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Dokumenter [1]
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…fected Host: Epidemiology and Pathogenesis in the Antiretroviral Era Curr HIV/AIDS Rep. 2015; 12: 6?15. HIV - persistence on ART & cure research:. Margolis et al: Latency reversal and viral clearance to cure HIV-1. Science. 2016; 253: aaf6517. PREP og PEP:. Fonner et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations: AIDS 2016 Jul 31;30(12):1973-83. Rodger et al.
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Clinical Infectious Diseases
11.03.2025
Abstract . Doxy-PEP is used to prevent chlamydia, syphilis and gonorrhea infections in sexual and gender minority men and transgender women. We describe a systematic process for developing algorithms that allow for the identification of doxy-PEP prescriptions. Using an identified algorithm will allow for improved monitoring of implementation and effectiveness.
PLoS One Infectious Diseases
11.03.2025
by Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney . Natriuretic peptides (NPs) bind to glomerular podocytes and attenuate glomerular injury. The beneficial effects of NPs are negatively regulated by the NP clearance receptor (NPRC), which is highly expressed in podocytes. To determine if inhibiting NPRC is podocyte protective, we examined the effects of deleting NPRC in both cultured podocytes and in vivo.
Trends in Microbiology
7.03.2025
…among microorganisms, many of which have developed protection mechanisms. While well-characterized protection mechanisms involve relatively large proteins – such as exporters or compound- or target-modifying enzymes – we discuss how small proteins and peptides can also confer protection. Recent technological advances have revealed the functional capacity and importance of the small proteome, as well as its potential for de novo evolution.
Science Advances
6.03.2025
Science Advances, Volume 11, Issue 10, March 2025.
Lancet Microbe
4.03.2025
Within hours of being sworn in as US President on Jan 20, 2025, Donald Trump signed an executive order withdrawing his country from WHO.
PLoS One Infectious Diseases
12.02.2025
…by Pratchaya Muangrod, Wiriya Charoenchokpanich, Sittiruk Roytrakul, Vilai Rungsardthong, Sawanya Charoenlappanit, Benjamaporn Wonganu, Lueacha Tabtimmai, Phumin Chamsodsai, Federico Casanova, Benjawan Thumthanaruk . The identification of multifunctional peptides derived from marine byproducts represents a significant challenge in the field. In Thailand, the fisheries industry exports salted jellyfish, which results in low-value byproducts primarily employed for animal feed.
PLoS One Infectious Diseases
12.02.2025
…s however have been shown to induce substantially stronger Ab responses than CCVs in Parkinson’s Disease, and so may be capable of overcoming IL-31 tolerance to effectively treat CP. In this report, WISIT vaccines presenting ten different IL-31-specific peptides were compared to CCVs presenting the same peptides. Multiple response parameters were assessed, including Ab titers induced, avidity of these Abs, and IL-31 signaling inhibition.
Science Advances
6.02.2025
Science Advances, Volume 11, Issue 6, February 2025.
Proceedings of the National Academy of Sciences
30.01.2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 4, January 2025. SignificanceThe bacterial cell wall needs to be expanded for growth, and this process requires the cleavage of cell wall crosslinks. While cell wall hydrolase activity is essential for this expansion, excessive activity can compromise the cell wall and .
Proceedings of the National Academy of Sciences
30.01.2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 4, January 2025. SignificanceDuring the recent COVID-19 pandemic, the pathogen SARS-CoV-2 continuously mutated to produce new strains, challenging the development of therapeutics. To develop a mutation-tolerant anti-infective drug, we focused on the fact that while .
PLoS One Infectious Diseases
24.01.2025
by Rui Mi, Xuejun Li, Yajie Li, Xingfan Du . Objective This study aimed to evaluate the positive effects on anti-oxidation, anti-inflammation, and microbial composition optimization of diabetic mice using tussah (Antheraea pernyi) silk fibroin peptides (TSFP), providing the theoretical foundation for making the use of silk resources of A. pernyi and incorporating as a supplement into the hypoglycemic foods. Method The animal model of diabetes was established successfully.
PLoS One Infectious Diseases
24.01.2025
…tance due to countless biological properties. Cordyceps militaris contains bioactive compounds with antioxidant, antimicrobial and anti-cancerous properties. This study was projected to analyze the potentials of biometabolites and to extract antimicrobial peptides and protein from the C. militaris. An in-vitro analysis of biometabolites and antimicrobial peptides was performed to investigate their pharmacological potentials followed by quantification and characterization of extracted protein.
Antimicrobial Agents And Chemotherapy
15.01.2025
Antimicrobial Agents and Chemotherapy, Ahead of Print.
Proceedings of the National Academy of Sciences
9.01.2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 1, January 2025. SignificanceThe need for antibiotics that target infections from gram-negative pathogens is a growing global health concern. Here, we show that antibiotics with activity against gram-positive organisms can be repurposed to target gram-negative species by .
Journal of Infectious Diseases
25.12.2024
Among doxycycline post-exposure prophylaxis (doxy-PEP) eligible men, Staphylococcus aureus tetracycline non-susceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for multi-drug-resistant S. aureus, underscoring the importance of surveillance.
PLoS One Infectious Diseases
21.12.2024
by Ahmad M. Al-Omari, Yazan H. Akkam, Ala’a Zyout, Shayma’a Younis, Shefa M. Tawalbeh, Khaled Al-Sawalmeh, Amjed Al Fahoum, Jonathan Arnold . Antimicrobial peptides (AMPs) are excellent at fighting many different infections. This demonstrates how important it is to make new AMPs that are even better at eliminating infections.
Trends in Microbiology
17.12.2024
While establishing symbiotic relationships with nitrogen-fixing soil bacteria certain legumes produce nodule-specific cysteine rich peptides. These peptides turn the bacteria into terminally differentiated non-replicative bacteroids. Here, we discuss the properties, essentiality, emerging clinical and agricultural applications, and the need to study the detailed mechanism of action of these peptides.
Proceedings of the National Academy of Sciences
13.12.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 50, December 2024. SignificanceThis study provides the experimentally-derived quantitative populations of antiparallel β sheet registries of both wild-type (WT) and dominant fusion-defective Valine-2 to Glutamate-2 (V2E) mutant of the membrane-bound HIV gp41 fusion peptide.
Antimicrobial Agents And Chemotherapy
9.12.2024
Antimicrobial Agents and Chemotherapy, Ahead of Print.
PLoS One Infectious Diseases
5.12.2024
by Luyang Cao, Chao Dai, Zhongjie Li, Zheng Fan, Yu Song, Yingliang Wu, Zhijian Cao, Wenxin Li .
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Medscape Infectious Diseases
18.01.2025
Dr Jessica A. Penney and Sherry Chen at the Centers for Disease Control and Prevention provide guidance on doxy-PEP for STI prevention. . CDC Expert Commentary
Medscape Infectious Diseases
12.12.2024
Antimicrobial peptides have not typically lived up to their promise, especially when it comes to beating antibiotic resistance, but novel avenues could see them reach the clinic yet. . Medscape Medical News
Medscape Infectious Diseases
19.11.2024
Approximately 80% of patients who started STI-PEP via telehealth remained in HIV PrEP care after 3 months . Medscape Medical News
Medscape Infectious Diseases
25.06.2024
An antimicrobial peptide spray demonstrates promise in managing mild to moderate diabetic foot complications. . Medscape Diabetes & Endocrinology
ProMED
17.03.2025
… emphasise the establishment of dedicated centres at the. district level for treatment of dog-bite injuries given the fact that. rabies is fatal in 100 per cent of cases. . Deaths from the infection are preventable with prompt post-exposure. prophylaxis (PEP) by stopping the virus from reaching the central. nervous system. . Rabies can be completely prevented if the wound is immediately and. thoroughly flushed and washed with soap and flowing water, followed by.
ProMED
9.03.2025
…tulism - USA (04): (TX) wound, injection drug related, 2020-21. promedmail.org/post/20220527.8703504 . Botulism - USA (03): (WA) probable case, home-canned food, fatal. promedmail.org/post/20220428.8702905 . Botulism - USA (02): jarred sweet peppers, risk, recall. promedmail.org/post/20220421.8702754 . . Note: This content and the data herein may not be copied, reproduced,. scraped, redistributed, reused, or repurposed alone or together with.
ProMED
5.03.2025
…tulism - USA (04): (TX) wound, injection drug related, 2020-21. promedmail.org/post/20220527.8703504 . Botulism - USA (03): (WA) probable case, home-canned food, fatal. promedmail.org/post/20220428.8702905 . Botulism - USA (02): jarred sweet peppers, risk, recall. promedmail.org/post/20220421.8702754 . . Note: This content and the data herein may not be copied, reproduced,. scraped, redistributed, reused, or repurposed alone or together with.
ProMED
3.03.2025
…ed the prevalence of potentially pathogenic and. antimicrobial-resistant _E. coli_ in raw milk and dairy products from. Kafrelsheikh and Algarbia Governorates, Egypt. 210 samples including. raw buffalo milk, goat milk, Domiati cheese, Domiati cheese with. pepper, rayeb, and yogurt were analyzed. The prevalence of _E. coli_. was 26.2%, with the highest occurrence in buffalo milk (68.0%) and the. lowest in rayeb (7.5%). Based on ERIC-PCR, 84 non-clonal _E. coli_.
ProMED
27.02.2025
…condition such as diabetes (most. common risk factor), renal disease, cirrhosis, thalassemia, alcohol. dependence, immunosuppressive therapy, chronic obstructive lung. disease, cystic fibrosis, and excess kava consumption. Kava is an. herbal member of the pepper family that can be associated with chronic. liver disease. . Melioidosis may present at any age, but peaks in the fourth and fifth. decades of life, affecting men more than women. In addition, although.
ProMED
21.02.2025
…ns or symptoms of illness (cough, sore throat, headache, and. myalgia), which began 6 days after illness onset in cat 1A). The. household 1 members who received testing received a 10-day course of. twice-daily oral oseltamivir as postexposure prophylaxis (PEP) at the. time of testing; the dairy farmworker declined testing and PEP.††. Adolescent 1B reported a 'dry croupy' cough 6 days after onset of. illness in cat 1A that was attributed to severe allergies.
ProMED
21.02.2025
…idrug therapy] alone have. proven insufficient to interrupt transmission. WHO recommends contact. tracing (household, neighbourhood, and social contacts), accompanied. by the administration of a single dose of rifampicin as post-exposure. prophylaxis (SDR-PEP)'. (www.who.int/news-room/fact-sheets/detail/leprosy). . 'If left untreated, advanced Hansen's disease can cause the. following: . - Paralysis and crippling of hands and feet . - Shortening of toes and fingers due to reabsorption .
ProMED
14.02.2025
…tulism - USA (04): (TX) wound, injection drug related, 2020-21. promedmail.org/post/20220527.8703504 . Botulism - USA (03): (WA) probable case, home-canned food, fatal. promedmail.org/post/20220428.8702905 . Botulism - USA (02): jarred sweet peppers, risk, recall. promedmail.org/post/20220421.8702754 . . Note: This content and the data herein may not be copied, reproduced,. scraped, redistributed, reused, or repurposed alone or together with.
ProMED
14.02.2025
…condition such as diabetes (most. common risk factor), renal disease, cirrhosis, thalassemia, alcohol. dependence, immunosuppressive therapy, chronic obstructive lung. disease, cystic fibrosis, and excess kava consumption. Kava is an. herbal member of the pepper family that can be associated with chronic. liver disease. . Melioidosis may present at any age, but peaks in the 4th and 5th. decades of life, affecting men more than women. In addition, although.
ProMED
13.02.2025
…his family about the incident, and since there were. no significant injuries, the attack went unnoticed. . [Byline: Aishwarya Nair] . . -- . Communicated by: . ProMED . via . ProMED-SoAs . [Had the boy been treated with rabies post-exposure prophylaxis (PEP),. his life would have been saved. . . 'The incubation period for rabies is typically 2-3 months but may vary. from one week to one year, depending on factors such as the location. of virus entry and the viral load'.
ProMED
12.02.2025
…tulism - USA (04): (TX) wound, injection drug related, 2020-21. promedmail.org/post/20220527.8703504 . Botulism - USA (03): (WA) probable case, home-canned food, fatal. promedmail.org/post/20220428.8702905 . Botulism - USA (02): jarred sweet peppers, risk, recall. promedmail.org/post/20220421.8702754 . . Note: This content and the data herein may not be copied, reproduced,. scraped, redistributed, reused, or repurposed alone or together with.
ProMED
9.02.2025
…a, jaundice. (yellowing of the skin or eyes) and abdominal pain and seek medical. attention if symptoms develop. . [Byline: Alaina Walsh] . . -- . Communicated by: . ProMED . [It is not stated when the exposures have occurred. Postexposure. prophylaxis (PEP) with hepatitis A virus vaccine or immune globulin. (IG) prevents infection with hepatitis A virus when administered. within 2 weeks of exposure. The fact that PEP is not mentioned might. suggest that the exposures were more than 14 days ago.
ProMED
5.02.2025
…hip. . [Byline: Thanh Ha - Tan Luc] . . -- . Communicated by: . ProMED . via . ProMED-MBDS . ['Immediate medical attention following suspected rabies exposure is. critical. Medical care following a rabies exposure is called. post-exposure prophylaxis or PEP. PEP includes wound care, a dose of. human rabies immune globulin (HRIG), and a series of 4 or 5 rabies. vaccines, which must be administered as soon as possible after. exposure. This care is vital to prevent the disease from developing.
Medscape Infectious Diseases
4.02.2025
The U.S. State Department said on Saturday that the President's Emergency Plan for AIDS Relief (PEPFAR) — the world's leading HIV initiative - was covered by a waiver for. . Reuters Health Information
ProMED
29.01.2025
…condition such as diabetes (most. common risk factor), renal disease, cirrhosis, thalassemia, alcohol. dependence, immunosuppressive therapy, chronic obstructive lung. disease, cystic fibrosis, and excess kava consumption. Kava is an. herbal member of the pepper family that can be associated with chronic. liver disease. . Melioidosis may present at any age, but peaks in the 4th and 5th. decades of life, affecting men more than women. In addition, although.
ProMED
28.01.2025
…lly. Swiss cheese, can be implicated in histamine poisoning. The symptoms. of histamine poisoning generally resemble the symptoms encountered. with IgE-mediated food allergies. The symptoms include nausea,. vomiting, diarrhea, an oral burning sensation or peppery taste, hives,. itching, red rash, and hypotension. The onset of the symptoms usually. occurs within a few minutes after ingestion of the implicated food,. and the duration of symptoms ranges from a few hours to 24 h.