in patients with trauma at risk for massive transfusion. CONCLUSIONS: This review provides a summary and perspective on the potential impact of the most relevant articles in 2023 describing advances in the pharmacotherapeutic care of critically ill patients.
Læs mere Tjek på PubMedMichinobu KuwaeYusuke YokoyamaStephen TimsMichaela FroehlichL. Keith FifieldTakahiro AzeNarumi TsugekiHideyuki DoiYoshiki SaitoaCenter for Marine Environmental Studies, Ehime University, Matsuyama 790-8577, JapanbAtmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa 277-8564, JapancResearch School of Physics, The Australian National University, Canberra, ACT 2601, AustraliadThe Faculty of Law, Matsuyama University, Matsuyama 790-8578, JapaneGraduate School of Informatics, Kyoto University, Kyoto 606-8501, JapanfEstuary Research Center, Shimane University, Matsue 690-8504, JapangGeological Survey of Japan, The National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8567, Japan
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedImrul ShahriarMohini KamraAnanda Kumar KanduluruCharity Lynn CampbellThanh Hiep NguyenMadduri SrinivasaraoPhilip S. LowaJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907bEradivir Inc., West Lafayette, IN 47906cDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedAbhimanyuSantiago Carrero LonglaxTomoki NishiguchiMalik LadkiDaanish SheikhAmera L. MartinezEmily M. MaceSandra L. GrimmThaleia CaldwellAlexandra Portillo VarelaRajagopal V. SekharAnna M. MandalakasMandla MlotshwaSibuse GinidzaJeffrey D. CirilloRobert S. WallisMihai G. NeteaReinout van CrevelCristian CoarfaAndrew R. DiNardoaDepartment of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX 77030bDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030cDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032dDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030eDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030fTranslational Metabolism Unit, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030gEpidemiology, Human Genetics & Environmental Sciences, University of Texas-UTHealth School of Public Health, Houston, TX 77030hClinical Infectious Disease Group, German Center for Infectious Research (DZIF), Clinical tuberculosis (TB) Unit, Research Center Borstel, Borstel 27246, GermanyiThe Aurum institute, Johannesburg 2006, South AfricajDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Johannesburg, Johannesburg 2006, South AfricakDepartment of Medicine, Vanderbilt University, Nashville, TN 37232lCenter for Airborne Pathogen Research and Imaging, Texas A&M College of Medicine, Bryan, TX 77843mDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106nVanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37232oDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, NetherlandspDepartment of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn 53113, GermanyqNuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford OX1 4BH, United Kingdom
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedQuigly DragotakesPatrick W. JohnsonMatthew R. BurasRickey E. CarterMichael J. JoynerEvan BlochKelly A. GeboDaniel F. HanleyJeffrey P. HendersonLiise-anne PirofskiShmuel ShohamJonathon W. SenefeldAaron A.R. TobianChad C. WigginsR. Scott WrightNigel S. PanethDavid J. SullivanArturo CasadevallaDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 21205bDivision of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL 32224cDivision of Biostatistics and Clinical Trials, Department of Quantitative Health Sciences, Scottsdale, AZ 85259dDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL 32224eDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN 55905fDepartment of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205gDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205hDepartment of Neurology, Brain Injury Outcomes Division, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21205iDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Louis, St. Louis, MO 63110jDivision of Infectious Diseases, Albert Einstein College of Medicine, New York, NY 10461kDepartment of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, IL 61801lDepartment of Kinesiology, Michigan State University, East Lansing, MI 48823mDepartments of Cardiovascular Medicine and Human Research Protection Program, Mayo Clinic, Rochester, MN 55905nDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI 48823oDepartment of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48823
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedSubhan Hadi KusumaTaishi KakizukaMitsuru HattoriTakeharu NagaiaGraduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, JapanbDepartment of Biomolecular Science and Engineering, SANKEN, Osaka University, Ibaraki, Osaka 567-0047, JapancTransdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka 565-0871, JapandResearch Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido 001-0020, Japan
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedQizhao MaJing LiShuxing YuJing ZhouYaqi LiuXinyue WangDingwei YeYumeng WuTao GongQiong ZhangLingyun WangJing ZouYuqing LiaLaboratory of Oral Microbiology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinabDepartment of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinacDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510dLaboratory of Archaeological Repository, Center for Archaeological Science, Sichuan University, Chengdu 610041, China
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedWon JungTai-Yen ChenAce George SantiagoPeng ChenaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853bDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138cDepartment of Chemistry, University of Houston, Houston, TX 77204d10x Genomics, Pleasanton, CA 94588
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedAbraham O. OluwoleNeha V. KalmankarMichela GuidaJack L. BennettGiovanna PoceJani R. BollaCarol V. RobinsonaDepartment of Chemistry, University of Oxford, Oxford OX1 3QZ, United KingdombThe Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, United KingdomcDepartment of Chemistry and Technologies of Drug, Sapienza University of Rome, Rome 00185, ItalydDepartment of Biology, University of Oxford, Oxford OX1 3RB, United Kingdom
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedMohamad Wessam AlnouriKenneth Anthony RoquidRémy BonnavionHaaglim ChoJan HeeringJeonghyeon KwonYannick JägerShengPeng WangStefan GüntherNina WettschureckGerd GeisslingerRobert GurkeChrista E. MüllerEwgenij ProschakStefan OffermannsaDepartment of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim 61231, GermanybFraunhofer Institute for Translational Medicine and Pharmacology and Fraunhofer Cluster of Excellence for Immune Mediated Diseases, Frankfurt am Main 60596, GermanycCardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi’an 710061, ChinadMax Planck Institute for Heart and Lung Research, Deep Sequencing Platform, Bad Nauheim 61231, GermanyeCenter for Molecular Medicine, Goethe University Frankfurt, Frankfurt 60590, GermanyfExcellence Cluster Cardiopulmonary Institute (CPI), Bad Nauheim Bad 61231, GermanygGerman Center for Cardiovascular Research (DZHK), Rhine-Main site, Bad Nauheim 61231, GermanyhInstitute of Clinical Pharmacology, Goethe University, Frankfurt am Main 60590, GermanyiPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn 53121, GermanyjPharmaCenter Bonn, University of Bonn, Bonn 53121, GermanykInstitute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt 60438, Germany
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedAdam W. CarricoDaniel T. RyanJohnny BeronaBenjamin S. DominguezJoshua M. SchrockThomas W. McDadeMichael NewcombRichard T. D’AquilaBrian MustanskiaHealth Promotion and Disease Prevention, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199bBiobehavioral Consulting, Miami Shores, FL 33138cInstitute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Chicago, IL 60611dDepartment of Anthropology, Northwestern University, Evanston, IL 60208eDepartment of Medicine Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedJack FitzgeraldaDepartment of Ethics, Governance, and Society, Vrije Universiteit Amsterdam, School of Business and Economics, Amsterdam 1081HV, The Netherlands
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedStephen A. RainsAdam S. RichardsaDepartment of Communication, University of Arizona, Tucson, AZ 85721-0025bDepartment of Communication Studies, Furman University, Greenville, SC 29613-1000
Proceedings of the National Academy of Sciences, 10.10.2024
Tilføjet 10.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 41, October 2024.
Læs mere Tjek på PubMedAnna SchumannAhmed GaballaMartin Wiedmann1Department of Food Science, Cornell University, Ithaca, New York, USA2Graduate Field of Biomedical and Biological Sciences, Cornell University, Ithaca, New York, USACorrella S. Detweiler
Microbiology and Molecular Biology Reviews, 10.10.2024
Tilføjet 10.10.2024
Emma Starbuck
Lancet Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
Viral times: reflections on the COVID-19 and HIV pandemics explores how the COVID-19 pandemic can shape our understanding of the HIV pandemic, and vice versa. The book is a compilation of 16 papers written by 28 authors, and includes case studies from eleven different countries. The book was edited by Jaime García-Iglesias, Maurice Nagington, and Peter Aggleton, and it is targeted towards a range of specialist backgrounds, as well as the general reader.
Læs mere Tjek på PubMedDelia Ortega-Lenis, David Arango-Londoño, Freddy Hernández, Paula Moraga
PLoS One Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
by Delia Ortega-Lenis, David Arango-Londoño, Freddy Hernández, Paula Moraga Dengue is a vector-borne disease that has increased over the past two decades, becoming a global public health emergency. The transmission of dengue is contingent upon various factors, among which climate variability plays a significant role. However, there remains substantial uncertainty regarding the underlying mechanisms. This study aims to investigate the spatial and temporal patterns of dengue risk and to quantify the associated risk factors in Valle del Cauca, Colombia, from 2001 to 2019. To achieve this, a spatio-temporal Bayesian hierarchical model was developed, integrating delayed and non-linear effects of climate variables, socio-economic factors, along with spatio-temporal random effects to account for unexplained variability. The results indicate that average temperature is positively associated with dengue risk 0-2 months later, showing a 35% increase in the risk. Similarly, high precipitation levels lead to increased risk approximately 2-3 months later, while relative humidity showed a constant risk within a 6 months-lag. These findings could be valuable for local health authorities interested in developing early warning systems to predict future risks in advance.
Læs mere Tjek på PubMedLizandre Keren Ramos da Silveira, Ana Paula P. Velosa, Sergio Catanozi, Marco Aurélio A. Pereira, Antonio dos Santos Filho, Fabio Luiz N. Marques, Daniele de Paula Faria, Caroline Cristiano Real, Sandra de M. Fernezlian, Amanda Flores Yanke, Zelita Aparecida de J. Queiroz, Vitória Elias Contini, Thays de Matos Lobo, Solange Carrasco, Camila Machado Baldavira, Cláudia Goldenstein-Schainberg, Ricardo Fuller, Vera L. Capelozzi, Walcy R. Teodoro
PLoS One Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
by Lizandre Keren Ramos da Silveira, Ana Paula P. Velosa, Sergio Catanozi, Marco Aurélio A. Pereira, Antonio dos Santos Filho, Fabio Luiz N. Marques, Daniele de Paula Faria, Caroline Cristiano Real, Sandra de M. Fernezlian, Amanda Flores Yanke, Zelita Aparecida de J. Queiroz, Vitória Elias Contini, Thays de Matos Lobo, Solange Carrasco, Camila Machado Baldavira, Cláudia Goldenstein-Schainberg, Ricardo Fuller, Vera L. Capelozzi, Walcy R. Teodoro We hypothesized that after synovial injury, collagen V (Col V) expose occult antigens, and Col V autoantibodies develop, indicating the loss of immune tolerance against this molecule, thus leading to damage to mesenchymal-derived cells as well as the extracellular matrix in experimental arthritis. Thus, the present study investigated the effects of oral administration of Col V on the synovium after the development of inflammation in mBSA/CFA-induced arthritis. After fourteen days of intraarticular administration of mBSA, 10 male Lewis rats were orally administered Col V (500 μg/300 μL) diluted in 0.01 N acetic acid (IA-Col V group). The arthritic group (IA group, n = 10) received only intraarticular mBSA. An intra-articular saline injection (20 μL) was given to the control group (CT-Col V, n = 5). IA group presented damaged synovia, the expansion of the extracellular matrix by cellular infiltrate, which was characterized by T and B lymphocytes, and fibroblastic infiltration. In contrast, after Col V oral immunotherapy IA-Col V group showed a significant reduction in synovial inflammation and intense expression of IL-10+ and FoxP3+ cells, in addition to a reduction in Col V and an increase in Col I in the synovia compared to those in the IA group. Furthermore, an increase in IL-10 production was detected after IA-Col V group spleen cell stimulation with Col V in vitro. PET imaging did not differ between the groups. The evaluation of oral treatment with Col V, after mBSA/CFA-induced arthritis in rats, protects against inflammation and reduces synovial tissue damage, through modulation of the synovial matrix, showing an immunotherapeutic potential in inhibiting synovitis.
Læs mere Tjek på PubMedRenee Bolijn, Annemieke M. W. Spijkerman, Henrike Galenkamp, Anneke Blokstra, Liza Coyer, Anders Boyd, Maria Prins, Karien Stronks
PLoS One Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
by Renee Bolijn, Annemieke M. W. Spijkerman, Henrike Galenkamp, Anneke Blokstra, Liza Coyer, Anders Boyd, Maria Prins, Karien Stronks Background During the first waves of the COVID-19 pandemic, SARS-CoV-2 antibody prevalence (seroprevalence) was lower in older compared to younger adults. We studied age group differences in SARS-CoV-2 seroprevalence, across ethnic groups, and assessed the explanatory value of factors that increase the exposure to the virus, and factors related to susceptibility, given the level of exposure. Methods We analysed cross-sectional data from 2,064 participants from the multi-ethnic HELIUS study (Amsterdam, The Netherlands). SARS-CoV-2 seroprevalence at the second wave of infections was compared between age groups (0.05), but age patterns varied across ethnic groups. Age group differences in SARS-CoV-2 seroprevalence were most pronounced in the Dutch majority group, with the highest prevalence ratio in the youngest group (2.55, 95%CI 0.93–6.97) and the lowest in the oldest group (0.53, 95%CI 0.16–1.74), compared to the middle-aged group. In ethnic minority groups, age group differences were smaller. In all groups, patterns did not substantially change after adjustments for exposure and susceptibility variables. Conclusion We found no evidence of age group differences in SARS-CoV-2 seroprevalence, particularly for ethnic minority groups, even when accounting for exposure and susceptibility. While early prevention strategies particularly aimed at protecting older adults against SARS-CoV-2 infections, seroprevalence was similar across age groups in ethnic minority groups. Thus, older adults in ethnic minority groups may pose a target group for additional prevention strategies for future infectious disease outbreaks.
Læs mere Tjek på PubMedMathias Mlewa, Helmut A. Nyawale, Shimba Henerico, Ivon Mangowi, Aminiel Robert Shangali, Anselmo Mathias Manisha, Felix Kisanga, Benson R. Kidenya, Hyasinta Jaka, Semvua B. Kilonzo, Mariam M. Mirambo, Stephen E. Mshana
PLoS One Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
by Mathias Mlewa, Helmut A. Nyawale, Shimba Henerico, Ivon Mangowi, Aminiel Robert Shangali, Anselmo Mathias Manisha, Felix Kisanga, Benson R. Kidenya, Hyasinta Jaka, Semvua B. Kilonzo, Mariam M. Mirambo, Stephen E. Mshana Background Chronic hepatitis B virus (HBV) infection is still a major public health problem. In response to the World Health Organization (WHO), Tanzania implemented immunization and treatment to achieve the eradication of HBV infection by 2030. To achieve this goal, frequent updates of demographic data, antiviral therapy eligibility, and uptake are essential. We therefore evaluated demographic data, antiviral therapy eligibility, and uptake among chronically HBV-infected patients attending at Bugando Medical Centre (BMC), Tanzania. Methods A cross-sectional study enrolled 196 chronic HBV patients from April 23, 2023, to October 10, 2023, at BMC, where 100 and 96 patients were retrospectively and prospectively enrolled, respectively. Study’s ethical clearance and permission were observed by the Catholic University of Health and Allied Sciences/Bugando Medical Centre research ethics and review committee and the Bugando Medical Centre management respectively. For all patients, socio-demographic data and whole blood samples were obtained. Full blood picture, alanine and aspartate amino transferases, and HBV viral load parameters were determined. Aspartate-Platelet Ratio Index (APRI) and Fibrosis Four (FIB-4) scores were calculated according to their respective formulas. Therapy eligibility and uptake were evaluated according to the 2015 WHO HBV prevention, treatment, and care guidelines. The data were summarized and analysed using STATA version 15. Results The median age for all patients was 39 [IQR: 32–47.5] years. Nearly all study patients, 99% (194/196), were older than 20 years old, with significant male dominance (73.5% [144/196] versus 26.5% [52/196]; p
Læs mere Tjek på PubMedSophia Rasheeqa Ismail, Ranina Radzi, Puteri Sofia Nadira Megat Kamaruddin, Ezarul Faradianna Lokman, Han Yin Lim, Nusaibah Abdul Rahim, Hui Yin Yow, Daarshini Arumugam, Alex Ngu, Annie Ching Yi Low, Eng Hwa Wong, Sapna Patil, Priya Madhavan, Ruslin Bin Nordin, Esther van der Werf, Nai Ming Lai
PLoS One Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
by Sophia Rasheeqa Ismail, Ranina Radzi, Puteri Sofia Nadira Megat Kamaruddin, Ezarul Faradianna Lokman, Han Yin Lim, Nusaibah Abdul Rahim, Hui Yin Yow, Daarshini Arumugam, Alex Ngu, Annie Ching Yi Low, Eng Hwa Wong, Sapna Patil, Priya Madhavan, Ruslin Bin Nordin, Esther van der Werf, Nai Ming Lai Children are susceptible to infections due to frequent participation in school group activities and their often-suboptimal hygiene practices. Frequent infections in children affect school attendance, academic performances, and general health. The effectiveness of school-based hygiene-related intervention programmes need to be informed by updated high-quality synthesised evidence. In this systematic review, we searched PubMed and Cochrane CENTRAL for randomised and non-randomised interventional studies that evaluated school-based hygiene-related interventions. We assessed risk-of-bias (Cochrane risk-of-bias 2 tool), performed random-effect meta-analysis (RevMan 5.4) and rated certainty-of-evidence (GRADE). Thirty-nine trials (41 reports), published from 2011 to 2024 from 22 countries were included. Twenty-three studies contributed data for meta-analysis. All school-based interventions were compared with standard curriculum and demonstrated very low to low certainty-of-evidence due to study methodological limitations and imprecision. Hand-body hygiene interventions may improve knowledge, attitudes and practices (SMD 2.30, 95%CI 1.17 to 3.44, 6 studies, 7301 participants), increase handwashing practices (RR 1.75, 95%CI 1.41 to 2.17, 5 studies, 5479 participants), and reduce infection-related absenteeism (RR 0.74, 95%CI 0.66 to 0.83, 5 studies, 1017852 observations). Genital hygiene interventions may improve attitude (SMD 6.53, 95%CI 2.40 to 10.66, 2 studies, 2644 participants) and practices (RR 2.44, 95%CI 1.28 to 4.68, 1 study, 1201 participants). However, intervention effects on oral hygiene appeared mixed, with worsening of the oral hygiene score (SMD 3.12, 95%CI 1.87 to 4.37, 2 studies, 652 participants) but improved dental hygiene (SMD -0.33, 95%CI -0.53 to -0.13, 3 studies, 4824 participants) and dental caries scores (SMD -0.34, 95%CI -0.52 to -0.16, 4 studies, 2352 participants). Limited evidence suggests that interventions targeting hand-body and genital hygiene practices may improve knowledge, practices, and infection-related absenteeism. However, the effects on oral hygiene intervention appeared mixed. Future research should strengthen randomisation and intervention documentation, and evaluate hygiene-related behaviour, academic performances and health outcomes.
Læs mere Tjek på PubMedA. BoastW. ZhangH. SoeorgG. GonisA. Di CarloA. DaleyN. CurtisB. McWhinneyJ. P. J. UngererA. LeiJ. F. StandingA. Gwee1Department of General Medicine and Laboratory Services, The Royal Children’s Hospital Melbourne, Parkville, Australia2Antimicrobials and Infectious Diseases Group, Murdoch Children’s Research Institute, Melbourne, Australia3Department of Paediatrics, The University of Melbourne, Melbourne, Australia4Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom5Department of Chemical Pathology, Pathology Queensland, Brisbane, Australia6Faculty of Health and Behavioural Sciences, University of Queensland, Brisbane, Australia7Department of Pharmacy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United KingdomAndreas H. Groll
Antimicrobial Agents And Chemotherapy, 9.10.2024
Tilføjet 9.10.2024
Kiyoharu FukushimaYuki MatsumotoYuko AbeKazuki HashimotoDaisuke MotookaSeigo KitadaHaruko SaitoSho KomukaiEriko FukuiTakayuki NiitsuHiroshi NabeshimaYasuharu NagahamaJune YamauchiTadayoshi NittaTakuro NiiTakanori MatsukiKazuyuki TsujinoKeisuke MikiYasushi ShintaniAtsushi KumanogohShizuo AkiraShota NakamuraHiroshi Kida1Department of Respiratory Medicine, National Hospital Organization, Osaka Toneyama Medical Center, Toyonaka, Osaka, Japan2Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan3Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, Osaka, Japan4Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Osaka, Japan5Global Center for Medical Engineering and Informatics, Suita, Osaka, Japan6Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases (RIMD), Osaka University, Suita, Osaka, Japan7Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan8Kitada Respiratory Clinic, Yao, Osaka, Japan9Department of Clinical Laboratory, National Hospital Organization, Osaka Toneyama Medical Centre, Toyonaka, Osaka, Japan10Department of Biomedical Statistics, Graduate School of Medicine, Osaka University, Osaka, Japan11Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan12Center for Infectious Disease Education and Research, Osaka University, Japan for Infectious Disease Education and Research, Osaka University, Toyonaka, Osaka, JapanSean Wasserman
Antimicrobial Agents And Chemotherapy, 9.10.2024
Tilføjet 9.10.2024
Infection, 9.10.2024
Tilføjet 9.10.2024
Abstract Purpose To compare the clinical severity of Human Adenovirus (HAdV) infection with other viral diseases in a cohort of children, evaluating presentation, therapy, and outcome. Methods We conducted a retrospective multicenter cohort study in Italian children hospitalized from January to December 2023 for respiratory symptoms. The study included children with HAdV infection presenting primarily with respiratory symptoms. Patients with isolated gastrointestinal involvement or coinfection with bacteria were excluded. Results A total of 171 children were enrolled: 98 with HAdV infection (age 44.3 ± 37.9 months) and 73 with other viruses (age 20.4 ± 27.2 months). In the first group, 57.1% had a coinfection with one or more additional viruses. The most common symptoms were fever (89.8%), cough (73.5%) and sore throat (52%). Respiratory distress and hypoxemia were more frequent in the non-HAdV group. Children with HAdV infection demonstrated significantly higher C-reactive protein levels (50.8 ± 54.2 vs. 16.5 ± 33.8 mg/L, p
Læs mere Tjek på PubMedInfection, 9.10.2024
Tilføjet 9.10.2024
Infection, 9.10.2024
Tilføjet 9.10.2024
Abstract Gas gangrene is a rare presentation of a necrotizing fasciitis, caused by Clostridium perfringens, C. septicum and other clostridial species. With its rapid progression it is a potentially life-threatening infection, that poses as a challenge in the clinical management requiring an interdisciplinary approach. Here we present a 62-year-old woman, who developed neutropenic fever while undergoing chemotherapy for triple negative breast cancer. She presented with a high fever, reporting little pain in her left thigh accompanied by redness and induration locally. Subsequently the patient developed pain and redness of the back of the left hand. The initial findings suggested cellulitis and immediate empiric treatment with intravenous meropenem was started. Despite the antibiotic treatment the patient rapidly developed septic shock along with progression of the local infection. Emergency surgical debridement revealed extensive necrosis of the soft tissues including extensive myonecrosis of the thigh. On the left hand an extensive debridement was performed, the left lower limb could not be preserved and exarticulation of the left hip was required. Microbiologically C. septicum was isolated in different samples, confirming gas gangrene. As there was no local entry portal on the skin, hematogenous seeding from intestinal translocation in this neutropenic patient was suspected. The empiric antibiotic treatment was tailored to intravenous penicillin and complemented with clindamycin for toxin inhibition. Following radical debridement and antibiotic treatment, the patient could be stabilized. After repetitive debridement wound closure was achieved and the patient was discharged for rehabilitation. Antibiotic treatment was continued for four weeks. This rare case of gas gangrene in a neutropenic patient shows the complexity in the diagnostic and therapeutic management of necrotizing soft tissue infections in immunocompromised patients. It particularly highlights the importance of an interdisciplinary management with fast recognition of the disease and rapid, if needed radical, surgical debridement as well as tailored antibiotic treatment for a successful outcome.
Læs mere Tjek på PubMedInfection, 9.10.2024
Tilføjet 9.10.2024
Abstract Cefiderocol is a new siderophore-beta-lactam antibiotic used for the treatment of severe multidrug-resistant infections like sepsis, hospital-acquired and ventilator-associated pneumonia in adults, but there are only single reports on its use in the neonatal population. We describe the successful cefiderocol treatment of a newborn with pneumogenic sepsis due to Stenotrophomonas maltophilia.
Læs mere Tjek på PubMedJennifer Kneas Travis, Lindsey M. Costantini
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Markus H. Kainulainen, Jessica R. Harmon, Elif Karaaslan, Jackson Kyondo, Amy Whitesell, Sam Twongyeirwe, Jason H. Malenfant, Jimmy Baluku, Aaron Kofman, Éric Bergeron, Michelle A. Waltenburg, Luke Nyakarahuka, Stephen Balinandi, Caitlin M. Cossaboom, Mary J. Choi, Trevor R. Shoemaker, Joel M. Montgomery, Christina F. Spiropoulou
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Qing Tan, Hongli Yang, Yong He, Xia Shen, Lin Sun, Xiaoyan Du, Gangqiang Lin, Na Zhou, Nishi Wang, Qian Zhou, Dan Liu, Xiaoyan Xu, Libo Zhao, Peng Xie
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Jing Li, Yujie Xin, Siwei Zhang, Yanling Li, Mingjuan Jiang, Senmiao Zhang, Li Yang, Jing Yang, Pengfei Cao, Jianhong Lu
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Haiyun Zhou, Danlei Chen, Xuanwen Ru, Qingyi Shao, Simiao Chen, Ruiying Liu, Rui Gu, Jiayi Shen, Qing Ye, Dongqing Cheng
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Tsutomu Itagaki, Kenichi Komabayashi, Mika Sasaki, Naomi Ogawa, Junji Seto, Yoko Aoki, Tatsuya Ikeda, Yoko Matsuzaki, Katsumi Mizuta
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Zhikun Zeng, Lanxin Jia, Jiahao Zheng, Xuanxuan Nian, Zhegang Zhang, Liangjun Chen, Xiaoqi Chen, Yirong Li, Jiayou Zhang
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Kristen Andreatta, Michelle L. D'Antoni, Silvia Chang, Aiyappa Parvangada, Ross Martin, Christiana Blair, Debbie Hagins, Princy Kumar, Jason T. Hindman, Hal Martin, Christian Callebaut
Journal of Medical Virology, 9.10.2024
Tilføjet 9.10.2024
Eleonora Cella, Vagner Fonseca, Francesco Branda, Stephane Tosta, Keldenn Moreno, Gabriel Schuab, Sobur Ali, Svetoslav Nanev Slavov, Fabio Scarpa, Luciane Amorim Santos, Simone Kashima, Eduan Wilkinson, Houriiyah Tegally, Carla Mavian, Alessandra Borsetti, Francesca Caccuri, Marco Salemi, Tulio de Oliveira, Taj Azarian, Ana Maria Bispo de Filippis, Luiz Carlos Junior Alcantara, Giancarlo Ceccarelli, Arnaldo Caruso, Vittorio Colizzi, Alessandro Marcello, José Lourenço, Massimo Ciccozzi, Marta Giovanetti
International Journal of Infectious Diseases, 9.10.2024
Tilføjet 9.10.2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded RNA virus, emerged in late 2019 and quickly spread worldwide, overwhelming healthcare systems [1]. This ongoing transmission led to new variants with increased ability to spread and infect people [2]. A key mutation in the spike protein, D614G, appeared early in the pandemic; this variant quickly became dominant, replacing the original strain by June 2020 [3]. Between October and December 2020, WHO has identified five concerning variants (VOC) - Alpha, Beta, Delta, Gamma, and Omicron - that spread easily and evade immunity [4-7], hindering pandemic control efforts.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
A phase 3 clinical trial evaluating the safety and efficacy of a messenger RNA (mRNA) combination vaccine for COVID-19 and influenza had mixed results, the vaccine’s manufacturers announced. The vaccine was a collaboration between BioNTech and Pfizer and was tested among more than 8000 healthy adults aged 18 to 64 years.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
Researchers have suspected that there’s a link between chronic low-grade inflammation and psychiatric disorders. Now, a recent cohort study points to specific inflammatory biomarkers that might be associated with an increased risk of depression, anxiety, and stress-related disorders.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
An experimental malaria vaccine could offer protection during pregnancy for up to 2 years without a booster dose, according to a randomized clinical trial conducted in Mali. The 3-dose vaccine, known as Plasmodium falciparum sporozoite (PfSPZ) vaccine, had previously been tested successfully in adults in other parts of Africa.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
Previous studies suggest twice-yearly mass distribution of the antibiotic azithromycin reduces childhood mortality in sub-Saharan Africa. The World Health Organization (WHO) has approved the practice with stipulations limiting distribution to infants aged 1 to 11 months, citing concerns about antimicrobial resistance.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
This Medical News story discusses new guidelines for the use of pemivibart, a monoclonal antibody marketed as Pemgarda, as preexposure prophylaxis against COVID-19 in immunocompromised individuals.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
The Original Investigation titled “Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial,” published on January 12, 2023, was corrected to fix the Role of Funder/Sponsor statement. The Role of Funder/Sponsor statement should have read “The National Center for Advancing Translational Sciences had a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.” This article was corrected online.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
This JAMA Clinical Guidelines Synopsis summarizes the 2022 recommendations on evaluation of suspected antibiotic allergies from the American Academy of Allergy, Asthma & Immunology and American College of Allergy, Asthma & Immunology.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
The COVID-19 pandemic has had devastating consequences globally, and the immediate and short-term consequences of SARS-CoV-2 infection have been well described. Although most individuals recover, many endure longer-lasting effects, referred to as long COVID, post-COVID condition, or postacute sequelae of SARS-CoV-2 (PASC). PASC is composed of a heterogeneous collection of symptoms and conditions that can affect virtually any organ system, with common manifestations including fatigue, cough, malaise, and pain. Those at increased risk for long COVID include females, those hospitalized due to acute COVID-19, and individuals with underlying comorbidities. Several hypotheses have been proposed to explain the underlying pathophysiology, which is likely multifactorial, including immune dysregulation, autoimmunity and immune printing, microvascular clotting with endothelial dysfunction, and impaired neurological signaling.
Læs mere Tjek på PubMedJournal of the American Medical Association, 9.10.2024
Tilføjet 9.10.2024
This observational cohort study examines the symptoms experienced by children after SARS-CoV-2 infection and how these symptoms differ by age (6-11 years vs 12-17 years).
Læs mere Tjek på PubMed