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Andrew B. Lawson, Joanne Kim
PLoS One Infectious Diseases, 11.07.2024
Tilføjet 11.07.2024
Muhammad Rooman, Yasir Assad, Sadia Tabassum, Samia Sultan, Sultan Ayaz, Muhammad Fiaz Khan, Shahid Niaz Khan, Rehman Ali
PLoS One Infectious Diseases, 11.07.2024
Tilføjet 11.07.2024
by Muhammad Rooman, Yasir Assad, Sadia Tabassum, Samia Sultan, Sultan Ayaz, Muhammad Fiaz Khan, Shahid Niaz Khan, Rehman Ali
Læs mere Tjek på PubMedImmunity, 11.07.2024
Tilføjet 11.07.2024
Publication date: 9 July 2024 Source: Immunity, Volume 57, Issue 7 Author(s): Laurent Abel, Jean-Laurent Casanova
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Epidemiology of shigellosis has drastically changed in recent years due to globalization and sexual risk behaviors. Here, through whole-genome sequencing, we characterized two ESBL-producing Shigella sonnei strains (ShSoBUH1 and ShSoBUH2) carrying a blaCTX−M−15 among men who have sex with men (MSM), who had not recently traveled and presented sexual risk behaviors. Both strains harbored IncB/O/K/Z and IncFII plasmids, which carry aadA1, aadA5, sul1, sul2, dfrA1, dfrA17, mph(A), erm(B), tet(B), qacE and blaCTX−M−15 genes conferring resistance to 2nd and 3rd generation cephalosporins, cotrimoxazole, erythromycin, azithromycin and quinolones. IncFII plasmids containing blaCTX−M−15 from ShSoBUH1 and ShSoBUH2 presented 99,8–99,9% similarity with plasmids from another five CTX-M-15 S. sonnei strains detected in Belgium and Switzerland. A single-nucleotide polymorphism (SNP) analysis determined that the study strains differed by 361 SNPs, belonging to different clusters. To the best of our knowledge, this is the first report describing two extensively drug-resistant (XDR) CTX-M-15 S. sonnei strains in MSM.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose Diagnosis of (European) Lyme neuroborreliosis has been based on clinical presentation, cerebrospinal fluid (CSF) pleocytosis and demonstration of intrathecal borrelial antibody synthesis (ITBAS) to document Borrelia burgdorferi s. l. infection. It is not known if other criteria to document Borrelia infection may contribute to the diagnosis. Methods We compared the sensitivity of three individual criteria (ITBAS, CSF Borrelia culture, and the presence of erythema migrans [EM]) to confirm the diagnosis of early Lyme neuroborreliosis in 280 patients ≥ 15 years of age evaluated at a Lyme borreliosis outpatient clinic in Slovenia. The patients had either radicular pain of new onset or involvement of a cranial nerve but without radicular pain, each in conjunction with CSF pleocytosis. Evaluation was of patients who had each of the three confirmatory criteria assessed, and for whom at least one criterion was positive. Results Analysis of 280 patients, 120 women and 160 men, median age 57 (range 15–84) years, revealed that ITBAS was the most frequently observed positive criterion (85.4%), followed by EM (52.9%), and by a positive CSF Borrelia culture (9.6%). Of the 280 patients, 154 (55%) met only one criterion (43.2% ITBAS only, 10.7% EM only, and 1.1% positive CSF culture only), whereas 42.1% met two criteria. Only 2.9% of patients were positive by all three criteria. Conclusion Although ITBAS was the most frequent criterion for confirmation for Borrelia infection, the presence of EM alone confirmed an additional 10.7% of patients and a positive CSF Borrelia culture alone added another 1.1%.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose Intestinal protozoan parasites among Asian schoolchildren are a subject of concern due to their prevalence and potential health impact. Understanding and addressing this issue is crucial for public health in the region. Methods We conducted a comprehensive search for articles published up to December 2023 across four databases, including Scopus, PubMed, ProQuest, and Web of Science. To estimate the combined prevalence, a random-effects model with a 95% confidence interval (CI) was applied, and the statistical analysis was performed using meta-analysis packages in R version (3.6.1). This study is registered with PROSPERO (CRD42023481146). Results Among 131 eligible articles, the prevalence of intestinal protozoan parasites was 0.208 (95% CI = 0.180–0.238). Lebanon and Tajikistan had the highest country-level prevalence at 0.851 and 0.836, respectively, with Giardia duodenalis being the most prevalent species at 0.082. Conclusion In summary, our study highlights the urgent public health issue of protozoan parasites among Asian schoolchildren due to poor sanitation and water quality. Immediate interventions are essential, considering climate and socioeconomic factors, to combat these infections and improve overall health.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose Many curricula promote frontal teaching approaches, potentially decreasing interaction and motivation – also within infection prevention & control and infectious diseases (IPC/ID). We aimed to investigate the implementation of three innovative teaching methods (ITM) within IPC/ID education: game-based learning (GBL), peer-teaching (PT) and misinformation detection (MID). Methods Multi-phase study involving third-year medical students was conducted. Phase-1 included a cross-sectional survey, assessing previous ITM-experience and interest to participate in phase-2, where the students were divided into teams. Each team prepared a video covering an IPC/ID-topic with deliberately placed misinformation, which had to be identified and corrected by the opposing team, followed by qualitative evaluation (phase-3). Finally, the MID-concept was incorporated into regular curricula in a non-competitive environment (phase-4) and evaluated within a cohort not involved in phases 1–3. Results 276 students responded to phase-1. 58% expressed interest in participating in phase-2. Roughly 59% [47–71%] CI-95% of respondents without previous PT-experience stated interest in PT, while the interest in GBL and MID was even higher. 19 students participated in phase-2. All topic MID-scores ranged between 6 and 8/10 points, except for emporiatrics (3/10). Post-hoc analysis revealed a positive student-perception of ITM, particularly GBL. Phase-4 received 103 responses with general positive evaluation. Major agreements existed on the usefulness of critical information evaluation for medical practice (82% [75–91%] CI-95%) and of MID during studies (69% [59–79%] CI-95%). Conclusion our results hint at a relatively high interest in ITM and show MID applicability in regular IPC/ID curricula, which could be of advantage for the learning environment.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Infection, 10.07.2024
Tilføjet 10.07.2024
Infection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose We aimed to develop and implement dosing recommendations for antimicrobials in obese and underweight patients within an academic hospital, and assess their impact on antibiotic prescribing. Methods A multi-step approach project was performed. First, obese and underweight patient prevalence and antimicrobial prescription frequency was determined in a point prevalence study. Second and third, a literature review and e-survey provided dosing evidence. Fourth, a consensus meeting was organized to formulate dosing recommendations. Fifth, these were implemented in our clinical validation service as six clinical rules continuously screening patients’ records for potentially inappropriate prescriptions (PIPs). Uptake was evaluated by documenting the number of advices and acceptance rate. Last, an interrupted time series analysis (ITS) compared pre- and post-implementation periods to measure the impact of the intervention on residual PIPs/day. A residual PIP was defined as a PIP which persisted up to 48 h. Results First, 41% of 15.896 hospitalized patients received antimicrobials over 20 days; of which 12% were obese and 9% underweight. Antibiotics were predominantly prescribed according to standard dosing regimens, adjusted to renal function. Next, six dosing recommendations, derived from literature, survey, and consensus, were implemented. In the fifth step, during an 18-week period, 219 advices were given, with 86% acceptance rate. Last, in the ITS analysis, at preintervention, a median of 75% residual PIPs/day existed, reduced to 0% postintervention. Use of clinical rules resulted in a significant immediate 84% relative reduction in residual PIPs (95% CI 0.55–0.94). Conclusion After conducting a literature review, e-survey, and seeking consensus from a panel of experts, dosing recommendations for antimicrobial treatment in both obese and underweight patients were developed. These recommendations have been successfully implemented into clinical practice, addressing the specific needs of these patient populations.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Infection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose To characterize the clinical relevance of S. saccharolyticus and to identify criteria to distinguish between infection and contamination. Methods We retrospectively investigated clinical features of patients with S. saccharolyticus detection between June 2009 and July 2021. Based on six criteria, infection was considered likely for patients with a score from 3 to 6 points, infection was considered unlikely for patients with a score from 0 to 2 points. We performed group comparison and logistic regression to identify factors than are associated with likely infection. In addition, whole genome sequencing (WGS) of 22 isolates was performed. Results Of 93 patients in total, 44 were assigned to the group “infection likely” and 49 to the group “infection unlikely”. Multiple regression analysis revealed “maximum body temperature during hospital stay” to have the strongest predictive effect on likely infection (adjusted odds ratio 4.40, 95% confidence interval 2.07–9.23). WGS revealed two different clades. Compared to isolates from clade A, isolates from clade B were more frequently associated with implanted medical devices (3/10 vs. 9/12, p = 0.046) and a shorter time to positivity (TTP) (4.5 vs. 3, p = 0.016). Both clades did neither differ significantly in terms of causing a likely infection (clade A 7/10 vs. clade B 5/12, p = 0.23) nor in median length of hospital stay (28 vs. 15.5 days, p = 0.083) and length of stay at the ICU (21 vs. 3.5 days, p = 0.14). Conclusion These findings indicate that S. saccharolyticus can cause clinically relevant infections. Differentiation between infection and contamination remains challenging.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose Listeria monocytogenes causes severe bacterial infections with the highest mortality rate among foodborne pathogens in Europe. Combination treatment with ampicillin and gentamicin is recommended for invasive manifestations. However, evidence to support this treatment approach remains limited due to a lack of randomised controlled trials. To explore this critical issue further, we conducted this retrospective, single-center study. Methods We identified all patients hospitalized with invasive listeriosis at the University Medical Center Hamburg-Eppendorf between 2009 and 2020 and analyzed the effect of gentamicin combination treatment versus monotherapy on 90-day mortality. Results In total, 36 patients with invasive listeriosis were included, of which 21 patients received gentamicin combination treatment and 15 received monotherapy. The mean age-adjusted Charlson Comorbidity Index (aaCCI) value was lower in the gentamicin combination treatment group (5.4 vs. 7.4). Neurolisteriosis was more common in the gentamicin group (81% vs. 20%). The 90-day mortality was with significantly lower in the gentamicin combination treatment group (10%) compared to the monotherapy group (60%). Multivariable cox regression analysis, adjusted for a propensity score computed based on neurolisteriosis, aaCCI and sex, revealed a significantly reduced hazard ratio of 0.07 (95% CI: 0.01–0.53, p = 0.01) for 90-day mortality for the gentamicin combination treatment. Conclusion This retrospective study highlights the benefit of gentamicin combination treatment in reducing the 90-day mortality rate among patients with invasive listeriosis. The high prevalence of monotherapy in this study cohort raises concerns about the adequacy of antibiotic therapy in clinical practice.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Paradoxical reactions (PR) to tuberculosis (TB) treatment are common during treatment, but have also been described after treatment. A presentation with recurrent signs or symptoms of TB after cure or completion of prior treatment needs to be differentiated between microbiological relapse and a paradoxical reaction. We searched all published literature on post-treatment PR, and present a synthesis of 30 studies, focusing on the epidemiology, diagnosis and management of this phenomenon. We report an additional case vignette. The majority of studies were of lymph node TB (LN-TB), followed by central nervous system TB (CNS-TB). A total of 112 confirmed and 42 possible post-treatment PR cases were reported. The incidence ranged between 3 and 14% in LN-TB and was more frequent than relapses, and between 0 and 2% in all TB. We found four reports of pulmonary or pleural TB post-treatment PR cases. The incidence did not differ by length of treatment, but was associated with younger age at initial diagnosis, and having had a PR (later) during treatment. Post-treatment PR developed mainly within the first 6 months after the end of TB treatment but has been reported many years later (longest report 10 years). The mainstays of diagnosis and management are negative mycobacterial cultures and anti-inflammatory treatment, respectively. Due to the favourable prognosis in LN-TB recurrent symptoms, a short period of observation is warranted to assess for spontaneous regression. In CNS-TB with recurrent symptoms, immediate investigation and anti-inflammatory treatment with the possibility of TB retreatment should be undertaken.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors that contribute to pathogenesis in acute and chronic infections. This review aims to summarize the impact of multidrug resistance on the virulence and fitness of P. aeruginosa. Although it is generally assumed that acquisition of resistant determinants is associated with a fitness cost, several studies support that resistance mutations may not be associated with a decrease in virulence and/or that certain compensatory mutations may allow multidrug resistance strains to recover their initial fitness. We discuss the interplay between resistance profiles and virulence from a microbiological perspective but also the clinical consequences in outcomes and the economic impact.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Infection, 10.07.2024
Tilføjet 10.07.2024
Abstract Immunosuppression constitutes a significant risk for community-acquired pneumonia (CAP). Nevertheless, specific causes of immunosuppression and their relevance for incidence, etiology and prognosis of CAP are insufficiently investigated. We conducted a population-based cohort study within a statutory health insurance in Germany from 2015 to 2018. CAP was retrieved by ICD-10-GM codes. Episodes of immunosuppression were identified by coded conditions (hematologic neoplasms, stem cell or organ transplantation, neutropenia, HIV, primary immunosuppressive syndromes) or treatments (immunosuppressants, antineoplastic drugs, systemic steroids). Endpoints were defined as occurrence of CAP (primary), hospitalization, 30-day mortality and CAP associated with rare pathogens. Our analysis utilized the Andersen-Gill model adjusted for sex, age, level of long-term care, vaccination status, community type and comorbidities. 942,008 individuals with 54,781 CAPs were included (hospitalization 55%, 30-day mortality 14.5%). 6% of individuals showed at least one episode of immunosuppression during the study period with systemic steroids (39.8%) and hematologic neoplasms (26.7%) being most common. Immunosuppression was recorded in 7.7% of CAPs. Besides classical risk factors such as age and level of long-term care, immunosuppressed patients were most prone to CAP (HR 2.4[2.3–2.5]) and consecutive death (HR 1.9[1.8–2.1]). Organ and stem cell transplantation (HR 3.2[2.6–4.0] and 2.8[2.1–3.7], respectively), HIV (HR 3.2[1.9–5.4]) and systemic steroids (> 20 mg prednisone daily dose equivalent (HR 2.7[2.4–3.1])) showed the highest risk for contracting CAP. CAP by rare pathogens was strongly associated with immunosuppression (HR 17.1[12.0–24.5]), especially HIV (HR 34.1[7.6–153]) and systemic steroids (HR 8.2[4.6–14.8]). Our study elucidates the relevance of particular immunosuppressive conditions including systemic steroids for occurrence and prognosis of CAP.
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Background Nocardia often causes pulmonary infection among those with chronic pulmonary disease or immunocompromising conditions. Trimethoprim-sulfamethoxazole (TMP-SMX) is recommended as first-line treatment, though little data exists regarding outcomes of different dosing regimens. Methods We performed a multicenter retrospective cohort study of adult patients with non-disseminated pulmonary nocardiosis initially treated with TMP-SMX monotherapy. Patients’ initial TMP-SMX dosing was categorized as high- (> 10 mg/kg/day), intermediate- (5–10 mg/kg/day) or low-dose (
Læs mere Tjek på PubMedInfection, 10.07.2024
Tilføjet 10.07.2024
Abstract Purpose Beta-lactam allergy (BLA) is associated with increased broad-spectrum antibiotic (Br-ABX) use and worse clinical outcomes. We evaluated our hospital-wide BLA protocol (BLA-P) that used following categories: intolerance, low-risk, and high-risk. Methods Hospitalized adult patients with listed BLA during 10/2021–12/2022 were eligible. Exclusions were critically ill, surgical, hospice or comfort care, or non-verbal patients. Assessment was counted each time a pharmacist evaluated BLA. Interventions were no further action (high-risk allergy, patient refusal, unstable clinical status), updated allergy label, or delabeled. Delabeling was done either based on antibiotic history (direct-delabeling), or via test-dose challenge for low-risk patients. Br-ABX usage was compared in the unique delabeled patients: the empiric antibiotic use 90 days post-delabeling versus pre-delabeling using McNemar test (SPSS). Results A total of 700 assessments in 631 patients were identified. 441 assessments in 377 patients (median 63 years-old, 41% male, 50% hematological cancer) met inclusion criteria. The assessments revealed 9% intolerance, 55% low-risk, 23% high-risk and 13% unknown reaction. Interventions resulted in no further action 7%, updated label 72%, and delabeling 21%. 65% of the delabeling was via direct-delabeling and 35% test-dose challenge. Among patients who received a test-dose challenge, 36/36(97%) had no documented allergic reactions, and 1/26(3%) developed a mild rash. The use of aztreonam (pre-delabeling 28% vs. post-delabeling 1.2%, p
Læs mere Tjek på PubMedLyu Xie, YanQin Wu, JinYong Jiang, HongNing Zhou
Journal of Medical Virology, 10.07.2024
Tilføjet 10.07.2024
Zhichao Liang, Changying Lin, Da Huo, Yang Yang, Zhaomin Feng, Shujuan Cui, Dan Wu, Zhenyong Ren, Dan Li, Lei Jia, Shuaibing Dong, Xiangfeng Dou, Yulan Sun, Zhiyong Gao, Renqing Li
Journal of Medical Virology, 10.07.2024
Tilføjet 10.07.2024
Xu Liu, Xi Liu, Chenyue Jin, Yuting Luo, Lianping Yang, Xinjiao Ning, Chao Zhuo, Fei Xiao
Clinical Microbiology and Infection, 10.07.2024
Tilføjet 10.07.2024
Prediction models help target patients at risk of multidrug-resistant organism (MDRO) colonisation or infection and could serve as tools informing clinical practices to prevent MDRO transmission and inappropriate empiric antibiotic therapy. However, limited evidence identifies which among the available models are of low risk of bias and suitable for clinical application.
Læs mere Tjek på PubMedMalte M. Tetens, Lars Haukali Omland, Nanna S. Andersen, Jette Bangsborg, Jacob Bodilsen, Ram B. Dessau, Svend Ellermann-Eriksen, Charlotte Sværke Jørgensen, Jens Kjølseth Møller, Alex Christian Yde Nielsen, Michael Pedersen, Kirstine K. Søgaard, Niels Obel, Anne-Mette Lebech
Clinical Microbiology and Infection, 10.07.2024
Tilføjet 10.07.2024
To identify diagnostic opportunities, we investigated healthcare-seeking behavior among patients with Lyme neuroborreliosis (LNB) within 28 weeks before diagnosis.
Læs mere Tjek på PubMedLeonard Leibovici, Julia Friedman
Clinical Microbiology and Infection, 10.07.2024
Tilføjet 10.07.2024
In 2023 we implemented a few major changes in CMI. We decided to invite editorial interns – people in early and mid-career – to join our Editorial Board. The purpose was twofold: to learn from people in training and mid-career on how we could better serve their needs; and to train a cadre of young people to serve as editors with CMI and other publications. In response to our call (1) we were pleasantly surprised to receive applications from 33 excellent candidates. Although we aimed at the beginning to invite one or two, we ended up inviting 7 outstanding people to join us as interns.
Læs mere Tjek på PubMedClinical & Experimental Immunology, 10.07.2024
Tilføjet 10.07.2024
Abstract Adult-onset immunodeficiency with antibodies to interferon-γ (AOID with AIGA), is a rare, acquired immunodeficiency causing susceptibility to disseminated non-tuberculous mycobacteria and other intracellular opportunistic infections. The diagnosis depends on demonstrating the presence of endogenous anti-interferon-γ antibodies (AIGA) that suppress Th1 cell mediated immunity. Bioluminescent immunoassays are a newly emerging immunoassay format which utilise the action of bioluminescent enzymes on a substrate for specific analyte detection. In-short, detecting antibodies are conjugated with a bioluminescent enzyme. The detecting antibodies bind the analyte of interest and produce light (luminescence) after addition of a substrate. The purpose of this study was to evaluate two newly developed bioluminescent immunoassays using Lumit® (Promega) technology as a diagnostic test for AOID with AIGA. Specific aims included the clinical validation of a new inhibition bioluminescent immunoassay technique to detect AIGA which block detection of interferon-γ (IFN-γ) in-vitro and correlation of inhibition bioluminescent immunoassay results with AOID with AIGA disease status. Two bioluminescent inhibition immunoassays were developed. One which adapted an existing kit from Promega (Lumit® Human IFN-γ Immunoassay) and one which was developed in-house. 87 healthy controls and 48 patients with previously diagnosed AOID with AIGA were recruited and tested using these two methods. Results showed both bioluminescent inhibition immunoassays were able to clearly discriminate between AOID with AIGA patients and healthy controls. The mean inhibition percentage between patient groups correlated with disease activity. Both assays appeared to be more sensitive when compared to the existing inhibition ELISA.
Læs mere Tjek på PubMedClinical & Experimental Immunology, 10.07.2024
Tilføjet 10.07.2024
Abstract Members of the T-cell immunoglobulin and mucin (TIM) family, which is crucial for T-cell function, are implicated in autoimmunity. TIM-1 and -3 play distinct roles in autoimmunity, with TIM-1 acting as a costimulatory molecule and TIM-3 regulating Th1 responses. We investigated the therapeutic potential of anti-TIM-1 (RMT1-10) and anti-TIM-3 (RMT3-23) antibodies in an autoimmune arthritis model. Zymosan A was used to induce arthritis in female SKG mice. The arthritis scores, histology, mRNA expression, cytokine levels, micro-CT, and flow cytometry results were obtained. The application of RMT1-10 reduced the arthritis scores, histological damage, and CD4+T cell infiltrations, and it suppressed interleukin (IL)-6 and -17A and reduced TIM-3 mRNA expressions. RMT3-23 also lowered arthritis severity, improved histology, and reduced serum levels of tumor necrosis factor (TNF)-α and IL-17A. RMT3-23 inhibited intracellular TNF-α and IL-6 and early apoptosis. An amelioration of autoimmune arthritis was achieved by blocking the TIM-1 and -3 signaling pathways via RMT1-10 and RMT3-23 administration, leading to a widespread decrease in inflammatory cytokines. Both antibodies exhibited therapeutic effects, suggesting TIM-1 and -3 as potential targets for rheumatoid arthritis.
Læs mere Tjek på PubMedClinical & Experimental Immunology, 10.07.2024
Tilføjet 10.07.2024
Abstract Neutrophil extracellular traps released by neutrophils are web-like DNA structures adhered to granulin proteins with bactericidal activity and can be an important mechanism for preventing pathogen dissemination or eliminating microorganisms. However, they also play important roles in diseases of other systems, such as the central nervous system. We tracked the latest advances and performed a review based on published original and review articles related to neutrophil extracellular traps and neurological diseases. Generally, neutrophils barely penetrate the blood-brain barrier into the brain parenchyma, but when pathological changes such as infection, trauma, or neurodegeneration occur, neutrophils rapidly infiltrate the central nervous system to exert their defensive effects. However, neutrophils may adversely affect the host when they uncontrollably release neutrophil extracellular traps upon persistent neuroinflammation. This review focused on recent advances in understanding the mechanisms and effects of neutrophil extracellular traps release in neurological diseases, and we also discuss the role of molecules that regulate neutrophil extracellular traps release in anticipation of clinical applications in neurological diseases.
Læs mere Tjek på PubMedClinical & Experimental Immunology, 10.07.2024
Tilføjet 10.07.2024
We read with great interest the recent publication by Preuß et al. on antibodies to beta tubulin 5 (anti-TBB5) in autoimmune liver diseases [1]. The group has previously done extensive work on the potential autoantigenic target of perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) in autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC), culminating in the likely identification of TBB5 as target of pANCA [2]. Based on the results however, the group now concludes that anti-TBB5 may be elevated in autoimmune liver diseases but is an unlikely target of pANCA.
Læs mere Tjek på PubMedSchaber, K., Arambepola, R., Schluth, C., Labrique, A. B., Mehta, S. H., Solomon, S. S., Cummings, D. A. T., Wesolowski, A.
BMJ Open, 10.07.2024
Tilføjet 10.07.2024
ObjectiveWe investigated whether a zip code’s location or demographics are most predictive of changes in daily mobility throughout the course of the COVID-19 pandemic. DesignWe used a population-level study to examine the predictability of daily mobility during the COVID-19 pandemic using a two-stage regression approach, where generalised additive models (GAM) predicted mobility trends over time at a large spatial level, then the residuals were used to determine which factors (location, zip code-level features or number of non-pharmaceutical interventions (NPIs) in place) best predict the difference between a zip code’s measured mobility and the average trend on a given date. SettingWe analyse zip code-level mobile phone records from 26 metropolitan areas in the USA on 15 March–31 September 2020, relative to October 2020. ResultsWhile relative mobility had a general trend, a zip code’s city-level location significantly helped to predict its daily mobility patterns. This effect was time-dependent, with a city’s deviation from general mobility trends differing in both direction and magnitude throughout the course of 2020. The characteristics of a zip code further increased predictive power, with the densest zip codes closest to a city centre tended to have the largest decrease in mobility. However, the effect on mobility change varied by city and became less important over the course of the pandemic. ConclusionsThe location and characteristics of a zip code are important for determining changes in daily mobility patterns throughout the course of the COVID-19 pandemic. These results can determine the efficacy of NPI implementation on multiple spatial scales and inform policy makers on whether certain NPIs should be implemented or lifted during the ongoing COVID-19 pandemic and when preparing for future public health emergencies.
Læs mere Tjek på PubMedUllman, A., Takashima, M., Gibson, V., Comber, E., Borello, E., Bradford, N., Byrnes, J., Cole, R., Eisenstat, D., Henson, N., Howard, P., Irwin, A., Keogh, S., Kleidon, T., Martin, M., McCleary, K., McLean, J., Moloney, S., Monagle, P., Moore, A., Newall, F., Noyes, M., Rowan, G., St John, A., Wood, A., Wolf, J., Ware, R.
BMJ Open, 10.07.2024
Tilføjet 10.07.2024
IntroductionCentral venous access devices (CVADs) are commonly used for the treatment of paediatric cancer patients. Catheter locking is a routine intervention that prevents CVAD-associated adverse events, such as infection, occlusion and thrombosis. While laboratory and clinical data are promising, tetra-EDTA (T-EDTA) has yet to be rigorously evaluated or introduced in cancer care as a catheter lock. Methods and analysisThis is a protocol for a two-arm, superiority type 1 hybrid effectiveness-implementation randomised controlled trial conducted at seven hospitals across Australia and New Zealand. Randomisation will be in a 3:2 ratio between the saline (heparinised saline and normal saline) and T-EDTA groups, with randomly varied blocks of size 10 or 20 and stratification by (1) healthcare facility; (2) CVAD type and (3) duration of dwell since insertion. Within the saline group, there will be a random allocation between normal and heparin saline. Participants can be re-recruited and randomised on insertion of a new CVAD. Primary outcome for effectiveness will be a composite of CVAD-associated bloodstream infections (CABSI), CVAD-associated thrombosis or CVAD occlusion during CVAD dwell or at removal. Secondary outcomes will include CABSI, CVAD-associated-thrombosis, CVAD failure, incidental asymptomatic CVAD-associated-thrombosis, other adverse events, health-related quality of life, healthcare costs and mortality. To achieve 90% power (alpha=0.05) for the primary outcome, data from 720 recruitments are required. A mixed-methods approach will be employed to explore implementation contexts from the perspective of clinicians and healthcare purchasers. Ethics and disseminationEthics approval has been provided by Children’s Health Queensland Hospital and Health Service Human Research Ethics Committee (HREC) (HREC/22/QCHQ/81744) and the University of Queensland HREC (2022/HE000196) with subsequent governance approval at all sites. Informed consent is required from the substitute decision-maker or legal guardian prior to participation. In addition, consent may also be obtained from mature minors, depending on the legislative requirements of the study site. The primary trial and substudies will be written by the investigators and published in peer-reviewed journals. The findings will also be disseminated through local health and clinical trial networks by investigators and presented at conferences. Trial registration numberACTRN12622000499785.
Læs mere Tjek på PubMedWambua, G. N., Stein, A., Seedat, S., Sijbrandij, M., Baisley, K., Shahmanesh, M., Seeley, J., Ngwenya, N.
BMJ Open, 10.07.2024
Tilføjet 10.07.2024
IntroductionAdolescents living with HIV (ALHIV) are an extremely vulnerable population, with the burden of mental health problems carefully documented together with the constraints for receiving timely and adequate management of the problems, especially in rural settings. Problem Management Plus (PM+) is a scalable psychological intervention for individuals impaired by distress in communities exposed to adversity. Initially developed for adult populations, few studies have assessed its potential to address adolescent distress. This study aims to co-adapt PM+ with an adherence component (PM+Adherence) for ALHIV and to evaluate its acceptability and feasibility in rural Kwa-Zulu Natal Province, South Africa. Methods and analysisWe will use a mixed-methods approach over three phases. The first phase will include a realist synthesis and collection of formative data from up to 60 ALHIV, caregivers and healthcare providers to inform the adaptation of WHO PM+, including the components of an adherence module. During the second phase, we will undertake the cultural adaptation of the PM+Adherence intervention. The third phase will involve a hybrid type 3 implementation strategy among ALHIV aged 16–19 years (n=50) to implement and evaluate the feasibility of the culturally co-adapted PM+Adherence. The feasibility indicators to be evaluated include reach, adoption, attrition, implementation and acceptability of the adapted intervention, which will be assessed qualitatively and quantitatively. In addition, we will assess preliminary effectiveness using an intention-to-treat approach on HIV-related indicators and mental health outcomes at baseline, end intervention, 2-month follow-up during the 6-month implementation. DiscussionWe expect that the PM+Adherence will be acceptable and can feasibly be delivered by lay counsellors in resource-limited rural KwaZulu-Natal. Ethics and disseminationEthical clearance has been obtained from the University of KwaZulu-Natal Biomedical Research Ethics Committee, (BREC/00005743/2023). Dissemination plans include presentations at scientific conferences, peer-reviewed publications and community level.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Background Aminoglycosides have been a cornerstone of the treatment of nosocomial infections caused by Pseudomonas aeruginosa for over 80 years. However, escalating emergence of resistance poses a significant challenge. Therefore, this study aimed to investigate the prevailing patterns of aminoglycoside resistance among clinical isolates of P. aeruginosa in Iran; as well as the underlying resistance mechanisms observed in patients referred to Ardabil hospitals. Methods A total of 200 isolates from five hospitals were evaluated. The resistance profiles of P. aeruginosa isolates to tobramycin, amikacin, and netilmicin were determined using the disk diffusion method. The capacity of aminoglycoside-resistant isolates to form biofilms was assessed through a phenotypic assay, and the results were confirmed using the gene amplification technique. The presence of genes associated with aminoglycoside resistance was detected using polymerase chain reaction (PCR). Quantitative reverse transcription PCR (qRT-PCR) was performed to measure the expression levels of genes encoding the MexXY-OprM efflux pump and PhoPQ two-component system (TCS). Results The prevalence of aminoglycoside-resistant P. aeruginosa isolates was 48%, with 94.7% demonstrating multidrug resistance (MDR). All aminoglycoside-resistant P. aeruginosa strains exhibited biofilm-forming capabilities and harbored all the genes associated with biofilm production. Among the nine genes encoding 16S rRNA methylase and aminoglycoside-modifying enzymes, three genes were detected in these isolates: aac(6’)-Ib (85.4%), ant(2’’)-Ia (18.7%), and aph(3’)-VI (3.1%). Additionally, all aminoglycoside-resistant P. aeruginosa isolates carried mexY and phoP genes, although the expression levels of mexY and phoP were 75% and 87.5%, respectively. Conclusion Given the considerably high prevalence of aminoglycoside-resistant P. aeruginosa strains, urgent measures are warranted to transition towards the use of novel aminoglycosides and to uphold vigilant surveillance of resistance patterns.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Background Coronavirus disease (COVID-19) may lead to serious complications and increased mortality. The outcomes of patients who survive the early disease period are burdened with persistent long-term symptoms and increased long-term morbidity and mortality. The aim of our study was to determine which baseline parameters may provide the best prediction of early and long-term outcomes. Methods The study group comprised 141 patients hospitalized for COVID-19. Demographic data, clinical data and laboratory parameters were collected. The main study endpoints were defined as in-hospital mortality and 1-year mortality. The associations between the baseline data and the study endpoints were evaluated. Prediction models were created. Results The in-hospital mortality rate was 20.5% (n = 29). Compared with survivors, nonsurvivors were significantly older (p = 0.001) and presented comorbidities, including diabetes (0.027) and atrial fibrillation (p = 0.006). Assessment of baseline laboratory markers and time to early death revealed negative correlations between time to early death and higher IL-6 levels (p = 0.032; Spearman rho − 0.398) and lower lymphocyte counts (p = 0.018; Pearson r -0.438). The one-year mortality rate was 35.5% (n = 50). The 1-year nonsurvivor subgroup was older (p
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Background We aimed to assess serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations in extrapulmonary tuberculosis (EPTB) patients and to evaluate the effect of vitamin D3 supplementation on their treatment course. Methods Serum 25(OH)D3concentrations were measured in 47 newly diagnosed EPTB patients and 42 controls. Vitamin D-deficient EPTB patients were randomly assigned to receive 50,000 IU of vitamin D3 (cholecalciferol) orally once a week for 6 weeks (total 300,000 IU), followed by maintenance doses of 1000 IU a day besides anti-TB drugs or the first line anti-TB treatment only. Follow up serum 25(OH)D3 concentrations were measured after 3 months of starting vitamin D3 supplementation. Both groups were evaluated for clinical, laboratory, and radiological outcomes after treatment. Results Serum 25(OH)D3 concentrations were significantly lower among TB cases (17.1 ± 5.5 nmol/L) compared to healthy controls (51.8 ± 27.3 nmol/L), and vitamin D deficiency was observed in all EPTB patients (n = 47). Patients in VD3 supplementation group had significantly higher weight gain and serum albumin level at 2 months and end of treatment, higher hemoglobin concentration at the end of treatment, significantly lower CRP and ESR at 2 months and at the end of treatment. In cases with TB pleurisy, a significant higher rate of full resolution of pleural fluid after 6 months of anti-TB treatment and shorter treatment duration were noted compared to the other group. Conclusions Vitamin D deficiency is prevalent in EPTB patients, in whom, vitamin D supplementation is a useful adjunctive therapy to anti-TB drugs and improves treatment course.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Introduction Alveolar echinococcosis (AE), caused by the larval forms of Echinococcus multilocularis, is a zoonotic disease affecting the liver, lungs, lymph nodes, kidneys, brain, bones, thyroid, and other organs. Diagnosing AE in a non-endemic area is usually challenging. With the rapid development and increasing application of sequencing techniques in recent years, metagenomic next-generation sequencing (mNGS) has become a powerful tool for diagnosing rare infectious diseases. Case Presentation A 45-year-old woman was admitted to the hospital for the presence of pulmonary shadows for more than 3 months. The lung computed tomography (CT) at a local hospital revealed scattered solid and quasi-circular nodules in the left upper lobe, left lower lobe, right middle lobe, and right lower lobe. The largest nodule was located in the dorsal part of the right lung, measuring 2.0 × 1.7 × 1.5 cm. Moreover, abdominal CT revealed one space-occupying lesion each in the left and right lobes. The pathological analysis of the lung biopsy specimen revealed infiltration of lymphocytes, plasma cells, and eosinophils in the alveolar wall and interstitial area. No pathogenic bacteria were observed in the sputum smear and culture tests. There were no parasite eggs in the stool. The mNGS of the lung puncture tissue revealed 6156 sequence reads matching E. multilocularis; thus, the condition was diagnosed as AE. Albendazole 400 mg was administered twice daily, and the patient was stable during follow-up. Conclusion This case emphasizes the role of mNGS in diagnosing AE. As a novel, sensitive, and accurate diagnostic method, mNGS could be an attractive approach for facilitating early diagnosis and prompt treatment of infectious diseases, especially when the infection was caused by rare pathogens.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Background There is an increasing disease trend for SARS-COV-2, so need a quick and affordable diagnostic method. It should be highly accurate and save costs compared to other methods. The purpose of this research is to achieve these goals. Methods This study analyzed 342 samples using TaqMan One-Step RT-qPCR and fast One-Step RT-LAMP (Reverse Transcriptase Loop-Mediated Isothermal Amplification). The One-Step LAMP assay was conducted to assess the sensitivity and specificity. Results The research reported positive samples using two different methods. In the RT-LAMP method, saliva had 92 positive samples (26.9%) and 250 negative samples (73.09%) and nasopharynx had 94 positive samples (27.4%) and 248 negative samples (72.51%). In the RT-qPCR method, saliva had 86 positive samples (25.1%) and 256 negative samples (74.8%) and nasopharynx had 93 positive samples (27.1%) and 249 negative samples (72.8%). The agreement between the two tests in saliva and nasopharynx samples was 93% and 94% respectively, based on Cohen’s kappa coefficient (κ) (P
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Background Sepsis is a frequent cause of admission to intensive care units (ICUs). High mortality rates are estimated globally, and in our country, few studies have reported one-year survival. The objective of this study is to determine one-year survival in patients with sepsis admitted to the ICU in Colombia, compared with the survival of patients admitted for other conditions. Methods Retrospective cohort study using administrative databases from the Ministry of Health of Colombia. One-year survival and the adjusted hazard ratio for survival, adjusted for comorbidities included in the Charlson Index, were determined using a Cox proportional hazards model for patients admitted for other causes as well as for those admitted for sepsis. This was then compared with an inverse propensity score weighting model. Results A total of 116.407 patients were initially admitted to the ICUs, with 12.056 (10.36%) diagnosed with sepsis. Within the first year, 4.428 (36.73%) patients died due to sepsis. Age and male gender were associated with an increased risk of death from sepsis, and the covariates associated with one-year mortality were as follows: age over 80 years with HR 9.91 (95% CI: 9.22–10.65), renal disease with HR 3.16 (95% CI: 3.03–3.29), primary tumoral disease with HR 2.07 (95% CI: 1.92–2.23), liver disease with HR 2.27 (95% CI: 2.07–2.50), and metastatic solid tumor with HR 2.03 (95% CI: 1.92–2.15). Conclusion This study revealed a high one-year sepsis mortality rate in the population, associated with variables such as age over 80 years, the presence of renal disease, liver disease, connective tissue diseases, and cancer. Men exhibited higher mortality compared to women.
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Introduction Tuberculous lymphadenitis (TBLN) is an infection of the lymph node caused by Mycobacterium tuberculosis. Histological diagnoses of presumptive patients are often accompanied by cytomorphological features. However, the sensitivities of these features are often precluded by the variable degrees of narrative similarities compared to other diagnostic modalities. Objective The aim of this study was to investigate and compare the cytomorphological and clinical features of presumptive TBLN patients with bacteriological detection methods. Methods A similar cohort of TBLN patients from our previous study who were enrolled prospectively from the ALERT Specialized Hospital, Addis Ababa, Ethiopia, was considered for this analysis. SPSS version 26 was used for data analysis. Descriptive analysis was conducted to characterize the study population using the independent variable and presented with frequency tables. The chi-square test was used to measure the association. A P-value of
Læs mere Tjek på PubMedBMC Infectious Diseases, 10.07.2024
Tilføjet 10.07.2024
Abstract Background Schistosomiasis remains a public health concern worldwide. It is responsible for more than 240 million cases in 78 countries, 40 million of whom are women of childbearing age. In the Senegal River basin, both Schistosoma haematobium and Schistosoma mansoni are very prevalent in school-age children. However, there is a lack of information on the burden of schistosomiasis in pregnant women, which can cause complications in the pregnancy outcome. This study aimed to determine the prevalence and associated factors of schistosomiasis in pregnant women. Methods We conducted a prospective cross-sectional study of pregnant women attending antenatal clinics at the health center of the Senegalese Sugar Company and at the hospital of Richard Toll between August and December 2021. The urine and stool samples collected were examined using microscopy techniques and quantitative polymerase chain reaction (qPCR) to detect the presence of S. haematobium and S. mansoni. The urines were previously tested using urine reagent strips to detect hematuria and proteinuria. Socio-demographical, clinical, and diagnostically data were recorded by the midwife and the gynaecologist. The data were analyzed using a logistic regression model. Results Among the 298 women examined for the infection by microscopic, 65 (21.81%) were infected with urogenital schistosomiasis, 10 (3.36%) with intestinal schistosomiasis, and 4 (1.34%) were co-infected with both types of schistosomiasis. Out of the 288 samples tested by qPCR, 146 (48.99%) were positive for S. haematobium, 49 (35.51%) for S. mansoni and 22 (15.94%) for both species (co-infection). Pregnant women having microscopic haematuria and proteinuria were significantly more infected (p
Læs mere Tjek på PubMedBenjamin E. GewurzGeorge MosialosAlan B. RickinsonSankar SwaminathanaDivision of Infectious Diseases, Brigham & Women’s Hospital, Boston, MA 02115bSchool of Biology, Department of Genetics Development and Molecular Biology, Aristotle University of Thessaloniki, Thessaloniki GR54124, GreececInstitute of Cancer and Genomic Sciences, Emeritus Professor of Cancer Studies, College of Medical and Dental Sciences University of Birmingham, Edgbaston, Birmingham B15 2TT, United KingdomdDivision of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedIrene Lara-SáezÁngeles MencíaEnrique RecueroYinghao LiMarta GarcíaMarta OteoMarta I. GallegoAna Belén EnguitaDiana de Prado-VerdúnSigen AWenxin WangRamón García-EscuderoRodolfo MurillasMirentxu SantosaCharles Institute of Dermatology, School of Medicine, University College Dublin, Belfield, Dublin D04 V1W8, IrelandbBiomedical Innovation Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, SpaincCB06/07/0019 Unit, Centro de Investigación Biomédica en Red en Enfermedades Raras, Madrid 28029, SpaindRegenerative Medicine and Tissue Bioengineering Group, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid 28040, SpaineCellular and Molecular Genitourinary Oncology Group, Institute of Biomedical Research Hospital “12 de Octubre”, Madrid 28041, SpainfDepartment of Biomedical Engineering, Polytechnic School, Carlos III University, Leganés, Madrid 28911, SpaingBiomedical Applications and Pharmacokinetics Unit, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid 28040, SpainhUnidad de Histología, Unidades Centrales Científico Tecnológicas, Instituto de Salud Carlos III, Madrid 28220, SpainiPathology Department, University Hospital “12 de Octubre”, Madrid 28041, SpainjResearch and Clinical Translation Center of Gene Medicine and Tissue Engineering, School of Public Health, Anhui University of Science and Technology, Huainan 232001, ChinakTumor Progression Mechanisms Program, Centro de Investigación Biomédica en Red de Cáncer, Madrid 28029, Spain
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedChandramohan NatarajanLinh H. D. LeManojkumar GunasekaranKevin J. TraceyDavid ChernoffYaakov A. LevineaSetPoint Medical, Valencia, CA 91355bInstitute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY 11030cDepartment of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549dDepartment of Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549eDivision of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm 171 76, Sweden
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedRobyn McConvilleJelte M. M. KrolRyan W. J. SteelMatthew T. O’NeillBethany K. DaveyAnthony N. HodderThomas NeblAlan F. CowmanNorman KnetemanJustin A. BoddeyaDivision of Infectious Diseases & Immune Defence, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, AustraliabDepartment of Medical Biology, University of Melbourne, Melbourne, VIC 3010, AustraliacDepartments of Surgery, University of Alberta, Edmonton, AB T6G 2E1, Canada
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedJennifer LeeKerry WellensteinAli RahnavardAndrew T. NelsonMarlena M. HolterBethany P. CummingsVladimir YeliseyevAngela CastoldiClary B. ClishLynn BryDionicio SiegelBarbara B. KahnaDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215bDepartment of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University, Washington, DC 20052cDivision of Pharmaceutical Chemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093dDepartment of Biomedical Sciences, Cornell University College of Veterinary Medicine, Cornell University, Ithaca, NY 14850eDepartment of Surgery, School of Medicine, University of California, Davis, Sacramento, CA 95817fDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California Davis School of Veterinary Medicine, Davis, CA 95616gMassachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115hLaboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife 50670-901, BraziliBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedQinghua WuNaimeh RafatianKarl T. WagnerJacob BlamerJacob SmithSargol OkhovatianPraful AggarwalErika Yan WangArinjay BanerjeeYimu ZhaoTrevor R. NashRick Xing Ze LuLuis Eduardo Portillo-EsquivelChen Yu LiUros KuzmanovSerena MandlaElizabeth VirleeShira LandauBenjamin Fook LaiAnthony O. GramoliniChuan LiuSharon FleischerTeodor VeresGordana Vunjak-NovakovicBoyang ZhangKaren MossmanUlrich BroeckelMilica RadisicaInstitute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, CanadabToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, CanadacDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, CanadadDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8, CanadaeDepartment of Pediatrics, Section of Genomic Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226fDepartment of Medicine, McMaster University, Toronto, ON L8S 4L8, CanadagVaccine and Infectious Disease Organization, Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5E3, CanadahDepartment of Biomedical Engineering, Columbia University, New York, NY 10027iDepartment of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L8, CanadajDepartment of Physiology, University of Toronto, Toronto, ON M5S 1A8, CanadakTed Rogers Centre for Heart Research, University of Toronto, Toronto, ON M5G 1M1, CanadalMedical Devices Research Center, Life Sciences Division, National Research Council Canada, Montreal, QC H4P 2R2, CanadamTerrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, CanadanDepartment of Medicine, Columbia University, New York, NY 10032
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedOlivia M. ManleyTucker J. ShriverTian XuIsaac A. MelendrezPhilip PalaciosScott A. RobsonYisong GuoNeil L. KelleherJoshua J. ZiarekAmy C. RosenzweigaDepartment of Molecular Biosciences, Northwestern University, Evanston, IL 60208bDepartment of Chemistry, Northwestern University, Evanston, IL 60208cDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611dDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedBrittany A. PetrosaGenomic Center for Infectious Diseases, Broad Institute of MIT and Harvard, Cambridge, MA 02142bHealth Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, MA 02139cHarvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA 02115dDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115
Proceedings of the National Academy of Sciences, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
Læs mere Tjek på PubMedLakshmi E. BatachariAlyssa Y. DaiEmily R. TroemelaSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093
Proceedings of the National Academy of Sciences: Immunology and Inflammation, 10.07.2024
Tilføjet 10.07.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 29, July 2024.
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