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Malaria Journal
26.03.2025
…Africa, where it accounts for high morbidity and mortality rates. Sierra Leone, including Port Loko District, continues to experience a high burden of malaria despite government interventions. This study evaluates the existing government interventions for malaria treatment at Port Loko Government Hospital, examining the socio-economic determinants contributing to malaria treatment failure. . Methods.
Malaria Journal
24.01.2025
… . Background. Informal Healthcare Providers (IHCPs), including Proprietary Patent Medicine Vendors (PPMVs), drug peddlers, traditional healers, and herbal drug sellers are often the first choice for malaria treatment, especially in urban slums. Unplanned urbanization significantly impacts malaria transmission by creating cities with inadequate safety nets and healthcare access, increasing reliance on IHCPs.
Malaria Journal
9.11.2024
. Abstract. . Background. In 2021, an estimated 750,000 people died from malaria. Despite this significant burden, globally, malaria incidence and mortality rates have substantially dropped over the last 30 years. However, growth in spending on malaria and improved outcomes have recently stagnated. This development has made it more important than ever to understand what constitutes efficient spending on malaria. .
BMC Infectious Diseases
8.11.2024
. Abstract. . Background. Testing and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective treatment on burden and transmission via field studies or routine surveillance systems is difficult and potentially unethical.
Malaria Journal
17.08.2024
… have shown that adherence to the World Health Organization (WHO) guidelines for the management of severe malaria reduces mortality in hospitalized children. This study aimed to determine the impact of targeted interventions on adherence to the WHO severe malaria treatment guidelines in children at a Ugandan hospital as part of a quality improvement initiative. . . . Methods.
Malaria Journal
13.06.2024
. Abstract. . Background. Malaria remains a major global health problem although there was a remarkable achievement between 2000 and 2015. Malaria drug resistance, along with several other factors, presents a significant challenge to malaria control and elimination efforts.
Malaria Journal
6.06.2024
…s for severe malaria. It also highlights preparedness when considering ways of protecting the utility of artemisinin-based therapies. . . . Target product profile. Severe malaria treatments must be highly potent, with rapid onset of antiparasitic activity to clear the infection as quickly as possible to prevent complications.
Malaria Journal
10.05.2024
. Abstract. . Background. Plasmodium vivax relapses due to dormant liver hypnozoites can be prevented with primaquine. However, the dose must be adjusted in individuals with glucose-6-phosphate-dehydrogenase (G6PD) deficiency. In French Guiana, assessment of G6PD activity is typically delayed until day (D)14 to avoid the risk if misclassification. This study assessed the kinetics of G6PD activity throughout P.
BMC Infectious Diseases
1.03.2025
. Abstract. . Background. The genetic diversity of Plasmodium falciparum provides the parasite with many effective immune evasion and drug resistance mechanisms. This phenomenon is a major problem in eradicating malaria globally. This study aimed to assess merozoite surface protein 2 polymorphisms in P. falciparum isolates from Northwest Ethiopia. . . . Method.
BMC Infectious Diseases
19.01.2025
…sed. The Pfdhfr 51I and 108 N pyrimethamine-resistance mutations were at fixation (100% frequency), and the Pfmdr1 Y184F mutation, which is linked to reduced susceptibility to several antimalarial drugs, especially those used in combination therapies for malaria treatment, was detected in 97.5% of the samples as mixed-genotype infections. . . . Conclusion.
Clinical Infectious Diseases
11.01.2025
Abstract . Background . Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed.Methods . G6PDd participants with P.
Malaria Journal
25.12.2024
… of TQ implementation. . . . Methods. This qualitative observational study in Manaus and Porto Velho municipalities evaluated the pilot implementation of the new P. vivax malaria treatment algorithm in high/medium-complexity healthcare units (phase one), then low-complexity units (phase two). Qualitative data collection began 30 days after the first TQ treatment in each phase, i.e., October 2021 and March 2022.
BMJ Open
30.11.2024
…nts participated in this study. The sample was allocated proportionally for the six health centres and participants were selected through systematic random sampling techniques. . Outcome measures. The primary outcome is the prevalence of delay in seeking malaria treatment. . Results. A total of 403 malaria patients with a mean age of 27.6±SD 14.26 years were included in this study. The prevalence of delayed malaria treatment seeking was 78.41% (95% CI 74.11%, 82.17%).
Malaria Journal
11.11.2024
. Abstract. . Background. Malaria remains a significant concern for children under five in malaria-endemic regions. Rwanda’s successful efforts in malaria treatment reduced nationwide cases, but high mortality persists in the Eastern and Southern provinces. This study aimed to investigate the clinical features of severe malaria and to identify the death risk factors among under-five children in Eastern province Hospitals.
Malaria Journal
9.11.2024
. Abstract. . Background. Malaria is a major cause of ill health and death in children in Africa. The disease also imposes a severe social and economic burden on households and health systems and is strongly associated with poverty. This study summarizes the most up-to-date cost of treating severe malaria in children in Africa. . . . Methods.
Malaria Journal
7.11.2024
… Background. Artemisinin-based combination therapy (ACT) is currently recommended for treatment of uncomplicated malaria. However, the emergence and spread of partial artemisinin resistance threatens their effectiveness for malaria treatment in sub-Saharan Africa where the burden of malaria is highest.
BMC Infectious Diseases
22.10.2024
… that three constituents named cosmosiin, stigmastanol, robinetin, and quercetin were highly active and could regulate the expression of Interleukin 6 (IL6) and Cysteine-aspartic acid protease 3 (CASP3), which may act as a potential therapeutic target for malaria treatment. These analyses are validated by molecular dynamics simulation which reflects on the overall structural stability of the intermolecular conformation and interactions.
Malaria Journal
11.10.2024
… Malaria affects children under the age of five and pregnant women, leading to high morbidity and mortality rates. In sub-Saharan Africa, Patent and Proprietary Medicine Vendors (PPMVs) have been identified as key players in the provision of malaria treatment due to their accessibility and availability in communities, but PPMVs are not usually tested before fever cases are treated as malaria or refer clients.
Trends in Parasitology
10.10.2024
…ins, such as fluorescent proteins and luciferases. This review discusses the advances in recently generated P. falciparum transgenic reporter lines, which will aid in the investigation of parasite physiology and the discovery of novel antimalarial drugs. Future prospects for the generation of new and superior human malaria parasite reporter lines are also discussed, and unresolved questions in malaria biology are highlighted to help boost support for the development and implementation of malaria treatments.
Malaria Journal
10.10.2024
…the second most common malaria parasite in Ethiopia. It has been treated with chloroquine (CQ) for the past seven decades. However, the emergence of CQ-resistant strains in the nation urged the Federal Ministry of Health of Ethiopia to review its national malaria treatment guideline in 2018. In the revised guideline, the first-line treatment for uncomplicated P. vivax infection is a combination of CQ and primaquine (PQ).
Aktuelle smitsomme sygdomme [1]
Aktuelle smitsomme sygdomme [1]
ProMED
28.03.2025
…alaria cases. Khurda district, under which Bhubaneswar falls,. reported 343 cases in 2024. The state reported 5 malaria deaths in. 2022, 4 in 2023, and 6 in 2024. . Mahaling also highlighted the steps taken by the govt to control the. situation. . 'Free malaria treatment is available at all govt hospitals. Around 49. 000 trained accredited social health activist (Asha) workers are there. in the villages to ensure that people get early diagnosis and complete. treatment for malaria.