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Dokumenter [1] Sider [2] Nyt fra tidsskrifterne [20] Aktuelle smitsomme sygdomme [5]

Dokumenter [1]

Endelig guideline: 01.09.2020 Version: 3 Guideline skal revideres senest: 01.09.2023 Arbejdsgruppens medlemmer: Peer Brehm Christensen, Christian Erikstrup, Jan Gerstoft, Terese Katzenstein, Alex Laursen, Suzanne Lunding, Birgitte Mørn og Nina Weis.


Sider [2]

…oft, Jens Lundgren, Alex Laursen, Niels Obel, Olav Larsen, Gitte Kronborg, Ann-Brit Eg Hansen Antiviral behandling af hiv smittede personer Fertilitetsbehandling ved HIV og hepatitis B og C HIV behandling af gravide HIV post exposure profylakse (PEP) Pre-exposure profylakse mod HIV (PrEP) Borrelia | Anne-Mette Lebech, Sigurdur Skarphedinsson Borrelia klaringsrapport COVID-19 | Marie Helleberg/Jens Lundgren, Lothar Wiese, Michael Dalager-Pedersen, Merete Storgaard,…

… Epidemiology and Pathogenesis in the Antiretroviral Era Curr HIV/AIDS Rep. 2015; 12: 6?15 | HIV - persistence on ART & cure research:Margolis et al: Latency reversal and viral clearance to cure HIV-1. Science. 2016; 253: aaf6517 | PREP og PEP:Fonner et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations: AIDS 2016 Jul 31;30(12):1973-83Rodger et al. Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Posi…


Nyt fra tidsskrifterne [20]

Der er mere end 20 resultater, måske du vil se flere resultater her?
Science Advances
14.04.2021
…of the current study. FHV infects through the acid-dependent endocytic pathway, where low pH triggers externalization of membrane-disrupting () peptides from the capsid interior. Using all-atom equilibrium and enhanced sampling simulations, the mechanism and energetics of peptide liberation and the effect of pH on this process are investigated. Our computations agree with experimental findings and reveal nanoscopic details regarding the pH control mechanism, which are not readily accessible in experiments.
Trends in Microbiology
6.04.2021
Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
PLoS One Infectious Diseases
17.03.2021
…Adewole, Eze M. Daniel Developing an efficacious vaccine for SARS-CoV-2 infection is critical to stemming COVID-19 fatalities and providing the global community with immune protection. We have used a bioinformatic approach to aid in designing an epitope peptide-based vaccine against the spike protein of the virus. Five antigenic B cell epitopes with viable antigenicity and a total of 27 discontinuous B cell epitopes were mapped out structurally in the spike protein for antibody recognition. We identified …
Infection and Immunity
8.02.2021
…els of the atoms in a system to discover nanoscale insights into the dynamic relationship between mechanism and biological function. Such insights can lay the framework for elucidating mechanism of action and optimizing antibiotic templates. Antimicrobial peptides represent a promising solution to escalating antimicrobial resistance given their lesser tendency to induce resistance than small molecule antibiotics. Simulations of these agents have already revealed how they interact with bacterial membranes an…
Antimicrobial Agents And Chemotherapy
31.08.2009
This article, published ahead of print on 28 July 2008, has been withdrawn by the authors. Although moderate synergy between P2-RANTES and C peptides can be observed with high statistical significance in cell fusion assays, this synergy was not able to be verified in HIV viral assays. The authors regret the overstatement of synergy and will revise the paper for publication at a later date.
Frontiers in Immunology
1.01.1970
…s an off the shelf immunotherapy. Here, we developed a PLGA-based nanoparticle vaccine that contains both the immunogenic cancer germline antigen NY-ESO-1 and an α-GalCer analog IMM60, as a novel iNKT cell agonist and dendritic cell transactivator. Three peptide sequences (85–111, 117–143, and 157–165) derived from immunodominant regions of NY-ESO-1 were selected. These peptides have a wide HLA coverage and were efficiently processed and presented by dendritic cells via various HLA subtypes. Co-deliv…
Frontiers in Immunology
1.01.1970
…them. This cytotoxic response is supposed to be limited to infected cells to avoid killing of healthy cells. To enable this, CD8+ T cells have T Cell Receptors (TCRs) which should discriminate between self and non-self through the recognition of antigenic peptides bound to Human Leukocyte Antigen class I (HLA-I) complexes—i.e., HLA-I immunopeptidomes—of patrolled cells. The majority of these antigenic peptides are produced by proteasomes through either peptide hydrolysis or peptide splicing. Proteasome-…
Critical Care Medicine
8.04.2021
Objectives: No standard therapy, including anticoagulation regimens, is currently recommended for coronavirus disease 2019. Aim of this study was to evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival. Design: Multicenter international prospective registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019). Setting: Hospitalized patients with coronavirus disease 2019. Patients: Five thousand eight hundred thirty-e…
PLoS One Infectious Diseases
7.04.2021
by Shana Kushner Gadarian, Sara Wallace Goodman, Thomas B. Pepinsky Objective To study the U.S. public’s health behaviors, attitudes, and policy opinions about COVID-19 in the earliest weeks of the national health crisis (March 20–23, 2020). Method We designed and fielded an original representative survey of 3,000 American adults between March 20–23, 2020 to collect data on a battery of 38 health-related behaviors, government policy preferences on COVID-19 response and worries about the pandemic. We…
BMJ Open
26.03.2021
Introduction Youth with brain-based disabilities (BBDs), as well as their parents/caregivers, often feel ill-prepared for the transfer from paediatric to adult healthcare services. To address this pressing issue, we developed the MyREADY TransitionTM BBD App, a patient-facing e-health intervention. The primary aim of this randomised controlled trial (RCT) was to determine whether the App will result in greater transition readiness compared with usual care for youth with BBD. Secondary aims included explorin…
Science Advances
14.04.2021
…of the current study. FHV infects through the acid-dependent endocytic pathway, where low pH triggers externalization of membrane-disrupting () peptides from the capsid interior. Using all-atom equilibrium and enhanced sampling simulations, the mechanism and energetics of peptide liberation and the effect of pH on this process are investigated. Our computations agree with experimental findings and reveal nanoscopic details regarding the pH control mechanism, which are not readily accessible in experiments.
PLoS One Infectious Diseases
14.04.2021
…ase which causes significant morbidity and mortality in koalas. The predominant pathogenic species, Chlamydia pecorum, causes severe ocular, urogenital and reproductive tract disease. In marsupials, including the koala, gene expansions of an antimicrobial peptide family known as cathelicidins have enabled protection of immunologically naïve pouch young during early development. We propose that koala cathelicidins are active against Chlamydia and other bacteria and fungi. Here we describe ten koala cathelic…
Immunity
13.04.2021
The impact of seasonal coronaviruses on immune responses to SARS-CoV-2 is an active area of research. Here, Lineburg et al identify CD8+ T cells specific for a conserved and immunodominant SARS-CoV-2 epitope in HLA-B7+ individuals. Furthermore, SARS-CoV-2 epitope-specific CD8+ T cells display cross-reactivity to beta but not alpha coronaviruses due to distinct peptide–HLA conformations.
BMJ Open
9.04.2021
…ly 10 000 paediatric chest X-ray images are currently being collected from an ongoing WHO-supported surveillance study in Bangladesh. Each image will be read by two trained clinicians/radiologists for the presence or absence of primary endpoint pneumonia (PEP) in each lung, as defined by the WHO. Images whose PEP labels are discordant in either lung will be reviewed by a third specialist and the final assignment will be made using a majority vote. Convolutional neural networks will be used for lung segmenta…
PLoS One Infectious Diseases
7.04.2021
by Shana Kushner Gadarian, Sara Wallace Goodman, Thomas B. Pepinsky Objective To study the U.S. public’s health behaviors, attitudes, and policy opinions about COVID-19 in the earliest weeks of the national health crisis (March 20–23, 2020). Method We designed and fielded an original representative survey of 3,000 American adults between March 20–23, 2020 to collect data on a battery of 38 health-related behaviors, government policy preferences on COVID-19 response and worries about the pandemic. We…
Trends in Microbiology
6.04.2021
Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
PLoS One Infectious Diseases
5.04.2021
…o CDBC. Among laboratory results, increased white blood cell counting (mainly neutrophil), lymphocytopenia, increased procalcitonin, erythrocyte sedimentation rate, C-reaction protein, D-dimer, blood urea nitrogen, lactate dehydrogenase, brain natriuretic peptide, myoglobin, blood sugar and decreased albumin are also observed, indicating multiple system functional damage. Radiology results suggested ground glass opacity mixed with high density effusion opacities and even pleural effusion. Conclusion The ag…
Science
2.04.2021
…applied X-ray fragment screening experiments with molecules of low complexity, our screen tested already approved drugs and drugs in clinical trials. From the three-dimensional protein structures, we identified 37 compounds that bind to Mpro. In subsequent cell-based viral reduction assays, one peptidomimetic and six non-peptidic compounds showed antiviral activity at non-toxic concentrations. We identified two allosteric binding sites representing attractive targets for drug development against SARS-CoV-2.
AIDS
31.03.2021
Objective: Abnormal deposition of the antimicrobial peptide amyloid beta (Aβ) is a characteristic of Alzheimer's Disease (AD). The objective of this study was to elucidate risk factors for brain Aβ in a cohort enriched for human immunodeficiency virus (HIV) and other neurotropic pathogens. Design: Cross-sectional cohort study. Methods: We examined autopsy brains of 257 donors with a mean age of 52.8 years; 62% were male; and 194 were HIV+ and 63 HIV-. Hyperphosphorylated tau (p-tau) and Aβ were…
Science
25.03.2021
…immunodeficiency virus (SIV) antigens elicit CD8+ T cells recognizing epitopes presented by major histocompatibility complex (MHC)-II and MHC-E, not MHC-Ia. These immune responses mediate replication arrest of SIV in 50 to 60% of monkeys. We show that the peptide VMAPRTLLL (VL9) embedded within the RhCMV protein Rh67 promotes intracellular MHC-E transport and recognition of RhCMV-infected fibroblasts by MHC-E-restricted CD8+ T cells. Deletion or mutation of viral VL9 abrogated MHC-E-restricted CD8+ T cell p…

Aktuelle smitsomme sygdomme [5]

ProMED
13.04.2021
Other Plant Disease -- SerbiaDuring a survey on tomato viruses conducted in Serbia, virus-like symptoms were observed in July 2019 in tomato plants (_Solanum lycopersicum_) grown in 2 separate plastic tunnels in Jablanica district. Affected plants showed yellow angular spots on the leaves accompanied by necrosis and distortion, as well as fruit discoloration. In these 2 tomato crops, disease incidence was estimated at 80%. Laboratory analysis (serological, molecular and biological tests) confirmed the pres…
Morbidity and Mortality Weekly Report (MMWR)
3.12.2020
This report describes sex differences in human immunodeficiency virus testing in sub-Saharan African countries.
Morbidity and Mortality Weekly Report (MMWR)
27.02.2020
When taken daily, preexposure prophylaxis (PrEP) reduces the risk of acquiring human immunodeficiency virus (HIV). PrEP is an important tool for preventing HIV among persons at substantial risk for HIV infection, including female sex workers, men who have sex with men, transgender women, and persons who inject drugs.
Morbidity and Mortality Weekly Report (MMWR)
27.11.2019
Human immunodeficiency virus (HIV) case-based surveillance continuously and systematically monitors HIV-positive patients throughout their clinical care until death.
Statens Serum Institut
14.12.2017
WHO har 1/12-2017 i en rapport fra Strategic Advisory Group of Experts on Immunization, SAGE, udgivet nye retningslinjer på baggrund af ny evidens om brugen af rabiesvacciner og rabies-immunglobulin (RIG).

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