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Medscape Infectious Diseases, 11.10.2024
Tilføjet 11.10.2024
Study shows COVID-19 was associated with higher self-reported incidence of fatigue and other symptoms. Medscape Medical News
Læs mereKevin A Brown, Sarah A Buchan, Adrienne K Chan, Andrew Costa, Nick Daneman, Gary Garber, Michael Hillmer, Aaron Jones, James M Johnson, Dylan Kain, Kamil Malikov, Richard G Mather, Allison McGeer, Kevin L Schwartz, Nathan M Stall and Jennie Johnstone
Eurosurveillance latest updates, 11.10.2024
Tilføjet 11.10.2024
BackgroundLate outbreak identification is a common risk factor mentioned in case reports of large respiratory infection outbreaks in long-term care (LTC) homes. AimTo systematically measure the association between late SARS-CoV-2 outbreak identification and secondary SARS-CoV-2 infection and mortality in residents of LTC homes. MethodsWe studied SARS-CoV-2 outbreaks across LTC homes in Ontario, Canada from March to November 2020, before the COVID-19 vaccine rollout. Our exposure (late outbreak identification) was based on cumulative infection pressure (the number of infectious resident-days) on the outbreak identification date (early: ≤ 2 infectious resident-days, late: ≥ 3 infectious resident-days), where the infectious window was −2 to +8 days around onset. Our outcome consisted of 30-day incidence of secondary infection and mortality, based on the proportion of at-risk residents with a laboratory-confirmed SARS-CoV-2 infection with onset within 30 days of the outbreak identification date. ResultsWe identified 632 SARS-CoV-2 outbreaks across 623 LTC homes. Of these, 36.4% (230/632) outbreaks were identified late. Outbreaks identified late had more secondary infections (10.3%; 4,437/42,953) and higher mortality (3.2%; 1,374/42,953) compared with outbreaks identified early (infections: 3.3%; 2,015/61,714; p
Læs mereRobert Dyrdak, Emma B Hodcroft, Sandra Broddesson, Malin Grabbe, Hildur Franklin, Magnus Gisslén, Maricris E Holm, Magnus Lindh, Joanna Nederby-Öhd, Johan Ringlander, Martin Sundqvist, Richard A Neher and Jan Albert
Eurosurveillance latest updates, 11.10.2024
Tilføjet 11.10.2024
BackgroundDespite the unprecedented measures implemented globally in early 2020 to prevent the spread of SARS-CoV-2, Sweden, as many other countries, experienced a severe first wave during the COVID-19 pandemic. AimWe investigated the introduction and spread of SARS-CoV-2 into Sweden. MethodsWe analysed stored respiratory specimens (n = 1,979), sampled 7 February–2 April 2020, by PCR for SARS-CoV-2 and sequenced PCR-positive specimens. Sequences generated from newly detected cases and stored positive specimens February–June 2020 (n = 954) were combined with sequences (Sweden: n = 730; other countries: n = 129,913) retrieved from other sources for Nextstrain clade assignment and phylogenetic analyses. ResultsTwelve previously unrecognised SARS-CoV-2 cases were identified: the earliest was sampled on 3 March, 1 week before recognised community transmission. We showed an early influx of clades 20A and 20B from Italy (201/328, 61% of cases exposed abroad) and clades 19A and 20C from Austria (61/328, 19%). Clade 20C dominated the first wave (20C: 908/1,684, 54%; 20B: 438/1,684, 26%; 20A: 263/1,684, 16%), and 800 of 1,684 (48%) Swedish sequences formed a country-specific 20C cluster defined by a spike mutation (G24368T). At the regional level, the proportion of clade 20C sequences correlated with an earlier weighted mean date of COVID-19 deaths. ConclusionCommunity transmission in Sweden started when mitigation efforts still focused on preventing influx. This created a transmission advantage for clade 20C, likely introduced from ongoing cryptic spread in Austria. Therefore, pandemic preparedness should have a comprehensive approach, including capacity for large-scale diagnostics to allow early detection of travel-related cases and community transmission.
Læs mereLuisa K Hallmaier-Wacker, Merel D van Eick, Olivier Briët, Hugues Delamare, Gerhard Falkenhorst, Sandrine Houzé, Harold Noël, Javiera Rebolledo, Wim Van Bortel and Céline M Gossner
Eurosurveillance latest updates, 11.10.2024
Tilføjet 11.10.2024
BackgroundAirport and luggage (also called Odyssean) malaria are chance events where Plasmodium infection results from the bite of an infected mosquito which was transported by aircraft from a malaria-endemic area. Infrequent case reports and a lack of central data collection challenge a comprehensive overview. AimTo update the epidemiological, clinical and biological understanding of airport and luggage malaria cases in Europe. MethodsWe conducted a systematic review of studies indexed from 1969 to January 2024 in MEDLINE, Embase and OpenGrey databases. A data call to EU/EEA and UK public health institutes was launched in December 2022. ResultsOf the 145 cases (89 cases from 48 studies and 56 cases from the data call) described from nine countries, 105 were classified as airport malaria, 32 as luggage malaria and eight as either airport or luggage malaria. Most airport malaria cases were reported in France (n = 52), Belgium (n = 19) and Germany (n = 9). Half of cases resided or worked near or at an international airport (mean distance of 4.3 km, n = 28). Despite disruptions in air travel amid the COVID-19 pandemic, one third of cases reported since 2000 occurred between 2018 and 2022, with a peak in 2019. ConclusionWhile airport and luggage malaria cases are rare, reports in Europe have increased, highlighting the need for effective prevention measures and a more structured surveillance of cases in Europe. Prevention measures already in place such as aircraft disinsection should be assessed for compliance and effectiveness.
Læs mereECDC
ECDC COVID-19 updates, 11.10.2024
Tilføjet 11.10.2024
This focused after-action review (AAR) investigated the use of evidence in the Finnish advice-making process for school interventions from December 2021 to January 2022, when the SARS-CoV-2 Omicron variant was circulating and schools remained open.
Læs mereStatens Serum Institut, 11.10.2024
Tilføjet 11.10.2024
Statens Serum Institut, 10.10.2024
Tilføjet 10.10.2024
Udmattelse som senfølge efter smitte med covid-19 er mindre udbredt end frygtet, viser nyt studie fra Statens Serum Institut. Udviklingen ses især efter, at vaccinationerne blev indført, og at omikron-varianten blev den fremherskende covid-19-variant.
Læs mereMedscape Infectious Diseases, 8.10.2024
Tilføjet 8.10.2024
Nearly 90% of babies who had to be hospitalized with COVID-19 had mothers who didn\'t get the vaccine while they were pregnant. KFF Health News
Læs mereBrechje de Gier, Jan van de Kassteele, Liselotte van Asten, Annelot F Schoffelen, ISIS-AR study group, Mariette Hooiveld, Margreet JM te Wierik, Nina M van Sorge and Hester E de Melker
Eurosurveillance latest updates, 5.10.2024
Tilføjet 5.10.2024
BackgroundAfter most COVID-19 pandemic control measures were lifted in 2022, many infectious diseases re-emerged. An increase in invasive group A streptococcal (iGAS) infections among adults and young children was reported by several countries. Viral infections including influenza and varicella, known risk factors for iGAS infection, also increased. AimTo estimate the proportion of GAS skin and soft tissue infections (SSTI) and pneumonia/sepsis in children (≤ 5 years) attributable to varicella, and the proportion of GAS pneumonia/sepsis in children and adults attributable to potentially predisposing respiratory viruses influenza A and B, RSV, hMPV and SARS-CoV-2 in the Netherlands. MethodsWe performed time series regression using weekly data on respiratory viruses, varicella and non-invasive GAS infections and GAS isolates cultured from blood, lower airways, skin, pus and wounds, from January 2010 to March 2023. ResultsIn 2010–19, 50% (95% CI: 36–64) of GAS SSTI in children were attributable to varicella. Between January 2022 and March 2023, 34% (95% CI: 24–43) of GAS SSTI cases were attributable to varicella. Of iGAS pneumonia/sepsis between January 2022 and March 2023, 34% (95% CI: 20–49) and 25% (95% CI: 18–32) was attributable to respiratory virus infections in children and adults, respectively, with the largest contributor (17%) being influenza A. ConclusionsPredisposing viral infections likely contributed to, but cannot fully explain, the observed iGAS increase among children and adults in 2022–23 in the Netherlands. Public health measures to control viral infections, such as vaccination against varicella or influenza, might reduce the iGAS disease burden.
Læs mereMorbidity and Mortality Weekly Report (MMWR), 4.10.2024
Tilføjet 4.10.2024
This report describes the percentage of older adults with a COVID-19 diagnosis who received a recommended COVID-19 antiviral medication.
Læs mereMorbidity and Mortality Weekly Report (MMWR), 4.10.2024
Tilføjet 4.10.2024
Medscape Infectious Diseases, 3.10.2024
Tilføjet 3.10.2024
Physicians detail their predictions on the upcoming COVID-19 and flu season, sharing recommendations to increase patient awareness and advise on vaccinations. WebMD Health News
Læs mereMedscape Infectious Diseases, 2.10.2024
Tilføjet 2.10.2024
The COVID-19 pandemic highlighted the urgent need to modernize public health data systems. Health providers play a key role, says CDC\'s Dr. Jennifer Layden. CDC Expert Commentary
Læs mereStatens Serum Institut, 1.10.2024
Tilføjet 1.10.2024
Statens Serum Institut påviser, at covid-19 har været forbundet med mere end dobbelt så mange indlæggelser og dødsfald set i forhold til influenza.
Læs mereMedscape Infectious Diseases, 28.09.2024
Tilføjet 28.09.2024
A new study hints at a possible connection between infections and unexplained infant deaths. Medscape Medical News
Læs mereMorbidity and Mortality Weekly Report (MMWR), 27.09.2024
Tilføjet 27.09.2024
Medscape Infectious Diseases, 26.09.2024
Tilføjet 26.09.2024
A new COVID-19 variant called XEC is on the rise, and it has experts who track variants on alert. WebMD Health News
Læs mereMedscape Infectious Diseases, 21.09.2024
Tilføjet 21.09.2024
The EMA has approved Penbraya for protection against invasive meningococcal disease and an update of the composition of two COVID-19 vaccines. Medscape Medical News
Læs mereStatens Serum Institut, 20.09.2024
Tilføjet 20.09.2024
Repræsentanter fra 22 lande i Europa samt ECDC og WHO mødes i denne uge i København til en 3-dages workshop for at udveksle erfaringer og diskutere nye metoder og muligheder til overvågning af overdødelighed under epidemier som covid-19 og influenza.
Læs mereECDC
ECDC COVID-19 updates, 18.09.2024
Tilføjet 18.09.2024
This Reporting Protocol describes data collection for influenza, COVID-19, and other respiratory viruses (such as RSV or new viruses of public health concern) in the EU/EEA and wider WHO European Region. Data collection is integrated for most datasets in line with the operational considerations for respiratory virus surveillance in Europe.
Læs mereMedscape Infectious Diseases, 17.09.2024
Tilføjet 17.09.2024
The use of antipsychotics for schizophrenia was associated with higher risk for severe cases of COVID-19 and non–COVID-19 respiratory infections but not mild infection. Medscape Medical News
Læs mereEero Poukka, Jori Perälä, Hanna Nohynek, Sirkka Goebeler, Kari Auranen, Tuija Leino and Ulrike Baum
Eurosurveillance latest updates, 13.09.2024
Tilføjet 13.09.2024
BackgroundLong-term effectiveness data on bivalent COVID-19 boosters are limited. AimWe evaluated the long-term protection of bivalent boosters against severe COVID-19 among ≥ 65-year-olds in Finland. MethodsIn this register-based cohort analysis, we compared the risk of three severe COVID-19 outcomes among ≥ 65-year-olds who received a bivalent booster (Original/Omicron BA.1 or Original/BA.4–5; exposed group) between 1/9/2022 and 31/8/2023 to those who did not (unexposed). We included individuals vaccinated with at least two monovalent COVID-19 vaccine doses before 1/9/2022 and ≥ 3 months ago. The analysis was divided into two periods: 1/9/2022–28/2/2023 (BA.5 and BQ.1.X predominating) and 1/3/2023–31/8/2023 (XBB predominating). The hazards for the outcomes between exposed and unexposed individuals were compared with Cox regression. ResultsWe included 1,191,871 individuals. From 1/9/2022 to 28/2/2023, bivalent boosters were associated with a reduced risk of hospitalisation due to COVID-19 (hazard ratio (HR): 0.45; 95% confidence interval (CI): 0.37–0.55), death due to COVID-19 (HR: 0.49; 95% CI: 0.38–0.62), and death in which COVID-19 was a contributing factor (HR: 0.40; 95% CI: 0.31–0.51) during 14–60 days since vaccination. From 1/3/2023 to 31/8/2023, bivalent boosters were associated with lower risks of all three severe COVID-19 outcomes during 61–120 days since a bivalent booster (e.g. HR: 0.53; 95% CI: 0.39–0.71 for hospitalisation due to COVID-19); thereafter no notable risk reduction was observed. No difference was found between Original/Omicron BA.1 and Original/BA.4–5 boosters. ConclusionBivalent boosters initially reduced the risk of severe COVID-19 outcomes by ca 50% among ≥ 65-year-olds, but protection waned over time. These findings help guide vaccine development and vaccination programmes.
Læs mereStatens Serum Institut, 13.09.2024
Tilføjet 13.09.2024
En ekstra vaccination mod covid-19 giver en markant sundhedsgevinst til immunsvækkede personer, viser en ny nordisk undersøgelse, som Statens Serum Institut (SSI) har ledet.
Læs mereStatens Serum Institut, 12.09.2024
Tilføjet 12.09.2024
Statens Serum Institut (SSI) er i fuld gang med at udsende invitationer til vaccination mod influenza og covid-19 til alle, der er fyldt 65 år. SSI sikrer også, at vaccinerne leveres, så vaccinationsstederne er klar den 1. oktober, hvor vaccinationsperioden begynder.
Læs mereMorbidity and Mortality Weekly Report (MMWR), 11.09.2024
Tilføjet 11.09.2024
This report describes the Advisory Committee on Immunization Practices\' recommendations for the 2024-25 COVID-19 vaccines.
Læs mereMedscape Infectious Diseases, 11.09.2024
Tilføjet 11.09.2024
Pfizer and Moderna mRNA vaccines are updated to better match currently circulating COVID strains, while the Novavax adjuvant will target the JN.1 variant — a predecessor of KP.2. Medscape Medical News
Læs mereMartin Šmíd, Tamara Barusová, Jiří Jarkovský, Ondřej Májek, Tomáš Pavlík, Lenka Přibylová, Josefína Weinerová, Milan Zajíček and Jan Trnka
Eurosurveillance latest updates, 30.08.2024
Tilføjet 30.08.2024
BackgroundCOVID-19 remains a major infectious disease with substantial implications for individual and public health including the risk of a post-infection syndrome, long COVID. The continuous changes in dominant variants of SARS-CoV-2 necessitate a careful study of the effect of preventative strategies. AimWe aimed to estimate the effectiveness of post-vaccination, post-infection and hybrid immunity against severe cases requiring oxygen support caused by infections with SARS-CoV-2 variants BA1/2 and BA4/5+, and against long COVID in the infected population and their changes over time. MethodsWe used a Cox regression analysis with time-varying covariates and calendar time and logistic regression applied to national-level data from Czechia from December 2021 until August 2023. ResultsRecently boosted vaccination, post-infection and hybrid immunity provide significant protection against a severe course of COVID-19, while unboosted vaccination more than 10 months ago has a negligible protective effect. The post-vaccination immunity against the BA1/2 or BA4/5+ variants, especially based on the original vaccine types, appears to wane rapidly compared with post-infection and hybrid immunity. Once infected, however, previous immunity plays only a small protective role against long COVID. ConclusionVaccination remains an effective preventative measure against a severe course of COVID-19 but its effectiveness wanes over time thus highlighting the importance of booster doses. Once infected, vaccines may have a small protective effect against the development of long COVID.
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