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Initial diagnostik og behandling af formodet akut bakteriel meningitis.
Udgiver: Dansk Selskab for Infektionsmedicin 2018
Rapport og anbefaling vedrørende ulemper og fordele ved henholdsvis at undlade eller gennemføre lumbalpunktur for patienter i blodfortyndende behandling mistænkt for akut bakteriel meningitis.
Denne vejledning er tiltænkt diagnostik og behandling af formodet Lyme neuroborreliose hos voksne. Vejledningen er udarbejdet som et supplement til Borrelia klaringsrapport (2014).
Rekommandationer for profylakse og vaccination ved aspleni.
Denne vejledning dækker anbefalinger omhandlende vaccinationer, antibiotika profylakse og patientinformation om generelle forholdsregler for at beskytte personer med aspleni mod infektioner.
Version 1.2, 22.10.2024. Ændringer siden version 1.1:
Vaccination mod Haemophilus influenzae ændret til 1 dosis (fejlagtigt angivet 3 doser).
Menveo beskytter efter 1 dosis (fejlagtigt angivet som nødvendigt med 2…
Af Rikke Krogh-Madsen, formand for Dansk Selskab for Infektionsmedicin.
Der er lige nu massivt fokus på læger der har begået fejl. Aktuelt drejer det sig om behandling af meningokoksygdom. Bestyrelsen for Dansk Selskab for Infektionsmedicin (DSI) kender ikke til detaljerne i de konkrete sager og har ikke set sagsakterne. Dette er derfor en generel udtalelse som tager udgangspunkt i udmeldingen fra Patienterstatningen vedr. de tre meningokok-sager.
…ard, Morten Sodemann og Marie Nørredam
Influenza:
Jens Lundgren (tovholder), Thomas Benfield, Jan Gerstoft, Isik Johansen, Gitte Kronborg, Henrik Nielsen, Lene Surland Knudsen, Merete Storgaard og Lars Skov Dalgaard
Influenza,
Meningitis og encephalitis:
Christian Brandt (tovholder), Helene Mens, Lars Omland, Lykke Larsen, Jacob Bodilsen, Lothar Wiese, Birgitte Rønde Hansen, Hans Rudolf von Lüttchau, Henrik Nielsen (referent)
Akut bakteriel meningitis,
Viral meningitis,…
…isikoen for bakteriel infektion og sepsis er svært forhøjet ved manglende miltfunktion som følge af splenektomi samt kongenit eller funktionel aspleni. Alvorlige infektioner skyldes primært Streptococcus pneumoniae, Haemophilus influenzae og Neisseria meningitidis.
Risikoen for svær infektion ved malaria og dyrebid er også markant forhøjet.
Vaccination, antibiotika profylakse/tidlig behandling og adækvat patient information er afgørende for forebyggelse af infektioner…
.
Sted:
Auditorium A, Forskningens Hus, Aalborg Universitets Hospital, Syd, Søndre Skovvej 15, 9000 Aalborg.
Program:
Torsdag d. 19/9.
09.30-10.00 Kaffe og velkomst.
10.00-10.15 DASGIB og andre nationale samarbejder HN.
10.15-11.00 Viral meningitis. Christian Brandt.
11.00-11.10 PAUSE.
11.10-11.40 Infektiøs encephalitis (del 1). Jacob Bodilsen.
11.40-12.00 Kursister – CASE gruppe 1.
12.00-13.00 FROKOST.
13.00-13.40 Infektiøs encephalitis (del 2). Jacob Bodilsen…
…dicinske semi-intensive enheder fra de forskellige regioner. Herudover er det meningen at relevante instrukser og forskningsprojekter vil blive gjort tilgængelige for deling.
Undervisning/informationsmateriale:
IMA Herlev Hospital præsentation
Instrukser:
Under opbygning
Forskningsprojekter:
Under opbygning
Kontaktpersoner:
Christian Søborg. MD PhD,. Senior Consultant. Department of Infectious diseases. Copenhagen University Hospital at Herlev. E-mail: borg1@dadlnet.dk
…e Bengaard Andersen kommenterer: Læs ikke denne artikel - med mindre du har særlig tuberkulose interesse. Men hvem har ikke det i vores selskab?
'Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis' af Feng Sun og kolleger publiceret i Antimicrobial Agents and Chemotherapy - et retrospektivt studie fra Kina, der antyder at Linezolid kan give et godt bidrag til behandling af tuberkuløs meningitis…
… Johansen kommenterer: Et trist resultat: I 2013 rapporterede Ruslami et al. (Lancet Infect Dis. 2013 Jan;13(1):27-35) nedsat mortalitet ved IV administrering af en øget dosis Rifampicin og Moxifloxacin i blot 14 dage til ca. 60 patienter med tuberkuløs meningitis - efterfulgt af standard behandling. Der var derfor store forventninger til denne store kliniske trial, hvor effekten af øget Rifampicin dosis samt et flourquinolon (per oralt) blev undersøgt på ca. 700 Vietnamesiske patienter…
Professor Troels Lillebæk kommenterer: I denne Nature Communications artikel beskrives det hvordan det, for første gang nogensinde, er lykkedes at inducere en længerevarende effekt af en tuberkulose vaccine ved at kombinere gammelkendte BCG med 8 antigener i en subunitvaccine. Efter min mening det mest lovende tuberkulosevaccineforsøg til dato, som giver håb om en effektiv vaccine i fremtiden.
…ndgrens studie af, hvornår man kan holde op med at give pneumocyste-profylakse til HIV-smittede eller de Gans studiet, der ændrede fik indført dexamethason i retningslinjerne for purulent meningitis.
Her er formentlig et nyt studie, der kommer til at få indflydelse på standardbehandlingen af patienter med svær pneumoni.
Læs en gang - og døm selv - jeg tager den med til næste års "Journal Highlights of the year", men tænkte at den måske allerede nu var god at få kendskab til. God læselyst :-)
Nyt fra tidsskrifterne [+20]
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PLoS One Infectious Diseases
22.05.2025
by Sylvie Nguyen, Jeanne Godon, Jean-Paul Pais de Barros, David Masson, Lionel Piroth, Mathieu Blot, Meningotoxemia collaboration group . Introduction Lipopolysaccharide (LPS) is a major virulence factor during both meningococcal and Haemophilus influenzae meningitis. Pneumococcus does not produce LPS but could be responsible for bacterial digestive translocation as a consequence of sepsis. We addressed this question in the context of pneumococcal meningitis…
Journal of Infectious Diseases
14.05.2025
BMC Infectious Diseases
13.05.2025
…y rare and predominantly affect immunocompromised patients, exhibiting a high overall mortality rate. Tuberculosis infections, although they can occur in immunocompetent individuals, are more prevalent in those with compromised immune systems. Tuberculous meningitis (TBM), the most severe manifestation of tuberculosis, is associated with a high fatality rate. Co-infection with both pathogens is unusual…
International Journal of Infectious Diseases
8.05.2025
Bacterial meningitis is a severe infection with a high mortality rate. In a systematic analysis, it was estimated that there were 2.82 million cases of bacterial meningitis and 318,400 deaths worldwide in 2016 [1]. In North America, the annual incidence rate of bacterial meningitis has been estimated to range between 1.4 and 3.4 cases per 100,000 [2,3].
Current Opinion in Infectious Diseases
1.05.2025
Purpose of review . We review recent advances in diagnosis and treatment of chronic meningitis, focusing on tuberculous meningitis (TBM), cryptococcal meningitis (CM), syphilitic meningitis, neuroborreliosis, and recurrent chronic meningitis. Noninfectious causes and unique challenges faced in resource-limited settings are also considered. Recent findings . Novel biomarkers are being identified that may be useful for the diagnosis of TBM [i.e…
Current Opinion in Infectious Diseases
1.05.2025
Purpose of review . This review addresses the multifaceted nature of aseptic meningitis, a condition with diverse infectious and noninfectious etiologies. Despite its common presentation in clinical settings, over half of the cases remain without an identified cause, necessitating a comprehensive examination of diagnostic and management strategies…
Emerging Infectious Diseases
30.04.2025
Research - Metagenomic Identification of Fusarium solani Strain as Cause of US Fungal Meningitis Outbreak Associated with Surgical Procedures in Mexico, 2023
Journal of Infectious Diseases
29.04.2025
Abstract . Background . Several ongoing clinical trials are evaluating high-dose rifampicin (up to 35 mg/kg) for tuberculous meningitis (TBM). However, rifampicin pharmacokinetics at higher doses is not fully characterized, particularly in cerebrospinal fluid (CSF), the site of TBM disease.Methods …
Clinical Infectious Diseases
26.04.2025
Abstract . The promising results of the Ambition-CM trial in persons with HIV have sparked interest in treating non-HIV-associated cryptococcal meningitis with single 10mg/kg liposomal amphotericin B, combined with oral flucytosine and fluconazole. However, caution is warranted when applying this approach to non-HIV organ transplant recipients, whose immune status may vary due to the effects of immunosuppressive drugs…
BMC Infectious Diseases
24.04.2025
Bacterial meningitis is a severe infectious disease. Study of bacterial meningitis of children in recent years are limited. It is unclear whether there have been any changes in the epidemiological characteristics of bacterial meningitis during the years of the COVID-19 pandemic. The purpose of this study was to describe a large, nationwide study of bacterial meningitis in China. We analyzed data of hospitalized patients with bacterial meningitis from 30 hospitals in China from 2016—2021…
BMC Infectious Diseases
23.04.2025
… . Objective. This retrospective cohort study aimed to investigate the clinical manifestations, underlying conditions, laboratory findings, imaging findings, treatments, and outcomes of adult patients diagnosed with HCMV meningitis or encephalitis at a single medical center in East Asia over a 6-year period. . Methods…
BMC Infectious Diseases
22.04.2025
. Background. Meningitis during the neonatal period is a potentially devastating condition with high morbidity and mortality. Pathogens cause meningitis varying with gestational age at birth, age at presentation, and geographic location. . Methods…
BMC Infectious Diseases
16.04.2025
. Background. In 2017, WHO published a list of bacteria for which new antibiotics are urgently needed. The main bacteria are common causes of nosocomial meningitis. The key focuses are carbapenem resistance, vancomycin resistance, methicillin resistance, and extended-spectrum beta-lactamase (ESBL) production…
BMC Infectious Diseases
11.04.2025
. Background. Spinal tuberculosis is a rare condition that can result in significant neurological impairments. It is typically classified into two main types based on the anatomical involvement: parenchymal and meningeal. However, existing studies have not provided systematic reports that clarify the differences in aetiology, pathophysiological mechanisms, and clinical presentations between these two types. . Methods…
Journal of Infectious Diseases
9.04.2025
Abstract . Tuberculous meningitis (TBM) remains the most lethal form of tuberculosis (TB). Despite significant physiological differences, adults, and children with TBM receive similar treatment and are often grouped together in research. Consequently, differences in TBM characteristics across the lifespan are poorly understood but may be relevant to developing more effective and age-appropriate interventions…
BMC Infectious Diseases
6.04.2025
. Background. Tuberculous meningitis (TBM) is the most severe form of tuberculosis, with high morbidity and mortality. This retrospective study evaluates the clinical efficacy of linezolid in patients with TBM. . Methods. We analyzed 99 TBM patients treated at the Shanghai Public Health Clinical Center from June 2013 to March 2020…
BMJ Open
3.04.2025
. Introduction. Childhood tuberculous meningitis (TBM) is a devastating disease. The long-standing WHO recommendation for treatment is 2 months of intensive phase with isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E), followed by 10 months of isoniazid and rifampicin. In 2022, WHO released a conditional recommendation that 6 months of intensified antituberculosis therapy (ATT) could be used as an alternative for drug-susceptible TBM…
American Journal of Tropical Medicine and Hygiene
3.04.2025
. . Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 112 Issue: 4 Pages: 856-858. .
American Journal of Tropical Medicine and Hygiene
3.04.2025
. . Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 112 Issue: 4 Pages: 942-942. .
International Journal of Infectious Diseases
2.04.2025
Probiotics, defined as live microorganisms that confer health benefits when administered in adequate quantities [1], have demonstrated efficacy in reducing neonatal complications including necrotizing enterocolitis (NEC), all-cause mortality, late-onset sepsis, and feeding intolerance [2]. Clostridium butyricum (C. butyricum) is a strict anaerobe, producing butyric acid as a metabolic byproduct, hence also called butyric acid bacteria. C…
Aktuelle smitsomme sygdomme [+20]
Der er mere end 20 resultater, måske du vil se flere resultater her?
Eurosurveillance latest updates
26.04.2025
In November 2023, a cluster of two invasive meningococcal disease (IMD) cases caused by serogroup B Neisseria meningitidis (MenB) occurred in elderly residents (≥ 70 years) of a dementia care home in England. An epidemiological investigation was conducted and public health actions, including infection control measures and antibiotic chemoprophylaxis, were implemented to prevent further cases…
Medscape Infectious Diseases
18.04.2025
The panel was due to vote on influenza vaccine recommendations but delayed that to its June meeting. . Medscape Medical News
ProMED
15.04.2025
. . .
MENINGITIS,
MENINGOCOCCAL - NIGERIA (05): UPDATE. ************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Thu 10 Apr 2025 . Source: Leadership [edited] .
leadership.ng/outbreak-of-meningitis-2/ . . . The country is witnessing a resurgence in the outbreak of infectious…
Eurosurveillance latest updates
11.04.2025
In January–February 2025, a community outbreak of Neisseria meningitidis serogroup B was reported in Aragón, Spain, with nine confirmed cases. This represents a 27-fold increase vs the previous 3 years. Five cases had respiratory co-infections; seven were attributed to complex CC213. Epidemiological investigations revealed a potential link to a school setting, though direct transmission could not be confirmed…
ProMED
9.04.2025
. . .
MENINGITIS,
MENINGOCOCCAL - NIGERIA (04): UPDATE. ************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Mon 7 Apr 2025 . Source: Premium Times [edited] .
www.premiumtimesng.com/health/786312-meningitis-kebbi-sokoto-lead-as-nigeria-records-1858-suspected-cases.html . . …
ProMED
1.04.2025
. . . AMEBIC
MENINGOENCEPHALITIS, PRIMARY - USA: (ARKANSAS, NEW MEXICO). FATAL, 2023. *****************************************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . In this post: . [1] Arkansas - _Naegleria fowleri_, splash pool . [2] New Mexico - _Acanthamoeba_, contaminated tap water . . ****** …
ProMED
29.03.2025
. . .
MENINGITIS,
MENINGOCOCCAL - NIGERIA (03): FATAL. ***********************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Thu 27 Mar 2025 . Source: Punch [edited] .
punchng.com/meningitis-kebbi-katsina-lead-as-ncdc-records-807-suspected-cases-74-deaths/ . . . The Nigeria Centre for Disease Control and Prevention (NCDC) said the…
Morbidity and Mortality Weekly Report (MMWR)
28.03.2025
This report describes a fatal case of Naegleria fowleri infection associated with a splash pad in Arkansas.
Medscape Infectious Diseases
27.03.2025
Children with pneumococcal meningitis have a lower risk for 30-day mortality when treated with early adjunctive dexamethasone, a study shows. . Medscape News UK
ProMED
25.03.2025
. . .
MENINGITIS,
MENINGOCOCCAL - NIGERIA (02): (KEBBI) FATAL. *******************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Wed 19 Mar 2025 . Source: Daily Trust [edited] .
dailytrust.com/meningitis-death-toll-rises-to-55-in-kebbi/ . . . The Kebbi State Government says the death toll in the outbreak of…
ProMED
16.03.2025
. . .
MENINGITIS, VIRAL - INDIA: (KERALA). ***********************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Thu 13 Mar 2025 . Source: TimesNow [edited] .
www.timesnownews.com/health/meningitis-cases-surge-in-kochi-2-kids-infected-3-show-symptoms-is-your-child-at-risk-article-118960219 . . . Five students from St…
ProMED
14.03.2025
. . .
MENINGITIS,
MENINGOCOCCAL - NIGERIA: (KEBBI) FATAL. **************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Tue 11 Mar 2025 . Source: Newsday.com [edited] .
www.newsday.com/news/nation/nigeria-meningitis-outbreak-kebbi-m92852 . . . Nigerian authorities confirmed Tuesday [11 Mar 2025] that a
meningitis…
ProMED
28.02.2025
. . .
MENINGITIS - TUNISIA: (KAIROUAN) UNIVERSITY STUDENTS, FATAL, REQUEST. FOR INFORMATION. ************************************************************************************. A ProMED-mail post.
www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases.
www.isid.org . Date: Mon 24 Feb 2025 . Source: AlArarby Algadid [in Arabic, trans. & summ. Mod.MM, edited] .
tinyurl.com/kanuk898 . . …