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Ning Yu, Shigang Chen, Yumeng Liu, Peng Wang, Longlong Wang, Ningning Hu, He Zhang, Xiao Li, Huijun Lu, Ningyi Jin
Journal of Medical Virology, 5.09.2024
Tilføjet 5.09.2024
American Journal of Tropical Medicine and Hygiene, 5.09.2024
Tilføjet 5.09.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 3 Pages: 603-605
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 5.09.2024
Tilføjet 5.09.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 3 Pages: 606-609
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 5.09.2024
Tilføjet 5.09.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 3 Pages: 610-616
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 5.09.2024
Tilføjet 5.09.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 3 Pages: 617-621
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 5.09.2024
Tilføjet 5.09.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 3 Pages: 622-626
Læs mere Tjek på PubMedCara E. BrookCarly RozinsJennifer A. BohlVida AhyongSophana CheaLiz FahsbenderRekol HuySreyngim LayRithea LeangYimei LiChanthap LonSomnang ManMengheng OumGraham R. NorthrupFabiano OliveiraAndrea R. PachecoDaniel M. ParkerKatherine YoungMichael BootsCristina M. TatoJoseph L. DeRisiChristina YekJessica E. ManningaDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637bDepartment of Science, Technology, and Society, York University, Toronto, ON M3J 1P3, CanadacLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20892dChan Zuckerberg Biohub, San Francisco, CA 94158eInternational Center of Excellence in Research, National Institute of Allergy and Infectious Diseases, NIH, Phnom Penh 120801, CambodiafChan Zuckerberg Initiative, Redwood City, CA 94063gNational Center for Parasitology, Entomology, and Malaria Control, Phnom Penh 120801, CambodiahCenter for Computational Biology, University of California, Berkeley, CA 94720iDepartment of Population Health and Disease Prevention, University of California, Irvine, CA 92697jDepartment of Epidemiology and Biostatistics, University of California, Irvine, CA 92697kDepartment of Biological Sciences, University of Texas, El Paso, TX 79968lDepartment of Integrative Biology, University of California, Berkeley, CA 94720
Proceedings of the National Academy of Sciences, 4.09.2024
Tilføjet 4.09.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 36, September 2024.
Læs mere Tjek på PubMedSarunya Maneerattanasak, Thundon Ngamprasertchai, Yin May Tun, Narisa Ruenroengbun, Prasert Auewarakul, Kobporn Boonnak
International Journal of Infectious Diseases, 29.08.2024
Tilføjet 29.08.2024
In Asia, dengue virus (DENV), Zika virus (ZIKV), and chikungunya virus (CHIKV) infections pose significant public health threats, which could result in substantially increased morbidity and mortality rates. These viruses, collectively known as arboviruses, share similarities in their epidemiology, transmission, and clinical manifestations. They often cause mild, subtle, or nonspecific clinical symptoms, while also potentially leading to severe and life-threatening complications [1]. Their rapid transmission is primarily facilitated through mosquito bites, notably by Aedes aegypti and Ae.
Læs mere Tjek på PubMedMohammed Seid, Esayas Aklilu, Abebe Animut
PLoS One Infectious Diseases, 24.08.2024
Tilføjet 24.08.2024
by Mohammed Seid, Esayas Aklilu, Abebe Animut Mosquito-borne viral diseases such as dengue fever, chikungunya, and yellow fever have been documented in Ethiopia since the 1960s. However, the efficacy of public health insecticides against Aedes aegypti that transmits these viruses remains poorly understood in the country, particularly in the Afar Region. Thus, the aim of the study was to assess the susceptibility status of Ae. aegypti to deltamethrin, permethrin, alpha-cypermethrin, pirimiphos-methyl, bendiocarb, and propoxur insecticides. Larvae and pupae of Aedes species were collected from Awash Arba, Awash Sebat, and Werer towns of the Afar Region of Ethiopia during July-October 2022, brought to the Aklilu Lemma Institute of Pathobiology, insectary and reared to adults. Non-blood-fed, 3–5 days-old females Ae. aegypti were exposed to pyrethroid, carbamate, and organophosphate insecticide impregnated papers in tube test following the standard guidelines. Knockdown rates were noted at 10 minutes interval until one hour. The mortality in mosquitoes was recorded 24 hours after 60 minutes of exposure. The mortality rates of Ae. aegypti exposed to propoxur were 87% in all the study towns. Similarly, 88% mortality in Ae. aegypti was recorded when tested with bendiocarb in Awash Sebat and Awash Arba towns. Suspected resistance of Ae. aegypti (95% mortality) to alpha-cypermethrin was observed in Awash Arba town. However, Ae. aegypti collected from all the three sites was observed to be susceptible to deltamethrin, permethrin, and pirimiphos-methyl. Ae. aegypti was resistant to 0.1% bendiocarb and 0.1% propoxur and possibly resistant to 0.05% alpha-cypermethrin. On the other hand, it was susceptible to 0.05% deltamethrin, 0.75% permethrin, and 0.25% pirimiphos-methyl. Thus, vector control products with deltamethrin, permethrin, and pirimiphos-methyl can be used in the control of adult Ae. aegypti in the Afar Region of Ethiopia. However, further studies should be carried out to evaluate the susceptibility status of Ae. aegypti to alpha-cypermethrin in the Awash Arba area.
Læs mere Tjek på PubMedPhu Nguyen Trong Tran, Noppachai Siranart, Theerapon Sukmark, Umaporn Limothai, Sasipha Tachaboon, Terapong Tantawichien, Chule Thisyakorn, Usa Thisyakorn, Nattachai Srisawat
Journal of Medical Virology, 22.08.2024
Tilføjet 22.08.2024
BMC Infectious Diseases, 21.08.2024
Tilføjet 21.08.2024
Abstract Background Rapid point-of-care tests for malaria are now widely used in many countries to guide the initial clinical management of patients presenting with febrile illness. With China having recently achieved malaria elimination, better understanding regarding the identity and distribution of major non-malarial causes of febrile illnesses is of particular importance to inform evidence-based empirical treatment policy. Methods A systematic review of published literature was undertaken to characterise the spectrum of pathogens causing non-malaria febrile illness in China (1980–2015). Literature searches were conducted in English and Chinese languages in six databases: Ovid MEDLINE, Global Health, EMBASE, Web of Science™ – Chinese Science Citation Database SM, The China National Knowledge Infrastructure (CNKI), and WanFang Med Online. Selection criteria included reporting on an infection or infections with a confirmed diagnosis, defined as pathogens detected in or cultured from samples from normally sterile sites, or serological evidence of current or past infection. The number of published articles, reporting a given pathogen were presented, rather than incidence or prevalence of infection. Results A total of 57,181 records from 13 provinces of China where malaria used to be endemic were screened, of which 392 met selection criteria and were included in this review. The review includes 60 (15.3%) records published from 1980 to 2000, 211 (53.8%) from 2001 to 2010 and 121 (30.9%) from 2011 to 2015;. Of the 392 records, 166 (42.3%) were from the eastern region of China, 120 (30.6%) were from the south-west, 102 (26.0%) from south-central, and four (1.0%) were multi-regional studies. Bacterial infections were reported in 154 (39.3%) records, viral infections in 219 (55.9%), parasitic infections in four (1.0%), fungal infections in one (0.3%), and 14 (3.6%) publications reported more than one pathogen group. Participants of all ages were included in 136 (34.7%) studies, only adults in 75 (19.1%), only children in 17 (4.3%), only neonates in two (0.5%) and the age distribution was not specified in 162 (41.3%) records. The most commonly reported bacterial pathogens included Typhoidal Salmonella (n = 30), Orientia/ Rickettsia tsutsugamushi (n = 31), Coxiella burnetii (n = 17), Leptospira spp. (n = 15) and Brucella spp. (n = 15). The most commonly reported viral pathogens included Hantavirus/Hantaan virus (n = 89), dengue virus (DENV) (n = 76 including those with unknown serovars), Japanese encephalitis virus (n = 21), and measles virus (n = 15). The relative lack of data in the western region of the country, as well as in in neonates and children, represented major gaps in the understanding of the aetiology of fever in China. Conclusions This review presents a landscape of non-malaria pathogens causing febrile illness in China over 36 years as the country progressed toward malaria elimination. These findings can inform guidelines for clinical management of fever cases and infection surveillance and prevention, and highlight the need to standardize operational and reporting protocols for better understanding of fever aetiology in the country.
Læs mere Tjek på PubMedEskild Petersen, Linzy Elton, Najmul Haider, Timothy D McHugh, Osman Dar, Avinash Sharma, Pam Luka, Tieble Traore, Edgar Simulundu, Esam I Azhar, Francine Ntoumi, Moses J Bockarie, Ziad A Memish, Alimuddin Zumla
International Journal of Infectious Diseases, 20.08.2024
Tilføjet 20.08.2024
The risk of outbreaks of arthropod-borne pathogens arising from mass gathering events is ever increasing due to the rising number of travellers from arbovirus endemic areas, and the expansion and adaptation of arthropod vectors such as mosquitoes worldwide due to climate and environmental change [1-4]. Indeed, introduction of dengue virus (DENV) was a concern at the recent Olympic Games in Paris 2024, Japan 2020 and Brazil 2014 but outbreaks did not happen [5-7].
Læs mere Tjek på PubMedInfection, 17.08.2024
Tilføjet 17.08.2024
Abstract In this image, the autors reinterprate “The Thinker” from Auguste Rodin to transfer knowledge about dengue fever, which can range from flu-like illness to severe hemorrhagic fever. By fostering awareness and understanding of dengue fever, we strive to empower individuals and communities in the ongoing fight against dengue and other infectious threats.
Læs mere Tjek på PubMedHinh Ly
Journal of Medical Virology, 17.08.2024
Tilføjet 17.08.2024
Journal of the American Medical Association, 17.08.2024
Tilføjet 17.08.2024
Dengue virus infections have surged worldwide this year, including in Puerto Rico, which declared a public health emergency in March. Amid rising cases in the US—nearly 2400 as of the second week of July—the US Centers for Disease Control and Prevention (CDC) has issued a statement cautioning clinicians, public health officials, and the public about an increased risk of contracting the illness.
Læs mere Tjek på PubMedInfection, 16.08.2024
Tilføjet 16.08.2024
Abstract In this image, the autors reinterprate “The Thinker” from Auguste Rodin to transfer knowledge about dengue fever, which can range from flu-like illness to severe hemorrhagic fever. By fostering awareness and understanding of dengue fever, we strive to empower individuals and communities in the ongoing fight against dengue and other infectious threats.
Læs mere Tjek på PubMedBMC Infectious Diseases, 9.08.2024
Tilføjet 9.08.2024
Abstract Liver injury with marked elevation of aspartate aminotransferase enzyme (AST) is commonly observed in dengue infection. To understand the pathogenesis of this liver damage, we compared the plasma levels of hepatic specific, centrilobular predominant enzymes (glutamate dehydrogenase, GLDH; glutathione S transferase-α, αGST), periportal enriched 4-hydroxyphenylpyruvate dioxygenase (HPPD), periportal predominant arginase-1 (ARG-1), and other non-specific biomarkers (paraoxonase-1, PON-1) in patients with different outcomes of dengue infection. This hospital-based study enrolled 87 adult dengue patients, stratified into three groups based on plasma AST levels ( 400 U/L) in a 1:1:1 ratio (n = 40, n = 40, n = 40, respectively. The new liver enzymes in the blood samples from the 4th to 6th days of their illness were measured by commercial enzyme-linked immunosorbent assay (ELISA) or colorimetric kits. Based on the diagnosis at discharge days, our patients were classified as 40 (46%) dengue without warning signs (D), 35 (40.2%) dengue with warning signs (DWS), and 11 (12.6%) severe dengue (SD) with either shock (two patients) or AST level over 1000 U/L (nine patients), using the 2009 WHO classification. The group of high AST (> 400 U/L) also had higher ALT, GLDH, ARG-1, and HPPD than the other groups, while the high (> 400 U/L) and moderate (80–400 U/L) AST groups had higher ALT, αGST, ARG-1, and HPPD than the low AST group (
Læs mere Tjek på PubMedThe Lancet Infectious Diseases
Lancet Infectious Diseases, 9.08.2024
Tilføjet 9.08.2024
Arboviral infections have hit South America heavily in the past decade, with the epidemic of Zika virus in 2015–16, and recurrent outbreaks of chikungunya and dengue, the latter of which is affecting Brazil with a particularly high number of cases this year. In addition, the region is now facing the re-emergence of another little-known arbovirus, Oropouche virus, on an unprecedented scale.
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 8.08.2024
Tilføjet 8.08.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 2 Pages: 403-411
Læs mere Tjek på PubMedBMC Infectious Diseases, 6.08.2024
Tilføjet 6.08.2024
Mauricio L Nogueira, Monica A T Cintra, José A Moreira, Elizabeth G Patiño, Patricia Emilia Braga, Juliana C V Tenório, Lucas Bassolli de Oliveira Alves, Vanessa Infante, Daniela Haydee Ramos Silveira, Marcus Vínicius Guimarães de Lacerda, Dhelio Batista Pereira, Allex Jardim da Fonseca, Ricardo Queiroz Gurgel, Ivo Castelo-Branco Coelho, Cor Jesus Fernandes Fontes, Ernesto T A Marques, Gustavo Adolfo Sierra Romero, Mauro Martins Teixeira, André M Siqueira, Viviane Sampaio Boaventura, Fabiano Ramos, Erivaldo Elias Júnior, José Cassio de Moraes, Stephen S Whitehead, Alejandra Esteves-Jaramillo, Tulin Shekar, Jung-Jin Lee, Julieta Macey, Sabrina Gozlan Kelner, Beth-Ann G Coller, Fernanda Castro Boulos, Esper G Kallás, Phase 3 Butantan-DV Working Group
Lancet Infectious Diseases, 6.08.2024
Tilføjet 6.08.2024
A single dose of Butantan-DV was generally well tolerated and efficacious against symptomatic VCD (caused by DENV-1 and DENV-2) for a mean of 3·7 years. These findings support the continued development of Butantan-DV to prevent dengue disease in children, adolescents, and adults regardless of dengue serostatus.
Læs mere Tjek på PubMedMuhammad Azeem, Ghulam Mustafa, Sibtain Ahmed, Amna Mushtaq, Muhammad Arshad, Muhammad Usama, Muhammad Farooq
PLoS One Infectious Diseases, 6.08.2024
Tilføjet 6.08.2024
by Muhammad Azeem, Ghulam Mustafa, Sibtain Ahmed, Amna Mushtaq, Muhammad Arshad, Muhammad Usama, Muhammad Farooq Viral diseases pose a serious global health threat due to their rapid transmission and widespread impact. The RNA-dependent RNA polymerase (RdRp) participates in the synthesis, transcription, and replication of viral RNA in host. The current study investigates the antiviral potential of secondary metabolites particularly those derived from bacteria, fungi, and plants to develop novel medicines. Using a virtual screening approach that combines molecular docking and molecular dynamics (MD) simulations, we aimed to discover compounds with strong interactions with RdRp of five different retroviruses. The top five compounds were selected for each viral RdRp based on their docking scores, binding patterns, molecular interactions, and drug-likeness properties. The molecular docking study uncovered several metabolites with antiviral activity against RdRp. For instance, cytochalasin Z8 had the lowest docking score of –8.9 (kcal/mol) against RdRp of SARS-CoV-2, aspulvinone D (–9.2 kcal/mol) against HIV-1, talaromyolide D (–9.9 kcal/mol) for hepatitis C, aspulvinone D (–9.9 kcal/mol) against Ebola and talaromyolide D also maintained the lowest docking score of –9.2 kcal/mol against RdRp enzyme of dengue virus. These compounds showed remarkable antiviral potential comparable to standard drug (remdesivir –7.4 kcal/mol) approved to target RdRp and possess no significant toxicity. The molecular dynamics simulation confirmed that the best selected ligands were firmly bound to their respective target proteins for a simulation time of 200 ns. The identified lead compounds possess distinctive pharmacological characteristics, making them potential candidates for repurposing as antiviral drugs against SARS-CoV-2. Further experimental evaluation and investigation are recommended to ascertain their efficacy and potential.
Læs mere Tjek på PubMedBMC Infectious Diseases, 3.08.2024
Tilføjet 3.08.2024
BMC Infectious Diseases, 3.08.2024
Tilføjet 3.08.2024
BMC Infectious Diseases, 3.08.2024
Tilføjet 3.08.2024
Kasem U. Salim, Francisco S. Álvarez, Alec M. Chan-Golston, Colleen C. Naughton, Ricardo Cisneros, Andrea Joyce
PLoS One Infectious Diseases, 2.08.2024
Tilføjet 2.08.2024
by Kasem U. Salim, Francisco S. Álvarez, Alec M. Chan-Golston, Colleen C. Naughton, Ricardo Cisneros, Andrea Joyce Dengue fever is a mosquito-borne illness that infects 390 million people annually. Dengue outbreaks in Guatemala have been occurring more often and at increased rates since the first dengue outbreak in Guatemala in the 1970s. This study will examine environmental and socioeconomic factors associated with dengue in Guatemala at the municipality (county) level. Socioeconomic factors included population density, Mayan population, economic activity, and attending school. Environmental factors included average minimum annual temperature and annual precipitation. The relationship between environmental and socioeconomic variables and dengue fever incidence was initially evaluated through univariate zero-inflated negative binomial models, and then again through three zero-inflated multivariate negative binomial regression models. For all three models, elevation was considered a predictor of zero-inflation. In the combined model, there was a positive relationship between minimum temperature, economic activity and dengue fever incidence, and a negative relationship between population density, Mayan population and dengue fever. Predicted rates of dengue fever incidence and adjusted confidence intervals were calculated after increasing minimum yearly temperature by 1°C and 2°C. The three municipalities with the highest minimum yearly temperature (El Estor, Iztapa, and Panzós) and the municipality of Guatemala, all had an increase in the magnitude of the risk of dengue fever incidence following 1°C and 2°C increase in temperature. This research suggests that these socioeconomic and environmental factors are associated with risk of dengue in Guatemala. The predicted rates of dengue fever also highlight the potential effect that climate change in the form of increasing temperature can have on dengue in Guatemala.
Læs mere Tjek på PubMedJournal of Infectious Diseases, 30.07.2024
Tilføjet 30.07.2024
Abstract Background The aim of this study was to compare the predictive performance of three statistical models—logistic regression, classification tree, and structural equation model (SEM)—in predicting severe dengue illness.Methods/findings We adopted modified classification of dengue illness severity based on WHO 1997 guideline. Predictive models were constructed using demographic factors and laboratory indicators on the day of fever occurrence. We developed statistical predictive models using data from two hospital cohorts in Thailand, consisting of 257 Thai children. Different predictive models for each category of severe dengue illness were developed employing logistic regression, classification tree, and SEM. The probability of discrimination of each model for severe output of disease was analyzed with external validation data sets from 55 and 700 patients not used in model development. From external validation using predictors on the day of presentation to the hospital, the area under the receiver operating characteristic curve was between 0.65 and 0.84 for the regression model. It was between 0.73 and 0.85 for SEM models. Classification tree models showed good results of sensitivity, ranging from 0.95 to 0.99. However, they showed poor specificity ranging from 0.10 to 0.44.Conclusions Our study showed that SEM is comparable to logistic regression or classification tree, which was widely used for more severe form of dengue prediction.
Læs mere Tjek på PubMedBMC Infectious Diseases, 30.07.2024
Tilføjet 30.07.2024
Abstract Background Dengue fever remains a significant public health challenge in tropical and subtropical regions, with its transmission dynamics being influenced by both environmental factors and human mobility. The Dominican Republic, a biodiversity hotspot in the Caribbean, has experienced recurrent dengue outbreaks, yet detailed understanding of the virus\'s transmission pathways and the impact of climatic factors remains limited. This study aims to elucidate the recent transmission dynamics of the dengue virus (DENV) in the Dominican Republic, utilizing a combination of genomic sequencing and epidemiological data analysis, alongside an examination of historical climate patterns. Methods We conducted a comprehensive study involving the genomic sequencing of DENV samples collected from patients across different regions of the Dominican Republic over a two-year period. Phylogenetic analyses were performed to identify the circulation of DENV lineages and to trace transmission pathways. Epidemiological data were integrated to analyze trends in dengue incidence and distribution. Additionally, we integrated historical climate data spanning several decades to assess trends in temperature and their potential impact on DENV transmission potential. Results Our results highlight a previously unknown north–south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures. Conclusion This multidisciplinary study reveals intricate patterns of dengue virus transmission in the Dominican Republic, characterized by the co-circulation of multiple DENV lineages and a novel transmission pathway. The observed correlation between rising temperatures and increased dengue transmission potential emphasizes the need for integrated climate-informed strategies in dengue control efforts. Our findings offer critical insights for public health authorities in the Dominican Republic and similar settings, guiding resource allocation and the development of preparedness strategies to mitigate the impacts of climate change on dengue transmission.
Læs mere Tjek på PubMedBMC Infectious Diseases, 26.07.2024
Tilføjet 26.07.2024
Abstract Background Dengue infection is a mosquito-borne, endemic viral disease, particularly in developing countries. Here, we report the results of the clinicodemographic, serologic profile and the monthly occurrence of a recent dengue fever outbreak in Puntland State (Somalia). Methodology We analyzed the data of 956 dengue-suspected patients who were investigated using the rapid diagnostic testing (RDT) method for detecting NS1 (dengue virus non-structural protein) and IgM antibodies employing the SD Biosensor Dengue Dou NS Ag and IgM test kit (Germany) at the Puntland Public Health Referral Laboratory from November 21, 2022, to May 27, 2023. Results We found that 118 cases were positive for dengue among the suspected patients enrolled in the present study. Of these cases, 76.2% were dengue NSI positive, 13.6% were dengue IgM positive, and 10.2% were both NSI and IgM positive. The number of females and males in the confirmed cases was equal, and most (48.3%) were aged 20 years or less. 43.1% of them lived in the Nugal region, particularly in Garowe. Clinically, fever was the most frequent symptom (88.9%). The cases peaked in December 2022 but dropped from January to March, with a slight rise in February, and then increased in April and May 2023. Conclusion This study highlights the clinicodemographic characteristics, seroprevalence, and monthly occurrence of dengue in Puntland. We recommend improving vector control measures, enhancing case management, strengthening dengue surveillance, developing an early warning system, and conducting future studies to characterize the circulating strains.
Læs mere Tjek på PubMedThe Lancet
Lancet, 26.07.2024
Tilføjet 26.07.2024
2024 is the worst year for dengue cases on record. As of July 23, over 10 million cases of dengue have been reported from 176 countries across all WHO regions (although the Americas account for most cases), with more than 24 000 severe cases and 6508 deaths. This figure already surpasses the number of cases in 2023, which was also a record year. There is no doubt that dengue, a vector-borne disease caused by four serologically related viruses, is a major infectious disease threat to health. Over the past two decades, there has been a tenfold increase in reported cases, and even this figure is likely an underestimate.
Læs mere Tjek på PubMedNathália Mariana Santos Sansone, Matheus Negri Boschiero, Fernando Augusto Lima Marson
International Journal of Infectious Diseases, 26.07.2024
Tilføjet 26.07.2024
Dengue is one of the most common zoonoses in Latin America (LATAM), accounting for almost 60% of all cases worldwide [1]. This mosquito-borne disease is caused by an arbovirus, transmitted by the bite of a female species of Aedes aegypti [2]. Dengue is divided into four serotypes: DEN-1, DEN-2, DEN-3, and DEN-4 [2]. Infection by different serotypes is associated with the same disease and a wide clinical phenotype. Infection with a serotype causes long-term immunity against this specific serotype and short-term (∼2-3 months) against the other three serotypes [3].
Læs mere Tjek på PubMedLeïla Lefèvre, Christophe Vincent-Titeca, Clémence Garcia, Laura Temime, Kévin Jean
International Journal of Infectious Diseases, 24.07.2024
Tilføjet 24.07.2024
The Ile-de-France Region (IDFR), which is set to host the Paris 2024 Olympics, is experiencing a concerning rise in imported cases of chikungunya, Zika, and dengue arboviral diseases [1]. The escalating presence of the Aedes albopictus mosquito, a competent vector for these diseases in temperate climates, is a significant threat [1]. The first dengue outbreak in the IDFR last fall underscored the local vulnerability to this risk [1].
Læs mere Tjek på PubMedJournal of the American Medical Association, 23.07.2024
Tilføjet 23.07.2024
Individuals with a previous infection with Zika virus may be more vulnerable to symptomatic infections of certain types of dengue virus, according to a cohort study of 3412 children aged 2 to 17 years old in Nicaragua.
Læs mere Tjek på PubMedCabada, M. M., Aguilar, P. V., Rodas, J. D., Hidalgo, M., Mozo, K., Gonzalez-Diaz, E. S., Jimenez-Coello, M., Diaz, F. J., Dacso, M. M., Ortega-Pacheco, A., Arboleda, M., Walker, D. H., Weaver, S. C., Melby, P. C.
BMJ Open, 23.07.2024
Tilføjet 23.07.2024
IntroductionAcute undifferentiated febrile illnesses (AUFIs) impose a large burden in the tropics. Understanding of AUFI’s epidemiology is limited. Insufficient diagnostic capacity hinders the detection of outbreaks. The lack of interconnection in healthcare systems hinders timely response. We describe a protocol to study the epidemiology and aetiologies of AUFI and pathogen discovery in strategic areas of Latin America (LA). Methods and analysisGlobal Infectious Diseases Network investigators comprising institutions in Colombia, Dominican Republic, México, Perú and the USA, developed a common cohort study protocol. The primary objective is to determine the aetiologies of AUFI at healthcare facilities in high-risk areas. Data collection and laboratory testing for viral, bacterial and parasitic agents are performed in rural and urban healthcare facilities and partner laboratories. Centralised laboratory and data management cores deploy diagnostic tests and data management tools. Subjects >6 years with fever for
Læs mere Tjek på PubMedRodrigo L. Vancini, Marilia S. Andrade, and Claudio A. B. de Lira
Science, 19.07.2024
Tilføjet 19.07.2024
BMC Infectious Diseases, 17.07.2024
Tilføjet 17.07.2024
Abstract Background Dengue fever has become a significant worldwide health concern, because of its high morbidity rate and the potential for an increase in mortality rates due to lack of adequate treatment. There is an immediate need for the development of effective medication for dengue fever. Methods Homology modeling of dengue virus (DENV) non-structural 4B (NS4B) protein was performed by SWISS-MODEL to predict the 3D structure of the protein. Structure validation was conducted using PROSA, PROCHECK, Ramachandran plot, and VERIFY-3D. MOE software was used to find out the in-Silico inhibitory potential of the five triterpenoids against the DENV-NS4B protein. Results The SWISS-MODEL was employed to predict the three-dimensional protein structure of the NS4B protein. Through molecular docking, it was found that the chosen triterpenoid NS4B protein had a high binding affinity interaction. It was observed that the NS4B protein binding energy for 15-oxoursolic acid, betulinic acid, ursolic acid, lupeol, and 3-o-acetylursolic acid were − 7.18, − 7.02, − 5.71, − 6.67 and − 8.00 kcal/mol, respectively. Conclusions NS4B protein could be a promising target which showed good interaction with tested triterpenoids which can be developed as a potential antiviral drug for controlling dengue virus pathogenesis by inhibiting viral replication. However, further investigations are necessary to validate and confirm their efficacy.
Læs mere Tjek på PubMedClinical Infectious Diseases, 16.07.2024
Tilføjet 16.07.2024
Abstract Background Obesity is on the rise globally in adults and children, including in tropical areas where diseases such as dengue have a substantial burden, particularly in children. Obesity impacts the risk of severe dengue disease; however, the impact on dengue virus (DENV) infection and dengue cases remains an open question.Methods We used 9 years of data from 5,940 children in the Pediatric Dengue Cohort Study in Nicaragua to examine whether pediatric obesity is associated with increased susceptibility to DENV infection and symptomatic presentation. Analysis was performed using Generalized Estimating Equations adjusted for age, sex, and pre-infection DENV antibody titers.Results From 2011 to 2019, children contributed 26,273 person-years of observation, and we observed an increase in the prevalence of overweight (from 12% to 17%) and obesity (from 7% to 13%). There were 1,682 DENV infections and 476 dengue cases in the study population. Compared to participants with normal weight, participants with obesity had higher odds of DENV infection (Adjusted Odds Ratio [aOR] 1.21, 95% confidence interval [CI] 1.03-1.42) and higher odds of dengue disease given infection (aOR 1.59, 95% CI 1.15-2.19). Children with obesity infected with DENV showed increased odds of presenting fever (aOR 1.46, 95% CI 1.05-2.02), headache (aOR 1.51, 95% CI 1.07-2.14), and rash (aOR 2.26, 95% CI 1.49-3.44) when compared with children with normal weight.Conclusions Our results indicate that obesity is associated with increased susceptibility to DENV infection and dengue cases in children, independently of age, sex, and pre-infection DENV antibody titers.
Læs mere Tjek på PubMedClinical Infectious Diseases, 16.07.2024
Tilføjet 16.07.2024
Abstract Background Dengue is an increasing threat to global health. This exploratory analysis evaluated the immunogenicity, safety, and vaccine efficacy (VE) of a live-attenuated tetravalent dengue vaccine (TAK-003) in participants enrolled in the phase 3 DEN-301 trial (NCT02747927), stratified by baseline age (4–5 years; 6–11 years; or 12–16 years).Methods Participants were randomized 2:1 to receive 2 doses of TAK-003, administered 3 months apart, or placebo. Dengue serostatus was evaluated at enrolment. VE against virologically-confirmed dengue (VCD) and hospitalized VCD; immunogenicity (geometric mean titers; GMTs); and safety were evaluated per age group through ∼4 years post-vaccinationResults VE against VCD across serotypes was 43.5% (95% confidence interval: 25.3%, 57.3%) for 4–5 year-olds; 63.5% (56.9%, 69.1%) for 6–11 year-olds, and 67.7% (57.8%, 75.2%) for 12–16 year-olds. VE against hospitalized VCD was 63.8% (21.1%, 83.4%), 85.1% (77.1%, 90.3%), and 89.7% (77.9%, 95.2%), for the three age groups, respectively. GMTs remained elevated against all four serotypes for ∼4 years post-vaccination, with no evident differences across age groups. No clear differences in safety by age were identified.Conclusions This exploratory analysis shows TAK-003 was efficacious in dengue prevention across age groups in children and adolescents 4-16 years of age living in dengue endemic areas. Relatively lower VE in 4–5 year-olds was potentially confounded by causative serotype distribution, small sample size, and VE by serotype, and should be considered in benefit-risk evaluations in this age group.
Læs mere Tjek på PubMedHinh Ly Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA
Virulence, 13.07.2024
Tilføjet 13.07.2024
Elliza Mansor, Norliza Ahmad, Nor Afiah Mohd Zulkefli, Poh Ying Lim
PLoS One Infectious Diseases, 13.07.2024
Tilføjet 13.07.2024
by Elliza Mansor, Norliza Ahmad, Nor Afiah Mohd Zulkefli, Poh Ying Lim Background and objective Pregnant mothers are at risk of many adverse pregnancy outcomes, including infants with low birth weight (LBW). The World Health Organization aimed to achieve a 30% reduction in the number of LBW infants by the year 2025. In this study, we aimed to determine the incidence and determinants of LBW infants among pregnant mothers attending government health clinics in Peninsular Malaysia. Material and methods A prospective cohort study “Relative Risk of Determinants of Adverse Pregnancy Outcomes Among Pregnant Mothers Attending Government Health Clinics, Peninsular Malaysia, PEN-MUM” was conducted from March 2022 until March 2023 at 20 government health clinics in Peninsular Malaysia that were randomly selected through a multistage sampling method. Malaysian pregnant mothers between 18 and 49 years old were recruited at 12–18 weeks of gestation and followed up at three time points: 1 (24–28 weeks of gestation), 2 (36–40 weeks of gestation), and 3 (post-delivery). Eight exposure factors of LBW were studied: gestational weight gain, dengue infection, urinary tract infection, COVID-19 infection, gestational hypertension, preeclampsia, maternal anemia, and gestational diabetes mellitus (GDM). Results Among 507 participants enrolled in the cohort, 40 were lost to follow-up. A total of 467 were included in the final analysis, giving an attrition rate of 7.9%. The incidence of LBW infants in Peninsular Malaysia was 14.3%. After adjusting for three covariates (ethnicity, employment status, and gestational age at birth), three determinants of LBW were identified. The risk of giving birth to LBW infants was higher among those with inadequate gestational weight gain (aRR = 2.86, 95% CI: 1.12, 7.37, p = 0.03), gestational hypertension (aRR = 4.12; 95% CI: 1.66, 10.43; p = 0.002), and GDM (aRR = 2.21; 95% CI: 1.18, 4.14; p = 0.013) during the second and third trimesters. Conclusions The incidence of LBW infants in Peninsular Malaysia can be considered high. Having inadequate gestational weight gain, gestational hypertension, and GDM in the second and third trimesters increased the risk of LBW infants by threefold, fivefold, and twofold respectively. Thus, intervention strategies should target prevention, early detection, and treatment of gestational hypertension and GDM, as well as promoting adequate weight gain during antenatal care.
Læs mere Tjek på PubMedBMC Infectious Diseases, 12.07.2024
Tilføjet 12.07.2024
Abstract Background Dengue fever has become a significant worldwide health concern, because of its high morbidity rate and the potential for an increase in mortality rates due to lack of adequate treatment. There is an immediate need for the development of effective medication for dengue fever. Methods Homology modeling of dengue virus (DENV) non-structural 4B (NS4B) protein was performed by SWISS-MODEL to predict the 3D structure of the protein. Structure validation was conducted using PROSA, PROCHECK, Ramachandran plot, and VERIFY-3D. MOE software was used to find out the in-Silico inhibitory potential of the five triterpenoids against the DENV-NS4B protein. Results The SWISS-MODEL was employed to predict the three-dimensional protein structure of the NS4B protein. Through molecular docking, it was found that the chosen triterpenoid NS4B protein had a high binding affinity interaction. It was observed that the NS4B protein binding energy for 15-oxoursolic acid, betulinic acid, ursolic acid, lupeol, and 3-o-acetylursolic acid were − 7.18, − 7.02, − 5.71, − 6.67 and − 8.00 kcal/mol, respectively. Conclusions NS4B protein could be a promising target which showed good interaction with tested triterpenoids which can be developed as a potential antiviral drug for controlling dengue virus pathogenesis by inhibiting viral replication. However, further investigations are necessary to validate and confirm their efficacy.
Læs mere Tjek på PubMedTalha Burki
Lancet, 12.07.2024
Tilføjet 12.07.2024
The Paediatric Dengue Cohort Study has now been running for 20 years, including data on thousands of children and driving discoveries across virology. Talha Burki reports.
Læs mere Tjek på PubMedBharti Pathak, Aparna Chakarvarty, Nakka Veena Rani, Anuja Krishnan
Journal of Medical Virology, 9.07.2024
Tilføjet 9.07.2024
American Journal of Tropical Medicine and Hygiene, 3.07.2024
Tilføjet 3.07.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 1 Pages: 1-2
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 3.07.2024
Tilføjet 3.07.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 1 Pages: 5-10
Læs mere Tjek på PubMedAmerican Journal of Tropical Medicine and Hygiene, 3.07.2024
Tilføjet 3.07.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 111 Issue: 1 Pages: 102-106
Læs mere Tjek på PubMedXiao Hu, Jiamin Song, Guoguo Ye, Miao Zhu, Jianfeng Lan, Lijiao Zeng, Zhiyi Ke, Jing Yuan
Journal of Medical Virology, 3.07.2024
Tilføjet 3.07.2024
Journal of Infectious Diseases, 30.06.2024
Tilføjet 30.06.2024
Abstract There is an increasing global burden from chikungunya virus (CHIKV). Bangladesh reported a major epidemic in 2017, however, it was unclear if there had been prior widespread transmission. We conducted a nationally representative seroprevalence survey in 70 randomly selected communities immediately prior to the epidemic. We found 69/2,938 (2.4%) of sampled individuals were seropositive to CHIKV. Being seropositive to dengue virus (aOR 3.13 [95% CIs: 1.86-5.27]), male sex (aOR 0.59 [95% CIs: 0.36-0.99]), and community presence of Aedes aegypti mosquitoes (aOR: 1.80, 95% CI: 1.05–3.07) were significantly associated with CHIKV seropositivity. Using a spatial prediction model, we estimated that across the country, 4.99 (95% CI: 4.89 - 5.08) million people had been previously infected. These findings highlight high population susceptibility prior to the major outbreak and that previous outbreaks must have been spatially isolated.
Læs mere Tjek på PubMedGarnica, Marcia; Ramos, Jessica Fernandes; Machado, Clarisse Martins
Current Opinion in Infectious Diseases, 29.06.2024
Tilføjet 29.06.2024
Purpose of review Arbovirus infections are a challenge for immunocompromised hosts who travel to or live in endemic regions or who receive organs or tissues from donors who travel or live in such areas. This review addresses Dengue (DENV), Chikungunya (CHIKV), and Zika (ZIKV) infections in hematological patients, hematopoietic cell or solid organ transplant recipients, and people with HIV (PWH). Recent findings Transmission is mainly due through Aedes mosquito bite. DENV and ZIKV may also be transmitted through blood, tissues or donor grafts. Clinical manifestations are quite similar and diagnosis requires laboratory confirmation to provide appropriate management. The best diagnostic method is PCR since serology may present false negative results in immunocompromised patients, or cross-reactivity as in the case of DENV and ZIKV. There is no specific treatment for any of these infections. Summary Educational and preventive measures are the best strategy: vector control, knowledge of the vector\'s habits, protection against mosquito bites, avoiding travel to endemic areas or with a current epidemic, and avoiding nonvector transmission according to local recommendations for donor deferral. Vaccination, currently only available for DENV, has not yet been studied in immunocompromised patients and is not currently recommended.
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