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This report describes updated public health service guidelines for testing transplant candidates under 12 years of age for HIV, Hepatitis B, and Hepatitis C.

This report describes new HIV diagnoses reported to CDC from 2019 to 2020 and declines in HIV testing during the same period.

Educating primary care clinicians about preexposure prophylaxis for HIV could help ease the shortage in clinicians who prescribe the drugs, a study found. …

Cervical cancer is an AIDS-defining illness and is a leading cause of cancer death among women with HIV. …

Rapid diagnosis and whole genome sequencing confirmed a case of monkeypox in an HIV-positive individual receiving antiretroviral therapy. The patient had a normal CD4+ T-cell count and suppressed HIV viral load and presented with a genital rash in Melbourne, Australia after return from Europe in May 2022. He subsequently developed systemic illness and disseminated rash and 11 days after symptom onset, he was hospitalised to manage painful bacterial cellulitis of the genital area.…

This report describes economic circumstances associated with transgender women accessing HIV prevention and healthcare.

Due to the COVID-19 pandemic, 2020 was likely a "lost year" in the public health battle against the long-lasting HIV epidemic in the US, a public health official says. …

A sophisticated criminal enterprise has been operating at scale to distribute and profit from counterfeit HIV drugs. The details read like a best-selling crime novel. …

Advocates say it's one of the strongest rulings in years for people living with HIV. …

Introduction

Users of pre-exposure prophylaxis (PrEP) require periodic testing for HIV, sexually transmitted infections (STI) and renal function. Before PrEP was made free of charge through statutory health insurance in late 2019, PrEP users in Germany had to pay for testing themselves.

Aim

We investigated self-reported HIV, STI and renal function testing frequencies among self-funded PrEP users in Germany, factors associated with infrequent testing, and STI diagnoses.

Methods

A cross-sectional anonymous online survey in 2018 and 2019 recruited current PrEP users via dating apps for men who have sex with men (MSM), a PrEP community website, anonymous testing sites and friends. We used descriptive methods and logistic regression for analysis.

Results

We recruited 4,848 current PrEP users. Median age was 37 years (interquartile range (IQR): 30–45), 88.7% identified as male, and respectively 26.3%, 20.9% and 29.2% were tested less frequently for HIV, STI and renal function than recommended. Participants with lower STI testing frequency were significantly less likely to report STI diagnoses during PrEP use, especially among those with many partners and inconsistent condom use. Factors most strongly associated with infrequent testing included not getting tested before starting PrEP, using PrEP from informal sources and on-demand/intermittent PrEP use.

Discussion

In a setting of self-funded PrEP, many users obtained medical tests less frequently than recommended, which can lead to missed diagnoses. Barriers to testing should be addressed to enable proper medical supervision. The suitability of testing frequencies to PrEP users with less frequent risk exposures needs to be evaluated.…

Introduction

Despite increased use of pre-exposure prophylaxis (PrEP) in Germany, HIV infection rates are not declining and little is known about how this prevention method affects the prevalence of sexually transmitted infections (STI) among men who have sex with men (MSM).

Aim

We studied, in a large multicentre cohort, STI point prevalence, co-infection rates, anatomical location and influence of PrEP.

Methods

The BRAHMS study was a prospective cohort study conducted at 10 sites in seven major German cities that enrolled MSM reporting increased sexual risk behaviour. At screening visits, MSM were tested for Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Treponema pallidum (TP), and given a behavioural questionnaire. With binomial regression, we estimated prevalence ratios (PR) and 95% confidence intervals (CI) for the association of PrEP and STI.

Results

We screened 1,043 MSM in 2018 and 2019, with 53.0% currently using PrEP. At screening, 370 participants (35.5%) had an STI. The most common pathogen was MG in 198 (19.0%) participants, followed by CT (n = 133; 12.8%), NG (n = 105; 10.1%) and TP (n = 37; 3.5%). Among the 370 participants with at least one STI, 14.6% (n = 54) reported STI-related symptoms. Infection prevalence was highest at anorectal site (13.4% MG, 6.5% NG, 10.2% CT). PrEP use was not statistically significant in adjusted models for STI (PR: 1.10; 95% CI: 0.91–1.32), NG/CT, only NG or only CT.

Conclusions

Prevalence of asymptomatic STI was high, and PrEP use did not influence STI prevalence in MSM eligible for PrEP according to national guidelines.…

In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017–19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.…

This report describes programmatic gains of HIV treatment during the pandemic.

The big-data era has arrived in HIV epidemiology, allowing researchers to better track viruses through communities and the effect of those viruses in communities. …

The rules were issued clarifying that health plans need to cover the costs of prescription drugs to prevent HIV infection, lab tests, and medical appointments, at no cost. The erroneous billing continues. …

This report describes an analysis of HIV infection data collected during surveillance in Malawi.

A third person who has been 'cured' of HIV through a unique transplant of stem cells has given hope for a larger-scale way to beat back the HIV epidemic that has plagued the world for four decades. …

Since the Mississippi baby captured the imagination of scientists, researchers have been looking for a way to replicate that treatment-free remission. Should preemptive HIV ART apply to infants too? …

Archived data for, and repository of, the maps in support of the Council Recommendation on a coordinated approach to travel measures in the EU.

This report describes COVID-19 vaccination coverage among adults diagnosed with HIV infection.

This report describes social vulnerability and rates of HIV diagnoses among black adults.

One year after the World Health Organization recommended a vaginal ring to protect women from HIV following years of research — some done in the US — the ring will not be coming to US clinics. Here's why. …

Partner notification (PN) is an essential element of sexually transmitted infection (STI) control. It enables identification, treatment and advice for sexual contacts who may benefit from additional preventive interventions such as HIV pre- and post-exposure prophylaxis. PN is most effective in reducing STI transmission when it reaches individuals who are most likely to have an STI and to engage in sexual behaviour that facilitates STI transmission, including having multiple and/or new sex partners. Outcomes of PN practice need to be measurable in order to inform standards. They need to address all five stages in the cascade of care: elicitation of partners, establishing contactable partners, notification, testing and treatment. In the United Kingdom, established outcome measures cover only the first three stages and do not take into account the type of sexual partnership. We report an evidence-based process to develop new PN outcomes and inform standards of care. We undertook a systematic literature review, evaluation of published information on types of sexual partnership and a modified Delphi process to reach consensus. We propose six new PN outcome measures at five stages of the cascade, including stratification by sex partnership type. Our framework for PN outcome measurement has potential to contribute in other domains, including Covid-19 contact tracing.…

Gilead Sciences said on Tuesday that tampered and counterfeit versions of its HIV treatments worth $250 million were sold to pharmacies over 2 years by a network of drug distributors and suppliers. …

This report describes a Kanawha County HIV outbreak during the COVID-19 pandemic among people who inject drugs.

This report describes HIV prevalence among young women in Lesotho.

Now that medical science has solved the HIV treatment paradigm, it might be time to shift to patient experience to end the AIDS epidemics. …