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BMC Infectious Diseases, 26.07.2024
Tilføjet 26.07.2024
Abstract Background Dengue infection is a mosquito-borne, endemic viral disease, particularly in developing countries. Here, we report the results of the clinicodemographic, serologic profile and the monthly occurrence of a recent dengue fever outbreak in Puntland State (Somalia). Methodology We analyzed the data of 956 dengue-suspected patients who were investigated using the rapid diagnostic testing (RDT) method for detecting NS1 (dengue virus non-structural protein) and IgM antibodies employing the SD Biosensor Dengue Dou NS Ag and IgM test kit (Germany) at the Puntland Public Health Referral Laboratory from November 21, 2022, to May 27, 2023. Results We found that 118 cases were positive for dengue among the suspected patients enrolled in the present study. Of these cases, 76.2% were dengue NSI positive, 13.6% were dengue IgM positive, and 10.2% were both NSI and IgM positive. The number of females and males in the confirmed cases was equal, and most (48.3%) were aged 20 years or less. 43.1% of them lived in the Nugal region, particularly in Garowe. Clinically, fever was the most frequent symptom (88.9%). The cases peaked in December 2022 but dropped from January to March, with a slight rise in February, and then increased in April and May 2023. Conclusion This study highlights the clinicodemographic characteristics, seroprevalence, and monthly occurrence of dengue in Puntland. We recommend improving vector control measures, enhancing case management, strengthening dengue surveillance, developing an early warning system, and conducting future studies to characterize the circulating strains.
Læs mere Tjek på PubMedThe Lancet
Lancet, 26.07.2024
Tilføjet 26.07.2024
2024 is the worst year for dengue cases on record. As of July 23, over 10 million cases of dengue have been reported from 176 countries across all WHO regions (although the Americas account for most cases), with more than 24 000 severe cases and 6508 deaths. This figure already surpasses the number of cases in 2023, which was also a record year. There is no doubt that dengue, a vector-borne disease caused by four serologically related viruses, is a major infectious disease threat to health. Over the past two decades, there has been a tenfold increase in reported cases, and even this figure is likely an underestimate.
Læs mere Tjek på PubMedNathália Mariana Santos Sansone, Matheus Negri Boschiero, Fernando Augusto Lima Marson
International Journal of Infectious Diseases, 26.07.2024
Tilføjet 26.07.2024
Dengue is one of the most common zoonoses in Latin America (LATAM), accounting for almost 60% of all cases worldwide [1]. This mosquito-borne disease is caused by an arbovirus, transmitted by the bite of a female species of Aedes aegypti [2]. Dengue is divided into four serotypes: DEN-1, DEN-2, DEN-3, and DEN-4 [2]. Infection by different serotypes is associated with the same disease and a wide clinical phenotype. Infection with a serotype causes long-term immunity against this specific serotype and short-term (∼2-3 months) against the other three serotypes [3].
Læs mere Tjek på PubMedLeïla Lefèvre, Christophe Vincent-Titeca, Clémence Garcia, Laura Temime, Kévin Jean
International Journal of Infectious Diseases, 24.07.2024
Tilføjet 24.07.2024
The Ile-de-France Region (IDFR), which is set to host the Paris 2024 Olympics, is experiencing a concerning rise in imported cases of chikungunya, Zika, and dengue arboviral diseases [1]. The escalating presence of the Aedes albopictus mosquito, a competent vector for these diseases in temperate climates, is a significant threat [1]. The first dengue outbreak in the IDFR last fall underscored the local vulnerability to this risk [1].
Læs mere Tjek på PubMedJournal of the American Medical Association, 23.07.2024
Tilføjet 23.07.2024
Individuals with a previous infection with Zika virus may be more vulnerable to symptomatic infections of certain types of dengue virus, according to a cohort study of 3412 children aged 2 to 17 years old in Nicaragua.
Læs mere Tjek på PubMedCabada, M. M., Aguilar, P. V., Rodas, J. D., Hidalgo, M., Mozo, K., Gonzalez-Diaz, E. S., Jimenez-Coello, M., Diaz, F. J., Dacso, M. M., Ortega-Pacheco, A., Arboleda, M., Walker, D. H., Weaver, S. C., Melby, P. C.
BMJ Open, 23.07.2024
Tilføjet 23.07.2024
IntroductionAcute undifferentiated febrile illnesses (AUFIs) impose a large burden in the tropics. Understanding of AUFI’s epidemiology is limited. Insufficient diagnostic capacity hinders the detection of outbreaks. The lack of interconnection in healthcare systems hinders timely response. We describe a protocol to study the epidemiology and aetiologies of AUFI and pathogen discovery in strategic areas of Latin America (LA). Methods and analysisGlobal Infectious Diseases Network investigators comprising institutions in Colombia, Dominican Republic, México, Perú and the USA, developed a common cohort study protocol. The primary objective is to determine the aetiologies of AUFI at healthcare facilities in high-risk areas. Data collection and laboratory testing for viral, bacterial and parasitic agents are performed in rural and urban healthcare facilities and partner laboratories. Centralised laboratory and data management cores deploy diagnostic tests and data management tools. Subjects >6 years with fever for
Læs mere Tjek på PubMedRodrigo L. Vancini, Marilia S. Andrade, and Claudio A. B. de Lira
Science, 19.07.2024
Tilføjet 19.07.2024
BMC Infectious Diseases, 17.07.2024
Tilføjet 17.07.2024
Abstract Background Dengue fever has become a significant worldwide health concern, because of its high morbidity rate and the potential for an increase in mortality rates due to lack of adequate treatment. There is an immediate need for the development of effective medication for dengue fever. Methods Homology modeling of dengue virus (DENV) non-structural 4B (NS4B) protein was performed by SWISS-MODEL to predict the 3D structure of the protein. Structure validation was conducted using PROSA, PROCHECK, Ramachandran plot, and VERIFY-3D. MOE software was used to find out the in-Silico inhibitory potential of the five triterpenoids against the DENV-NS4B protein. Results The SWISS-MODEL was employed to predict the three-dimensional protein structure of the NS4B protein. Through molecular docking, it was found that the chosen triterpenoid NS4B protein had a high binding affinity interaction. It was observed that the NS4B protein binding energy for 15-oxoursolic acid, betulinic acid, ursolic acid, lupeol, and 3-o-acetylursolic acid were − 7.18, − 7.02, − 5.71, − 6.67 and − 8.00 kcal/mol, respectively. Conclusions NS4B protein could be a promising target which showed good interaction with tested triterpenoids which can be developed as a potential antiviral drug for controlling dengue virus pathogenesis by inhibiting viral replication. However, further investigations are necessary to validate and confirm their efficacy.
Læs mere Tjek på PubMedClinical Infectious Diseases, 16.07.2024
Tilføjet 16.07.2024
Abstract Background Obesity is on the rise globally in adults and children, including in tropical areas where diseases such as dengue have a substantial burden, particularly in children. Obesity impacts the risk of severe dengue disease; however, the impact on dengue virus (DENV) infection and dengue cases remains an open question.Methods We used 9 years of data from 5,940 children in the Pediatric Dengue Cohort Study in Nicaragua to examine whether pediatric obesity is associated with increased susceptibility to DENV infection and symptomatic presentation. Analysis was performed using Generalized Estimating Equations adjusted for age, sex, and pre-infection DENV antibody titers.Results From 2011 to 2019, children contributed 26,273 person-years of observation, and we observed an increase in the prevalence of overweight (from 12% to 17%) and obesity (from 7% to 13%). There were 1,682 DENV infections and 476 dengue cases in the study population. Compared to participants with normal weight, participants with obesity had higher odds of DENV infection (Adjusted Odds Ratio [aOR] 1.21, 95% confidence interval [CI] 1.03-1.42) and higher odds of dengue disease given infection (aOR 1.59, 95% CI 1.15-2.19). Children with obesity infected with DENV showed increased odds of presenting fever (aOR 1.46, 95% CI 1.05-2.02), headache (aOR 1.51, 95% CI 1.07-2.14), and rash (aOR 2.26, 95% CI 1.49-3.44) when compared with children with normal weight.Conclusions Our results indicate that obesity is associated with increased susceptibility to DENV infection and dengue cases in children, independently of age, sex, and pre-infection DENV antibody titers.
Læs mere Tjek på PubMedClinical Infectious Diseases, 16.07.2024
Tilføjet 16.07.2024
Abstract Background Dengue is an increasing threat to global health. This exploratory analysis evaluated the immunogenicity, safety, and vaccine efficacy (VE) of a live-attenuated tetravalent dengue vaccine (TAK-003) in participants enrolled in the phase 3 DEN-301 trial (NCT02747927), stratified by baseline age (4–5 years; 6–11 years; or 12–16 years).Methods Participants were randomized 2:1 to receive 2 doses of TAK-003, administered 3 months apart, or placebo. Dengue serostatus was evaluated at enrolment. VE against virologically-confirmed dengue (VCD) and hospitalized VCD; immunogenicity (geometric mean titers; GMTs); and safety were evaluated per age group through ∼4 years post-vaccinationResults VE against VCD across serotypes was 43.5% (95% confidence interval: 25.3%, 57.3%) for 4–5 year-olds; 63.5% (56.9%, 69.1%) for 6–11 year-olds, and 67.7% (57.8%, 75.2%) for 12–16 year-olds. VE against hospitalized VCD was 63.8% (21.1%, 83.4%), 85.1% (77.1%, 90.3%), and 89.7% (77.9%, 95.2%), for the three age groups, respectively. GMTs remained elevated against all four serotypes for ∼4 years post-vaccination, with no evident differences across age groups. No clear differences in safety by age were identified.Conclusions This exploratory analysis shows TAK-003 was efficacious in dengue prevention across age groups in children and adolescents 4-16 years of age living in dengue endemic areas. Relatively lower VE in 4–5 year-olds was potentially confounded by causative serotype distribution, small sample size, and VE by serotype, and should be considered in benefit-risk evaluations in this age group.
Læs mere Tjek på PubMedHinh Ly Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA
Virulence, 13.07.2024
Tilføjet 13.07.2024
Elliza Mansor, Norliza Ahmad, Nor Afiah Mohd Zulkefli, Poh Ying Lim
PLoS One Infectious Diseases, 13.07.2024
Tilføjet 13.07.2024
by Elliza Mansor, Norliza Ahmad, Nor Afiah Mohd Zulkefli, Poh Ying Lim Background and objective Pregnant mothers are at risk of many adverse pregnancy outcomes, including infants with low birth weight (LBW). The World Health Organization aimed to achieve a 30% reduction in the number of LBW infants by the year 2025. In this study, we aimed to determine the incidence and determinants of LBW infants among pregnant mothers attending government health clinics in Peninsular Malaysia. Material and methods A prospective cohort study “Relative Risk of Determinants of Adverse Pregnancy Outcomes Among Pregnant Mothers Attending Government Health Clinics, Peninsular Malaysia, PEN-MUM” was conducted from March 2022 until March 2023 at 20 government health clinics in Peninsular Malaysia that were randomly selected through a multistage sampling method. Malaysian pregnant mothers between 18 and 49 years old were recruited at 12–18 weeks of gestation and followed up at three time points: 1 (24–28 weeks of gestation), 2 (36–40 weeks of gestation), and 3 (post-delivery). Eight exposure factors of LBW were studied: gestational weight gain, dengue infection, urinary tract infection, COVID-19 infection, gestational hypertension, preeclampsia, maternal anemia, and gestational diabetes mellitus (GDM). Results Among 507 participants enrolled in the cohort, 40 were lost to follow-up. A total of 467 were included in the final analysis, giving an attrition rate of 7.9%. The incidence of LBW infants in Peninsular Malaysia was 14.3%. After adjusting for three covariates (ethnicity, employment status, and gestational age at birth), three determinants of LBW were identified. The risk of giving birth to LBW infants was higher among those with inadequate gestational weight gain (aRR = 2.86, 95% CI: 1.12, 7.37, p = 0.03), gestational hypertension (aRR = 4.12; 95% CI: 1.66, 10.43; p = 0.002), and GDM (aRR = 2.21; 95% CI: 1.18, 4.14; p = 0.013) during the second and third trimesters. Conclusions The incidence of LBW infants in Peninsular Malaysia can be considered high. Having inadequate gestational weight gain, gestational hypertension, and GDM in the second and third trimesters increased the risk of LBW infants by threefold, fivefold, and twofold respectively. Thus, intervention strategies should target prevention, early detection, and treatment of gestational hypertension and GDM, as well as promoting adequate weight gain during antenatal care.
Læs mere Tjek på PubMedBMC Infectious Diseases, 12.07.2024
Tilføjet 12.07.2024
Abstract Background Dengue fever has become a significant worldwide health concern, because of its high morbidity rate and the potential for an increase in mortality rates due to lack of adequate treatment. There is an immediate need for the development of effective medication for dengue fever. Methods Homology modeling of dengue virus (DENV) non-structural 4B (NS4B) protein was performed by SWISS-MODEL to predict the 3D structure of the protein. Structure validation was conducted using PROSA, PROCHECK, Ramachandran plot, and VERIFY-3D. MOE software was used to find out the in-Silico inhibitory potential of the five triterpenoids against the DENV-NS4B protein. Results The SWISS-MODEL was employed to predict the three-dimensional protein structure of the NS4B protein. Through molecular docking, it was found that the chosen triterpenoid NS4B protein had a high binding affinity interaction. It was observed that the NS4B protein binding energy for 15-oxoursolic acid, betulinic acid, ursolic acid, lupeol, and 3-o-acetylursolic acid were − 7.18, − 7.02, − 5.71, − 6.67 and − 8.00 kcal/mol, respectively. Conclusions NS4B protein could be a promising target which showed good interaction with tested triterpenoids which can be developed as a potential antiviral drug for controlling dengue virus pathogenesis by inhibiting viral replication. However, further investigations are necessary to validate and confirm their efficacy.
Læs mere Tjek på PubMedTalha Burki
Lancet, 12.07.2024
Tilføjet 12.07.2024
The Paediatric Dengue Cohort Study has now been running for 20 years, including data on thousands of children and driving discoveries across virology. Talha Burki reports.
Læs mere Tjek på PubMedBharti Pathak, Aparna Chakarvarty, Nakka Veena Rani, Anuja Krishnan
Journal of Medical Virology, 9.07.2024
Tilføjet 9.07.2024
American Journal of Tropical Medicine and Hygiene, 3.07.2024
Tilføjet 3.07.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 1 Pages: 1-2
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 3.07.2024
Tilføjet 3.07.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 1 Pages: 5-10
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 3.07.2024
Tilføjet 3.07.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 1 Pages: 102-106
Læs mere Tjek på PubMedXiao Hu, Jiamin Song, Guoguo Ye, Miao Zhu, Jianfeng Lan, Lijiao Zeng, Zhiyi Ke, Jing Yuan
Journal of Medical Virology, 3.07.2024
Tilføjet 3.07.2024
Journal of Infectious Diseases, 30.06.2024
Tilføjet 30.06.2024
Abstract There is an increasing global burden from chikungunya virus (CHIKV). Bangladesh reported a major epidemic in 2017, however, it was unclear if there had been prior widespread transmission. We conducted a nationally representative seroprevalence survey in 70 randomly selected communities immediately prior to the epidemic. We found 69/2,938 (2.4%) of sampled individuals were seropositive to CHIKV. Being seropositive to dengue virus (aOR 3.13 [95% CIs: 1.86-5.27]), male sex (aOR 0.59 [95% CIs: 0.36-0.99]), and community presence of Aedes aegypti mosquitoes (aOR: 1.80, 95% CI: 1.05–3.07) were significantly associated with CHIKV seropositivity. Using a spatial prediction model, we estimated that across the country, 4.99 (95% CI: 4.89 - 5.08) million people had been previously infected. These findings highlight high population susceptibility prior to the major outbreak and that previous outbreaks must have been spatially isolated.
Læs mere Tjek på PubMedGarnica, Marcia; Ramos, Jessica Fernandes; Machado, Clarisse Martins
Current Opinion in Infectious Diseases, 29.06.2024
Tilføjet 29.06.2024
Purpose of review Arbovirus infections are a challenge for immunocompromised hosts who travel to or live in endemic regions or who receive organs or tissues from donors who travel or live in such areas. This review addresses Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV) infections in hematological patients, hematopoietic cell or solid organ transplant recipients, and people with HIV (PWH). Recent findings Transmission is mainly due through Aedes mosquito bite. DENV and ZIKV may also be transmitted through blood, tissues or donor grafts. Clinical manifestations are quite similar and diagnosis requires laboratory confirmation to provide appropriate management. The best diagnostic method is PCR since serology may present false negative results in immunocompromised patients, or cross-reactivity as in the case of DENV and ZIKV. There is no specific treatment for any of these infections. Summary Educational and preventive measures are the best strategy: vector control, knowledge of the vector\'s habits, protection against mosquito bites, avoiding travel to endemic areas or with a current epidemic, and avoiding nonvector transmission according to local recommendations for donor deferral. Vaccination, currently only available for DENV, has not yet been studied in immunocompromised patients and is not currently recommended.
Læs mere Tjek på PubMedAbinash Mallick, Soumi Sukla, Abhishek De, Subhajit Biswas
Journal of Medical Virology, 28.06.2024
Tilføjet 28.06.2024
Madineh Abbasi, Morteza Zaim, Mahmood Moosazadeh, Mahasti Alizadeh, Abbasali Dorosti, Simin Khayatzadeh, Seyed Hassan Nikookar, Ahmad Raeisi, Fatemeh Nikpoor, Abdolreza Mirolyaie, Behrooz Naghili Hokmabad, Ahad Bazmani, Farzad Kaveh, Somayeh Azimi, Ahmadali Enayati
PLoS One Infectious Diseases, 22.06.2024
Tilføjet 22.06.2024
by Madineh Abbasi, Morteza Zaim, Mahmood Moosazadeh, Mahasti Alizadeh, Abbasali Dorosti, Simin Khayatzadeh, Seyed Hassan Nikookar, Ahmad Raeisi, Fatemeh Nikpoor, Abdolreza Mirolyaie, Behrooz Naghili Hokmabad, Ahad Bazmani, Farzad Kaveh, Somayeh Azimi, Ahmadali Enayati Background Dengue fever (DF) is increasingly recognized as one of the world’s major mosquito-borne diseases and causes significant morbidity and mortality in tropical and subtropical countries. Appropriate and timely diagnosis and risk stratification for severe disease are crucial in the appropriate management of this illness. Healthcare providers (HCPs) play a key role in dengue fever diagnosis, management and prevention. The present study was conducted to determine the knowledge, attitudes and practices (KAP) among HCPs in East Azerbaijan Province, Iran. Methods A cross-sectional survey among 948 HCPs, using a structured questionnaire, was conducted in East Azerbaijan Province from May to July 2022. Data analysis was undertaken using descriptive methods, the Chi-square test or Fisher’s exact test, and logistic regression. A P-value
Læs mere Tjek på PubMedMalaria Journal, 18.06.2024
Tilføjet 18.06.2024
Abstract The recently released 2023 World Malaria Report sheds light on an alarming reality: despite preventive measures, malaria remains a severe issue in Burkina Faso. As researchers in the field working on malaria in Burkina Faso, the assessment suggests significant underreporting, especially in remote areas with limited healthcare access. In addition, the confusion arising from similar diseases, such as dengue, further complicates the situation. Aligning with the 2023 World Health Organization recommendations, it is time to advocate for tailored strategies in high-burden areas by emphasizing community involvement in data collection awareness campaigns for effective disease management to combat the invisible crisis lurking within communities.
Læs mere Tjek på PubMedZunera Jamal, Syed Adnan Haider, Rabia Hakim, Fahad Humayun, Muhammad Umar Farooq, Muhammad Ammar, Babak Afrough, Leena Inamdar, Muhammad Salman, Massab Umair
Journal of Medical Virology, 12.06.2024
Tilføjet 12.06.2024
Guanyong Ou, Jiexiang Liu, Rongrong Zou, Yuchen Gu, Shiyu Niu, Juzhen Yin, Jing Yuan, Zhijun Qu, Yang Yang, Yingxia Liu
Journal of Medical Virology, 12.06.2024
Tilføjet 12.06.2024
Biao Hu, Jianping Chen, Zongtao Sun
Trends in Microbiology, 9.06.2024
Tilføjet 9.06.2024
The transmission of flaviviruses, such as dengue virus (DENV) and Zika virus (ZIKV), poses a significant threat to global public health. Zhang et al. recently showed that Rosenbergiella sp. YN46 (Rosenbergiella_YN46), a bacterium from the mosquito gut, inhibits flavivirus transmission and thus offers a potential biocontrol strategy with broad public health implications.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 8.06.2024
Tilføjet 8.06.2024
Abstract Background Dengue vascular permeability syndrome is the primary cause of death in severe dengue infections. The protective versus potentially pathogenic role of dengue NS1 antibodies are not well understood. The main goal of this analysis was to characterize the relationship between free NS1 concentration and NS1 antibody titers in primary and secondary dengue infection in order to better understand the presence and duration of NS1 antibody complexes in clinical dengue infections.Methods Hospitalized participants with acute dengue infection were recruited from Northern Colombia between 2018 to 2020. Symptom assessment including dengue signs and symptoms, chart review and blood collection was performed. Primary versus secondary Dengue was assessed serologically. NS1 titers and anti-NS1 antibodies were measured daily.Results Patients with secondary infection have higher antibody titers than those in primary infection, and we find a negative correlation between anti-NS1 antibody titer and NS1 protein. We demonstrate that in a subset of secondary infection, there are indeed NS1 antibody-antigen complexes at the admission day during the febrile phase that are not detectable by the recovery phase. Furthermore, dengue infection status is associated with higher circulating sialidases.Discussion The negative correlation between antibody and protein suggests that antibodies may play a role in clearing this viral protein.
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 5.06.2024
Tilføjet 5.06.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 6 Pages: 1165-1171
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 5.06.2024
Tilføjet 5.06.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 6 Pages: 1172-1177
Læs mere Tjek på PubMedBaihui Xu, Pranav Tewari, Tun Linn Thein, Leo Yee Sin, David Chien Boon Lye, Po Ying Chia, Jue Tao Lim
Journal of Medical Virology, 4.06.2024
Tilføjet 4.06.2024
Umaporn Limothai, Sasipha Tachaboon, Janejira Dinhuzen, Jasleen Singh, Akarathep Leewongworasingh, Phandee Watanaboonyongcharoen, Stefan Fernandez, Taweewun Hunsawong, Aaron R. Farmer, Terapong Tantawichien, Usa Thisyakorn, Nattachai Srisawat
Journal of Medical Virology, 2.06.2024
Tilføjet 2.06.2024
Jakub Wudarski, Simindokht Aliabadi, Monika Gulia-Nuss
Trends in Parasitology, 1.06.2024
Tilføjet 1.06.2024
Vector-borne diseases (VBDs) impose devastating effects on human health and a heavy financial burden. Malaria, Lyme disease, and dengue fever are just a few examples of VBDs that cause severe illnesses. The current strategies to control VBDs consist mainly of environmental modification and chemical use, and to a small extent, genetic approaches. The genetic approaches, including transgenesis/genome modification and gene-drive technologies, provide the basis for developing new tools for VBD prevention by suppressing vector populations or reducing their capacity to transmit pathogens. The regulatory elements such as promoters are required for a robust sex-, tissue-, and stage-specific transgene expression. As discussed in this review, information on the regulatory elements is available for mosquito vectors but is scant for other vectors.
Læs mere Tjek på PubMedYongkang ChenYuan LiLu LuPeng Zou1Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, ChinaMiguel Angel Martinez
Antimicrobial Agents And Chemotherapy, 30.05.2024
Tilføjet 30.05.2024
Abdoul-Aziz Maiga, Aboubacar Sombié, Nicolas Zanré, Félix Yaméogo, Souleymane Iro, Jean Testa, Antoine Sanon, Ousmane Koita, Hirotaka Kanuka, Philip J. McCall, David Weetman, Athanase Badolo
PLoS One Infectious Diseases, 30.05.2024
Tilføjet 30.05.2024
by Abdoul-Aziz Maiga, Aboubacar Sombié, Nicolas Zanré, Félix Yaméogo, Souleymane Iro, Jean Testa, Antoine Sanon, Ousmane Koita, Hirotaka Kanuka, Philip J. McCall, David Weetman, Athanase Badolo Background Ae. aegypti is the vector of important μ arboviruses, including dengue, Zika, chikungunya and yellow fever. Despite not being specifically targeted by insecticide-based control programs in West Africa, resistance to insecticides in Ae. aegypti has been reported in countries within this region. In this study, we investigated the status and mechanisms of Ae. aegypti resistance in Niamey, the capital of Niger. This research aims to provide baseline data necessary for arbovirus outbreak prevention and preparedness in the country. Methods Ovitraps were used to collect Ae. aegypti eggs, which were subsequently hatched in the insectary for bioassay tests. The hatched larvae were then reared to 3–5-day-old adults for WHO tube and CDC bottle bioassays, including synergist tests. The kdr mutations F1534C, V1016I, and V410L were genotyped using allele-specific PCR and TaqMan qPCR methods. Results Ae. aegypti from Niamey exhibited moderate resistance to pyrethroids but susceptibility to organophosphates and carbamates. The kdr mutations, F1534C, V1016I and V410L were detected with the resistant tri-locus haplotype 1534C+1016L+410L associated with both permethrin and deltamethrin resistance. Whereas the homozygote tri-locus resistant genotype 1534CC+1016LL+410LL was linked only to permethrin resistance. The involvement of oxidase and esterase enzymes in resistance mechanisms was suggested by partial restoration of mosquitoes’ susceptibility to pyrethroids in synergist bioassays. Conclusion This study is the first report of Ae. aegypti resistance to pyrethroid insecticides in Niamey. The resistance is underpinned by target site mutations and potentially involves metabolic enzymes. The observed resistance to pyrethroids coupled with susceptibility to other insecticides, provides data to support evidence-based decision-making for Ae. aegypti control in Niger.
Læs mere Tjek på PubMedBMC Infectious Diseases, 29.05.2024
Tilføjet 29.05.2024
Abstract Background In Thailand, the Department of Disease Control (DDC) regularly performs visual larval surveys throughout the country to monitor dengue fever outbreaks. Since 2016, the DDC switched from a paper-based to a digital-based larval survey process. The significant amount of larval survey data collected digitally presents a valuable opportunity to precisely identify the villages and breeding habitats that are vulnerable to dengue transmission. Methods The study used digitally collected larval survey data from 2017 to 2019. It employed larval indices to evaluate the risk of dengue transmission in villages based on seasonal, regional, and categorical perspectives. Furthermore, the study comprehensively scrutinized each container category by employing different measures to determine its breeding preference ratio. Results The result showed that villages with a very high-risk of dengue transmission were present year-round in all regions, with the highest proportion during the rainy season. The Southern region had more high-risk villages during the winter season due to rainfall. Slums and residential communities were more vulnerable to dengue than commercial areas. All container categories could potentially serve as breeding habitats for dengue-carrying mosquitoes, with abandoned containers being the most significant breeding sites. Conclusions The risk of dengue transmission was present year-round throughout Thailand. This underscores the importance of community and government initiatives, along with sustained public awareness campaigns and active community engagement, to efficiently and permanently eradicate mosquito breeding habitats. It should be noted that larval indices may not strongly correlate with dengue cases, as indicated by the preliminary analysis. However, they offer valuable insights into potential breeding sites for targeted preventive measures.
Læs mere Tjek på PubMedBMC Infectious Diseases, 29.05.2024
Tilføjet 29.05.2024
Abstract Background In Thailand, the Department of Disease Control (DDC) regularly performs visual larval surveys throughout the country to monitor dengue fever outbreaks. Since 2016, the DDC switched from a paper-based to a digital-based larval survey process. The significant amount of larval survey data collected digitally presents a valuable opportunity to precisely identify the villages and breeding habitats that are vulnerable to dengue transmission. Methods The study used digitally collected larval survey data from 2017 to 2019. It employed larval indices to evaluate the risk of dengue transmission in villages based on seasonal, regional, and categorical perspectives. Furthermore, the study comprehensively scrutinized each container category by employing different measures to determine its breeding preference ratio. Results The result showed that villages with a very high-risk of dengue transmission were present year-round in all regions, with the highest proportion during the rainy season. The Southern region had more high-risk villages during the winter season due to rainfall. Slums and residential communities were more vulnerable to dengue than commercial areas. All container categories could potentially serve as breeding habitats for dengue-carrying mosquitoes, with abandoned containers being the most significant breeding sites. Conclusions The risk of dengue transmission was present year-round throughout Thailand. This underscores the importance of community and government initiatives, along with sustained public awareness campaigns and active community engagement, to efficiently and permanently eradicate mosquito breeding habitats. It should be noted that larval indices may not strongly correlate with dengue cases, as indicated by the preliminary analysis. However, they offer valuable insights into potential breeding sites for targeted preventive measures.
Læs mere Tjek på PubMedJournal of the American Medical Association, 25.05.2024
Tilføjet 25.05.2024
Millions of people in the Americas have been infected with dengue and more than 1000 have died in the first 3 months of 2024, tripling the number of dengue cases that occurred in 2023 during the same period, according to a statement by the Pan American Health Organization (PAHO). Last year, more than 4.5 million cases of the mosquito-borne illness were reported in the region, which itself was a record. Still, the case fatality rate remained low, a trend that Jarbas Barbosa, MD, PhD, MS, the director of PAHO, called “very encouraging.”
Læs mere Tjek på PubMedBMC Infectious Diseases, 25.05.2024
Tilføjet 25.05.2024
Abstract Background In Thailand, the Department of Disease Control (DDC) regularly performs visual larval surveys throughout the country to monitor dengue fever outbreaks. Since 2016, the DDC switched from a paper-based to a digital-based larval survey process. The significant amount of larval survey data collected digitally presents a valuable opportunity to precisely identify the villages and breeding habitats that are vulnerable to dengue transmission. Methods The study used digitally collected larval survey data from 2017 to 2019. It employed larval indices to evaluate the risk of dengue transmission in villages based on seasonal, regional, and categorical perspectives. Furthermore, the study comprehensively scrutinized each container category by employing different measures to determine its breeding preference ratio. Results The result showed that villages with a very high-risk of dengue transmission were present year-round in all regions, with the highest proportion during the rainy season. The Southern region had more high-risk villages during the winter season due to rainfall. Slums and residential communities were more vulnerable to dengue than commercial areas. All container categories could potentially serve as breeding habitats for dengue-carrying mosquitoes, with abandoned containers being the most significant breeding sites. Conclusions The risk of dengue transmission was present year-round throughout Thailand. This underscores the importance of community and government initiatives, along with sustained public awareness campaigns and active community engagement, to efficiently and permanently eradicate mosquito breeding habitats. It should be noted that larval indices may not strongly correlate with dengue cases, as indicated by the preliminary analysis. However, they offer valuable insights into potential breeding sites for targeted preventive measures.
Læs mere Tjek på PubMedBMC Infectious Diseases, 18.05.2024
Tilføjet 18.05.2024
Abstract Background Dengue Viral Infection (DVI) has become endemic in Pakistan since the first major outbreak in Karachi in 1996. Despite aggressive measures taken by relevant authorities, Pakistan has been dealing with a worsening dengue crisis for the past two decades. DHF is severe form of dengue infection which is linked with significant morbidity and mortality. Early identification of severe dengue infections can reduce the morbidity and mortality. In this context we planned current study in which we find out the different factors related with DHF as well as clinical laboratory features of DHF and compare them to DF so that patients can be best evaluated for DHF and managed accordingly at admission. Methods Retrospective study conducted over a period of 6 years (2013–2018) in two tertiary care hospitals in Pakistan. Data were collected by using a pre-structured data collection form. Data were statistically analyzed to determine the clinical and laboratory characteristics of DVI and risk factors of dengue hemorrhagic fever (DHF). Results A total 512 dengue cases (34.05 ± 15.08 years; Male 69.53%) were reviewed. Most common clinical manifestations of DVI were fever (99.60%), headache (89.1%), chills (86.5%), rigors (86.5%), myalgia (72.3%). Less common clinical manifestations were vomiting (52.5%), arthralgia (50.2%) and skin rashes (47.5%). Furthermore, nasal bleeding (44.1%), gum bleeding (32.6%), pleural effusion (13.9%) and hematuria (13.1%) were more profound clinical presentations among DHF patients. Mortality rate was 1.5% in this study. Logistic regression analysis indicated that delayed hospitalization (OR: 2.30) and diabetes mellitus (OR:2.71), shortness of breath (OR:2.21), association with risk groups i.e., living near stagnant water, travelling to endemic areas, living in endemic regions (OR:1.95), and presence of warning signs (OR:2.18) were identified as risk factors of DHF. Statistically we found that there is strong association of diabetes mellitus (DM) with DHF while the patient suffering from DM individually had higher odds (2.71) of developing DHF than patients without disease. Conclusions The current study demonstrated that the clinical and laboratory profiles of DF and DHF are significantly distinct. Significant predictors of DHF were advanced age, diabetes mellitus, ascites, pleural effusion, thick gallbladder and delayed hospitalization. The identification of these factors at early stage provides opportunities for the clinicians to identify high risk patients and to reduce dengue-related morbidity and mortality.
Læs mere Tjek på PubMedMaria Paula de Souza Sampaio, Mateus Santana do Rosário, Lorena Cunha Martins, Luiza Vieira Luedy Trindade, Marcos Vinicius Lima de Oliveira Francisco, Bernardo Gratival Gouvea Costa, Gessica Almeida Vasconcelos, Italo Andrade Barbosa Lima, Yasmin Santos Freitas Macêdo, Fernanda Maria Lessa Carvalho, Marina Borges Rabelo de Santana, Ricardo Khouri, Hegger Fritsch, Joilson Xavier, Vagner Fonseca, Marta Giovanetti, Arabela Leal e Silva de Mello, Felicidade Mota Pereira, Gubio Soares Campos, Pedro Antonio Pereira de Jesus, Daniel Santana Farias, Murilo de Santos Souza, Adilson Junior Pinto Galvão, Felipe Oliveira Costa, Marcia Carvalho Bessa, Janeusa Rita Leite Primo Chagas, Celia Silvany, Jose Mário Meira Teles, Maricelia Maia de Lima, Tarsis Leonardo Almeida Farias, Tiago Gräf, Isadora Cristina de Siqueira
International Journal of Infectious Diseases, 16.05.2024
Tilføjet 16.05.2024
Viral encephalitis is mainly characterized by fever, headache, and decreased consciousness. Although, in most cases, the underlying cause of encephalitis is unknown, viruses of the Herpesviridae family are the most common, accounting for 50 to 75% of identified agents [1]. In the Americas, the most common arboviruses related to encephalitis are West Nile virus (WNV) and St. Louis encephalitis virus (SLEV) [1]. On the other hand, encephalitis has uncommonly been associated with Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV) viral infections.
Læs mere Tjek på PubMedJue Tao Lim, Somya Bansal, Chee Seng Chong, Borame Dickens, Youming Ng, Lu Deng, Caleb Lee, Li Yun Tan, Grace Chain, Pei Ma, Shuzhen Sim, Cheong Huat Tan, Alex R Cook, Lee Ching Ng
Lancet Microbe, 16.05.2024
Tilføjet 16.05.2024
Our results demonstrated the potential of Wolbachia-mediated incompatible insect technique for strengthening dengue control in tropical cities, where dengue burden is the greatest.
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