BackgroundCarriage of multidrug-resistant organisms (MDROs) in humans constitutes an important public health concern. Cross-transmission of bacteria between animals and humans has been demonstrated before. AimOur aim was to quantify the risk factor ‘pet ownership’ for MDRO colonisation in hospital patients. MethodsWe performed a matched case–control study from 2019 to 2022 in Berlin, Germany and compared MDRO-positive and MDRO-negative patients in terms of contact with pets and other risk factors for MDRO acquisition. Patients completed a questionnaire-based interview and provided nasal and rectal swabs. Pet owners provided swab samples from the throat and stool of their pets (dogs and cats). Phenotypically matching samples of owners and pets were analysed via whole genome sequencing. ResultsThe analyses included 2,891 patients. Reported pet ownership was 17.7% in MDRO-positives (154/871) and 23.4% in MDRO-negatives (472/2,020). Among 397 owner–pet pairs, we identified one pair sharing genotypically indistinguishable pathogens (0.3%). A risk factor analysis of pet ownership was performed for carriers of meticillin-resistant Staphylococcus aureus (MRSA) (OR = 0.662; 95% CI: 0.343–1.277), vancomycin-resistant enterococci (VRE) (OR = 0.764; 95% CI: 0.522–1.118) and multidrug-resistant Gram-negative bacteria (MDR-GNB) (OR = 0.819; 95% CI: 0.620–1.082). Colonisation with MDRO was rare in pets, and dogs were more often colonised than cats (MRSA: 0% vs 0%, VRE: 1.5% vs 1.0%, MDR-GNB: 17.2% vs 3.6%). ConclusionTransmission of MDROs between humans and pets is possible though rare. In an urban living space, neither cat nor dog ownership appears as a relevant risk factor for MDRO carriage in hospital patients. …

Researchers who uncovered a fresh class of antibiotics used a new process — explainable AI — that could propel drug discovery. Medscape Medical News…

BackgroundAntimicrobial resistance (AMR) is of public health concern worldwide. AimWe aimed to summarise the German AMR situation for clinicians and microbiologists. MethodsWe conducted a systematic review and meta-analysis of 60 published studies and data from the German Antibiotic-Resistance-Surveillance (ARS). Primary outcomes were AMR proportions in bacterial isolates from infected patients in Germany (2016–2021) and the case fatality rates (2010–2021). Random and fixed (common) effect models were used to calculate pooled proportions and pooled case fatality odds ratios, respectively. ResultsThe pooled proportion of meticillin resistance in Staphylococcus aureus infections (MRSA) was 7.9% with a declining trend between 2014 and 2020 (odds ratio (OR) = 0.89; 95% CI: 0.886–0.891; p 

Referencelaboratoriet for Antibiotikaresistens på Statens Serum Institut opgør hvert kvartal antallet af blodforgiftninger forårsaget af MRSA samt dødsfald som følge af disse.

Referencelaboratoriet for Antibiotikaresistens på Statens Serum Institut opgør hvert kvartal antallet af blodforgiftninger forårsaget af MRSA samt dødsfald som følge af disse.

Der var i 2013 en stor stigning i antallet af patienter, der fik infektioner med multiresistente bakterier som VRE og CPE på de danske hospitaler. Derimod fastholdtes antallet af hospitals MRSA infektioner på samme lave niveau som året før. Det viser årets DANMAP rapport fra Statens Serum Institut og DTU Fødevareinstituttet.