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Clinical Microbiology and Infection
7.05.2025
We have read with interest the publication by Leroux et al. (2025) exploring factors associated with fulminant pertussis in infants
Re: ‘Safety of pertussis vaccination in pregnancy and effectiveness in infants’ by Kildegaard et al.
Clinical Microbiology and Infection
7.05.2025
We recently read a study published by Kildegaard et al.[1], which evaluated the safety and efficacy of Tdap vaccination during pregnancy based on the Danish nationwide registry data system. Despite the rigorous design of the study, there are still several limitations. Firstly, the study period (2019-2023) spanned the outbreak and prevention period of the COVID-19 pandemic. During the pandemic, people's awareness of hygiene and protection increased, and social distancing measures reduced exposure risks.
Current Opinion in Infectious Diseases
1.05.2025
Purpose of review . Cases of whooping cough (pertussis) have rebounded strongly from the very low incidence observed during the pandemic. This re-emergence is characterized by changes in epidemiology. Here we describe the importance of genomics to monitor and understand the drivers to these changes. Recent findings . Changes in the genotype of strains isolated during recent outbreaks suggests that the pandemic disturbed the global Bordetella pertussis population structure.
International Journal of Infectious Diseases
24.04.2025
Pertussis remains a significant global health challenge despite widespread immunization programs [1]. The introduction of whole-cell pertussis vaccines (WCVs) in the 1940s and subsequent transition to acellular pertussis vaccines (ACVs) initially achieved substantial disease control [2]. However, recent epidemiological data have revealed concerning shifts in pertussis dynamics, with increasing cases reported even in populations maintaining high vaccination coverage [3,4].
Clinical Microbiology and Infection
23.04.2025
In 2024, Slovenia recorded the highest number of confirmed pertussis cases since the introduction of pertussis vaccination in the national vaccination program. In November 2023, the number of reported pertussis cases began to rise in Slovenia, peaking in March 2024. A total of 1,916 confirmed cases were reported in 2024. 52% of cases occurred in individuals under 15 years of age, with 5% of these being infants under 1 year of age.
Tropical Medicine & International Health
23.04.2025
Tropical Medicine &International Health, EarlyView.
Proceedings of the National Academy of Sciences
10.04.2025
Proceedings of the National Academy of Sciences, Volume 122, Issue 14, April 2025. SignificanceAntibodies neutralizing pertussis toxin (PT) prevent the severe clinical symptoms associated with infection byBordetella pertussis. However, the molecular basis of effective PT-targeted immunity is poorly understood. To gain insight into PT-.
BMC Infectious Diseases
28.03.2025
. Background. Pertussis is a highly contagious respiratory disease. Even though vaccination has reduced the incidence, cases have resurfaced in certain regions due to immune escape and waning vaccine efficacy. Identifying high-risk patients to mitigate transmission and avert complications promptly is imperative. Nevertheless, the current diagnostic methods, including PCR and bacterial culture, are time-consuming and expensive.
Lancet Infectious Diseases
26.03.2025
Vaccinating women with Tdap-IPV in pregnancy was safe and well tolerated in a sub-Saharan African setting and boosted the quantity and quality of pertussis-specific antibodies in infants in early life. Although Tdap-IPV was associated with relative blunting of the immune response to the DTwP primary vaccination series, pertussis-specific antibody quality and memory B-cell responses were nevertheless preserved, regardless of the vaccine given during pregnancy.
Clinical Microbiology and Infection
20.03.2025
Recent surges in pertussis spread have renewed focus on pertussis vaccination strategies. Denmark implemented pertussis vaccination during pregnancy in 2019 to protect infants under three months. This nationwide study assessed the real-world safety and effectiveness of acellular pertussis vaccination during pregnancy.
Emerg Microbes Infect
19.03.2025
Volume 14, Issue 1, December 2025 .
BMC Infectious Diseases
2.03.2025
… positive cases throughout Cambodia and in the city of Antananarivo, Madagascar, between 2017 and 2019. The PS, in which Bordetella diagnostics (qPCR) were performed, included infants aged ≤6 months presenting with ≥5 days of cough associated with one pertussis-like symptom. CCI was performed using qPCR and serology regardless of clinical signs. . . . Results.
Emerg Microbes Infect
28.02.2025
Volume 14, Issue 1, December 2025 .
Journal of Infectious Diseases
27.02.2025
…ety endpoints included reactogenicity events within 7 days and adverse events (AEs) through 1 month after vaccination. Primary immunogenicity objectives were to describe immune responses induced by GBS6+Tdap versus Tdap+placebo and versus GBS6+placebo for pertussis, tetanus, and diphtheria Tdap antigens and the 6 GBS6 antigens.Results . Overall, 304 participants received study vaccination. Most reactogenicity events were mild or moderate in severity and balanced across vaccine groups.
Critical Care Explorations
21.02.2025
OBJECTIVES: . Malignant pertussis, the most severe manifestation of Bordetella pertussis infection, is characterized by multiple organ failure and a high mortality rate despite advanced intensive care measures. Hyperleukocytosis is the hallmark of malignant pertussis and necessitates urgent and aggressive interventions. Among the therapeutic options, leukoreduction via whole blood exchange (BE) transfusion has been associated with significant procedural risks and potential clinical deterioration.
BMC Infectious Diseases
12.02.2025
. Abstract. . Background. While parents were traditionally the main reservoir for infant pertussis, transmission sources may have shifted with China’s multi-child policy. Our study aimed to investigate the household transmission patterns and clinical characteristics of pertussis in infants. . . . Methods.
Infection and Immunity
23.01.2025
Infection and Immunity, Ahead of Print.
Emerg Microbes Infect
10.01.2025
Volume 14, Issue 1, December 2025 .
Bibliometrics analysis and knowledge mapping of pertussis vaccine research: trends from 1994 to 2023
Infection
18.10.2024
. Abstract. . Purpose. This study aims to use bibliometric methods to explore the evolving landscape, hotspots, and emerging frontiers of pertussis vaccine research, providing deeper insights into the current research landscape and guiding future vaccine development efforts. . . . Methods.
PLoS One Infectious Diseases
1.10.2024
…Monica Dwi Hartanti, Novaria Sari Dewi Panjaitan, Sunarno Sunarno, Nathalia Ningrum, Armedy Ronny Hasugian, Rita Marleta Dewi, Sarwo Handayani, Masri Sembiring Maha, Firda Fairuza, Meiriani Sari, Dita Setiati, Christina Safira Whinie Lestari . Bordetella pertussis infection is a highly contagious respiratory disease that can cause complications such as pneumonia and death. A total of 62,646 cases of pertussis worldwide were reported by WHO in 2022.
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Medscape Infectious Diseases
1.05.2025
Tetanus-diphtheriaa-acellular pertussis–inactivated polio virus vaccination during pregnancy is safe and boosts pertussis-specific antibody responses in infants. . Medscape Medical News
ProMED
17.04.2025
. . . PERTUSSIS - COLOMBIA (03): (BOGOTA). ***********************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Tue 15 Apr 2025 . Source: Infobae, Argentina [in Spanish, machine trans., abridged,. edited] . www.infobae.com/colombia/2025/04/15/alerta-por-dramatico-aumento-de-casos-de-tos-ferina-en-bogota-en-medellin-tambien-estudian-evolucion-de-la-enfermedad/ .
ProMED
13.04.2025
. . . PERTUSSIS - MEXICO (03): MORE CASES, FATALITIES. ***********************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date:: Fri 11 Apr 2025 . Source: Reto Diario, México [in Spanish, machine trans., edited] . retodiario.com/nacional/2025/04/11/alerta-por-brote-de-tos-ferina-en-mexico-suman-696-casos-y-37-muertes/ . . .
Medscape Infectious Diseases
11.04.2025
Australians are preparing for significant numbers of respiratory infections this winter, as cases of influenza, RSV, and pertussis surge earlier than expected. . Medscape Medical News
ProMED
4.04.2025
. . . PERTUSSIS - USA (06): (LOUISIANA) INFANT, FATAL. ***********************************************. A ProMED-mail post. www.promedmail.org. ProMED-mailis a program of the. International Society for Infectious Diseases. www.isid.org . Date: Thu 3 Apr 2025 . Source: KETV-7/CNN [edited] . www.ketv.com/article/rising-pertussis-whooping-cough-cases-louisiana/64376803 . . . Whooping cough cases climb nationally, 2 infants die in Louisiana .
ProMED
25.03.2025
. . . PERTUSSIS - PERU: (LORETO) ALERT. ********************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Wed 19 Mar 2025 14:29 PET . Source: RPP, Perú [in Spanish, machine trans., abridged, edited] . rpp.pe/peru/loreto/reportan-mas-de-370-casos-de-tos-ferina-tras-brote-de-la-enfermedad-en-iquitos-y-datem-del-maranon-noticia-1622942 . . .
ProMED
10.03.2025
. . . PERTUSSIS - MEXICO (02): INFANT, FATAL, ALERT. *********************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Sat 8 Mar 2025 . Source: Azteca Yucatan [in Spanish, machine trans., abridged, edited] . www.aztecayucatan.com/noticias/atencion-bebe-de-1-ano-muere-a-causa-de-tosferina-hay-mas-de-100-casos-de-esta-enfermedad . . .
ProMED
6.03.2025
. . . PERTUSSIS - MEXICO: INCREASED CASES. ***********************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Mon 3 Mar 2025 . Source: Mexico News Daily [abridged, edited] . mexiconewsdaily.com/news/mexican-authorities-issue-alert-following-rise-whooping-cough-cases/ . . . Mexican health authorities issue alert following rise in whooping. cough cases .
ProMED
5.03.2025
. . . PERTUSSIS - USA (05): (OKLAHOMA, IDAHO). ***************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . [1] Oklahoma . Date: Mon 3 Mar 2025 18:30 CST . Source: KFOR [edited] . kfor.com/news/local/oklahoma-seeing-largest-whooping-cough-outbreak-in-decades-experts-say/ . . . Oklahoma health experts are raising concerns about the rise in.
ProMED
4.03.2025
. . . PERTUSSIS - USA (04): (PENNSYLVANIA) PITTSBURGH AREA. ****************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Mon 3 Mar 2025 . Source: Patch [abridged, edited] . patch.com/pennsylvania/pittsburgh/whooping-cough-cases-skyrocket-pittsburgh-area . . . Whooping cough cases skyrocket in Pittsburgh area .
ProMED
3.03.2025
. . . PERTUSSIS - COLOMBIA (02): (BOGOTA) INFANT DEATH. ************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Fri 28 Feb 2025 . Source: W Radio, Colombia [in Spanish, machine trans., abridged,. edited] . www.wradio.com.co/2025/03/01/confirman-muerte-de-un-menor-de-edad-por-tos-ferina-en-bogota-autoridades-lanzan-alerta/ . . .
ProMED
19.02.2025
. . . PERTUSSIS - COLOMBIA: (ANTIOQUIA) INDIGENOUS PEOPLE, FATALITIES. ***************************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Mon 17 Feb 2025 . Source: El Colombiano, Colombia [in Spanish, machine trans., edited] . www.elcolombiano.com/antioquia/brote-tos-ferina-deja-cuatro-muertos-2025-urrao-antioquia-CA26623515 . . .
ProMED
15.02.2025
. . . PERTUSSIS - USA (03): CDC, 2024 STATISTICS, FATALITIES. ******************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Tue 11 Feb 2025 . Source: CBS News [edited] . www.cbsnews.com/news/whooping-cough-deaths-us-most-since-2017/ . . . USA records most whooping cough deaths since 2017 .
ProMED
13.02.2025
. . . PERTUSSIS - BOLIVIA: (SANTA CRUZ) FATAL. ***************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Tue 11 Feb 2025 . Source: ABI (Agencia Boliviana de Información) [in Spanish, machine. trans., abridged, edited] .
ProMED
9.02.2025
. . . PERTUSSIS - USA (02): (WASHINGTON) PEDIATRIC, FATAL. ***************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Wed 5 Feb 2024 . Source: Spokane Regional Health District (SRHD) [edited] . srhd.org/news/srhd-reports-pertussis-death-in-spokane-county . . . The Spokane Regional Health District (SRHD) announced the first.
ProMED
29.01.2025
. . . PERTUSSIS - USA: (WEST VIRGINIA, OHIO, SOUTH DAKOTA) FATAL. **********************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . [1] West Virginia, Ohio . Date: Thu 23 Jan 2025 22:20 EST . Source: WSAZ [edited] . www.wsaz.com/2025/01/22/whooping-cough-outbreak-reported/ . . .
ProMED
20.01.2025
. . . PERTUSSIS - BRAZIL: DRAMATIC INCREASES, FATALITIES. **************************************************. A ProMED-mail post. www.promedmail.org. ProMED-mail is a program of the. International Society for Infectious Diseases. www.isid.org . Date: Wed 8 Jan 2025 . Source: Folha de São Paulo [in Portuguese, machine trans., edited] .
Medscape Infectious Diseases
24.12.2024
Recombinant pertussis booster vaccines provided sustained immunity against whooping cough in adolescents and young adults, showed a recent follow-up study of a clinical trial. . Medscape Medical News
Eurosurveillance latest updates
6.12.2024
Since April 2024, a pertussis epidemic has been ongoing in Finland with 2,215 notified cases by end October. Of them, 30.1% (n = 667) were aged 10–14 years. Of the 462 Bordetella pertussis isolates characterised, one was macrolide-resistant (minimum inhibitory concentration (MIC) of erythromycin, azithromycin and clarithromycin > 256 μg/mL). The resistant isolate was serotype FIM2, vaccine antigen pertactin-deficient and harboured ptxP3 allele. The emergence of macrolide-resistant B.
Medscape Infectious Diseases
27.11.2024
Numbers higher than pre-pandemic fuel concerns about waning vaccination. . Medscape Medical News