Søgning på udtrykket 'pep' giver 32 resultater

Dokumenter [1] Sider [2] Nyt fra tidsskrifterne [20] Aktuelle smitsomme sygdomme [8]

Dokumenter [1]

Endelig guideline: 01.09.2020 Version: 3 Guideline skal revideres senest: 01.09.2023 Arbejdsgruppens medlemmer: Peer Brehm Christensen, Christian Erikstrup, Jan Gerstoft, Terese Katzenstein, Alex Laursen, Suzanne Lunding, Birgitte Mørn og Nina Weis.

Sider [2]

…erstoft, Jens Lundgren, Alex Laursen, Niels Obel, Olav Larsen, Gitte Kronborg, Ann-Brit Eg Hansen Antiviral behandling af hiv smittede personer Fertilitetsbehandling ved HIV og hepatitis B og C HIV behandling af gravide HIV post exposure profylakse (PEP) Pre-exposure profylakse mod HIV (PrEP) Borrelia Anne-Mette Lebech, Sigurdur Skarphedinsson Borrelia klaringsrapport COVID-19 Marie Helleberg/Jens Lundgren, Lothar Wiese, Michael Dalager-Pedersen, Merete Storgaard, Isik Somu…

… Epidemiology and Pathogenesis in the Antiretroviral Era Curr HIV/AIDS Rep. 2015; 12: 6?15 | HIV - persistence on ART & cure research:Margolis et al: Latency reversal and viral clearance to cure HIV-1. Science. 2016; 253: aaf6517 | PREP og PEP:Fonner et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations: AIDS 2016 Jul 31;30(12):1973-83Rodger et al. Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Posi…

Nyt fra tidsskrifterne [20]

Der er mere end 20 resultater, måske du vil se flere resultater her?
PLoS One Infectious Diseases
by Ester Lilian Acen, Irene Andia Biraro, William Worodria, Moses L. Joloba, Bill Nkeeto, Joseph Musaazi, David Patrick Kateete Background Tuberculosis remains a global threat and a public health problem that has eluded attempts to eradicate it. Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease. The human cathelicidin LL-37 has both antimicrobial and immunomodulatory properties and is dependent on vitamin D status. This systematic review attempts to compare v…
Antimicrobial Agents And Chemotherapy
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Inflammasomes are multiprotein complexes that execute pyroptosis in response to cytosolic danger signals. DPP9 regulates the CARD8 inflammasome by unknown mechanisms. Here, Sharif et al. report cryo-EM structures of CARD8 bound to DPP9 and show that this complex inhibits CARD8 inflammasome activation downstream of the proteasome.
Infection and Immunity
Infection and Immunity, <a href="https://journals.asm.org/toc/iai/0/ja">Volume 0, Issue ja</a>, -Not available-.
Antimicrobial Agents And Chemotherapy
…urgently needed. The injectisome type III secretion system (T3SS), required by dozens of Gram-negative bacteria for virulence but largely absent from non-pathogenic bacteria, is an attractive antimicrobial target. We previously identified synthetic cyclic peptomers, inspired by the natural product phepropeptin D, that inhibit protein secretion through the Yersinia Ysc and Pseudomonas aeruginosa Psc T3SSs, but do not inhibit bacterial growth. Here we describe identification of an isomer, 4EpDN, that is two-f…
Antimicrobial Agents And Chemotherapy
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Science Advances
…of the current study. FHV infects through the acid-dependent endocytic pathway, where low pH triggers externalization of membrane-disrupting () peptides from the capsid interior. Using all-atom equilibrium and enhanced sampling simulations, the mechanism and energetics of peptide liberation and the effect of pH on this process are investigated. Our computations agree with experimental findings and reveal nanoscopic details regarding the pH control mechanism, which are not readily accessible in experiments.
Trends in Microbiology
Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
PLoS One Infectious Diseases
…Adewole, Eze M. Daniel Developing an efficacious vaccine for SARS-CoV-2 infection is critical to stemming COVID-19 fatalities and providing the global community with immune protection. We have used a bioinformatic approach to aid in designing an epitope peptide-based vaccine against the spike protein of the virus. Five antigenic B cell epitopes with viable antigenicity and a total of 27 discontinuous B cell epitopes were mapped out structurally in the spike protein for antibody recognition. We identified …
Infection and Immunity
…els of the atoms in a system to discover nanoscale insights into the dynamic relationship between mechanism and biological function. Such insights can lay the framework for elucidating mechanism of action and optimizing antibiotic templates. Antimicrobial peptides represent a promising solution to escalating antimicrobial resistance given their lesser tendency to induce resistance than small molecule antibiotics. Simulations of these agents have already revealed how they interact with bacterial membranes an…
Antimicrobial Agents And Chemotherapy
This article, published ahead of print on 28 July 2008, has been withdrawn by the authors. Although moderate synergy between P2-RANTES and C peptides can be observed with high statistical significance in cell fusion assays, this synergy was not able to be verified in HIV viral assays. The authors regret the overstatement of synergy and will revise the paper for publication at a later date.
Frontiers in Immunology
…an off the shelf immunotherapy. Here, we developed a PLGA-based nanoparticle vaccine that contains both the immunogenic cancer germline antigen NY-ESO-1 and an α-GalCer analog IMM60, as a novel iNKT cell agonist and dendritic cell transactivator. Three peptide sequences (85-111, 117-143, and 157-165) derived from immunodominant regions of NY-ESO-1 were selected. These peptides have a wide HLA coverage and were efficiently processed and presented by dendritic cells via various HLA subtypes. Co-delivery of…
Frontiers in Immunology
…them. This cytotoxic response is supposed to be limited to infected cells to avoid killing of healthy cells. To enable this, CD8+ T cells have T Cell Receptors (TCRs) which should discriminate between self and non-self through the recognition of antigenic peptides bound to Human Leukocyte Antigen class I (HLA-I) complexes”i.e., HLA-I immunopeptidomes”of patrolled cells. The majority of these antigenic peptides are produced by proteasomes through either peptide hydrolysis or peptide splicing. Proteasome-…
Critical Care Medicine
Objectives: No standard therapy, including anticoagulation regimens, is currently recommended for coronavirus disease 2019. Aim of this study was to evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival. Design: Multicenter international prospective registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019). Setting: Hospitalized patients with coronavirus disease 2019. Patients: Five thousand eight hundred thirty-e…
PLoS One Infectious Diseases
by Shana Kushner Gadarian, Sara Wallace Goodman, Thomas B. Pepinsky Objective To study the U.S. public™s health behaviors, attitudes, and policy opinions about COVID-19 in the earliest weeks of the national health crisis (March 20-23, 2020). Method We designed and fielded an original representative survey of 3,000 American adults between March 20-23, 2020 to collect data on a battery of 38 health-related behaviors, government policy preferences on COVID-19 response and worries about the pandemic. We tes…
BMJ Open
Introduction Youth with brain-based disabilities (BBDs), as well as their parents/caregivers, often feel ill-prepared for the transfer from paediatric to adult healthcare services. To address this pressing issue, we developed the MyREADY TransitionTM BBD App, a patient-facing e-health intervention. The primary aim of this randomised controlled trial (RCT) was to determine whether the App will result in greater transition readiness compared with usual care for youth with BBD. Secondary aims included explorin…
BMC Infectious Diseases
…icipants develop symptoms consistent with COVID-19. For those individuals that seroconvert and/or test positive by SARS-CoV-2 PCR, or receive the SARS-CoV-2 vaccine, additional studies of T cell activation and cytokine production in response to SARS-CoV-2 peptide pools and analysis of Natural Killer cell numbers and function will be conducted on that participant’s cryopreserved baseline peripheral blood mononuclear cells (PBMCs). Following the first year of this study we will further analyze those partici…
Microbe-derived acetate activates the Drosophila immunodeficiency pathway in a subset of intestinal enteroendocrine cells (EECs), which regulates expression of antimicrobial and enteroendocrine peptides. Jugder et al. reveal that acetate induces chromatin remodeling within EECs by specifically modulating the function of the Tip60 histone acetyltransferase complex via a Tip60-steroid hormone axis that is conserved in mammals.
International Journal of Infectious Diseases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative virus for coronavirus disease 2019 (COVID-19). Cell entry of SARS-CoV-2 depends on angiotensin-converting enzyme II (ACE2), which is a membrane-associated zinc peptidase, and transmembrane serine protease 2 (TMPRSS2), which is a cellular serine protease (Zhou et al., 2020b; Hoffmann et al., 2020; Hirano and Murakami, 2020). ACE2 is homologous with, but acts antagonistically to, angiotensin-converting enzyme (ACE), and has the crit…
Journal of Acquired Immune Deficiency Syndromes
…. Radin and Sachathep contributed equally to this article Funding: This research has been supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) through the U.S. Centers for Diseases Control and Prevention under the terms of Cooperative Agreements 1U2GGH000994 and 5NU2GGH001226. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the funding agencies. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Aktuelle smitsomme sygdomme [8]

Morbidity and Mortality Weekly Report (MMWR)
This report describes the impact of COVID-19 on HIV viral load testing in PEPFAR-supported countries.
Other Plant Disease -- SerbiaDuring a survey on tomato viruses conducted in Serbia, virus-like symptoms were observed in July 2019 in tomato plants (_Solanum lycopersicum_) grown in 2 separate plastic tunnels in Jablanica district. Affected plants showed yellow angular spots on the leaves accompanied by necrosis and distortion, as well as fruit discoloration. In these 2 tomato crops, disease incidence was estimated at 80%. Laboratory analysis (serological, molecular and biological tests) confirmed the pres…
Morbidity and Mortality Weekly Report (MMWR)
This report describes sex differences in human immunodeficiency virus testing in sub-Saharan African countries.
Morbidity and Mortality Weekly Report (MMWR)
When taken daily, preexposure prophylaxis (PrEP) reduces the risk of acquiring human immunodeficiency virus (HIV). PrEP is an important tool for preventing HIV among persons at substantial risk for HIV infection, including female sex workers, men who have sex with men, transgender women, and persons who inject drugs.
Morbidity and Mortality Weekly Report (MMWR)
Human immunodeficiency virus (HIV) case-based surveillance continuously and systematically monitors HIV-positive patients throughout their clinical care until death.
Statens Serum Institut
WHO har 1/12-2017 i en rapport fra Strategic Advisory Group of Experts on Immunization, SAGE, udgivet nye retningslinjer på baggrund af ny evidens om brugen af rabiesvacciner og rabies-immunglobulin (RIG).
Morbidity and Mortality Weekly Report (MMWR)
This report describes the impact of COVID-19 on HIV viral load testing in PEPFAR-supported countries.
Rabies -- PakistanA man from the city of Thatta in Sindh province, Pakistan died from rabies after a dog bite due to the local hospital not having rabies post-exposure prophylaxis (PEP). The victim was reportedly attacked by a rabid dog around a week ago and suffered injuries on the head and torso. Relatives took him to the local civil hospital only to find anti-rabies vaccine was not available. Doctors there recommended the family take him to a private hospital; however, they could not afford the cost


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