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Dokumenter [1]
Version: 3.
Sider [2]
[…] atelektase og visse grundsygdomme, der kan påvirke luftvejsrensningen (neuromuskulære sygdomme, kroniske lungesygdomme), blevet anbefalet. Dette er ikke evidensbaseret, men i og med at komplikationsraten er lav kan lungefysioterapi overvejes hos udvalgte patienter.43,44 Systemiske steroider Overvej systemisk steroid ved svær CAP og behov for high-flow ilt, non-invasiv eller invasiv ventilation (A). Rationale: Ud fra den seneste evidens fra fire metaanalyser45–48 der også […]
[…] in the Antiretroviral Era Curr HIV/AIDS Rep. 2015; 12: 6?15 HIV - persistence on ART & cure research:Margolis et al: Latency reversal and viral clearance to cure HIV-1. Science. 2016; 253: aaf6517 PREP og PEP:Fonner et al. Effectiveness and safety of oral HIV preexposure prophylaxis for all populations: AIDS 2016 Jul 31;30(12):1973-83Rodger et al. Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using […]
Nyt fra tidsskrifterne [+20]
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Science Advances
7. november 2025
Science Advances, Volume 11, Issue 45, November 2025.
PLoS One Infectious Diseases
31. oktober 2025
[…] adult brain tumours. Whilst T cell recruitment into ZIKV-infected brain tumours is becoming well documented, the specific mechanisms through which they are activated are poorly understood. We address this by employing a combined global proteome and immunopeptidome mass spectrometry approach to describe, for the first time, human leukocyte antigen (HLA) presentation of ZIKV peptides on the surface of infected brain tumour cells. We first show that antigen processing and presentation by HLA class I (HLA-I) […]
Proceedings of the National Academy of Sciences
30. oktober 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 44, November 2025. SignificanceRheumatoid arthritis is an autoimmune disease characterized by the presence of antibodies against citrullinated epitopes. The source of such peptides and trigger leading to the disease onset are still under debate. In this paper, we show that ...
Proceedings of the National Academy of Sciences
28. oktober 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 44, November 2025. SignificanceAntimicrobial peptides (AMPs) are potent natural antibiotics, effective against resistant bacteria, yet their precise mechanisms of action remain unclear. Traditionally, it is believed that AMPs form structural pores in bacterial membranes. ...
Proceedings of the National Academy of Sciences
22. oktober 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. SignificanceThe dual oxidase 2 (Duox2)/reactive oxygen species (ROS) system and the Relish/antimicrobial peptides (AMP) pathway have traditionally been regarded as distinct branches of arthropod antibacterial immunity. However, this study reveals that ...
Proceedings of the National Academy of Sciences: Immunology and Inflammation
17. oktober 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. SignificanceThe dual oxidase 2 (Duox2)/reactive oxygen species (ROS) system and the Relish/antimicrobial peptides (AMP) pathway have traditionally been regarded as distinct branches of arthropod antibacterial immunity. However, this study reveals that ...
PLoS One Infectious Diseases
13. oktober 2025
[…] Tom A. W. Schoufour, Linda Voogd, Kees L.M.C. Franken, Tom H.M. Ottenhoff, Ruud H.M. Wijdeven, Simone A. Joosten Human leukocyte antigen E (HLA-E) communicates cellular health to natural killer (NK) cells through presentation of peptides derived from the leader sequence of classical major histocompatibility complex class I (MHC-I), inhibiting NK cell activation and lysis of healthy cells. Besides this canonical role, HLA-E can also present peptides from pathogens such as Mycobacterium […]
PLoS One Infectious Diseases
9. oktober 2025
[…] Marcela Flórez-Castillo Antimicrobial resistance represents a critical global public health challenge, leading to increased mortality and morbidity due to the ineffectiveness of current antibiotics against bacterial infections. Antimicrobial peptides (AMPs) offer a promising alternative for treating bacterial infections because of their broad-spectrum activity, biocompatibility, and rapid bactericidal action. Recent studies have demonstrated that Ib-M peptides exhibit bactericidal activity against […]
AIDS
8. oktober 2025
Introduction: We assessed implementation of TB services among children living with HIV (CLHIV) (
Virulence
1. oktober 2025
Volume 16, Issue 1, December 2025 .
Proceedings of the National Academy of Sciences
25. september 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 38, September 2025.
Proceedings of the National Academy of Sciences
5. september 2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceMembrane active peptides are cationic amphipathic molecules that disrupt biological membranes to perform their function. Antimicrobial peptides, which are permeabilizing, kill bacteria and cancer cells, making them promising candidates to ...
Microbiology and Molecular Biology Reviews
30. august 2025
Microbiology and Molecular Biology Reviews, Ahead of Print.
Journal of Infectious Diseases
14. august 2025
[…] the Plasmodium circumsporozoite protein (CSP). We have now developed a chimeric peptide, PfAg, contained regions from Plasmodium falciparum CSP and AgTRIO. Mice administered PfAg generated robust humoral responses against both PfCSP and AgTRIO. Following exposure to PfCSP-expressing Plasmodium berghei-infected mosquitoes, PfAg-immunized inbred C57BL/6 and outbred CD-1 mice had significantly improved survival compared to control animals. These data will aid in the development of a new malaria […]
Journal of Acquired Immune Deficiency Syndromes
4. august 2025
No abstract available
PLoS One Infectious Diseases
23. juli 2025
[…] characteristics, we have explored the possibility to develop approach against SARS-CoV-2 infection, less dependent on viral variants. This paper is a continuation of our previous research, where we have used the RRM model to design de novo peptide CovA, capable to prevent SARS-CoV-2 interaction with ACE2 receptor on host cells. Using Inhibitor Screening Assay Kits and viral replication in SARS-CoV-2/Vero E6 cells model, it has been previously shown that CovA can prevent viral interaction with […]
Science Advances
19. juli 2025
Science Advances, Volume 11, Issue 29, July 2025.
PLoS One Infectious Diseases
18. juli 2025
[…] control their native populations in PR. Additionally, these coquis expressed several antimicrobial peptides, which were previously reported to be absent in coquis. These peptides may play a role in the invasiveness of the common coqui and its tolerance to urban and degraded habitats. We also provide novel draft transcriptomes of close relatives of E. coqui: Eleutherodactylus planirostris, Eleutherodactylus johnstonei, Eleutherodactylus cochranae, and Pristimantis […]
Current Opinion in Critical Care
11. juli 2025
[…] of review This review aims to synthesize current evidence on the expanding role of glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) beyond glycemic control, particularly in the context of critical illness. With growing recognition of their anti-inflammatory, immunomodulatory, and organ-protective properties, GLP-1RAs show promise in managing complications such as sepsis, acute respiratory distress syndrome (ARDS), acute kidney injury, and multiorgan dysfunction. This review explores their […]
Science
11. juli 2025
Science, Volume 389, Issue 6756, Page 135-135, July 2025.
Aktuelle smitsomme sygdomme [+20]
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Medscape Infectious Diseases
31. juli 2025
Findings could support new vaccine development to mitigate rapid virus mutation. Medscape Medical News
Medscape Infectious Diseases
15. juli 2025
French health officials received dozens of reports of needle pricks at a public festival, sparking fear about HIV and chemical submission. Medscape News UK
Medscape Infectious Diseases
18. januar 2025
Dr Jessica A. Penney and Sherry Chen at the Centers for Disease Control and Prevention provide guidance on doxy-PEP for STI prevention. CDC Expert Commentary
Medscape Infectious Diseases
12. december 2024
Antimicrobial peptides have not typically lived up to their promise, especially when it comes to beating antibiotic resistance, but novel avenues could see them reach the clinic yet. Medscape Medical News
Medscape Infectious Diseases
19. november 2024
Approximately 80% of patients who started STI-PEP via telehealth remained in HIV PrEP care after 3 months Medscape Medical News
Eurosurveillance latest updates
31. oktober 2025
We report a confirmed autochthonous human case of classical rabies in Romania involving an individual in their mid-40s from Iași county, who was bitten by a free-roaming dog in February 2025. The case did not receive post-exposure prophylaxis (PEP) and died from rabies in July 2025. This event highlights critical gaps in rabies prevention, the importance of timely PEP, and the need for continued vigilance in rabies surveillance and public health communication.
ProMED
3. august 2025
[…] Peppler DPhil, Adjunct Associate Professor, University of Alberta, Canada If you can’t imagine a world without ProMED, please join us now by selecting a subscription plan at www.promedmail.org/subscribe. If you have any questions, please contact us here. Sincerely, Julia Maxwell Director of Disease Surveillance ISID ProMED Support 867 Boylston Street, 5th Floor #1985, Boston, MA 02116 Unsubscribe - Unsubscribe Preferences Kill the Newsletter! feed […]
ProMED
16. maj 2025
[…] a \'more streamlined user interface,\' and Dale Menges (Pharm.D., Pharmacist at New Mexico State University) says, \'Updated format is clean, easy to navigate.\' We also wanted to share a valuable comment from Mark S. Peppler (DPhil, Adjunct Associate Professor, Division of Medical Laboratory Science, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada). Mark wrote us and said \'Delighted for the search function! I need that for […]
ProMED
17. april 2025
[…] direct contact with mucosa (e.g., eyes, mouth, oropen wounds). Once clinical symptoms appear, rabies is virtually 100%fatal\' (www.who.int/news-room/fact-sheets/detail/rabies). \'Rabies deaths are preventable with prompt post-exposure prophylaxis(PEP) by stopping the virus from reaching the central nervous system.PEP consists of thorough wound washing, administration of a course ofhuman rabies vaccine and, when indicated, rabies immunoglobulins(RIG)\' […]
ProMED
15. april 2025
[…] Respiratory failure can occur. - Mod.LL ProMED map:Lviv, Lviv Oblast, Ukraine:promedmail.org/promed-post?place=8723651,9359] [See Also:Botulism - Ukraine (02): (DP)promedmail.org/post/20250324.8723118 Botulism - Russia: (RO) canned pepperspromedmail.org/post/20250320.8723028 Botulism - Ukraine: (LV) canned meatpromedmail.org/post/20250319.8722980 Botulism - Uzbekistan: (BU) canned tomatoes, fatalpromedmail.org/post/20250210.8722012 Botulism - Iran: (KE) canned […]
ProMED
14. april 2025
[…] of 20 children with fatal KD across 5 decades, 10from the United States and 10 from Japan, and were absent in 19 of 20infant controls (P < .001). We also found that all 12 childrenwithacute KD generated plasmablast(s) recognizing the previously reportedpeptide antigen. Taken together, these results point to 1 predominantcausative agent of KD across many decades and geographic areas andshould direct future KD research studies.\' The identity of this potential cause is yet unknown but theobservation may […]
ProMED
11. april 2025
[…] aggressive treatment and supportive care, includingcontinuous fluid drainage and mechanical ventilation\'. \'Anthrax post-exposure prophylaxis and treatment ---------------------------- \'Antibiotics Antibiotics can be used for post-exposure prophylaxis (PEP) to preventanthrax from developing in people who have been exposed but are notsymptomatic. All types of anthrax infection can be treated withantibiotics. Two of the most common antibiotics given offer the sameprotection against anthrax: - […]
ProMED
11. april 2025
[…] health concern in the Asia-Pacific Region. The disease ispredominantly transmitted by domestic dogs; it is almost invariablyfatal once clinical signs appear. Successful rabies control includes:(i) prompt access to post-exposure prophylaxis (PEP) following anexposure, including thorough wound washing, a series of rabiesvaccines, and in some cases, rabies immunoglobulin (RIG)/rabiesmonoclonal antibodies (RmAbs); (ii) mass dog vaccination to preventdisease transmission at its source; and (iii) […]
ProMED
8. april 2025
[…] of all domestic carnivores. Nevertheless, the incidence ofhuman and animal rabies cases remained steady with an average of 20human deaths per year, and an average of 120 000 people are exposed torabies yearly and eventually go through PEP procedure\'(doi.org/10.1016/j.prevetmed.2018.07.011). The following study, published in July 2024, aimed to assess theknowledge, attitude, and practice (KAP) of Algerian universitystudents regarding rabies: doi.org/10.3390/ani14152193. […]
ProMED
3. april 2025
[…] Botulism - USA (04): (TX) wound, injection drug related, 2020-21promedmail.org/post/20220527.8703504 Botulism - USA (03): (WA) probable case, home-canned food, fatalpromedmail.org/post/20220428.8702905 Botulism - USA (02): jarred sweet peppers, risk, recallpromedmail.org/post/20220421.8702754 Note: This content and the data herein may not be copied, reproduced,scraped, redistributed, reused, or repurposed alone or together withany other data without the express consent of ISID or […]
ProMED
30. marts 2025
[…] and territoriesacross the globe. Up to 95% of human deaths occur in Africa and Asiawhere dog rabies is poorly controlled and disproportionately affectspoor rural communities where control programmes and access toappropriate post-exposure prophylaxis (PEP) is limited ornon-existent. \'Because rabies is under-reported, mis- and under-diagnosed, data onhuman deaths, access to vaccines, and occurrence in animal populationsis limited. Currently, these data are more likely to indicate thepresence of the […]
ProMED
29. marts 2025
[…] 1990, over 80 people have died from rabies after an exposureduring travel. Rabies is prevalent globally except in Antarctica. InAfrica, Asia, and specific areas of Central and South America, rabiesin dogs is still a major problem. Additionally, access to PEP may behard to get in those places. As a result, tens of thousands of peopledie of the disease each year. \'When traveling, it is important to keep your distance from wild andunfamiliar animals, including dogs and cats. Before traveling abroad,consult […]
ProMED
18. marts 2025
[…] Botulism - USA (04): (TX) wound, injection drug related, 2020-21promedmail.org/post/20220527.8703504 Botulism - USA (03): (WA) probable case, home-canned food, fatalpromedmail.org/post/20220428.8702905 Botulism - USA (02): jarred sweet peppers, risk, recallpromedmail.org/post/20220421.8702754 Note: This content and the data herein may not be copied, reproduced,scraped, redistributed, reused, or repurposed alone or together withany other data without the express consentof ISID or […]
ProMED
17. marts 2025
[…] also emphasise the establishment of dedicated centres at thedistrict level for treatment of dog-bite injuries given the fact thatrabies is fatal in 100 per cent of cases. Deaths from the infection are preventable with prompt post-exposureprophylaxis (PEP) by stopping the virus from reaching the centralnervous system. Rabies can be completely prevented if the wound is immediately andthoroughly flushed and washed with soap and flowing water, followed byan effective anti-rabies vaccine series and RIG […]
ProMED
9. marts 2025
[…] Botulism - USA (04): (TX) wound, injection drug related, 2020-21promedmail.org/post/20220527.8703504 Botulism - USA (03): (WA) probable case, home-canned food, fatalpromedmail.org/post/20220428.8702905 Botulism - USA (02): jarred sweet peppers, risk, recallpromedmail.org/post/20220421.8702754 Note: This content and the data herein may not be copied, reproduced,scraped, redistributed, reused, or repurposed alone or together withany other data without the express consent of ISID or […]