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BMC Infectious Diseases
25.03.2025
…ior antibiotic treatment or without parental consent were excluded from the study. Blood samples were collected and analyzed for routine blood parameters, liver and kidney function metrics, levels of C-reactive protein (CRP), procalcitonin (PCT), lactic acid, and PTX-3. . Results. The incidence of premature rupture of membranes was significantly lower in the sepsis and localized infection groups compared to the non-infected group (22.86%, 11.11%, and 2.63%; P
BMJ Open
6.03.2025
. Introduction. Antimicrobial resistance is a major global health threat, driven largely by the misuse and overuse of antibiotics. Point-of-care (POC) tests for inflammatory biomarkers like procalcitonin (PCT) have shown promise in reducing unnecessary antibiotic prescriptions. The hybrid type II ImpPro trial aims to evaluate the implementation and effectiveness of POC-PCT on antibiotic prescriptions by primary care physicians (PCP) in French-speaking Switzerland.
BMC Infectious Diseases
5.02.2025
. Abstract. . Objectives. Procalcitonin (PCT) is a critical diagnostic biomarker for bacterial infections in patients. Numerous studies have shown that PCT have high sensitivity and specificity for diagnosing bloodstream infection. However, the cut-off value of PCT for the diagnosis of bloodstream infections in patients with hematolgic diseases is still unclear and unreliable. . . .
Clinical Microbiology and Infection
30.01.2025
Antimicrobial resistance (AMR) has been estimated to be associated with 4.9 million deaths annually, directly causing 1.3 million of these fatalities [1]. Recent trend analyses predict that these figures will rise significantly over the next 25 years. Projections suggest that as many as 102 million deaths worldwide could be averted during this period through improved management of infections [2].
BMC Infectious Diseases
17.01.2025
. Abstract. . Background. To assess the value of combined Monocyte Distribution Width (MDW) and Procalcitonin (PCT) detection in diagnosing and predicting neonatal sepsis outcomes. . . . Methods.
BMJ Open
22.12.2024
. Objectives. Intensive care unit (ICU) clinicians stop antibiotics more often, with a negative infection: point-of-care test (PCR-POCT). Simulated cases of diagnostic uncertainty regarding infection resolution led clinicians to choose options such as procalcitonin (PCT) and/or PCR-POCTs +/– de-escalation to aid stop decisions. We hypothesised that a direct infection indicator, PCR-POCT, would influence stop judgements more than indirect PCT.
Clinical Microbiology and Infection
9.12.2024
To analyze the effect and safety of PCT-guided antibiotic therapy in patients with AECOPD.
Critical Care Explorations
25.10.2024
OBJECTIVES: . To evaluate the effect of procalcitonin-guided management on the duration of antibiotic therapy in critically ill cancer patients with sepsis. DESIGN: . Randomized, controlled, single-blinded trial. SETTING: . A comprehensive multidisciplinary cancer hospital in Jordan. PATIENTS: . Adults with cancer treated in the ICU who were started on antibiotics for suspected infection, met the SEPSIS-3 criteria, and were expected to stay in the ICU greater than or equal to 48 hours.
International Journal of Infectious Diseases
4.10.2024
At the emergency department (ED) a urinary tract infection (UTI) is frequently suspected as the cause of inflammation or illness.1 Accurate confirmation or exclusion of a UTI in the ED time window can be challenging since urine culture (UC) results are unavailable during an ED visit.
BMC Infectious Diseases
12.09.2024
. Abstract. Inflammation is a potential risk factor of voriconazole (VCZ) overdose, procalcitonin (PCT) is reported to act as a diagnostic marker for bacterial infections. However, the association of PCT with VCZ trough serum concentrations (VCZ-Cmin) is not fully clear. Our study aims to investigate the associations between PCT and VCZ-Cmin.
Critical Care Medicine
9.07.2024
Objectives: . In sepsis treatment, antibiotics are crucial, but overuse risks development of antibiotic resistance. Recent guidelines recommended the use of procalcitonin to guide antibiotic cessation, but solid evidence is insufficient. Recently, concerns were raised that this strategy would increase recurrence. Additionally, optimal protocol or difference from the commonly used C-reactive protein (CRP) are uncertain.
BMC Infectious Diseases
11.04.2025
…osed with SFTS were enrolled, including 216 (87.8%) patients in the non-DIC group and 30 (12.2%) patients in the DIC group. ALT, AST, ALP, GGT, LDH, creatinine, cystatin-C, amylase, lipase, CK, CK-MB, troponin I, BNP, PT, PTA, APTT, TT, FDP, D-dimer, CRP, procalcitonin, IL-6, SAA, ESR, ferritin levels, and viral load were significantly higher in patients with DIC. The cumulative survival rate of patients with DIC was significantly lower than that of patients without DIC.
International Journal of Infectious Diseases
2.04.2025
A 63-year-old man with rheumatoid arthritis on methotrexate and iguratimod presented with a seven-day fever, cough, and dyspnea. Laboratory tests revealed leukopenia (1,200/μL), elevated C-reactive protein (35.5 mg/dL), procalcitonin (11.5 ng/mL), and hepatic and renal dysfunction. Chest CT showed multiple cavitary lesions and infiltrates in both lungs with bilateral pleural effusion (Figure 1).
BMJ Open
28.03.2025
… estimated glomerular filtration rate, procalcitonin, albumin, ferritin and bilirubin among PLWD with and without SARS-CoV-2 infection. . Conclusions. SARS-CoV-2 infection is associated with elevated risks of mortality and acute kidney injury and poor glycaemic control in PLWD, alongside increased levels of inflammatory and coagulation biomarkers. These findings underscore the urgent need for tailored clinical management strategies for PLWD with COVID-19. . PROSPERO registration number. CRD42023418039. .
BMC Infectious Diseases
27.03.2025
…otic lesions, indicative of mucormycosis. Following the diagnosis of acute myeloid leukemia (AML), the patient experienced severe complications, including septic shock. Despite appropriate treatment, inflammatory markers, such as C-reactive protein (CRP), procalcitonin (PCT), and IL-6, were significantly elevated. CRRT with Cytosorb was initiated to manage hypercytokinemia and improve the patient’s clinical status. . Intervention.
Critical Care Explorations
16.03.2025
…mponent. Longitudinal analyses revealed that seven proteins were elevated in persistent AKI compared with no AKI.
Journal of the American Medical Association
26.02.2025
This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antibiotics while maintaining treatment safety measured by 28-day all-cause mortality.
PLoS One Infectious Diseases
14.02.2025
…nts, of whom 45 were diagnosed with bacterial infections. A confirmed bacterial infection was defined as documented bacteriological evidence in any bacterial sample. Clinical parameters and biological markers (including cortisol, C-reactive protein (CRP), procalcitonin, etc.) were recorded during the initial DKA phase. Multivariate regression analysis was employed to construct a diagnostic model.
BMC Infectious Diseases
30.01.2025
…aracteristics of immune response in children with SARS-CoV-2 infection and Mycoplasma pneumoniae infection, focusing on the changes in immune indicators such as eosinophils (EOS), immunoglobulin E (IgE), interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT). . . . Methods.
BMC Infectious Diseases
30.01.2025
…3%). Whereas 107/122 (87.7%) were discharged after a median of seven days, in-hospital mortality was 15/122 (12.3%) after a median of 16 days. Baseline factors associated with mortality were neutrophil-lymphocyte ratio > 8, D-dimer ≥ 1800 ng/mL, procalcitonin ≥ 1.0 ng/mL, and albumin 12 days, hospitalisation for ≥ 10 days, higher oxygen requirements with the resulting corticosteroid use, and healthcare-associated bacteraemia were associated with increased odds of mortality. .