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Søgning på udtrykket 'pep' giver 36 resultater

Dokumenter [1] Sider [2] Nyt fra tidsskrifterne [20] Aktuelle smitsomme sygdomme [12]

Dokumenter [1]

Endelig guideline: 01.09.2020 Version: 3 Guideline skal revideres senest: 01.09.2023 Arbejdsgruppens medlemmer: Peer Brehm Christensen, Christian Erikstrup, Jan Gerstoft, Terese Katzenstein, Alex Laursen, Suzanne Lunding, Birgitte Mørn og Nina Weis.


Sider [2]

…erstoft, Jens Lundgren, Alex Laursen, Niels Obel, Olav Larsen, Gitte Kronborg, Ann-Brit Eg Hansen Antiviral behandling af hiv smittede personer Fertilitetsbehandling ved HIV og hepatitis B og C HIV behandling af gravide HIV post exposure profylakse (PEP) Pre-exposure profylakse mod HIV (PrEP) Borrelia Anne-Mette Lebech, Sigurdur Skarphedinsson Borrelia klaringsrapport COVID-19 Marie Helleberg/Jens Lundgren, Lothar Wiese, Michael Dalager-Pedersen, Merete Storgaard, Isik Somu…

… Epidemiology and Pathogenesis in the Antiretroviral Era Curr HIV/AIDS Rep. 2015; 12: 6?15 | HIV - persistence on ART & cure research:Margolis et al: Latency reversal and viral clearance to cure HIV-1. Science. 2016; 253: aaf6517 | PREP og PEP:Fonner et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations: AIDS 2016 Jul 31;30(12):1973-83Rodger et al. Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Posi…


Nyt fra tidsskrifterne [20]

Der er mere end 20 resultater, måske du vil se flere resultater her?
Immunity
22.09.2021
The physiological relevance of RNAi in mammalian antiviral immunity remains to be addressed. Fang et al. demonstrate that the antiviral potency of RNAi can be successfully unlocked by abrogating enterovirus-encoded RNAi suppressor via rationally designed peptides, which exert potent anti-enteroviral efficacy in vitro and in vivo in an RNAi-dependent manner.
Antimicrobial Agents And Chemotherapy
13.09.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Science Advances
25.08.2021
The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in human physiology as the principal route for acquiring and retaining dietary nitrogen. A remarkable feature of the SLC15 family is their extreme substrate promiscuity, which has enabled the targeting of these transporters for the improvement of oral bioavailability for several prodrug molecules. Although recent structural and biochemical studies on bacterial homologs have identified conserved sites of proton and peptide…
Antimicrobial Agents And Chemotherapy
23.08.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Lancet
12.08.2021
The President's Emergency Plan for AIDS Relief (PEPFAR), the largest funder of HIV efforts in the world,1 has saved millions of lives since its 2003 launch. With COVID-19 disrupting the HIV response, PEPFAR is needed more than ever to assist more than 50 high HIV burden countries as they struggle to regain momentum against AIDS. Over the past 18 months, maintaining a continuity of HIV services—particularly for marginalised communities—has been an arduous challenge as the HIV and COVID-19 pandemics colli…
BMJ Open
30.07.2021
Introduction Neglected tropical diseases tend to cluster in the same poor populations and, to make progress with their control, they will have to be dealt with in an integrated manner. Peptide microarrays may be a solution to these problems, where diagnosis for co-infection can be detected simultaneously using the one tool. A meta-analysis using hierarchical models will be performed to assess the diagnostic accuracy of peptide microarrays for detecting schistosomiasis (Schistosoma mansoni and S. haematobium…
Infection and Immunity
6.07.2021
Infection and Immunity, <a href="https://journals.asm.org/toc/iai/0/ja">Volume 0, Issue ja</a>, -Not available-.
Journal of Infectious Diseases
18.06.2021
AbstractBackgroundCoronavirus disease 2019 (COVID-19) continues to be a major public health challenge globally. The identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-derived T-cell epitopes is of critical importance for peptide vaccines or diagnostic tools of COVID-19.MethodsIn this study, several SARS-CoV-2-derived human leukocyte antigen (HLA)-I binding peptides were predicted by NetMHCpan-4.1 and selected by Popcover to achieve pancoverage of the Chinese population. The top 5…
BMC Infectious Diseases
16.06.2021
…al bacterial dysbiosis. Limited data are available for intestinal fungal dysbiosis. Moreover, no effective therapeutic drugs are available for these microbiota dysbiosis. The aims of our study were to investigate the therapeutic potential of glucagon-like peptide 2 (GLP-2) for these microbiota dysbiosis in type 2 SBS rats. Methods 8-week-old male SD rats which underwent 80% small bowel resection, ileocecum resection, part…
PLoS One Infectious Diseases
11.06.2021
by Ester Lilian Acen, Irene Andia Biraro, William Worodria, Moses L. Joloba, Bill Nkeeto, Joseph Musaazi, David Patrick Kateete Background Tuberculosis remains a global threat and a public health problem that has eluded attempts to eradicate it. Low vitamin D levels have been identified as a risk factor for tuberculosis infection and disease. The human cathelicidin LL-37 has both antimicrobial and immunomodulatory properties and is dependent on vitamin D status. This systematic review attempts to compare v…
Antimicrobial Agents And Chemotherapy
24.05.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Immunity
20.05.2021
Inflammasomes are multiprotein complexes that execute pyroptosis in response to cytosolic danger signals. DPP9 regulates the CARD8 inflammasome by unknown mechanisms. Here, Sharif et al. report cryo-EM structures of CARD8 bound to DPP9 and show that this complex inhibits CARD8 inflammasome activation downstream of the proteasome.
Infection and Immunity
17.05.2021
Infection and Immunity, <a href="https://journals.asm.org/toc/iai/0/ja">Volume 0, Issue ja</a>, -Not available-.
Antimicrobial Agents And Chemotherapy
19.04.2021
…urgently needed. The injectisome type III secretion system (T3SS), required by dozens of Gram-negative bacteria for virulence but largely absent from non-pathogenic bacteria, is an attractive antimicrobial target. We previously identified synthetic cyclic peptomers, inspired by the natural product phepropeptin D, that inhibit protein secretion through the Yersinia Ysc and Pseudomonas aeruginosa Psc T3SSs, but do not inhibit bacterial growth. Here we describe identification of an isomer, 4EpDN, that is two-f…
Antimicrobial Agents And Chemotherapy
19.04.2021
Antimicrobial Agents and Chemotherapy, <a href="https://journals.asm.org/toc/aac/0/ja">Volume 0, Issue ja</a>, -Not available-.
Science Advances
14.04.2021
…of the current study. FHV infects through the acid-dependent endocytic pathway, where low pH triggers externalization of membrane-disrupting () peptides from the capsid interior. Using all-atom equilibrium and enhanced sampling simulations, the mechanism and energetics of peptide liberation and the effect of pH on this process are investigated. Our computations agree with experimental findings and reveal nanoscopic details regarding the pH control mechanism, which are not readily accessible in experiments.
Trends in Microbiology
6.04.2021
Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
PLoS One Infectious Diseases
17.03.2021
…Adewole, Eze M. Daniel Developing an efficacious vaccine for SARS-CoV-2 infection is critical to stemming COVID-19 fatalities and providing the global community with immune protection. We have used a bioinformatic approach to aid in designing an epitope peptide-based vaccine against the spike protein of the virus. Five antigenic B cell epitopes with viable antigenicity and a total of 27 discontinuous B cell epitopes were mapped out structurally in the spike protein for antibody recognition. We identified …
Infection and Immunity
8.02.2021
…els of the atoms in a system to discover nanoscale insights into the dynamic relationship between mechanism and biological function. Such insights can lay the framework for elucidating mechanism of action and optimizing antibiotic templates. Antimicrobial peptides represent a promising solution to escalating antimicrobial resistance given their lesser tendency to induce resistance than small molecule antibiotics. Simulations of these agents have already revealed how they interact with bacterial membranes an…
Antimicrobial Agents And Chemotherapy
31.08.2009
This article, published ahead of print on 28 July 2008, has been withdrawn by the authors. Although moderate synergy between P2-RANTES and C peptides can be observed with high statistical significance in cell fusion assays, this synergy was not able to be verified in HIV viral assays. The authors regret the overstatement of synergy and will revise the paper for publication at a later date.

Aktuelle smitsomme sygdomme [12]

ProMED
21.07.2021
Other Plant Disease -- RussiaA 20-ton consignment of Uzbek fresh tomatoes arrived in the Irkutsk region [Russia]. Rosselkhoznadzor [Federal Service for Veterinary and Phytosanitary Surveillance] sent samples for examination. Virological results revealed _Pepino mosaic virus_ by PCR method. The test confirms the presence of a dangerous virus in the product. The virus was detected for the 1st time in Irkutsk region. Currently, there is no means of combating the disease. Preventive measures should be observed …
ProMED
1.07.2021
Other Plant Disease -- New ZealandNew Zealand tomato exports to six countries have been stopped, after the _Pepino mosaic virus_ (PepMV) was discovered on crops. The Ministry for Primary Industries (MPI) has notified Australia, Japan, Thailand, Fiji, Tonga, and New Caledonia, because these countries consider PepMV a quarantine risk. The virus was first detected in an Auckland glasshouse and has subsequently been found in tomato production facilities in the wider region. The premises where PepMV has been fou…
Morbidity and Mortality Weekly Report (MMWR)
27.05.2021
This report describes the impact of COVID-19 on HIV viral load testing in PEPFAR-supported countries.
ProMED
13.04.2021
Other Plant Disease -- SerbiaDuring a survey on tomato viruses conducted in Serbia, virus-like symptoms were observed in July 2019 in tomato plants (_Solanum lycopersicum_) grown in 2 separate plastic tunnels in Jablanica district. Affected plants showed yellow angular spots on the leaves accompanied by necrosis and distortion, as well as fruit discoloration. In these 2 tomato crops, disease incidence was estimated at 80%. Laboratory analysis (serological, molecular and biological tests) confirmed the pres…
Morbidity and Mortality Weekly Report (MMWR)
3.12.2020
This report describes sex differences in human immunodeficiency virus testing in sub-Saharan African countries.
Morbidity and Mortality Weekly Report (MMWR)
27.02.2020
When taken daily, preexposure prophylaxis (PrEP) reduces the risk of acquiring human immunodeficiency virus (HIV). PrEP is an important tool for preventing HIV among persons at substantial risk for HIV infection, including female sex workers, men who have sex with men, transgender women, and persons who inject drugs.
Morbidity and Mortality Weekly Report (MMWR)
27.11.2019
Human immunodeficiency virus (HIV) case-based surveillance continuously and systematically monitors HIV-positive patients throughout their clinical care until death.
Statens Serum Institut
14.12.2017
WHO har 1/12-2017 i en rapport fra Strategic Advisory Group of Experts on Immunization, SAGE, udgivet nye retningslinjer på baggrund af ny evidens om brugen af rabiesvacciner og rabies-immunglobulin (RIG).
ProMED
18.07.2021
Rabies -- United StatesA trip to a theme park now has 2 guests having to undergo [preventative] treatment for rabies. The Hampton-Peninsula Health District has alerted guests a rabid fox attacked 2 people at Busch Gardens, Williamsburg [Virginia], WTKR reported. A boy was bitten on 5 Jul 2021 by the fox and had to have 4 injections of rabies treatment. [Post Exposure Prophylaxis or PEP - Mod.TG] WTKR reported. He is OK. A man was also exposed to the fox. The fox was captured and died shortly after, WAVY
ProMED
1.07.2021
Other Plant Disease -- New ZealandNew Zealand tomato exports to six countries have been stopped, after the _Pepino mosaic virus_ (PepMV) was discovered on crops. The Ministry for Primary Industries (MPI) has notified Australia, Japan, Thailand, Fiji, Tonga, and New Caledonia, because these countries consider PepMV a quarantine risk. The virus was first detected in an Auckland glasshouse and has subsequently been found in tomato production facilities in the wider region. The premises where PepMV has been fou…
Morbidity and Mortality Weekly Report (MMWR)
27.05.2021
This report describes the impact of COVID-19 on HIV viral load testing in PEPFAR-supported countries.
ProMED
26.04.2021
Rabies -- PakistanA man from the city of Thatta in Sindh province, Pakistan died from rabies after a dog bite due to the local hospital not having rabies post-exposure prophylaxis (PEP). The victim was reportedly attacked by a rabid dog around a week ago and suffered injuries on the head and torso. Relatives took him to the local civil hospital only to find anti-rabies vaccine was not available. Doctors there recommended the family take him to a private hospital; however, they could not afford the cost

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