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PLoS One Infectious Diseases
23.05.2025
…ins one of the leading causes of morbidity and mortality in critically ill children worldwide. Identifying reliable prognostic markers is essential for improving risk stratification and guiding targeted therapies. While some studies in adults suggest that procalcitonin (PCT) clearance may better predict sepsis outcomes, there is limited information regarding pediatric sepsis. This study aimed to evaluate whether PCT clearance is associated with mortality among children with severe sepsis and septic shock…
Journal of the American Medical Association
21.05.2025
To the Editor Although the ADAPT-Sepsis multicenter randomized clinical trial found that care guided by PCT measurement safely reduced antibiotic duration compared with standard care, several important considerations warrant further discussion.
Journal of the American Medical Association
21.05.2025
To the Editor We are writing to express some concerns about a recent trial of PCT-guided care compared with standard care to guide duration of antibiotics in hospitalized patients.
Journal of the American Medical Association
21.05.2025
To the Editor Given its diminishing role as a diagnostic tool to differentiate between bacterial and nonbacterial infections, PCT is increasingly being investigated for its ability to reduce the duration of antibiotic therapy. The current study by the ADAPT-Sepsis Collaborators reported a mean reduction of 0.88 days in the daily PCT-guided protocol compared with a mean duration of 10.7 (SD, 7.6) days in the standard care group—a relative reduction of 8.2%.
Journal of the American Medical Association
21.05.2025
…marker-guided antibiotic duration vs standard care in critically ill patients with sepsis, found that a procalcitonin (PCT) protocol decreased antibiotic duration (mean difference, 0.88 days; 95% CI, 0.19 to 1.58) but increased mortality (absolute difference, 1.57; 95% CI, −2.18 to 5.32). The authors, likely relying on the 95% CI for mortality being less than their 5.4% noninferiority margin, concluded, “Care guided by measurement of PCT reduces antibiotic duration safely compared with standard care.”
Journal of the American Medical Association
21.05.2025
In Reply We designed the ADAPT-Sepsis trial as a superiority study, addressing a prioritized research funding brief and international evidence gaps. Our sample size estimate, type I error rate, and power were largely driven by a clinical effectiveness outcome (total antibiotic treatment duration to 28 days after randomization) and not safety (28-day all-cause mortality)…
American Journal of Tropical Medicine and Hygiene
8.05.2025
. . Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 112 Issue: 5 Pages: 1060-1064. .
BMC Infectious Diseases
25.03.2025
…ior antibiotic treatment or without parental consent were excluded from the study. Blood samples were collected and analyzed for routine blood parameters, liver and kidney function metrics, levels of C-reactive protein (CRP), procalcitonin (PCT), lactic acid, and PTX-3. . Results. The incidence of premature rupture of membranes was significantly lower in the sepsis and localized infection groups compared to the non-infected group (22.86%, 11.11%, and 2.63%; P
BMJ Open
6.03.2025
. Introduction. Antimicrobial resistance is a major global health threat, driven largely by the misuse and overuse of antibiotics. Point-of-care (POC) tests for inflammatory biomarkers like procalcitonin (PCT) have shown promise in reducing unnecessary antibiotic prescriptions. The hybrid type II ImpPro trial aims to evaluate the implementation and effectiveness of POC-PCT on antibiotic prescriptions by primary care physicians (PCP) in French-speaking Switzerland…
BMC Infectious Diseases
5.02.2025
. Abstract. . Objectives. Procalcitonin (PCT) is a critical diagnostic biomarker for bacterial infections in patients. Numerous studies have shown that PCT have high sensitivity and specificity for diagnosing bloodstream infection. However, the cut-off value of PCT for the diagnosis of bloodstream infections in patients with hematolgic diseases is still unclear and unreliable. . . …
Clinical Microbiology and Infection
30.01.2025
Antimicrobial resistance (AMR) has been estimated to be associated with 4.9 million deaths annually, directly causing 1.3 million of these fatalities [1]. Recent trend analyses predict that these figures will rise significantly over the next 25 years. Projections suggest that as many as 102 million deaths worldwide could be averted during this period through improved management of infections [2]…
BMC Infectious Diseases
17.01.2025
. Abstract. . Background. To assess the value of combined Monocyte Distribution Width (MDW) and Procalcitonin (PCT) detection in diagnosing and predicting neonatal sepsis outcomes. . . . Methods…
BMJ Open
22.12.2024
. Objectives. Intensive care unit (ICU) clinicians stop antibiotics more often, with a negative infection: point-of-care test (PCR-POCT). Simulated cases of diagnostic uncertainty regarding infection resolution led clinicians to choose options such as procalcitonin (PCT) and/or PCR-POCTs +/– de-escalation to aid stop decisions. We hypothesised that a direct infection indicator, PCR-POCT, would influence stop judgements more than indirect PCT…
Clinical Microbiology and Infection
9.12.2024
To analyze the effect and safety of PCT-guided antibiotic therapy in patients with AECOPD.
Critical Care Explorations
25.10.2024
OBJECTIVES: . To evaluate the effect of procalcitonin-guided management on the duration of antibiotic therapy in critically ill cancer patients with sepsis. DESIGN: . Randomized, controlled, single-blinded trial. SETTING: . A comprehensive multidisciplinary cancer hospital in Jordan. PATIENTS: . Adults with cancer treated in the ICU who were started on antibiotics for suspected infection, met the SEPSIS-3 criteria, and were expected to stay in the ICU greater than or equal to 48 hours…
International Journal of Infectious Diseases
4.10.2024
At the emergency department (ED) a urinary tract infection (UTI) is frequently suspected as the cause of inflammation or illness.1 Accurate confirmation or exclusion of a UTI in the ED time window can be challenging since urine culture (UC) results are unavailable during an ED visit…
BMC Infectious Diseases
12.09.2024
. Abstract. Inflammation is a potential risk factor of voriconazole (VCZ) overdose, procalcitonin (PCT) is reported to act as a diagnostic marker for bacterial infections. However, the association of PCT with VCZ trough serum concentrations (VCZ-Cmin) is not fully clear. Our study aims to investigate the associations between PCT and VCZ-Cmin…
Critical Care Medicine
9.07.2024
Objectives: . In sepsis treatment, antibiotics are crucial, but overuse risks development of antibiotic resistance. Recent guidelines recommended the use of procalcitonin to guide antibiotic cessation, but solid evidence is insufficient. Recently, concerns were raised that this strategy would increase recurrence. Additionally, optimal protocol or difference from the commonly used C-reactive protein (CRP) are uncertain…
BMC Infectious Diseases
24.05.2025
…h evaluation (APACHE) II score(OR = 0.872, 95% CI 0.792–0.961), computed tomography (CT) total score(OR = 1.407, 95% CI 1.258–1.575), secretion color(OR = 2.719, 95% CI 1.562–4.734), mucosal edema(OR = 5.064, 95% CI 2.748-9.300), and procalcitonin (PCT) (OR = 0.871, 95% CI 0.806–0.941). The Area Under Curve (AUC) of the model in the development cohort and validation cohort was 0.913(95%CI 0.875–0.951) and 0.811(95%CI 0.739–0.883), respectively…
BMC Infectious Diseases
22.05.2025
…nce. The optimal model selected was further assessed, with model interpretability provided using SHapley Additive exPlanations (SHAP). . Result. Nine predictive factors were identified: Mechanical Ventilation, Procalcitonin (PCT), Interleukin-8 (IL-8), Interleukin-6 (IL-6), Blood Urea Nitrogen, Glucose, Creatine Kinase, Lactate Dehydrogenase, and Mean Platelet Volume (MPV)…