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Dokumenter [1]
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Sider [1]
…fected Host: Epidemiology and Pathogenesis in the Antiretroviral Era Curr HIV/AIDS Rep. 2015; 12: 6?15. HIV - persistence on ART & cure research:. Margolis et al: Latency reversal and viral clearance to cure HIV-1. Science. 2016; 253: aaf6517. PREP og PEP:. Fonner et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations: AIDS 2016 Jul 31;30(12):1973-83. Rodger et al. Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive…
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Journal of Infectious Diseases
25.12.2024
Among doxycycline post-exposure prophylaxis (doxy-PEP) eligible men, Staphylococcus aureus tetracycline non-susceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for multi-drug-resistant S. aureus, underscoring the importance of surveillance.
PLoS One Infectious Diseases
21.12.2024
by Ahmad M. Al-Omari, Yazan H. Akkam, Ala’a Zyout, Shayma’a Younis, Shefa M. Tawalbeh, Khaled Al-Sawalmeh, Amjed Al Fahoum, Jonathan Arnold . Antimicrobial peptides (AMPs) are excellent at fighting many different infections. This demonstrates how important it is to make new AMPs that are even better at eliminating infections. The fundamental transformation in a variety of scientific disciplines, which led to the emergence of machine learning techniques, has presented significant opportunities for the d…
Trends in Microbiology
17.12.2024
While establishing symbiotic relationships with nitrogen-fixing soil bacteria certain legumes produce nodule-specific cysteine rich peptides. These peptides turn the bacteria into terminally differentiated non-replicative bacteroids. Here, we discuss the properties, essentiality, emerging clinical and agricultural applications, and the need to study the detailed mechanism of action of these peptides.
Proceedings of the National Academy of Sciences
13.12.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 50, December 2024. SignificanceThis study provides the experimentally-derived quantitative populations of antiparallel β sheet registries of both wild-type (WT) and dominant fusion-defective Valine-2 to Glutamate-2 (V2E) mutant of the membrane-bound HIV gp41 fusion peptide.
Antimicrobial Agents And Chemotherapy
9.12.2024
Antimicrobial Agents and Chemotherapy, Ahead of Print.
PLoS One Infectious Diseases
5.12.2024
by Luyang Cao, Chao Dai, Zhongjie Li, Zheng Fan, Yu Song, Yingliang Wu, Zhijian Cao, Wenxin Li .
Proceedings of the National Academy of Sciences
4.12.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 49, December 2024. SignificanceBacterial natural products are one of the main sources of today’s therapeutics and mediate countless microbial interactions. However, biosynthetic insights at a whole-microbiome level that go beyond in silico analyses are relatively rare. Here,.
Proceedings of the National Academy of Sciences
4.12.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 49, December 2024. SignificanceCopper is both essential and toxic in excess. Bacteria face copper in their environments, notably in phagocytes, hence they have developed several defense mechanisms. We found a strategy of protection from copper, through the biosynthesis of .
Virulence
30.11.2024
Volume 15, Issue 1, December 2024 .
Trends in Microbiology
29.11.2024
During growth and division, the bacterial cell wall is remodeled, resulting in the liberation of peptidoglycan (PG) fragments which are typically reinternalized and recycled. Recycling of PG has been studied in a few model species, but its importance and diversity are not yet well understood. Here, we review how bacteria transport and recycle the components of their PG, highlighting updates and new findings.
PLoS One Infectious Diseases
25.11.2024
…gkran Chuakrut, Siripun Sarin, Rumpa Jutakanoke . The overuse and inappropriate use of antibiotics have led to the emergence of several antibiotic resistant bacteria. As a result, there is growing interest in exploring alternative agents as antimicrobial peptides (AMPs), which operate through unique mechanisms to effectively counteract bacterial resistance. In this study, peptides smaller than 3 kDa were isolated by cation exchange chromatography, anion exchange chromatography and reverse-phase chromatogra…
PLoS One Infectious Diseases
15.11.2024
…m. In addition to its well-documented capacity to mitigate inflammation, IL-10 can unexpectedly demonstrate pro-inflammatory characteristics under specific circumstances. The presence of both aspects emphasizes the vital need to identify the IL-10-induced peptide. To mitigate the drawbacks of manual identification, which include its high cost, this study introduces StackIL10, an ensemble learning model based on stacking, to identify IL-10-inducing peptides in a precise and efficient manner. Ten Amino-acid-c…
Antimicrobial Agents And Chemotherapy
7.11.2024
Antimicrobial Agents and Chemotherapy, Ahead of Print.
Journal of Medical Virology
15.10.2024
Journal of Medical Virology, Volume 96, Issue 10, October 2024.
Proceedings of the National Academy of Sciences
12.10.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 42, October 2024.
Journal of Acquired Immune Deficiency Syndromes
10.10.2024
…IV (PLHIV). In 2023, 140,000 adolescents were diagnosed with HIV, yet knowledge of HIV status and uptake of testing services remain critically low. Index testing – offering testing to contacts of PLHIV – is an important case-finding strategy. In 2021, PEPFAR expanded guidance to explicitly include older adolescents 15 to 19 years. We reviewed index testing data to assess uptake and case-finding trends among biological adolescent-aged children and siblings of PLHIV 10-19 years. Methods: . Routinely coll…
AIDS
28.09.2024
No abstract available
PLoS One Infectious Diseases
21.09.2024
…Xueliang Tian, Kun Luo . A significant population of biocontrol microorganisms resides in the rhizosphere of plants, which can be utilized for plant disease control. To explore the potential of rhizosphere soil microorganisms as biocontrol agents against pepper blight, a bacterial strain Pa608 was screened from rhizosphere soil of pepper and identified as Pseudomonas aeruginosa through morphological characteristics and 16S rRNA sequences. The result showed that the strain Pa608 demonstrated antagonistic ac…
Journal of Medical Virology
20.09.2024
Journal of Medical Virology, Volume 96, Issue 9, September 2024.
PLoS One Infectious Diseases
17.09.2024
…d potential drug targets. However, targeting RBPs with small molecules has so far been met with limited success as RNA-binding sites tend to be extended, shallow and dynamic with a mixture of charged, polar and hydrophobic interactions. Here, we show that peptide nucleic acids (PNAs) with nucleic acid-like binding properties and a highly stable peptide-like backbone can be used to target some RBPs. We have designed PNAs to mimic the short RNA stem-loop sequence required for the initiation of prokaryotic sig…
Aktuelle smitsomme sygdomme [6]
Aktuelle smitsomme sygdomme [6]
Medscape Infectious Diseases
12.12.2024
Antimicrobial peptides have not typically lived up to their promise, especially when it comes to beating antibiotic resistance, but novel avenues could see them reach the clinic yet. . Medscape Medical News
Medscape Infectious Diseases
19.11.2024
Approximately 80% of patients who started STI-PEP via telehealth remained in HIV PrEP care after 3 months . Medscape Medical News
Medscape Infectious Diseases
25.06.2024
An antimicrobial peptide spray demonstrates promise in managing mild to moderate diabetic foot complications. . Medscape Diabetes & Endocrinology
Medscape Infectious Diseases
6.03.2024
Postexposure prophylaxis with doxycycline reduced some sexually transmitted infection rates in half in certain populations but concerns about antibiotic resistance remain. . Medscape Medical News
Morbidity and Mortality Weekly Report (MMWR)
4.06.2024
This report describes a recommendation from CDC for clinicians to use doxy PEP to help reduce incidents of syphilis, chlamydia, and gonorrhea in populations at high risk for these infections.
Morbidity and Mortality Weekly Report (MMWR)
21.03.2024
This report describes trends in the initiation and completion of preventive treatment for tuberculosis in people with HIV through PEPFAR-supported programs.