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Søgeord (monkeypox) valgt.
23 emner vises.
Joo‐Hee Hwang, Jeong‐Hwan Hwang
Journal of Medical Virology, 15.05.2024
Tilføjet 15.05.2024
BMC Infectious Diseases, 14.05.2024
Tilføjet 14.05.2024
Abstract Background Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable therapeutic targets. Methods GEO Expression datasets characterizing mRNA profile changes in different host responses to poxviruses were analyzed for shared pathway identification, and then, the Protein–protein interaction (PPI) maps were built. The viral gene expression datasets of Monkeypox virus (MPXV) and Vaccinia virus (VACV) were used to identify the significant viral genes and further investigated for their binding to the library of targeting molecules. Results Infection with MPXV interferes with various cellular pathways, including interleukin and MAPK signaling. While most host differentially expressed genes (DEGs) are predominantly downregulated upon infection, marked enrichments in histone modifiers and immune-related genes were observed. PPI analysis revealed a set of novel virus-specific protein interactions for the genes in the above functional clusters. The viral DEGs exhibited variable expression patterns in three studied cell types: primary human monocytes, primary human fibroblast, and HeLa, resulting in 118 commonly deregulated proteins. Poxvirus proteins C6R derived protein K7 and K7R of MPXV and VACV were prioritized as targets for potential therapeutic interventions based on their histone-regulating and immunosuppressive properties. In the computational docking and Molecular Dynamics (MD) experiments, these proteins were shown to bind the candidate small molecule S3I-201, which was further prioritized for lead development. Results MPXV circumvents cellular antiviral defenses by engaging histone modification and immune evasion strategies. C6R-derived protein K7 binding candidate molecule S3I-201 is a priority promising candidate for treating Mpox.
Læs mere Tjek på PubMedBMC Infectious Diseases, 14.05.2024
Tilføjet 14.05.2024
Abstract Background Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable therapeutic targets. Methods GEO Expression datasets characterizing mRNA profile changes in different host responses to poxviruses were analyzed for shared pathway identification, and then, the Protein–protein interaction (PPI) maps were built. The viral gene expression datasets of Monkeypox virus (MPXV) and Vaccinia virus (VACV) were used to identify the significant viral genes and further investigated for their binding to the library of targeting molecules. Results Infection with MPXV interferes with various cellular pathways, including interleukin and MAPK signaling. While most host differentially expressed genes (DEGs) are predominantly downregulated upon infection, marked enrichments in histone modifiers and immune-related genes were observed. PPI analysis revealed a set of novel virus-specific protein interactions for the genes in the above functional clusters. The viral DEGs exhibited variable expression patterns in three studied cell types: primary human monocytes, primary human fibroblast, and HeLa, resulting in 118 commonly deregulated proteins. Poxvirus proteins C6R derived protein K7 and K7R of MPXV and VACV were prioritized as targets for potential therapeutic interventions based on their histone-regulating and immunosuppressive properties. In the computational docking and Molecular Dynamics (MD) experiments, these proteins were shown to bind the candidate small molecule S3I-201, which was further prioritized for lead development. Results MPXV circumvents cellular antiviral defenses by engaging histone modification and immune evasion strategies. C6R-derived protein K7 binding candidate molecule S3I-201 is a priority promising candidate for treating Mpox.
Læs mere Tjek på PubMedBMC Infectious Diseases, 11.05.2024
Tilføjet 11.05.2024
Abstract Background Monkeypox (Mpox) is an important human pathogen without etiological treatment. A viral-host interactome study may advance our understanding of molecular pathogenesis and lead to the discovery of suitable therapeutic targets. Methods GEO Expression datasets characterizing mRNA profile changes in different host responses to poxviruses were analyzed for shared pathway identification, and then, the Protein–protein interaction (PPI) maps were built. The viral gene expression datasets of Monkeypox virus (MPXV) and Vaccinia virus (VACV) were used to identify the significant viral genes and further investigated for their binding to the library of targeting molecules. Results Infection with MPXV interferes with various cellular pathways, including interleukin and MAPK signaling. While most host differentially expressed genes (DEGs) are predominantly downregulated upon infection, marked enrichments in histone modifiers and immune-related genes were observed. PPI analysis revealed a set of novel virus-specific protein interactions for the genes in the above functional clusters. The viral DEGs exhibited variable expression patterns in three studied cell types: primary human monocytes, primary human fibroblast, and HeLa, resulting in 118 commonly deregulated proteins. Poxvirus proteins C6R derived protein K7 and K7R of MPXV and VACV were prioritized as targets for potential therapeutic interventions based on their histone-regulating and immunosuppressive properties. In the computational docking and Molecular Dynamics (MD) experiments, these proteins were shown to bind the candidate small molecule S3I-201, which was further prioritized for lead development. Results MPXV circumvents cellular antiviral defenses by engaging histone modification and immune evasion strategies. C6R-derived protein K7 binding candidate molecule S3I-201 is a priority promising candidate for treating Mpox.
Læs mere Tjek på PubMedLuciana P.S. Finamor, Maria Cássia Mendes-Correa, Mônica Rinkevicius, Guilherme Macedo, Ester Cerdeira Sabino, Lucy Santos Villas-Boas, Anderson Vicente de Paula, Raissa Heloisa de Araujo-Heliodoro, Antonio Charlys da Costa, Steven S. Witkin, Keila Lima Carneiro Santos, Camila Palmeira, Gabriel Andrade, Maurílio Lucena, Dalton Santoro, Luci Meire Pereira da Silva, Cristina Muccioli
International Journal of Infectious Diseases, 4.05.2024
Tilføjet 4.05.2024
Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV) [1]. Ophthalmologic involvement, termed Monkeypox virus-related ophthalmic disease (MPXROD), encompasses a range of eye-related manifestations that can occur during Monkeypox virus (MPXV) infection. This includes lesions affecting both external structures, such as the periorbita and eyelids, as well as the ocular surface, including conditions like blepharoconjunctivitis, ulcerative keratitis, immune stromal and neurotrophic keratitis [2].
Læs mere Tjek på PubMedLulah Alnaji
PLoS One Infectious Diseases, 1.05.2024
Tilføjet 1.05.2024
by Lulah Alnaji This study integrates advanced machine learning techniques, namely Artificial Neural Networks, Long Short-Term Memory, and Gated Recurrent Unit models, to forecast monkeypox outbreaks in Canada, Spain, the USA, and Portugal. The research focuses on the effectiveness of these models in predicting the spread and severity of cases using data from June 3 to December 31, 2022, and evaluates them against test data from January 1 to February 7, 2023. The study highlights the potential of neural networks in epidemiology, especially concerning recent monkeypox outbreaks. It provides a comparative analysis of the models, emphasizing their capabilities in public health strategies. The research identifies optimal model configurations and underscores the efficiency of the Levenberg-Marquardt algorithm in training. The findings suggest that ANN models, particularly those with optimized Root Mean Squared Error, Mean Absolute Percentage Error, and the Coefficient of Determination values, are effective in infectious disease forecasting and can significantly enhance public health responses.
Læs mere Tjek på PubMedAngel N. Desai, Marion Koopmans, Ashley Otter, Martin P. Grobusch, Pikka Jokelainen, Barry Atkinson, Flavia Cunha, Sofia R. Valdoleiros, Veronica G. Preda, Francesco Maria Fusco, Chantal P. Rovers, Gilbert Greub, Antonino Di Caro, Lone Simonsen, Francine Ntoumi, Eskild Petersen
Clinical Microbiology and Infection, 30.04.2024
Tilføjet 30.04.2024
Mpox, a zoonotic disease resulting from infection with monkeypox virus (MPXV), was previously considered endemic to central- and west Africa. However, an ongoing global outbreak of clade IIb (previously known as West African clade) MPXV associated with human-to-human transmission primarily through sexual contact has occurred since May 2022, with introduction of MPXV to regions and countries that had previously only reported sporadic imported cases [1], [2].
Læs mere Tjek på PubMedCharlotte Hewel, Hanno Schmidt, Stefan Runkel, Wolfgang Kohnen, Susann Schweiger‐Seemann, André Michel, Sven‐Ernö Bikar, Bettina Lieb, Bodo Plachter, Thomas Hankeln, Matthias Linke, Susanne Gerber
Journal of Medical Virology, 25.04.2024
Tilføjet 25.04.2024
Clinical Infectious Diseases, 17.04.2024
Tilføjet 17.04.2024
Abstract Retrospective surveillance leveraging male rectal swab sample remnants from I Want The Kit from July 2021 through October 2023, identified one symptomatic and one asymptomatic mpox case at the peak of transmission in 2022. Although sporadic cases continue to be reported in Maryland, additional asymptomatic cases were not identified in this leveraged surveillance.
Læs mere Tjek på PubMedBMC Infectious Diseases, 16.04.2024
Tilføjet 16.04.2024
Abstract Background Monkeypox is an emerging infectious disease with confirmed cases and deaths in several parts of the world. In light of this crisis, this study aims to analyze the global knowledge pattern of monkeypox-related patents and explore current trends and future technical directions in the medical development of monkeypox to inform research and policy. Methods A comprehensive study of 1,791 monkeypox-related patents worldwide was conducted using the Derwent patent database by descriptive statistics, social network method and linear regression analysis. Results Since the 21st century, the number of monkeypox-related patents has increased rapidly, accompanied by increases in collaboration between commercial and academic patentees. Enterprises contributed the most in patent quantity, whereas the initial milestone patent was filed by academia. The core developments of technology related to the monkeypox include biological and chemical medicine. The innovations of vaccines and virus testing lack sufficient patent support in portfolios. Conclusions Monkeypox-related therapeutic innovation is geographically limited with strong international intellectual property right barriers though it has increased rapidly in recent years. The transparent licensing of patent knowledge is driven by the merger and acquisition model, and the venture capital, intellectual property and contract research organization model. Currently, the patent thicket phenomenon in the monkeypox field may slow the progress of efforts to combat monkeypox. Enterprises should pay more attention to the sharing of technical knowledge, make full use of drug repurposing strategies, and promote innovation of monkeypox-related technology in hotspots of antivirals (such as tecovirimat, cidofovir, brincidofovir), vaccines (JYNNEOS, ACAM2000), herbal medicine and gene therapy.
Læs mere Tjek på PubMedAlessandro ManconAngelo Roberto RaccagniGloria GagliardiDavide MoscheseAlberto RizzoAndrea GiacomelliMiriam CutreraFederica SalariFiorenza BracchittaSpinello AntinoriAndrea GoriGiuliano RizzardiniAntonella CastagnaMaria Rita GismondoSilvia NozzaDavide Miletoa Laboratory of Clincal Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli Sacco, Milan, Italyb Vita-Salute San Raffaele University, Milan, Italyc University of Milan, Milan, Italyd Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Milan, Italye Department of Infectious Diseases, San Raffaele Hospital, Milan, Italyf CNR-SCITEC, Istituto di Scienze e Tecnologie Chimiche “Giulio Natta”, via C. Golgi 19, 20133 Milan, Italy
Emerg Microbes Infect, 15.04.2024
Tilføjet 15.04.2024
Alhassan, J. A. K., Wills, O.
BMJ Open, 6.04.2024
Tilføjet 6.04.2024
BackgroundThe last 3 years have witnessed global health challenges, ranging from the pandemics of COVID-19 and mpox (monkeypox) to the Ebola epidemic in Uganda. Public health surveillance is critical for preventing these outbreaks, yet surveillance systems in resource-constrained contexts struggle to provide timely disease reporting. Although community health workers (CHWs) support health systems in low-income and middle-income countries (LMICs), very little has been written about their role in supporting public health surveillance. This review identified the roles, impacts and challenges CHWs face in public health surveillance in 25 LMICs. MethodsWe conducted a scoping review guided by Arksey and O’Malley’s framework. We exported 1,156 peer-reviewed records from Embase, Global Health and PubMed databases. After multiple screenings, 29 articles were included in the final review. ResultsCHWs significantly contribute to public health surveillance in LMICs including through contact tracing and patient visitation to control major infectious diseases such as HIV/AIDS, malaria, tuberculosis, Ebola, neglected tropical diseases and COVID-19. Their public health surveillance roles typically fall into four main categories including community engagement; data gathering; screening, testing and treating; and health education and promotion. The use of CHWs in public health surveillance in LMICs has been impactful and often involves incorporation of various technologies leading to improved epidemic control and disease reporting. Nonetheless, use of CHWs can come with four main challenges including lack of education and training, lack of financial and other resources, logistical and infrastructural challenges as well as community engagement challenges. ConclusionCHWs are important stakeholders in surveillance because they are closer to communities than other healthcare workers. Further integration and training of CHWs in public health surveillance would improve public health surveillance because CHWs can provide health data on ‘hard-to-reach’ populations. CHWs’ work in public health surveillance would also be greatly enhanced by infrastructural investments.
Læs mere Tjek på PubMedClinical Infectious Diseases, 5.04.2024
Tilføjet 5.04.2024
Clinical Infectious Diseases, 3.04.2024
Tilføjet 3.04.2024
Abstract Background After months of few mpox cases, an increased number of cases were reported in Chicago during May 2023; predominantly among fully vaccinated patients. We investigated the outbreak scope, differences between vaccinated and unvaccinated patients, and hypotheses for monkeypox virus (MPXV) infection after vaccination.Methods We interviewed patients and reviewed medical records to assess demographic, behavioral, and clinical characteristics, mpox vaccine status, and vaccine administration routes. We evaluated serum antibody levels after infection and compared patient viral genomes with MPXV sequences in available databases. We discussed potential vaccine compromise with partners who manufactured, handled, and administered vaccine associated with breakthrough infections.Results During March 18–June 27, 2023, we identified 49 mpox cases; 57% of these mpox patients were fully vaccinated (FV). FV patients received both JYNNEOS doses subcutaneously (57%), intradermally (7%), or via heterologous administration (36%). FV patients had more median sex partners (3, IQR=1-4) versus not fully vaccinated (NFV) patients (1, IQR=1-2). Thirty-six of 37 sequenced specimens belonged to lineage B.1.20 of clade IIb MPXV, which did not demonstrate any amino acid changes relative to B.1, the predominant lineage from May 2022. Vaccinated patients demonstrated expected humoral antibody responses; none were hospitalized. No vaccine storage excursions were identified. Approximately 63% of people at risk for mpox in Chicago were FV during this period.Conclusions Our investigation indicated cases were likely due to frequent behaviors associated with mpox transmission, even with relatively high vaccine effectiveness and vaccine coverage. Cases after vaccination might occur in similar populations.
Læs mere Tjek på PubMedHuisheng SunYiqi MiaoXingsheng YangLiang GuoQingyu LiJing WangJinrong LongZhen ZhangJingqi ShiJian LiYiming CaoChangxiao YuJierui MaiZhen RongJiannan FengShumei WangJing YangShengqi Wanga School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of Chinab Bioinformatics center of AMMS, Beijing, People’s Republic of Chinac Beijing Institute of Pharmacology and Toxicology, Beijing, People’s Republic of China
Emerg Microbes Infect, 1.04.2024
Tilføjet 1.04.2024
Sophie Edouard, Céline Boschi, Philippe Colson, Matthieu Million, Pierre-Edouard Fournier, Bernard La Scola, Florence Fenollar
International Journal of Infectious Diseases, 21.03.2024
Tilføjet 21.03.2024
Human monkeypox, a previously rare viral zoonosis, predominantly endemic to central and western Africa, emerged in May 2022 in non-endemic countries [1]. Initially confirmed in England [2], human autochthonous cases spread across 113 countries around the world, including 106 countries which had never previously reported monkeypox virus (MPXV) (https://www.cdc.gov/poxvirus/mpox/response/2022/world-map.html). Nearly 26,000 cases have been reported in Europe (https://monkeypoxreport.ecdc.europa.eu/).
Læs mere Tjek på PubMedBMC Infectious Diseases, 8.03.2024
Tilføjet 8.03.2024
Abstract Background and objective Monkeypox virus (MPXV) is the causative agent of monkeypox’s zoonotic infection and was declared a global emergency by the World Health Organization (WHO). Studies from different countries have shown insufficient knowledge among the general public on MPXV. This study aimed to assess the knowledge of the general public of Nepal on MPXV. Methods Three hundred people were interviewed in person in October 2022, and 282 complete responses were recorded. The questionnaire related to the knowledge of MPXV was derived from a previous study conducted among the general population of Saudi Arabia. Twenty-two questions were included that assessed the knowledge and attitude of Nepalese toward monkeypox. Statistical comparison between high and low knowledge was performed using Pearson’s Chi-square test. Logistic regression models were deployed to establish the relationship between participants’ knowledge and socio-demographic characteristics. Results Among the total respondents, 53.8% demonstrated high knowledge of monkeypox. People aged 18–25 years, unmarried people, and those living in urban areas had significantly higher levels of knowledge. Most respondents believed that MPXV is not a conspiracy or bioterrorism (63.1%) and agreed that it is likely to affect people’s social and economic life as COVID-19 did (67.0%). The history of COVID-19 vaccination (aOR: 2.980; 95%CI: 1.227, 7.236) and the younger age (aOR: 2.975; 95%CI: 1.097, 8.069) were found to be significant determinants of the knowledge of the participants on monkeypox. Conclusion We observed that most Nepalese populations had a high knowledge of monkeypox and that social media was the most valuable source of information.
Læs mere Tjek på PubMedJournal of Medical Virology, 8.03.2024
Tilføjet 8.03.2024
BMC Infectious Diseases, 7.03.2024
Tilføjet 7.03.2024
Abstract Background and objective Monkeypox virus (MPXV) is the causative agent of monkeypox’s zoonotic infection and was declared a global emergency by the World Health Organization (WHO). Studies from different countries have shown insufficient knowledge among the general public on MPXV. This study aimed to assess the knowledge of the general public of Nepal on MPXV. Methods Three hundred people were interviewed in person in October 2022, and 282 complete responses were recorded. The questionnaire related to the knowledge of MPXV was derived from a previous study conducted among the general population of Saudi Arabia. Twenty-two questions were included that assessed the knowledge and attitude of Nepalese toward monkeypox. Statistical comparison between high and low knowledge was performed using Pearson’s Chi-square test. Logistic regression models were deployed to establish the relationship between participants’ knowledge and socio-demographic characteristics. Results Among the total respondents, 53.8% demonstrated high knowledge of monkeypox. People aged 18–25 years, unmarried people, and those living in urban areas had significantly higher levels of knowledge. Most respondents believed that MPXV is not a conspiracy or bioterrorism (63.1%) and agreed that it is likely to affect people’s social and economic life as COVID-19 did (67.0%). The history of COVID-19 vaccination (aOR: 2.980; 95%CI: 1.227, 7.236) and the younger age (aOR: 2.975; 95%CI: 1.097, 8.069) were found to be significant determinants of the knowledge of the participants on monkeypox. Conclusion We observed that most Nepalese populations had a high knowledge of monkeypox and that social media was the most valuable source of information.
Læs mere Tjek på PubMedHajar Miranzadeh MahabadiY. C. James LinNatacha S. OgandoEman W. MoussaNazanin MohammadzadehOliver JulienNeal M. AltoRyan S. NoyceDavid H. EvansChristopher PoweraDepartment of Medicine, University of Alberta, Edmonton, AB T5N 2S2, CanadabDepartment of Medical Microbiology & Immunology, University of Alberta, Edmonton, AB T5N 2S2, CanadacDepartment of Biochemistry, University of Alberta, Edmonton, AB T5N 2S2, CanadadDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8816eLi Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T5N 2S2, Canada
Proceedings of the National Academy of Sciences, 21.02.2024
Tilføjet 21.02.2024
Proceedings of the National Academy of Sciences, Volume 121, Issue 8, February 2024.
Læs mere Tjek på PubMedBMC Infectious Diseases, 13.02.2024
Tilføjet 13.02.2024
Abstract Background The outbreak of mpox that occurred between 2022 and 2023 is primarily being transmitted through sexual contact. As of now, there is no consensus on the recommended duration of isolation to prevent sexual transmission of the virus. Moreover, this particular mpox outbreak has presented with distinct complications in comparison to previous occurrences. In this report, we present a case involving severe rectal bleeding from an ulcer in a mpox patient with a history of engaging in receptive sexual contact. Case presentation A 30-year-old Korean man presented at the hospital with complaints of fever, multiple skin lesions, and anal pain. Monkeypox virus polymerase chain reaction (PCR) results were positive for skin lesions on the penis and wrist. The patient received a 12-day course of tecovirimat due to anal symptoms and perianal skin lesions. Following isolation for 12 days and after all skin scabs had naturally fallen off, with no new skin lesions emerging for a consecutive 48 hours—conforming to the criteria of the Korean Disease Control and Prevention Agency—the patient was discharged. However, 1 day after discharge, the patient returned to the hospital due to hematochezia. His hemoglobin level had significantly dropped from 14.0 g/dL to 8.2 g/dL. Sigmoidoscopy unveiled a sizable rectal ulceration with exposed blood vessels, prompting the application of hemostasis through metal clipping. Subsequent monkeypox virus real-time PCR conducted on rectal tissue and swabs yielded positive results (with cycle threshold values of 28.48 and 31.23, respectively). An abdominal CT scan exposed a perirectal abscess, for which ampicillin-sulbactam was administered. Conclusion This case underscores the importance of monitoring for bleeding complications and confirming the resolution of rectal lesions before discharging patients from isolation, particularly in cases where patients have a history of engaging in receptive sexual contact with men or are presenting with anal symptoms.
Læs mere Tjek på PubMedYawen Cao, Wenbin Fang, Yingying Chen, Hengchuan Zhang, Ruyu Ni, Guixia Pan
Journal of Medical Virology, 1.02.2024
Tilføjet 1.02.2024
Yunjun Zhang, Xiaohua Zhou
Journal of Medical Virology, 1.02.2024
Tilføjet 1.02.2024