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Initial diagnostik og behandling af formodet akut bakteriel meningitis.
Udgiver: Dansk Selskab for Infektionsmedicin 2018
Rapport og anbefaling vedrørende ulemper og fordele ved henholdsvis at undlade eller gennemføre lumbalpunktur for patienter i blodfortyndende behandling mistænkt for akut bakteriel meningitis.
Denne vejledning er tiltænkt diagnostik og behandling af formodet Lyme neuroborreliose hos voksne. Vejledningen er udarbejdet som et supplement til Borrelia klaringsrapport (2014).
Af Rikke Krogh-Madsen, formand for Dansk Selskab for Infektionsmedicin.
Der er lige nu massivt fokus på læger der har begået fejl. Aktuelt drejer det sig om behandling af meningokoksygdom. Bestyrelsen for Dansk Selskab for Infektionsmedicin (DSI) kender ikke til detaljerne i de konkrete sager og har ikke set sagsakterne. Dette er derfor en generel udtalelse som tager udgangspunkt i udmeldingen fra Patienterstatningen vedr. de tre meningokok-sager.
ane Agergaard, Morten Sodemann og Marie Nørredam
Influenza:
Jens Lundgren (tovholder), Thomas Benfield, Jan Gerstoft, Isik Johansen, Gitte Kronborg, Henrik Nielsen, Lene Surland Knudsen, Merete Storgaard og Ole Kirk
Influenza,
Meningitis og encephalitis:
Christian Brandt (tovholder), Helene Mens, Lars Omland, Lykke Larsen, Jacob Bodilsen, Lothar Wiese, Birgitte Rønde Hansen, Hans Rudolf von Lüttchau, Henrik Nielsen (referent)
Akut bakteriel meningitis,
Viral meningitis,.
.
Sted:
Auditorium A, Forskningens Hus, Aalborg Universitets Hospital, Syd, Søndre Skovvej 15, 9000 Aalborg.
Program:
Torsdag d. 19/9.
09.30-10.00 Kaffe og velkomst.
10.00-10.15 DASGIB og andre nationale samarbejder HN.
10.15-11.00 Viral meningitis. Christian Brandt.
11.00-11.10 PAUSE.
11.10-11.40 Infektiøs encephalitis (del 1). Jacob Bodilsen.
11.40-12.00 Kursister – CASE gruppe 1.
12.00-13.00 FROKOST.
13.00-13.40 Infektiøs encephalitis (del 2). Jacob Bodilsen.
e Bengaard Andersen kommenterer: Læs ikke denne artikel - med mindre du har særlig tuberkulose interesse. Men hvem har ikke det i vores selskab?
'Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis' af Feng Sun og kolleger publiceret i Antimicrobial Agents and Chemotherapy - et retrospektivt studie fra Kina, der antyder at Linezolid kan give et godt bidrag til behandling af tuberkuløs meningitis.
Johansen kommenterer: Et trist resultat: I 2013 rapporterede Ruslami et al. (Lancet Infect Dis. 2013 Jan;13(1):27-35) nedsat mortalitet ved IV administrering af en øget dosis Rifampicin og Moxifloxacin i blot 14 dage til ca. 60 patienter med tuberkuløs meningitis - efterfulgt af standard behandling. Der var derfor store forventninger til denne store kliniske trial, hvor effekten af øget Rifampicin dosis samt et flourquinolon (per oralt) blev undersøgt på ca. 700 Vietnamesiske patienter.
ndgrens studie af, hvornår man kan holde op med at give pneumocyste-profylakse til HIV-smittede eller de Gans studiet, der ændrede fik indført dexamethason i retningslinjerne for purulent meningitis.
Her er formentlig et nyt studie, der kommer til at få indflydelse på standardbehandlingen af patienter med svær pneumoni.
Læs en gang - og døm selv - jeg tager den med til næste års "Journal Highlights of the year", men tænkte at den måske allerede nu var god at få kendskab til. God læselyst :-)
Nyt fra tidsskrifterne [+20]
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Infection
6.03.2025
. Background. Despite significant advances in prevention and treatment strategies, meningitis continues to pose a substantial global health challenge. The disease burden demonstrates marked geographical disparities, with disproportionate impact in resource-limited settings, particularly within the “meningitis belt” of Sub-Saharan Africa. The global meningitis burden is influenced by a complex interplay of environmental, behavioral, and socioeconomic determinants.
Infection
4.03.2025
. Abstract. . Background. Despite significant advances in prevention and treatment strategies, meningitis continues to pose a substantial global health challenge. The disease burden demonstrates marked geographical disparities, with disproportionate impact in resource-limited settings, particularly within the “meningitis belt” of Sub-Saharan Africa.
Clinical Infectious Diseases
22.02.2025
m agents with activity against DTR gram-negatives are available including cefiderocol, ceftazidime-avibactam, ceftolozane-tazobactam, imipenem-cilastatin-relebactam, meropenem-vaborbactam, and sulbactam-durlobactam. In this article, we review host and drug factors that influence an antibiotic’s likely effectiveness for the treatment of bacterial meningitis. We also review the preclinical and clinical data in support of or against each of the aforementioned agents for the treatment of bacterial meningitis.
Journal of Infectious Diseases
19.02.2025
Abstract . Background . Tuberculous meningitis (TBM)-related deaths occur early, often within weeks after initiation of treatment. Enhanced treatment early in the disease course with agents that effectively penetrate the central nervous system may improve outcomes in TBM.Methods .
Clinical Microbiology and Infection
14.02.2025
Intracranial devices may be used to treat or guide treatment of increased intracranial pressure in patients with pneumococcal meningitis. European guidelines do not recommend the routine use of intracranial devices in management of pneumococcal meningitis. However, in some countries, intracranial devices are used routinely, but the effect remains unknown.
International Journal of Infectious Diseases
31.01.2025
Human parechovirus (HPeV) infection is increasingly recognized as a cause of severe illness in infants, including sepsis, meningitis, encephalitis, and seizures [1]. In neonates, HPeV encephalitis is associated with white matter injury and neurodevelopmental sequelae [2,3]. To our knowledge, there are only three case reports of congenitally acquired parechovirus infection.
BMC Infectious Diseases
25.01.2025
. Abstract. . Background. Bacterial meningitis (BM) is a life-threatening central nervous system infection with potential for severe neurological sequelae. High mobility group box 1 (HMGB1) is known as a late inflammatory mediator associated with lethal pathology. This study aims to investigate the serial cerebrospinal fluid (CSF) concentrations of HMGB1 in children with BM and its relationship to neurological prognosis. .
Clinical Infectious Diseases
15.01.2025
Abstract . Background . More than half of people diagnosed with human immunodeficiency virus–associated cryptococcal meningitis are antiretroviral therapy (ART)-experienced. The impact of recent ART initiation (≤14 days) on outcomes from cryptococcal meningitis, and how to optimally manage ART in this patient population, are unknown.Methods .
American Journal of Tropical Medicine and Hygiene
9.01.2025
. . Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 112 Issue: 1 Pages: 30-36. .
Clinical Microbiology and Infection
12.12.2024
Biomarkers for paediatric bacterial meningitis are essential for accurate diagnosis.
American Journal of Tropical Medicine and Hygiene
4.12.2024
. . Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 6 Pages: 1247-1251. .
Journal of Medical Virology
15.11.2024
Journal of Medical Virology, Volume 96, Issue 11, November 2024.
BMC Infectious Diseases
8.11.2024
American Journal of Tropical Medicine and Hygiene
6.11.2024
. . Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 5 Pages: 1024-1026. .
BMC Infectious Diseases
6.11.2024
Current Opinion in Infectious Diseases
1.11.2024
Purpose of review . Recently, fungal meningitis outbreaks have occurred in association with neuraxial and epidural anesthesia in immunocompetent patients. Herein, we describe the course of those outbreaks, their diagnosis, treatment, prognosis, and lessons learned. Recent findings . Two outbreaks of Fusarium solani meningitis during 2022–2023 were associated with epidural anesthesia in two distant cities in Mexico (Durango and Matamoros).
BMC Infectious Diseases
23.10.2024
. Abstract. . Background. Pneumococcal meningitis, a vaccine-preventable disease caused by Streptococcus pneumoniae (Spn) is the leading bacterial meningitis in under five children. In April 2014, Uganda introduced routine immunization with 10-valent Pneumococcal Conjugate Vaccine (PCV10) for infants. The target coverage for herd immunity is ≥ 90% with three doses (PCV10-dose 3).
BMC Infectious Diseases
22.10.2024
bstract. . Background. Streptococcus pneumoniae (S. pneumoniae), Haemophilus influenzae (H. influenzae), and Neisseria meningitidis (N. meningitidis) are leading causes of childhood bacterial meningitis and preventable by vaccines.
BMC Infectious Diseases
18.10.2024
. Abstract. . Background. Tuberculous meningitis (TBM) is a severe central nervous system (CNS) infection with a challenging diagnosis due to inadequate detection methods. This study evaluated current clinical detection methods and their applicability. . . . Methods. A cohort of 514 CNS infection patients from 2018 to 2020 was studied.
BMC Infectious Diseases
17.10.2024
. Abstract. . Background. The diagnosis of healthcare-associated ventriculitis and meningitis (HCAVM) can be complex because multiple factors confound the interpretation of cerebrospinal fluid (CSF) tests. The cell index (CI) may help in the diagnosis of HCAVM. It does not incur additional medical cost and it avoids delays from the turnaround time of CSF cultures.
Aktuelle smitsomme sygdomme [+20]
Der er mere end 20 resultater, måske du vil se flere resultater her?
ProMED
16.03.2025
. . .
MENINGITIS, VIRAL - INDIA: (KERALA). ***********************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Thu 13 Mar 2025 . Source: TimesNow [edited] .
www.timesnownews.com/health/meningitis-cases-surge-in-kochi-2-kids-infected-3-show-symptoms-is-your-child-at-risk-article-118960219 . . . Five students from St.
ProMED
14.03.2025
. . .
MENINGITIS, MENINGOCOCCAL - NIGERIA: (KEBBI) FATAL. **************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Tue 11 Mar 2025 . Source: Newsday.com [edited] .
www.newsday.com/news/nation/nigeria-meningitis-outbreak-kebbi-m92852 . . . Nigerian authorities confirmed Tuesday [11 Mar 2025] that a
meningitis.
ProMED
28.02.2025
. . .
MENINGITIS - TUNISIA: (KAIROUAN) UNIVERSITY STUDENTS, FATAL, REQUEST. FOR INFORMATION. ************************************************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Mon 24 Feb 2025 . Source: AlArarby Algadid [in Arabic, trans. & summ. Mod.MM, edited] .
tinyurl.com/kanuk898 . . .
ProMED
11.02.2025
. . .
MENINGITIS - GHANA (02): (UPPER WEST) UPDATE. ********************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Fri 7 Jan 2025 . Source: MSN/Ghana News Agency [edited] .
tinyurl.com/367jekcn . . . Dr Sebastian Ngmenenso Sandaare, a National Democratic Congress (NDC). Member of Parliament (MP) for Daffiama Bussie Issa, has sounded the.
ProMED
6.02.2025
. . .
MENINGITIS, MENINGOCOCCAL - TAIWAN: FIRST CASE OF THE YEAR, ELDERLY,. FATAL. **************************************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Wed 5 Feb 2025 . Source: Focus Taiwan [edited] .
focustaiwan.tw/society/202502050005 . . . Taiwan has reported its 1st case of meningococcal
meningitis this year.
Medscape Infectious Diseases
14.05.2024
Meningitis was among three strong clinical risk factors identified in a nationwide, population-based study. . Medscape Medical News
Eurosurveillance latest updates
5.04.2024
Elizabethkingia anophelis is a multidrug-resistant pathogen causing high mortality and morbidity in adults with comorbidities and neonates. We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family’s residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings.
ProMED
17.03.2025
(NOO. syphilis), caused by _T. pallidum_ invading the central nervous. system, eyes, and ears, respectively, can occur in the primary,. secondary, latent, or tertiary stages of syphilis. NOO syphilis. manifestations are often debilitating and can include meningitis,. stroke, motor or sensory deficits, blindness, and hearing loss. . Data from the early to mid-2000s suggested that NOO syphilis was more. commonly identified among gay, bisexual, and other men who have sex.
ProMED
16.03.2025
ory droplets from coughing,. sneezing, or close contact with an infected person. It is most. contagious a few days before symptoms appear and up to 5 days after. swelling begins. While mumps is usually a mild illness, it can lead to. complications such as meningitis, encephalitis, hearing loss, or. inflammation of the testicles or ovaries, particularly in unvaccinated. individuals. . The most effective way to prevent mumps is through vaccination. The.
ProMED
11.03.2025
carlet fever, invasive. GAS/fatal, children
promedmail.org/post/20230304.8708735 . Streptococcus, gp A update (06): Denmark, invasive, new subvariant,. RFI
promedmail.org/post/20230222.8708507 . Streptococcus, gp A update (05): Canada, iGAS,
meningitis, child.
promedmail.org/post/20230209.8708260 . Streptococcus, gp A update (04): Croatia, invasive.
promedmail.org/post/20230201.8708092 . Streptococcus, gp A update (03): Denmark, invasive, increase, 2022.
ProMED
5.03.2025
res, generalised weakness, movement. disorders, loss of coordination and coma may develop over the next few. days. The encephalitis cannot be distinguished clinically from other. central nervous system infections. Milder forms of disease, such as. aseptic meningitis or undifferentiated febrile illness, can also. occur. . Recommendations . --------------- . For health professionals: . . - Clinicians should consider the possibility of JE virus infection in.
ProMED
4.03.2025
ians practicing in endemic regions about considering. this treatable disease in the differential diagnosis of acute febrile. illnesses, especially when accompanied with clinical neurological. features. . 'Recent findings: While the association of aseptic meningitis,. encephalitis, and meningoencephalitis with scrub typhus is well known,. more recently described neurological syndromes associated with scrub. typhus include acute disseminated encephalomyelitis, various cranial.
ProMED
1.03.2025
us Enterovirus, family Picornaviridae) are among. the most common viruses infecting humans worldwide. Enteroviruses are. associated with diverse clinical syndromes ranging from minor febrile. illness to severe, potentially fatal conditions (e.g., aseptic. meningitis, encephalitis, paralysis, myocarditis, and neonatal. enteroviral sepsis) and could be linked with the development of some. chronic diseases (e.g., type 1 diabetes and dilated cardiomyopathy).
ProMED
25.02.2025
ation against. transmission of infections. This update will additionally provide. guidance on the use of HIV+ donors in HIV+ recipients, the use of. HCV-viremic donors in non-viremic recipients, donors with endemic. infections, and donors with bacteremia,
meningitis, and encephalitis. Lastly, the guidance will summarize an approach to recipients with a. suspected donor-derived infection.' - Mod.LL . ProMED map:. United States:
promedmail.org/promed-post?place=8722393,106] . [See Also:. 2024 .
ProMED
25.02.2025
tested at the National Institute of. Biomedical Research (INRB) in Kinshasa, all negative for Ebola and. Marburg viruses. 'Differential diagnosis under investigation include. malaria, viral haemorrhagic fever, food or water poisoning, typhoid. fever, and meningitis,' the WHO said. Both Ebola and Marburg viruses. produce hemorrhagic (bleeding-related) fevers. . The earlier unexplained outbreak was initially reported on January 21. [2025] and is centered in Boloko Village in Bolomba Health District.