8 ud af 8 tidsskrifter valgt, søgeord (monkeypox) valgt, emner højest 180 dage gamle, sorteret efter nyeste først.
4 emner vises.
1
Multiple introductions of monkeypox virus to Ireland during the international mpox outbreak, May 2022 to October 2023
Gabriel Gonzalez, Michael Carr, Tomás M Kelleher, Emer O’Byrne, Weronika Banka, Brian Keogan, Charlene Bennett, Geraldine Franzoni, Patrice Keane, Cliona Kenna, Luke W Meredith, Nicola Fletcher, Jose Maria Urtasun-Elizari, Jonathan Dean, Ciaran Browne, Fiona Lyons, Brendan Crowley, Derval Igoe, Eve Robinson, Greg Martin, Jeff Connell, Cillian F De Gascun and Daniel Hare
Eurosurveillance latest updates, 19.04.2024
Tilføjet 19.04.2024
BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when a global epidemic of cases in non-endemic countries led to the declaration of a Public Health Emergency of International Concern. Cases of mpox in Ireland, a country without previous mpox reports, could reflect extended local transmission or multiple epidemiological introductions. AimTo elucidate the origins and molecular characteristics of MPXV circulating in Ireland between May 2022 and October 2023. MethodsWhole genome sequencing of MPXV from 75% of all Irish mpox cases (182/242) was performed and compared to sequences retrieved from public databases (n = 3,362). Bayesian approaches were used to infer divergence time between sequences from different subclades and evaluate putative importation events from other countries. ResultsOf 242 detected mpox cases, 99% were males (median age: 35 years; range: 15–60). All 182 analysed genomes were assigned to Clade IIb and, presence of 12 distinguishable subclades suggests multiple introductions into Ireland. Estimation of time to divergence of subclades further supports the hypothesis for multiple importation events from numerous countries, indicative of extended and sustained international spread of mpox. Further analysis of sequences revealed that 92% of nucleotide mutations were from cytosine to thymine (or from guanine to adenine), leading to a high number of non-synonymous mutations across subclades; mutations associated with tecovirimat resistance were not observed. ConclusionWe provide insights into the international transmission dynamics supporting multiple introductions of MPXV into Ireland. Such information supported the implementation of evidence-informed public health control measures.
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Outbreak of mpox caused by Monkeypox virus clade I in the Democratic Republic of the Congo
ECDC
ECDC Epidemiological Update, 5.04.2024
Tilføjet 5.04.2024
Since December 2023 there has been a large increase in the number of mpox cases reported in the Democratic Republic of the Congo (DRC).
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3
Ongoing mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo, 2024
Leandre Murhula Masirika, Jean Claude Udahemuka, Leonard Schuele, Pacifique Ndishimye, Saria Otani, Justin Bengehya Mbiribindi, Jean M. Marekani, Léandre Mutimbwa Mambo, Nadine Malyamungu Bubala, Marjan Boter, David F. Nieuwenhuijse, Trudie Lang, Ernest Balyahamwabo Kalalizi, Jean Pierre Musabyimana, Frank M. Aarestrup, Marion Koopmans, Bas B. Oude Munnink and Freddy Belesi Siangoli
Eurosurveillance latest updates, 15.03.2024
Tilføjet 15.03.2024
Since the beginning of 2023, the number of people with suspected monkeypox virus (MPXV) infection have sharply increased in the Democratic Republic of the Congo (DRC). We report near-to-complete MPXV genome sequences derived from six cases from the South Kivu province. Phylogenetic analyses reveal that the MPXV affecting the cases belongs to a novel Clade I sub-lineage. The outbreak strain genome lacks the target sequence of the probe and primers of a commonly used Clade I-specific real-time PCR.
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Mpox outbreak in France: epidemiological characteristics and sexual behaviour of cases aged 15 years or older, 2022
Catarina Krug, Arnaud Tarantola, Emilie Chazelle, Erica Fougère, Annie Velter, Anne Guinard, Yvan Souares, Anna Mercier, Céline François, Katia Hamdad, Laetitia Tan-Lhernould, Anita Balestier, Hana Lahbib, Nicolas Etien, Pascale Bernillon, Virginie De Lauzun, Julien Durand, Myriam Fayad, Investigation Team, Henriette De Valk, François Beck, Didier Che, Bruno Coignard, Florence Lot and Alexandra Mailles
Eurosurveillance latest updates, 15.12.2023
Tilføjet 15.12.2023
BackgroundLocally-acquired mpox cases were rarely reported outside Africa until May 2022, when locally-acquired-mpox cases occurred in various European countries. AimWe describe the mpox epidemic in France, including demographic and behavioural changes among a subset of cases, during its course. MethodsData were retrieved from the enhanced national surveillance system until 30 September 2022. Laboratory-confirmed cases tested positive for monkeypox virus or orthopoxviruses by PCR; non-laboratory-confirmed cases had clinical symptoms and an epidemiological link to a laboratory-confirmed case. A subset of ≥ 15-year-old male cases, notified until 1 August, was interviewed for epidemiological, clinical and sexual behaviour information. Association of symptom-onset month with quantitative outcomes was evaluated by t- or Wilcoxon tests, and with binary outcomes, by Pearson’s chi-squared or Fisher exact tests. ResultsA total of 4,856 mpox cases were notified, mostly in Île-de-France region (62%; 3,025/4,855). Cases aged ≥ 15 years were predominantly male (97%; 4,668/4,812), with 37 years (range: 15–81) as mean age. Between May and July, among the subset interviewed, mpox cases increased in regions other than Île-de-France, and mean age rose from 35 (range: 21–64) to 38 years (range: 16–75; p = 0.007). Proportions of cases attending men-who-have-sex-with-men (MSM) meeting venues declined from 60% (55/91) to 46% (164/359; p = 0.012); median number of sexual partners decreased from four (interquartile range (IQR): 1–10) to two (IQR: 1–4; p
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