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Dokumenter [2]
Disse rekommandationer retter sig mod voksne indlagt med mistænkt sepsis og septisk shock. Se flowchart på infmed.dk/bilag#sepsis_flowchart_(2021).pdf
Bilag med flowchart til vurdering og behandling af sepsis og septisk shock, se også infmed.dk/guidelines#sepsis_guidelines_(2021).pdf
Sider [1]
…ge, Jon Gitz Holler, Nordsjællands Hospital. 12. juni 2024 (dag 2): Sepsis, antibiotika, urinvejsinfektioner. Tid. Emne og underviser. 08.30 – 12.30. SEPSIS. 08.30 – 09.30. Det septiske shock. Professor, overlæge Anders Perner, Intensiv, RH. 09.30 – 09.45. Pause. 09.45 – 10.30. Definition og behandling af sepsis I. Overlæge Christian Fischer, Infektionsmedicin, Hvidovre…
Professor Court Petersen kommenterer: Velskreven oversigtsartikel, der bør læses af alle, der har med sepsispatienter at gøre. Artiklen "afliver" det noget forældede SIRS begreb. Andre 2013-artikler fra NEJM kan med stor fordel læses som supplement: "Circulatory shock" N Engl J Med. 2013;369(18):1726-34 "Resuscitation fluids" N Engl J Med. 2013;369(13):1243-51 "Ventilator-induced lung injury" N Engl J Med. 2013;369(22):2126-36
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Critical Care Explorations
19.06.2025
IMPORTANCE: . A characteristic pattern of bacterial and fungal septic shock is decreased left ventricular (LV) ejection fraction (LVEF) and modest dilatation of the LV. In survivors, the myocardial depression and dilatation are reversible within several days. In a cohort of 368 hospitalized COVID patients with shock from March 2020 to December 2021, 15 patients were identified with an echocardiogram determined depressed LVEF during acute shock, and a follow-up echocardiogram was performed. OBJECTIVES: …
Critical Care Medicine
19.06.2025
…. Medical ICU of a university teaching hospital. Patients: . Deeply sedated, intubated adult patients with moderate to severe ARDS with Pao2/Fio2 less than 150 mm Hg, with a positive end-expiratory pressure of greater than or equal to 5 cm H2O and septic shock monitored with a pulmonary arterial catheter. Interventions: . Sedation was switched from IV midazolam to sevoflurane inhalation. Measurements and Main Results: …
Critical Care Medicine
19.06.2025
…bjectives: . Hypotension is common in septic children, mean blood pressure (MBP) guides vasoactive agent titration. However, the Surviving Sepsis Guidelines for children were unable to recommend whether to target the 5th or 50th MBP percentile for septic shock. We aim to compare two MBP targets (5th vs. 50th percentile) for titrating vasoactive agents in septic shock patients. Design: . Single-center, open-label, randomized noninferiority trial. Setting: …
Critical Care Medicine
19.06.2025
Objectives: . Septic shock is the most severe and final stage of sepsis. These patients may have a higher risk for sepsis-associated acute kidney injury (AKI). The purpose of this study is to determine the frequency of AKI, major adverse kidney events at 30 days (MAKE-30), and use of renal replacement therapy (RRT) in patients with septic shock. We also aim to determine the association between stage of AKI and in-hospital mortality. Design: . Retrospective, multicenter, cohort study. Setting: …
International Journal of Infectious Diseases
18.06.2025
Streptococcal toxic shock syndrome (STSS) is a life-threatening bacterial disease with a sudden onset that rapidly progresses to multiple organ failure [1]. Since 20 adult patients who had serious infections with shock caused by Streptococcus pyogenes (Group A Streptococcus; GAS) were reported in the United States in 1989 [2], STSS caused by GAS has been a significant health concern in industrialized countries due to its high case fatality rate (CFR)…
PLoS One Infectious Diseases
7.06.2025
… systemic condition marked by excessive immune defense against infection. Within this research, we explored the serum concentration of S100A9 during hospital admission, aiming to assess its role and reliability as a viable biomarker for identifying septic shock and predicting mortality risk in sepsis…
Emerg Microbes Infect
4.06.2025
Volume 14, Issue 1, December 2025 .
PLoS One Infectious Diseases
29.05.2025
…s (UC). The increase in mitochondrial membrane permeability caused by the opening of the mitochondrial membrane permeability transition pore (mPTP) is a key link in the initiation of mitochondrial pathway apoptosis…
JAMA Network Open New Online
28.05.2025
This cohort study examines the associations of hydrocortisone use with the incidence and outcomes of requirement for kidney replacement therapy (KRT) for patients with septic shock.
Clinical Infectious Diseases
25.05.2025
sepsisseptic shockbeta-lactamsacute kidney injurymortality
Clinical Infectious Diseases
25.05.2025
Journal of the American Medical Association
21.05.2025
This multicenter study uses reinforcement learning to examine the treatment implications of a vasopressin initiation rule developed to improve short-term and hospital outcomes in critically ill adults with septic shock receiving norepinephrine.
Journal of the American Medical Association
21.05.2025
This JAMA Insights explores the use of portable point-of-care ultrasound and focused cardiac ultrasound imaging in the diagnosis and treatment of patients with sepsis and septic shock in the emergency department and intensive care unit.
Infection
16.05.2025
…ealed a hepatic abscess. Despite early antibiotic therapy, the patient rapidly developed refractory septic shock and died within 12 h. Blood cultures confirmed V. fluvialis. This case highlights the potential for severe V. fluvialis infections even in the absence of known seafood or seawater exposure. Given the global rise in raw seafood consumption, physicians should consider V. fluvialis as a potential pathogen in diabetic or immunocompromised patients presenting with hepatobiliary infections and sepsis.
Journal of Infectious Diseases
13.05.2025
Abstract . Japan recently experienced a record surge in streptococcal toxic shock syndrome (STSS). Our environmental surveillance study reveals that Streptococcus pyogenes persists seasonally, peaking in autumn and winter in rural Japan. The dominant emm1 M1UK sublineage and csrS mutations heighten virulence, highlighting the urgent need for targeted surveillance and interventions.
Science
9.05.2025
Science, Volume 388, Issue 6747, Page 594-594, May 2025.
BMJ Open
8.05.2025
… the initial therapeutic, the proportion of patients who develop secondarily septic shock, the orientation of patients after ED discharge and both day 7 and in-hospital mortality. We plan to randomise 312 patients. . Ethics and dissemination. Approved by the Ethics Committee CPP Ouest V on 18 January 2021 (ref: 20/075-2-20.10.16.57638). The dissemination plan includes presentations at scientific conferences and publication of results in a peer-reviewed journal. . Trial registration number. NCT04580888. .
Critical Care Explorations
3.05.2025
IMPORTANCE: . Sepsis is the leading cause of inpatient mortality in the United States. The optimal timing and volume of fluid resuscitation for septic shock remain a topic of debate. OBJECTIVES: . This study evaluated the effect of time to completion of at least 30 mL/kg of fluid and the impact of smaller fluid volumes on hospital outcomes among patients with septic shock. DESIGN, SETTING, AND PARTICIPANTS: …
Critical Care Medicine
3.05.2025
Objectives: . In the Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) trial, restriction of IV fluid volumes led to similar overall mortality in ICU patients with septic shock. We assessed if variation in standard IV fluid treatment intensity across sites impacted the effects of fluid restriction. Design: . Secondary analysis of randomized clinical trial. Setting: . ICU. Patients: . The CLASSIC trial enrolled adult ICU patients with septic shock…
Current Opinion in Infectious Diseases
1.05.2025
Purpose of review . This review highlights the complex pathophysiology of myocardial dysfunction in septic shock and emphasizes the need for early and repeated hemodynamic assessments to improve outcome. Recent findings . Septic cardiomyopathy is a complex, dynamic process driven by multiple mechanisms such as direct myocardial depression induced by host immune mediators (e.g., cytokines, nitric oxide) and/or bacterial toxins, and mitochondrial metabolic dysfunction…
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Medscape Infectious Diseases
25.04.2025
The VASST trial was first published in 2008 and has spawned 16 years of analysis and debate. Aaron Holley, MD, has vacillated on whether early vasopressin is the right call, but now he's all in. . Medscape Critical Care
ProMED
4.03.2025
. . . STREPTOCOCCAL TOXIC SHOCK SYNDROME - JAPAN. ******************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Mon 24 Feb 2025 . Source: Emerging Infectious Diseases [edited] . wwwnc.cdc.gov/eid/article/31/4/24-1076_article . . . Citation: Ujiie M. Emerging trends in streptococcal toxic shock. syndrome, Japan. Emerg Infect Dis. 2025;31(4)…
ProMED
26.02.2025
. . . SYPHILIS - VIET NAM: (CA MAU) CONGENITAL, PREVENTION, ANAPHYLACTIC. SHOCK, FATAL. *******************************************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Mon 24 Feb 2025 . Source: Tuoi Tre News [in Vietnamese, machine trans., edited] …
ProMED
15.02.2025
. . . MENINGOCOCCAL DISEASE - VIET NAM: SEPTIC SHOCK, FATAL. *****************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Thu 13 Feb 2025 . Source: VN Express [in Vietnamese, machine trans., edited] . vnexpress.net/mot-quan-nhan-tu-vong-do-nhiem-khuan-nao-mo-cau-4849299.html . . . A soldier died of meningococcal infection …
WHO Eastern Mediterranean Region news
27.04.2025
…in six high-burden countries: Afghanistan, Djibouti, Pakistan, Somalia, Sudan, and Yemen. . While malaria is receding in many parts of the world, our Region is facing a troubling rise in cases―driven by conflict, fragile health systems, climate-related shocks, and the increasing risk of resistance to drugs and insecticides. . Between 2015 and 2023, the estimated malaria incidence in the Region more than doubled to 17.9 cases per 1,000 people at risk. . But we are making progress…
ProMED
15.04.2025
…oning of 3 minors and 1 adult last weekend in. Bogotá has been identified, resulting in the deaths of 2 of the. minors. . The girls died on 5 and 10 Apr 2025, respectively, while receiving. medical careat the Santa Fe Foundation. The incident has caused shock. in the community; however, authorities clarified these were isolated. incidents and there is no evidence to suggest a public health. concern. . According to information published by 'Semana', the deceased minors…
ProMED
15.04.2025
… days with symptoms of sudden high fever, headache, vomiting,. and impaired consciousness. At that time, the patient quickly becomes. comatose, with necrotic hemorrhagic rashes appearing on the skin in. the context of acute adrenal insufficiency syndrome, shock, and rapid. death. . To prevent meningococcal disease, people should practice good personal. hygiene and hygiene in their living quarters, wear masks when in. contact with or caring for sick people, and take preventive medicine…
ProMED
8.04.2025
…m. The same type of bacteria, group A _Streptococcus_, is responsible for. strep throat -- a far milder infection. Invasive streptococi can. trigger necrotizing fasciitis, a soft tissue infection also known as. flesh-eating disease, or streptococcal toxic shock syndrome, an immune. reaction akin to sepsis that can lead to organ failure. . 'Within 24 to 48 hours, you could have very, very rapid. deterioration,' said Dr. Victor Nizet, a professor of pediatrics at. the University of California, San Diego…
ProMED
3.04.2025
…fever. . Initial symptoms of yellow fever can include fever, chills, severe. headache, back pain, general body aches, nausea, vomiting, fatigue. (feeling tired), and weakness. Severe symptoms include high fever,. yellow skin or eyes (jaundice), bleeding, shock, and organ failure. If. you think you or a family member might have yellow fever, see a doctor. or talk with a healthcare provider. . Visit the US Centers for Disease Control and Prevention (CDC) webpage…
ProMED
3.04.2025
…lead to poisoning for buyers who drink it. . When ingested, methanol can turn into a toxic substance that affects. many organs. This substance can cause damage to the central nervous. system, acute respiratory failure, heart failure, hypotension, severe. shock, acute kidney failure, blindness, etc. Treatment is often. difficult, with a high mortality rate. . Doctors recommend choosing alcohol with a clear origin and ensuring. food safety to drink. Be alert when experiencing fatigue, headache,…
ProMED
25.03.2025
…s associated with better outcomes. The study,. published this week [19 Mar 2025] in JAMA Network Open, found that. sepsis patients who received care that was noncompliant with the. Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and. Septic Shock Management Bundle (SEP-1) tended to be older, have more. comorbidities, and have more complex clinical presentation than those. who received compliant care. When those factors were accounted for,…
ProMED
25.03.2025
…ia [edited] . timesofindia.indiatimes.com/life-style/health-fitness/health-news/woman-in-delhi-ncr-dies-of-rabies-days-after-drinking-milk-from-infected-cow-report/articleshow/119330439.cms . . . A strange case from Delhi NCR's Greater Noida has shocked everyone. As. per reports, a woman residing in Greater Noida succumbed to rabies. after contracting the infection via cow milk. The reports have said. that the cow had rabies after being bitten by a stray dog. …
ProMED
25.03.2025
…eat blood pudding or slaughter pigs but still get. sick. The cause is eating raw infected pork, or coming into contact. with infected pigs through skin lesions or scratches during. processing. . In severe cases, the disease can progress rapidly to septic shock,. circulatory collapse, hypotension, severe blood clotting disorders,. hemorrhagic necrosis, embolism, multiple organ failure, coma and. death. . Many people think that if they do not eat pig blood pudding, they can…
ProMED
25.03.2025
…e . - Stress: transportation, social, nutritional . - Gastrointestinal disturbance: motility (especially colic), feed. change . . Clinical signs of salmonellosis include diarrhea, fever, lethargy,. anorexia, colic, localized infection, sepsis and septic shock. Foals. are commonly more seriously affected with profound systemic illness,. including hemorrhagic diarrhea, pneumonia, meningitis, inflammation of. growth plate and septic arthritis. . …
ProMED
17.03.2025
…rus. [infection] and was rushed to the hospital when the first signs of the. illness were detected on Friday [7 Mar 2025]. . However, her health deteriorated rapidly, leading to severe. cardiovascular and respiratory complications that caused refractory. shock. Sadly, she died on Sunday [9 Mar 2025]. . In response to this tragic event, health authorities immediately. activated preventive isolation protocols for those people who had. close contact with the victim. . Isolation of close contacts …
ProMED
13.03.2025
…ed with the 'flesh-eating bacteria' _Vibrio vulnificus_. . This type of bacteria lives in saltwater, brackish water or. parasitized shrimp and oysters, can cause blood infection and tissue. necrosis with high mortality rate, up to 50%, even 90% if septic shock. occurs. . Previously, the patient worked as a ship driver, was healthy, and had. no underlying medical conditions. After the fall, he treated the wound. himself by applying a plaster and rubbing oil without going to a. medical facility…
ProMED
12.03.2025
…death of sheep in herds. More than 20. sheep died in half an hour in Kerala Thanda, Mundargi taluk, Gadag. district. Anthrax infection is suspected. . A herd of 60 sheep has lost 20 of them. A herd of sheep belonging to. [PL] have died. The shepherds are shocked to see the death of the. sheep. . Animal Husbandry Department officials rushed to the spot and conducted. an inspection. They have expressed suspicion of anthrax infection. Doctors said that the sheep are dying due to bleeding from their noses…
ProMED
11.03.2025
…4 . ---- . Streptococcus, group A - Brazil: (PR) fatal, alert. promedmail.org/post/20241113.8720005 . Streptococcus, group A - Bolivia: (CB) fatal, alert. promedmail.org/post/20241113.8719963 . Streptococcus, group A - Japan: invasive, toxic shock. promedmail.org/post/20240618.8717090 . Streptococcus, group A - USA: (VT) bacteremia, drug injectors, 2020-23. promedmail.org/post/20240429.8716195 . 2023 . ---- . Streptococcus, gp A update (16): Argentina, iGAS, fatal…
ProMED
8.03.2025
…ent is from an area of. dengue risk presenting with fever of 2-7 days plus any of the. following features: . - There is evidence of plasma leakage, such as high or progressively. rising haematocrit; pleural effusions or ascites; circulatory. compromise or shock (tachycardia, cold and clammy extremities,. capillary refill time greater than 3 seconds, weak or undetectable. pulse, narrow pulse pressure or, in late shock, unrecordable blood. pressure). - There is significant bleeding…
ProMED
8.03.2025
… Feb 2025] in the Annals of Internal Medicine. For the study,. researchers at several University of California locations reviewed. literature assessing the relationship between the Centers for Medicare. and Medicaid Services (CMS) Severe Sepsis and Septic Shock Management. Bundle (SEP-1) and mortality. Implemented in 2015 by CMS, SEP-1 is a. bundle of measures that includes administration of broad-spectrum. antimicrobials within 3 hours of sepsis onset. Other elements of SEP-1…