Nyt fra tidsskrifterne
Ingen søgeord valgt.
44 emner vises.
BMC Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
Background Globally, multidrug-resistant tuberculosis (MDR-TB) is a major public health problem. The tuberculosis rate in Sierra Leone is 298 per 100,000 people, and Sierra Leone is considered a country with a high burden of tuberculosis. In Sierra Leone, there are few studies on the outcomes of MDR-TB treatment, especially those exacerbated by COVID-19. We identified factors associated with unfavorable treatment outcomes among people with MDR-TB in Sierra Leone. Methods We conducted a cross-sectional study to analyze hospital-based MDR-TB data from 2017 to 2021. Demographic, clinical, and treatment outcome data were extracted from the main MDR-TB referral hospital database. We defined unfavorable outcomes as patients who died, were lost to follow-up, or defaulted. We calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) to identify predictors of the outcomes of MDR-TB treatment. Results Between 2017 and 2021, 628 people with MDR-TB were reported at Lakka Hospital; 441 (71%) were male, with a median age of 25 years (interquartile ranges: 17–34). Clinically, 21% of the 628 MDR-TB patients were HIV positive, and 413 were underweight (66%). 70% (440) of MDR-TB patients received tuberculosis treatment. The majority of patients, 457 (73%), were treated with a short treatment regimen, and 126 (20%) experienced unfavorable outcomes. Age 45 years or younger (aOR = 5.08; CI:1.87–13.82), 21–45 years (aOR = 2.22; CI:140–3.54), tuberculosis retreatment (aOR = 3.23; CI:1.82–5.73), age group, HIV status (aOR = 2.16; CI:1.33–3.53), and malnourishment status (aOR = 1.79; CI:1.12–2.86) were significantly associated with unfavorable treatment outcomes for DR-TB patients. Conclusion This analysis revealed a high proportion of unfavorable treatment outcomes among MDR-TB patients in Sierra Leone. Malnourishment, TB retreatment, HIV coinfection, and age 45 years or younger were associated with unfavorable outcomes of MDR-TB treatment. Increasing patients’ awareness, mainly among young people, heightens treatment adherence and HIV monitoring by measuring the amount of HIV in patient blood, which can reduce adverse treatment outcomes in Sierra Leone and other sub-Saharan African countries.
Læs mere Tjek på PubMedBMC Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
Abstract Background Tuberculosis (TB) remains a global public health event of great concern, however epidemic data on TB covering entire areas during the special period of the COVID-19 epidemic have rarely been reported. We compared the dissemination and multidrug-resistance patterns of Mycobacterium tuberculosis complex (MTBC) in the main urban area of Luoyang City, China (including six municipal jurisdictions) and nine county and township areas under its jurisdiction, aimed to establish the epidemiology of TB in this region and to provide reference for precision anti-TB in places with similar settings. Methods From 2020 to 2022, sputum samples were collected from 18,504 patients with confirmed, suspected and unexcluded TB in 10 designated TB medical institutions. Insertion sequence 6110 was amplified by PCR (rpoB gene detection if necessary) to confirm the presence of MTBC. PCR-positive specimens were analyzed by multicolor melting curve analysis to detect multidrug resistance. Results Among the 18,504 specimens, 2675 (14.5%) were MTBC positive. The positive rate was higher in the main urban area than in the county and township areas (29.8% vs. 10.9%, p 60 years were the largest group infected with MTBC in the main urban area, compared with individuals aged
Læs mere Tjek på PubMedBMC Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
Abstract Background Sepsis is a life-threatening disease accompanied by disorders of the coagulation and immune systems. P2Y12 inhibitors, widely used for arterial thrombosis prevention and treatment, possess recently discovered anti-inflammatory properties, raising potential for improved sepsis prognosis. Method We conducted a retrospective analysis using the data from Medical Information Mart for Intensive Care-IV database. Patients were divided into an aspirin-alone group versus a combination group based on the use of a P2Y12 inhibitor or not. Differences in 30-day mortality, length of stay (LOS) in intensive care unit (ICU), LOS in hospital, bleeding events and thrombotic events were compared between the two groups. Result A total of 1701 pairs of matched patients were obtained by propensity score matching. We found that no statistically significant difference in 30-day mortality in aspirin-alone group and combination group (15.3% vs. 13.7%, log-rank p = 0.154). In addition, patients received P2Y12 inhibitors had a higher incidence of gastrointestinal bleeding (0.5% vs. 1.6%, p = 0.004) and ischemic stroke (1.7% vs. 2.9%, p = 0.023), despite having a shorter LOS in hospital (11.1 vs. 10.3, days, p = 0.043). Cox regression showed that P2Y12 inhibitor was not associated with 30-day mortality (HR = 1.14, 95% CI 0.95–1.36, p = 0.154). Conclusion P2Y12 inhibitors did not provide a survival benefit for patients with sepsis 3 and even led to additional adverse clinical outcomes.
Læs mere Tjek på PubMedDong AnZhuo LiAshley C. BeavisKelsey R. BriggsMason HarvillBiao HeaDepartment of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA 30602
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedPei-Yi (Alma) SuChih-Hsu ChangShin-Chwen Bruce YenHsiu-Yi WuWan-Ju TungYu-Pei HuYen-Yu Ian ChenMiao-Hsia LinChiaho ShihPei-Jer ChenKevin TsaiaInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, TaiwanbTaiwan International Graduate Program, National Yang-Ming Chiao-Tung University and Academia Sinica, Taipei 115, TaiwancInstitute of Biomedical Sciences Summer Undergraduate Internship Program, Academia Sinica, Taipei 115, TaiwandDepartment of Microbiology, National Taiwan University College of Medicine, Taipei 100, TaiwaneGraduate Institute of Cell Biology, College of Life Sciences, China Medical University, Taichung 404, TaiwanfNational Taiwan University Center for Genomic Medicine, National Taiwan University, Taipei 100, TaiwangGraduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 100, TaiwanhDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedAlexander HammelLia-Maria CucosIuliana CarasIrina IonescuCatalin TucureanuVlad TofanAdriana CostacheAdrian OnuLara HoepfnerMichael HipplerJuliane NeupertCostin-Ioan PopescuCrina StavaruNorica Branza-NichitaRalph BockaMax-Planck-Institut für Molekulare Pflanzenphysiologie, Department of Organelle Biology, Biotechnology and Molecular Ecophysiology, D-14476 Potsdam-Golm, GermanybInstitute of Biochemistry of the Romanian Academy, Department of Viral Glycoproteins, 060031 Bucharest, Romaniac”Cantacuzino” Medico-Military National Research Institute, 050096 Bucharest, RomaniadInstitute of Plant Biology and Biotechnology, University of Münster, D-48143 Münster, GermanyeInstitute of Plant Science and Resources, Okayama University, Kurashiki 710-0046, JapanfNIBIO, Norwegian Institute of Bioeconomy Research, NO-1431 Ås, Norway
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedSu DingVincent GrossiEllen C. HopmansNicole J. BaleCristiana Cravo-LaureauJaap S. Sinninghe DamstéaDepartment of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, Texel SZ 1797, The NetherlandsbLaboratoire de Géologie de Lyon: Terre, Planètes, Environnement, CNRS, Université Claude Bernard Lyon 1, Villeurbanne 69622, FrancecInstitut des Sciences Analytiques et de Physico-chimie pour l’environnement et les Matériaux, Universite de Pau et des Pays de l’Adour, CNRS, Pau 64000, FrancedDepartment of Earth Sciences, Faculty of Geosciences, Utrecht University, Utrecht, CB 3584, The Netherlands
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedEllen A. KearneyPunam AmratiaSu Yun KangPaul A. AgiusKefyalew Addis AleneKatherine O’FlahertyWin Han OoJulia C. CuttsWin HtikeDaniela Da Silva GoncalvesZahra RazookAlyssa E. BarryDamien DrewAung ThiKyaw Zayar AungHtin Kyaw ThuMyat Mon TheinNyi Nyi ZawWai Yan Min HtayAung Paing SoeJames G. BeesonJulie A. SimpsonPeter W. GethingEwan CameronFreya J. I. FowkesaDisease Elimination Program, Burnet Institute, Melbourne, VIC 3004, AustraliabCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, AustraliacMalaria Atlas Project, Telethon Kids Institute, Perth, WA 6009, AustraliadBiostatistics Unit, Faculty of Health, Deakin University, Melbourne, VIC 3125, AustraliaeFaculty of Health Sciences, Curtin University, Perth, WA 6102, AustraliafHealth Security and Malaria Program, Burnet Institute Myanmar, Yangon 11201, MyanmargDepartment of Medicine at the Doherty Institute, The University of Melbourne, Melbourne, VIC 3000, AustraliahInstitute for Physical and Mental Health and Clinical Translation, School of Medicine, Deakin University, Geelong, VIC 3216, AustraliaiDepartment of Public Health, Myanmar Ministry of Health and Sports, Nay Pyi Taw 15011, MyanmarjDepartment of Infectious Diseases, The University of Melbourne, Melbourne, VIC 3000, AustraliakDepartment of Microbiology, Monash University, Melbourne, VIC 3800, AustralialCentral Clinical School, Monash University, Melbourne, VIC 3004, AustraliamDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedRémi PorteMarcy BelloyAlexis AudibertEmilie BassotAmel AïdaMarine AlisRomain Miranda-CapetAurélie JourdesKlaas P. J. M. van GisbergenFrédérick MassonNicolas BlanchardaToulouse Institute for Infectious and Inflammatory Diseases, Infinity, Inserm, CNRS, University of Toulouse, Toulouse 31300, FrancebPhysiology and Cancer Programme, Champalimaud Research, Champalimaud Foundation, Lisbon 1400-038, Portugal
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedYuan-Ting GuoJi-Bin JiangGuan-Rong QiaoRong-Hua LuoXin ZhouRong HuaChang-Bo ZhengZhen LiuaCollege of Life Sciences, Northwest University, Xi’an 710127, ChinabState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, ChinacUniversity of Chinese Academy of Sciences, Beijing 100049, ChinadSchool of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, ChinaeKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, ChinafYunnan Key Laboratory of Biodiversity Information, Kunming 650201, ChinagKey Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China
Proceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedProceedings of the National Academy of Sciences, 12.06.2024
Tilføjet 12.06.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 24, June 2024.
Læs mere Tjek på PubMedThe PLOS ONE Editors
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
Jiwoo Han, Kyung Lib Jang
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
by Jiwoo Han, Kyung Lib Jang All-trans retinoic acid (ATRA), recognized as the principal and most biologically potent metabolite of vitamin A, has been identified for its inhibitory effects on hepatitis B virus (HBV) replication. Nevertheless, the underlying mechanism remains elusive. The present study reveals that ATRA induces E6-associated protein (E6AP)-mediated proteasomal degradation of HBx to suppress HBV replication in human hepatoma cells in a p53-dependent pathway. For this effect, ATRA induced promoter hypomethylation of E6AP in the presence of HBx, which resulted in the upregulation of E6AP levels in HepG2 but not in Hep3B cells, emphasizing the p53-dependent nature of this effect. As a consequence, ATRA augmented the interaction between E6AP and HBx, resulting in substantial ubiquitination of HBx and consequent reduction in HBx protein levels in both the HBx overexpression system and the in vitro HBV replication model. Additionally, the knockdown of E6AP under ATRA treatment reduced the interaction between HBx and E6AP and decreased the ubiquitin-dependent proteasomal degradation of HBx, which prompted a recovery of HBV replication in the presence of ATRA, as confirmed by increased levels of intracellular HBV proteins and secreted HBV levels. This study not only contributes to the understanding of the complex interactions between ATRA, p53, E6AP, and HBx but also provides an academic basis for the clinical employment of ATRA in the treatment of HBV infection.
Læs mere Tjek på PubMedSatoshi Yamate, Chieko Ishiguro, Haruhisa Fukuda, Satoshi Hamai, Yasuharu Nakashima
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
by Satoshi Yamate, Chieko Ishiguro, Haruhisa Fukuda, Satoshi Hamai, Yasuharu Nakashima Background Rebamipide has been widely co-prescribed with non-steroidal anti-inflammatory drugs (NSAIDs) in Japan for decades. This study aimed to evaluate the effectiveness of rebamipide in preventing upper gastrointestinal bleeding in new users of NSAIDs without risk factors of NSAID-induced ulcers other than age. Methods A nested case-control study was conducted using medical claims data of 1.66 million inhabitants of 17 municipalities participating in Japan’s Longevity Improvement & Fair Evidence study. The cohort entry (t0) corresponded to a new user of NSAIDs for osteoarthritis or low back pain. Patients with risk factors of NSAID-induced ulcers other than age were excluded. Cases were defined as patients who underwent gastroscopy for upper gastrointestinal bleeding (occurrence date was defined as index date). A maximum of 10 controls were selected from non-cases at the index date of each case by matching sex, age, follow-up time, and type and dosage of NSAIDs. Exposure to rebamipide was defined as prescription status from t0 to index date: Non-user (rebamipide was not co-prescribed during the follow-up period), Continuous-user (rebamipide was co-prescribed from t0 with the same number of tablets as NSAIDs), and Irregular-user (neither Non-user nor Continuous-user). Conditional logistic regression analysis was conducted to estimate each category’s odds ratio compared to non-users. Findings Of 67,561 individuals who met the inclusion criteria, 215 cases and 1,516 controls were selected. Compared with that of Non-users, the odds ratios and 95% confidence interval were 0.65 (0.44–0.96) for Continuous-users and 2.57 (1.73–3.81) for Irregular-users. Conclusions Continuous co-prescription of rebamipide significantly reduced the risk of upper gastrointestinal bleeding in an Asian cohort of new users of NSAIDs with osteoarthritis or low back pain without risk factors other than age.
Læs mere Tjek på PubMedAlaa Dalky, Tamara Osama Quran, Sawsan Abuhammad, Haneen Mahyoub Al-Faraj, Salam Bani Hani, Mohammed ALBashtawy, Imad Rasheed Abu Khader, Mohammed Jallad, Basma Salameh
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
by Alaa Dalky, Tamara Osama Quran, Sawsan Abuhammad, Haneen Mahyoub Al-Faraj, Salam Bani Hani, Mohammed ALBashtawy, Imad Rasheed Abu Khader, Mohammed Jallad, Basma Salameh Background Despite the advantages of vaccination in preventing maternal and fetal problems, there were many concerns in the medical community regarding vaccine safety for pregnant women, and this has put obstetricians in a challenging situation when it comes to advising their pregnant patients on whether to obtain the vaccine Aim This study was performed to define the level of acceptance of COVID-19 vaccination and assess the impact of COVID-19 attitudes and knowledge on vaccine acceptance between pregnant and lactating Syrian women who are seeking prenatal care services at the clinics in Azraq refugee camp in Jordan. Method A quantitative, cross-sectional study utilizing a non-probability convenience sample. A validated and reliable self-administered questionnaire consisting of four sections was used. Results A total of 412 pregnant/lactating women was recruited The acceptance rate of the COVID-19 vaccine among participants was 86.5%. There was a significant positive moderate association between respondents’ attitudes and knowledge around the COVID-19 vaccine and their acceptance of the vaccine (r = .468, p < .001, r = .357, p < .001), respectively. Conclusion To effectively mitigate the COVID-19 pandemic and achieve collective protection, decision-makers must intensify the efforts in promoting the importance of maternal vaccination, especially in vulnerable communities that suffer the most from pandemic outcomes.
Læs mere Tjek på PubMedYuhao Jia, Zhicheng Yu, Zhen Hong
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
by Yuhao Jia, Zhicheng Yu, Zhen Hong Binary code similarity detection plays a crucial role in various applications within binary security, including vulnerability detection, malicious software analysis, etc. However, existing methods suffer from limited differentiation in binary embedding representations across different compilation environments, lacking dynamic high-level semantics. Moreover, current approaches often neglect multi-level semantic feature extraction, thereby failing to acquire precise semantic information about the binary code. To address these limitations, this paper introduces a novel detection solution called BinBcla. This method employs an enhanced pre-training model to generate instruction embeddings with dynamic semantics for binary functions. Subsequently, multi-feature fusion technique is utilized to extract local semantic information and long-distance global features from the code, respectively, employing self-attention to comprehend the structure information of the code. Finally, an improved cosine similarity method is employed to learn relationships among all elements of the distance vectors, thereby enhancing the model’s robustness to new sample functions. Experiments are conducted across different architectures, compilers, and optimization levels. The results indicate that BinBcla achieves higher accuracy, precision and F1 score compared to existing methods.
Læs mere Tjek på PubMedElisabeth Maria den Boogert, Fleur van Aar, Janneke C. M. Heijne
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
by Elisabeth Maria den Boogert, Fleur van Aar, Janneke C. M. Heijne Objectives Chlamydia trachomatis (chlamydia) is one of the most reported bacterial sexually transmitted infections (STI) worldwide. Chlamydia can cause long term complications such as pelvic inflammatory disease (PID), ectopic pregnancy (EP) and tubal factor infertility (TFI). Changing testing strategies, for example reduced asymptomatic testing, influence chlamydia surveillance, highlighting the need for exploring alternative ways of monitoring chlamydia. We investigated the possibility of introducing routine surveillance of chlamydia related long term complications. Methods A qualitative study including 15 in-depth interviews with a purposive sample of gynaecologists, general practitioners (GP), sexual health and emergency doctors was conducted in the Netherlands in 2021–2022. A semi-structured interview guide focused on experiences with diagnosis and registration of PID, EP and TFI and how a change in asymptomatic chlamydia testing strategy might influence this. Interviews were transcribed and analysed using a thematic approach. Results Analysis showed that gynaecologists most frequently reported diagnosing PID, EP and TFI. Other professions rarely diagnose these complications, with emergency doctors only diagnosing EP. Most respondents reported unique registration codes for PID and EP, but the coding for TFI is more ambiguous. They reflected that diagnosis and registration of PID, EP and TFI are handled differently within their professions. Most respondents acknowledged registration in diagnostic codes as a useful surveillance tool. They expressed concerns in representativeness (e.g. differences in interpretation of diagnosis criteria) and data quality for surveillance. Conclusions Patient files of gynaecologists are likely to be most complete for monitoring trends of diagnosed chlamydia related long term complications in the Netherlands. However, when establishing a chlamydia complication surveillance system, professionals should be engaged in further standardizing diagnosis and registration practices. This will improve the quality and interpretability of complication surveillance and facilitate comparison between countries.
Læs mere Tjek på PubMedWoon Tak Yuh, Jinhee Kim, Mi-Sook Kim, Jun-Hoe Kim, Young Rak Kim, Sum Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Young San Ko, Chi Heon Kim
PLoS One Infectious Diseases, 12.06.2024
Tilføjet 12.06.2024
by Woon Tak Yuh, Jinhee Kim, Mi-Sook Kim, Jun-Hoe Kim, Young Rak Kim, Sum Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Young San Ko, Chi Heon Kim During the first year of the COVID-19 pandemic, the Republic of Korea (ROK) experienced three epidemic waves in February, August, and November 2020. These waves, combined with the overarching pandemic, significantly influenced trends in spinal surgery. This study aimed to investigate the trends in degenerative lumbar spinal surgery in ROK during the early COVID-19 pandemic, especially in relation to specific epidemic waves. Using the National Health Information Database in ROK, we identified all patients who underwent surgery for degenerative lumbar spinal diseases between January 1, 2019 and December 31, 2020. A joinpoint regression was used to assess temporal trends in spinal surgeries over the first year of the COVID-19 pandemic. The number of surgeries decreased following the first and second epidemic waves (p
Læs mere Tjek på PubMedInfection and Immunity, 11.06.2024
Tilføjet 11.06.2024
Infection, 11.06.2024
Tilføjet 11.06.2024
Infection, 11.06.2024
Tilføjet 11.06.2024
Abstract This case reports a 14-month-old child with Staphylococcal Scalded Skin Syndrome (SSSS). The child presented generalized scaling erythema accompanied by skin pain, and perioral crusts and fissures and she required hospital admission for antibiotic treatment with intravenous cloxacillin and hidroelectrolyte replacement. SSSS is a blistering skin disorder, mainly affecting children, caused by specific Staphylococcus aureus strains producing exfoliative toxins. It shows erythema in skin folds progressing to blisters within 48 h, often with perioral crusts and fissures. Its diagnosis relies on clinical assessment and it often requires intravenous antibiotics for its treatment.
Læs mere Tjek på PubMedEnrique Ortega Gonzalez, María Dolores Ocete Mochón, Concepción Gimeno Cardona, María Martínez Roma, Moisés Diago Madrid, Neus Gómez Muñoz, Alba Carrodeguas, José Luis González-Sánchez, Miguel García Deltoro
International Journal of Infectious Diseases, 11.06.2024
Tilføjet 11.06.2024
Viral hepatitis accounts for a significant global disease burden and high mortality from liver cancer and cirrhosis. In 2019, 296 million people worldwide were living with chronic hepatitis B virus (HBV) infection and 58 million people with chronic hepatitis C virus (HCV) infection. [1]. The success in treating HCV with direct-acting antivirals may have shifted attention away from HBV. The World Health Organization (WHO) recommended focusing surveillance systems on identifying chronic HBV and HCV cases who are unaware of their infection or have been lost to follow-up [2].
Læs mere Tjek på PubMedZuo, L., Li, X., Wang, L., Yuan, H., Liao, Z., Zhou, S., Wu, J., Guan, X., Liu, Y.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
ObjectivesThis study aims to investigate the diagnostic value of heparin-binding protein (HBP) in sepsis and develop a sepsis diagnostic model incorporating HBP with key biomarkers and disease-related scores for rapid, and accurate diagnosis of sepsis in the intensive care unit (ICU). DesignClinical retrospective cross-sectional study. SettingA comprehensive teaching tertiary hospital in China. ParticipantsAdult patients (aged ≥18 years) who underwent HBP testing or whose blood samples were collected when admitted to the ICU. Main outcome measuresHBP, C reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), interleukin-6 (IL-6), lactate (LAC), Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) score were recorded. ResultsBetween March 2019 and December 2021, 326 patients were enrolled in this study. The patients were categorised into a non-infection group (control group), infection group, sepsis group and septic shock group based on the final diagnosis. The HBP levels in the sepsis group and septic shock group were 45.7 and 69.0 ng/mL, respectively, which were significantly higher than those in the control group (18.0 ng/mL) and infection group (24.0 ng/mL) (p
Læs mere Tjek på PubMedChen, W.-y., Guo, Z.-b., Kong, T.-y., Chen, W.-x., Chen, X.-h., Yang, Q., Wen, Y.-c., Wen, Q.-r., Zhou, F., Xiong, X.-m., Wen, D.-l., Zhang, Z.-h.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
IntroductionSevere septic cardiomyopathy (SCM) is one of the main causes of refractory septic shock (RSS), with a high mortality. The application of venoarterial extracorporeal membrane oxygenation (ECMO) to support the impaired cardiac function in patients with septic shock remains controversial. Moreover, no prospective studies have been taken to address whether venoarterial ECMO treatment could improve the outcome of patients with sepsis-induced cardiogenic shock. The objective of this study is to assess whether venoarterial ECMO treatment can improve the 30-day survival rate of patients with sepsis-induced refractory cardiogenic shock. Methods and analysisExtraCorporeal Membrane Oxygenation in the therapy for REfractory Septic shock with Cardiac function Under Estimated is a prospective, multicentre, non-randomised, cohort study on the application of ECMO in SCM. At least 64 patients with SCM and RSS will be enrolled in an estimated ratio of 1:1.5. Participants taking venoarterial ECMO during the period of study are referred to as cohort 1, and patients receiving only conventional therapy without ECMO belong to cohort 2. The primary outcome is survival in a 30-day follow-up period. Other end points include survival to intensive care unit (ICU) discharge, hospital survival, 6-month survival, quality of life for long-term survival (EQ-5D score), successful rate of ECMO weaning, long-term survivors’ cardiac function, the number of days alive without continuous renal replacement therapy, mechanical ventilation and vasopressor, ICU and hospital length of stay, the rate of complications potentially related to ECMO treatment. Ethics and disseminationThe trial has been approved by the Clinical Research and Application Institutional Review Board of the Second Affiliated Hospital of Guangzhou Medical University (2020-hs-51). Participants will be screened and enrolled from ICU patients with septic shock by clinicians, with no public advertisement for recruitment. Results will be disseminated in research journals and through conference presentations. Trial registration number NCT05184296.
Læs mere Tjek på PubMedKawakatsu, Y., Mosser, J. F., Adolph, C., Baffoe, P., Cheshi, F., Aiga, H., Watkins, D. A., Sherr, K. H.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
BackgroundNational-level coverage estimates of maternal and child health (MCH) services mask district-level and community-level geographical inequities. The purpose of this study is to estimate grid-level coverage of essential MCH services in Nigeria using machine learning techniques. MethodsEssential MCH services in this study included antenatal care, facility-based delivery, childhood vaccinations and treatments of childhood illnesses. We estimated generalised additive models (GAMs) and gradient boosting regressions (GB) for each essential MCH service using data from five national representative cross-sectional surveys in Nigeria from 2003 to 2018 and geospatial socioeconomic, environmental and physical characteristics. Using the best-performed model for each service, we map predicted coverage at 1 km2 and 5 km2 spatial resolutions in urban and rural areas, respectively. ResultsGAMs consistently outperformed GB models across a range of essential MCH services, demonstrating low systematic prediction errors. High-resolution maps revealed stark geographic disparities in MCH service coverage, especially between rural and urban areas and among different states and service types. Temporal trends indicated an overall increase in MCH service coverage from 2003 to 2018, although with variations by service type and location. Priority areas with lower coverage of both maternal and vaccination services were identified, mostly located in the northern parts of Nigeria. ConclusionHigh-resolution spatial estimates can guide geographic prioritisation and help develop better strategies for implementation plans, allowing limited resources to be targeted to areas with lower coverage of essential MCH services.
Læs mere Tjek på PubMedShanaube, K., Ndubani, R., Kelly, H., Webb, E., Mayaud, P., Lamberti, O., Fitzpatrick, J., Kasese, N., Sturt, A., Van Lieshout, L., Van Dam, G., Corstjens, P. L. A. M., Kosloff, B., Bond, V., Hayes, R., Terris-Prestholt, F., Webster, B., Vwalika, B., Hansingo, I., Ayles, H., Bustinduy, A. L.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
IntroductionMultiplathogen home-based self-sampling offers an opportunity to increase access to screening and treatment in endemic settings with high coinfection prevalence of sexually transmitted (HIV, Trichomonas vaginalis (Tv), human papillomavirus (HPV)) and non-sexually transmitted pathogens (Schistosoma haematobium (Sh)). Chronic coinfections may lead to disability (female genital schistosomiasis) and death (cervical cancer). The Zipime-Weka-Schista (Do self-testing sister!) study aims to evaluate the validity, acceptability, uptake, impact and cost-effectiveness of multipathogen self-sampling for genital infections among women in Zambia. Methods and analysisThis is a longitudinal cohort study aiming to enrol 2500 non-pregnant, sexually active and non-menstruating women aged 15–50 years from two districts in Zambia with 2-year follow-up. During home visits, community health workers offer HIV and Tv self-testing and cervicovaginal self-swabs for (1) HPV by GeneXpert and, (2) Sh DNA detection by conventional (PCR)and isothermal (recombinase polymerase assay) molecular methods. Schistosoma ova and circulating anodic antigen are detected in urine. At a clinic follow-up, midwives perform the same procedures and obtain hand-held colposcopic images. High-risk HPV positive women are referred for a two-quadrant cervical biopsy according to age and HIV status. A cost-effectiveness analysis is conducted in parallel. Ethics and disseminationThe University of Zambia Biomedical Research Ethics Committee (UNZABREC) (reference: 1858-2021), the London School of Hygiene and Tropical Medicine (reference: 25258), Ministry of Health and local superintendents approved the study in September 2021.Written informed consent was obtained from all participants prior to enrolment. Identifiable data collected are stored securely and their confidentiality is protected in accordance with the Data Protection Act 1998.
Læs mere Tjek på PubMedLiu, C.-W., Jeyakumar, N., McArthur, E., Sontrop, J. M., Myran, D. T., Schwartz, K. L., Sood, M. M., Tanuseputro, P., Garg, A. X.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
ObjectivesTo determine COVID-19 vaccine uptake among physicians in Ontario, Canada from 14 December 2020 to 13 February 2022. DesignPopulation-based retrospective cohort study. SettingAll registered physicians in Ontario, Canada using data from linked provincial administrative healthcare databases. Participants41 267 physicians (including postgraduate trainees) who were Ontario residents and registered with the College of Physicians and Surgeons of Ontario were included. Physicians who were out of province, had not accessed Ontario Health Insurance Plan-insured services for their own care for ≥5 years and those with missing identifiers were excluded. Primary and secondary outcome measuresPrimary outcomes were the proportions of physicians who were recorded to have received at least one, at least two and three doses of a Health Canada-approved COVID-19 vaccine by study end date. Secondary outcomes were how uptake varied by physician characteristics (including age, sex, specialty and residential location) and time elapsed between doses. ResultsOf 41 267 physicians, (56% male, mean age 47 years), 39 359 (95.4%) received at least one dose, 39 148 (94.9%) received at least two doses and 35 834 (86.8%) received three doses of a COVID-19 vaccine. Of those who received three doses, the proportions were 90.4% among those aged ≥60 years and 81.2–89.5% among other age groups; 88.7% among family physicians and 89% among specialists. 1908 physicians (4.6%) had no record of vaccination, and this included 3.4% of family physicians and 4.1% of specialists; however, 28% of this group had missing specialty information. ConclusionsIn Ontario, within 14 months of COVID-19 vaccine availability, 86.8% of physicians had three doses of a COVID-19 vaccine, compared with 45.6% of the general population. Findings may signify physicians’ confidence in the safety and effectiveness of COVID-19 vaccines.
Læs mere Tjek på PubMedLuo, S., Bao, F., Wu, H., Ma, W., Zhu, L., Huang, X., Yang, R., Peng, L., Gao, L., Wu, X., Zhong, L., Dong, Y., Li, B., Ma, W., Liu, A.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
Introduction Ixodes ticks are pivotal in transmitting diseases like Lyme disease and human granulocytic anaplasmosis, caused by Borrelia burgdorferi and Anaplasma phagocytophilum, respectively. These pathogens not only affect humans through single or multiple tick bites but also pose risks to animal hosts, leading to potential coinfections. Despite regional studies indicating significant prevalence, their global coinfection data remain sparse. This study aims to bridge this gap through a systematic review and meta-analysis of B. burgdorferi and A. phagocytophilum coinfections in Ixodes ticks worldwide. Addressing data limitations and study variability, it seeks to provide a nuanced understanding of coinfection patterns, their epidemiological implications and inform targeted prevention strategies. Methods and analysisFollowing Preferred Reporting Items for Systematic Review and Meta-analysis Protocols 2015 guidelines and PROSPERO registration, this study will undertake a thorough database search without constraints on language or publication date, using standardised screening and data extraction protocols. The quality and bias of studies will be evaluated using Joanna Briggs Institute tools. In the statistical analysis phase, conducted in R, we will initially determine the use of fixed or random-effects models based on the assessment of data heterogeneity. This choice will guide the framework for subsequent analyses. Within the selected model’s framework, we will perform subgroup analyses and meta-regression to investigate the effects of various factors, ensuring that each step is tailored to the initial model selection to maintain analytical consistency. Ethics and disseminationAs this study does not involve clinical research or data collection from subjects, ethical approval is not required. We will uphold ethical standards in synthesising and reporting data. Study outcomes will be published in peer-reviewed journals, communicating findings to the scientific community and contributing to the understanding of Ixodes tickborne diseases. PROSPERO registration numberCRD42023449735.
Læs mere Tjek på PubMedShi, Y., Gao, H., Yan, Y., Li, X., Ping, W., Yang, H., Du, Y.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
ObjectiveTo examine the associations between career choice motivation and professionalism among medical students based on gender in the context of COVID-19. DesignCross-sectional study. SettingThe study was conducted at a medical school in China. MethodsA total of 1421 second-year to fourth-year medical students participated in the survey using cluster sampling. They were asked to complete questionnaires on demographic information, career choice motivation and professionalism. Linear regression models were used to analyse the relationship between career choice motivations and professionalism based on gender differences. ResultsFemale medical students outperformed males in professionalism (p
Læs mere Tjek på PubMedMehboodi, F., Zamanzadeh, V., Rahmani, A., Dianat, I., Shabanloie, R.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
ObjectiveThis study explored the consequences of COVID-19 on the occupational safety and health of nurses. DesignQualitative conventional content analysis. Participants14 nurses selected by purposeful sampling method. SettingFive educational and non-educational hospitals in the Northwest of Iran. Data collection and analysisSemistructured interviews were used for data collection and analysed using conventional content analysis. ResultsTwo main categories have emerged from the data: reduced quality of professional life and post-traumatic growth. Reduced quality of professional life, which has two subcategories including job dissatisfaction and burnout, has a negative nature, and has had many negative effects on the physical, mental and well-being of nursing personnel during the coronavirus era. On the other hand, post-traumatic growth, with two subcategories that include promoting safe behaviour and gaining a positive self-concept, has a positive nature. ConclusionsMaintaining the occupational health and safety of nurses plays an important role in providing quality services to patients. Therefore, it is necessary for managers and policymakers to use the experiences related to the COVID-19 crisis, to prevent negative factors and strengthen positive factors, to maintain the safety and occupational health of nurses, and increase the quality of care.
Læs mere Tjek på PubMedSkjevling, L., Goll, R., Hanssen, H. M., Johnsen, P. H.
BMJ Open, 11.06.2024
Tilføjet 11.06.2024
IntroductionThe observed alteration of the intestinal microbiota in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the effect of transferring a healthy gut flora from a faecal donor using a faecal microbiota transplantation (FMT) will be explored in this trial. Methods and analysisThis is a protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial, with 12 months follow-up. 80 participants will be included and randomised (1:1:2) to either donor FMT (from two different donors) or placebo (autologous FMT). Participants will be included by the International Clinical Criteria for ME/CFS. The clinical measures of ME/CFS and disease activity include Modified DePaul Questionnaire, Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), 36-Item Short Form Health Survey (SF-36), ROMA IV criteria, Food Frequency Questionnaire, Repeatable Battery for the Assessment of Neuropsychological Status, heart rate variability testing and reports on the use of antibiotics and food supplements, as well as biobanking of blood, urine and faeces. The primary endpoint is proportion with treatment success in FSS score in donor versus autologous FMT group 3 months after treatment. Treatment success is defined as an FSS improvement of more than 1.2 points from baseline at 3 months after treatment. Adverse events will be registered throughout the study. Ethics and disseminationThe Regional Committee for Medical Research Ethics Northern Norway has approved the study. The study has commenced in May 2019. Findings will be disseminated in international peer-reviewed journal(s), submitted to relevant conferences, and trial participants will be informed via phone calls. Trial registration number NCT03691987.
Læs mere Tjek på PubMedBMC Infectious Diseases, 11.06.2024
Tilføjet 11.06.2024
Abstract We conducted a systematic review to explore the relationship between perceived risk for HIV acquisition and sexual HIV exposure among sexual and gender minorities. We included 39 studies divided into (i) correlations or associations, (ii) models using sexual HIV exposure as the outcome, and (iii) models using perceived risk for HIV acquisition as the outcome. The sample size range was from 55 to 16,667 participants, primarily cisgender men who have sex with men (73.3%) and White (51.3%). Sexual HIV exposure and perceived risk for HIV acquisition assessments and recall time frames across studies differed markedly. Most of studies (84.6%) found significant correlations, comparisons, or associations between different levels of perceived risk for HIV acquisition and high sexual HIV exposure. In addition, 51.3% of studies reported other variables associated with high sexual HIV exposure (i.e., misuse of substances or alcohol) or with high perceived risk for HIV acquisition (i.e., younger age). In conclusion, the association between perceived risk for HIV acquisition and sexual HIV exposure has shown to be consistent. However, the assessment for perceived risk for HIV acquisition should include more components of perception (i.e., an affective component), or for sexual HIV exposure should consider the different estimated sexual per-acts probability of acquiring HIV.
Læs mere Tjek på PubMedBMC Infectious Diseases, 11.06.2024
Tilføjet 11.06.2024
Abstract We conducted a systematic review to explore the relationship between perceived risk for HIV acquisition and sexual HIV exposure among sexual and gender minorities. We included 39 studies divided into (i) correlations or associations, (ii) models using sexual HIV exposure as the outcome, and (iii) models using perceived risk for HIV acquisition as the outcome. The sample size range was from 55 to 16,667 participants, primarily cisgender men who have sex with men (73.3%) and White (51.3%). Sexual HIV exposure and perceived risk for HIV acquisition assessments and recall time frames across studies differed markedly. Most of studies (84.6%) found significant correlations, comparisons, or associations between different levels of perceived risk for HIV acquisition and high sexual HIV exposure. In addition, 51.3% of studies reported other variables associated with high sexual HIV exposure (i.e., misuse of substances or alcohol) or with high perceived risk for HIV acquisition (i.e., younger age). In conclusion, the association between perceived risk for HIV acquisition and sexual HIV exposure has shown to be consistent. However, the assessment for perceived risk for HIV acquisition should include more components of perception (i.e., an affective component), or for sexual HIV exposure should consider the different estimated sexual per-acts probability of acquiring HIV.
Læs mere Tjek på PubMedBMC Infectious Diseases, 11.06.2024
Tilføjet 11.06.2024
Abstract Purpose Frailty is a vulnerable state to stressors due to the loss of physiological reserve as a result of multisystem dysfunction. The physiological and laboratory-based frailty index (FI-Lab), depending on laboratory values and vital signs, is a powerful tool to capture frailty status. The aim of this study was to assess the relationship between FI-Lab and in-hospital mortality in patients with septic shock. Methods Baseline data for patients with sepsis in the intensive care unit were retrieved from the Critical Care Medicine Database (MIMIC-IV, v2.2). The primary outcome was mortality during hospitalization. The propensity score matching (PSM) method was used to analyze the basic conditions during hospitalization between groups.The FI-Lab was analysed for its relationship with in-hospital mortality using logistic regression according to continuous and categorical variables, respectively, and described using the restricted cubic spline (RCS). Survival was compared between groups using Kaplan-Meier (KM) curves. Subgroup analyses were used to improve the stability of the results. Results A total of 9219 patients were included. A cohort score of 1803 matched patients was generated after PSM. The analyses showed that non-surviving patients with septic shock in the ICU had a high FI-Lab index (P
Læs mere Tjek på PubMedBMC Infectious Diseases, 11.06.2024
Tilføjet 11.06.2024
Abstract Purpose Frailty is a vulnerable state to stressors due to the loss of physiological reserve as a result of multisystem dysfunction. The physiological and laboratory-based frailty index (FI-Lab), depending on laboratory values and vital signs, is a powerful tool to capture frailty status. The aim of this study was to assess the relationship between FI-Lab and in-hospital mortality in patients with septic shock. Methods Baseline data for patients with sepsis in the intensive care unit were retrieved from the Critical Care Medicine Database (MIMIC-IV, v2.2). The primary outcome was mortality during hospitalization. The propensity score matching (PSM) method was used to analyze the basic conditions during hospitalization between groups.The FI-Lab was analysed for its relationship with in-hospital mortality using logistic regression according to continuous and categorical variables, respectively, and described using the restricted cubic spline (RCS). Survival was compared between groups using Kaplan-Meier (KM) curves. Subgroup analyses were used to improve the stability of the results. Results A total of 9219 patients were included. A cohort score of 1803 matched patients was generated after PSM. The analyses showed that non-surviving patients with septic shock in the ICU had a high FI-Lab index (P
Læs mere Tjek på PubMedOuli XieMark R. DaviesSteven Y. C. Tong1Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia2Monash Infectious Diseases, Monash Health, Melbourne, Australia3Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia4Victorian Infectious Disease Service, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, AustraliaGraeme N. ForrestLaurens Manning
Clinical Microbiology Reviews, 11.06.2024
Tilføjet 11.06.2024
Youjia Zhong, Alicia Y. H. Kang, Carina J. X. Tay, Hui’ En Li, Nurul Elyana, Chee Wah Tan, Wee Chee Yap, Joey M. E. Lim, Nina Le Bert, Kuan Rong Chan, Eugenia Z. Ong, Jenny G. Low, Lynette P. Shek, Elizabeth Huiwen Tham, Eng Eong Ooi
Nature, 11.06.2024
Tilføjet 11.06.2024
Nature, 11.06.2024
Tilføjet 11.06.2024
Xiaoyou Hu Xu Bai Fangling Tian Yifan Xing Yi Shi Yimin Tong Jin Zhong a CAS Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, People’s Republic of Chinab University of Chinese Academy of Sciences, Beijing, People’s Republic of Chinac Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of Chinad School of Life Science and Technology, ShanghaiTech University, Shanghai, People's Republic of China
Emerg Microbes Infect, 11.06.2024
Tilføjet 11.06.2024
Ah-Ra Lee Sang-Hyun Kim Su-Yeon Hong Sang-Ho Lee Jae Sang Oh Kyung Yong Lee Seong-Jun Kim Tomohiro Ishikawa Sang-Mu Shim Hee Il Lee Sang-Uk Seo a Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul, Republic of Koreab Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Koreac Department of Neurosurgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Koread Division of Cancer Biology, Research Institute, National Cancer Center, Goyang, Republic of Koreae Center for Infectious Disease Vaccine and Diagnosis Innovation (CEVI), Korea Research Institute of Chemical Technology, Daejeon, Republic of Koreaf Department of Microbiology, Dokkyo Medical University School of Medicine, Tochigi, Japang Division of Acute Virus Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of Koreah Division of Vectors and Parasitic Diseases, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea
Emerg Microbes Infect, 11.06.2024
Tilføjet 11.06.2024
Cintia Fabbri Marta Giovanetti Victoria Luppo Vagner Fonseca Jorge Garcia Cintia Barulli Mariel Feroci Sofia Perrone Doraldina Casoni Sergio Giamperetti Maria Cristina Alvarez Lopez Maria Delia Foussal Mauricio Figueredo Karina Salvatierra Sergio Lejona Natalia Ruiz Diaz Gonzalo Castro Gabriela Bravo Noelia Jackel Carina Sen Tomás Poklepovich Caride Leticia Franco Carlos Giovachini Jairo Mendez Rico Luiz Carlos Junior Alcantara Maria Alejandra Morales a Instituto Nacional de Enfermedaes Virales Humanas “Dr. Maiztegui”, ANLIS, Pergamino, Argentinab Department of Sciences and Technologies for Sustainable Development and One Health, Universita Campus Bio-Medico di Roma, Rome, Italyc Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazild Climate Amplified Diseases and Epidemics (CLIMADE), Minas Gerais, Brazile Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Salvador, Brazilf Hospital de Infecciosas Francisco Javier Muñiz, CABA, Buenos Aires, Argentinag Hospital General de Niños R. Gutiérrez, CABA, Buenos Aires, Argentinah Hospital Julio C. Perrando, Chaco, Argentinai Hospital de Alta Complejidad “Pte. Juan Domingo Perón”, Formosa, Argentinaj Laboratorio de Alta Complejidad de Posadas, Misiones, Argentinak CEMAR – Secretaria de Salud – Municipalidad de Rosario, Santa Fe, Argentinal Laboratorio Central de Redes y Programas de Corrientes, Corrientes, Argentinam Laboratorio Central de la Provincia de Cordoba, Córdoba, Argentinan Hospital Señor del Milagro, Salta, Argentinao Unidad Operativa, Centro Nacional de Genómica y Bioinformática, ANLISp Infectious Hazards Management, Health Emergencies Department (PHE), Pan American Health Organi-zation/World Health Organization (PAHO/WHO), Washington, DC, USAq Direccion de Epidemiologia, Minsiterio de Salud de la Nacion, Buenos Aires, Argentina
Emerg Microbes Infect, 11.06.2024
Tilføjet 11.06.2024
Scott M. Reid Alexander M. P. Byrne Fabian Z. X. Lean Craig S. Ross Andrei Pascu Richard Hepple Maria Dominguez Susanne Frost Vivien J. Coward Alejandro Núñez Joe James Levon Stephan James N. Aegerter Ian H. Brown Ashley C. Banyard a Virology Department, Animal and Plant Health Agency (APHA) Weybridge, Addlestone, UKb Pathology and Animal Sciences Department, APHA Weybridge, Addlestone, UKc APHA England Field Delivery, APHA Stafford, Stafford, UKd APHA Bridgwater, Bridgwater, UKe APHA England Field Delivery, Stroud, UKf APHA Bakewell, Bakewell, UKg WOAH/FAO International Reference Laboratory for Avian Influenza, APHA Weybridge, Addlestone, UKh Veterinary Exotic Notifiable Disease Unit (VENDU), London, UKi APHA Sand Hutton, National Wildlife Management Centre, York, UK
Emerg Microbes Infect, 11.06.2024
Tilføjet 11.06.2024
Zhi Zhang Lina Li Hongsheng Wang Xin Ran Yuan Chen Xinyao Liu Yuping Ran a Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, People’s Republic of Chinab Department of Dermatovenereology, Henan Provincial People’s Hospital (People’s Hospital of Zhengzhou University), Zhengzhou, People’s Republic of Chinac Laboratory of Mycobacteria, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People’s Republic of China
Emerg Microbes Infect, 11.06.2024
Tilføjet 11.06.2024
Ryosuke Nakai, Hiroyuki Kusada, Fumihiro Sassa, Ayaka Makino, Susumu Morigasaki, Hisayoshi Hayashi, Naoki Takaya, Hideyuki Tamaki
PLoS One Infectious Diseases, 11.06.2024
Tilføjet 11.06.2024
by Ryosuke Nakai, Hiroyuki Kusada, Fumihiro Sassa, Ayaka Makino, Susumu Morigasaki, Hisayoshi Hayashi, Naoki Takaya, Hideyuki Tamaki Our previous studies indicate the abundant and diverse presence of yet-to-be-cultured microorganisms in the micropore-filtered fractions of various environmental samples. Here, we isolated a novel bacterium (designated as strain TMPK1T) from a 0.45-μm-filtered soil suspension by using a gel-filled microwell array device comprising 900 microwells and characterized its phylogenetic and physiological features. This strain showed low 16S rRNA gene sequence identities (
Læs mere Tjek på PubMed