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17 emner vises.
1
U.S. Preparedness and Response to Increasing Clade I Mpox Cases in the Democratic Republic of the Congo - United States, 2024
Morbidity and Mortality Weekly Report (MMWR), 16.05.2024
Tilføjet 16.05.2024
This report describes the investigation of cases in the Democratic Republic of the Congo (DRC), CDC\'s support to DRC, and U.S. public health preparedness activities to date.
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2
Anorectal lymphogranuloma venereum among men who have sex with men: a 3-year nationwide survey, France, 2020 to 2022
Olivia Peuchant, Cécile Laurier-Nadalié, Laura Albucher, Carla Balcon, Amandine Dolzy, Nadège Hénin, Arabella Touati, Cécile Bébéar and on behalf of the Anachla study group
Eurosurveillance latest updates, 10.05.2024
Tilføjet 10.05.2024
BackgroundIn France, lymphogranuloma venereum (LGV) testing switched from universal to selective testing in 2016. AimTo investigate changes in LGV-affected populations, we performed a nationwide survey based on temporarily reinstated universal LGV testing from 2020 to 2022. MethodsEach year, during three consecutive months, laboratories voluntarily sent anorectal Chlamydia trachomatis-positive samples from men and women to the National Reference Centre for bacterial sexually transmitted infections. We collected patients’ demographic, clinical and biological data. Genovars L of C. trachomatis were detected using real-time PCR. In LGV-positive samples, the ompA gene was sequenced. ResultsIn 2020, LGV positivity was 12.7% (146/1,147), 15.2% (138/907) in 2021 and 13.3% (151/1,137) in 2022 (p > 0.05). It occurred predominantly in men who have sex with men (MSM), with rare cases among transgender women. The proportion of HIV-negative individuals was higher than that of those living with HIV. Asymptomatic rectal LGV increased from 36.1% (44/122) in 2020 to 52.4% (66/126) in 2022 (p = 0.03). Among users of pre-exposure prophylaxis (PrEP), LGV positivity was 13.8% (49/354) in 2020, 15.6% (38/244) in 2021 and 10.9% (36/331) in 2022, and up to 50% reported no anorectal symptoms. Diversity of the LGV ompA genotypes in the Paris region increased during the survey period. An unexpectedly high number of ompA genotype L1 variant was reported in 2022. ConclusionIn rectal samples from MSM in France, LGV positivity was stable, but the proportion of asymptomatic cases increased in 2022. This underscores the need of universal LGV testing and the importance of continuous surveillance.
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3
Contact tracing management of a measles case in a paediatric hospital: experience of the local public health unit, Portugal, January 2024
Daniel Saldanha Resendes, António Tomás, Mariana Pinção Cardoso, Sebastian von Schreeb, Rita Miranda Ferrão, Paula Vasconcelos, Maria Helena Almeida, Bruno Novo Castro, Vasco Ricoca Peixoto, Renato Lourenço Silva and Margarida de Morais
Eurosurveillance latest updates, 26.04.2024
Tilføjet 26.04.2024
In January 2024, a child was diagnosed with measles in a paediatric hospital in Lisbon. Of 123 contacts, 39 (32%) were not fully immunised, presenting a risk for a potential outbreak. The public health unit initiated control measures and identified challenges during the response, such as the lack of interoperability between information systems and accessing vaccination records. The lessons learned prompted changes to national contact tracing procedures for measles, further strengthening Portugal’s preparedness.
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4
Questioning risk compensation: pre-exposure prophylaxis (PrEP) and sexually transmitted infections among men who have sex with men, capital region of Denmark, 2019 to 2022
Sebastian von Schreeb, Susanne Kriegel Pedersen, Hanne Christensen, Kristina Melbardis Jørgsensen, Lene Holm Harritshøj, Frederik Boetius Hertz, Magnus Glindvad Ahlström, Anne-Mette Lebech, Suzanne Lunding, Lars Nørregaard Nielsen, Jan Gerstoft, Gitte Kronborg and Frederik N Engsig
Eurosurveillance latest updates, 29.03.2024
Tilføjet 29.03.2024
BackgroundPre-exposure prophylaxis (PrEP) effectively prevents HIV, but its association with sexually transmitted infections (STIs) has raised concerns about risk compensation, potentially impacting the expansion of PrEP programmes. AimWe examined the relationship between PrEP and the incidence of chlamydia, gonorrhoea and syphilis. MethodsIn this prospective cohort study, we compared STI rates before and after PrEP initiation among users in the capital region of Denmark (2019–2022), calculating incidence rate ratios adjusted for age and testing frequency (aIRR). To pinpoint when increases began, we plotted weekly STI rates, adjusting the timeline to correspond with PrEP initiation. ResultsThe study included 1,326 PrEP users with a median age of 35 years. The STI incidence rate per 100,000 person-years rose from 35.3 before to 81.2 after PrEP start, with an aIRR of 1.35 (95% CI: 1.18–1.56). Notably, this increase preceded PrEP initiation by 10–20 weeks. Specific aIRR for chlamydia, gonorrhoea and syphilis were 1.23 (95% CI: 1.03–1.48), 1.24 (95% CI: 1.04–1.47) and 1.15 (95% CI: 0.76–1.72), respectively. In subanalyses for anatomical sites aIRR was 1.26 (95% CI: 1.01–1.56) for rectal chlamydia and 0.66 (95% CI: 0.45–0.96) for genital gonorrhoea. ConclusionWe found a 35% increase in STI incidence associated with PrEP use. It started before PrEP initiation, challenging the assumption that PrEP leads to risk compensation. Instead, the data suggest that individuals seek PrEP during periods of heightened sexual risk-taking. Consequently, PrEP programmes should include sexual health consultations, STI testing, treatment and prevention strategies to prevent HIV and improve sexual health.
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5
Public health and social measures for health emergencies and pandemics in the EU/EEA: recommendations for strengthening preparedness planning
ECDC
ECDC COVID-19 updates, 20.03.2024
Tilføjet 20.03.2024
This guidance outlines key strategic and operational considerations to inform pandemic preparedness planning round the design and implementation of public health and social measures in community settings in the EU/EEA.
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6
AstraZeneca to Invest 650 Million Pounds in UK to Boost Pandemic Preparedness
Medscape Infectious Diseases, 7.03.2024
Tilføjet 7.03.2024
AstraZeneca plans to invest 650 million pounds ($826.80 million) in Britain to boost research, development and manufacturing of vaccines, the government announced on... Reuters Health Information
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7
Laboratory Support for influenza and SARS-CoV-2 for Europe: AURORAE
ECDC
ECDC COVID-19 updates, 15.02.2024
Tilføjet 15.02.2024
AURORAE provides laboratory support for surveillance, preparedness and response to COVID-19 and influenza and strengthens the capacity for genomic epidemiology and public health bioinformatics through interdisciplinary training, which is crucial for response during a pandemic or unexpected major public health events.
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8
MMWR Supplement: Characteristics Associated with Pre-Exposure Prophylaxis Discussion and Use Among Transgender Women Without HIV Infection - National HIV Behavioral Surveillance Among Transgender Women, Seven Urban Areas, United States, 2019-2020
Morbidity and Mortality Weekly Report (MMWR), 26.01.2024
Tilføjet 26.01.2024
This report examines whether transgender women who report behaviors associated with HIV acquisition were more likely to have had discussions with their clinician about pre-exposure prophylaxis (PrEP) and used PrEP.
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9
Long-Acting PrEP in Europe's Fight Against HIV
Medscape Infectious Diseases, 1.12.2023
Tilføjet 1.12.2023
Europe\'s advances in HIV prevention strategies, including PrEP and long-acting retrovirals, bring hope amidst persistent access challenges and disparities. Medscape Medical News
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10
Helping Patients Stay Safe From Respiratory Viruses
Medscape Infectious Diseases, 14.11.2023
Tilføjet 14.11.2023
CDC\'s Demetre Daskalakis, MD, MPH, discusses how to prepare for the 2023-2024 fall and winter virus season. CDC Expert Commentary
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11
Routine Vaccination Coverage - Worldwide, 2022
Morbidity and Mortality Weekly Report (MMWR), 26.10.2023
Tilføjet 26.10.2023
From 2021 to 2022, global coverage with the first dose of diphtheria-tetanus-pertussis-containing vaccine increased from 86% to 89%, and with the first dose of measles-containing vaccine from 81% to 84%, but neither returned to 2019 prepandemic coverage levels of 90% and 86%, respectively.
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12
Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022
Pengfei Cui, Jianzhong Shi, Cheng Yan, Congcong Wang, Yuancheng Zhang, Yaping Zhang, Xin Xing, Yuan Chen, Jie Zhang, Liling Liu, Xianying Zeng, Guobin Tian, Chengjun Li, Yasuo Suzuki, Guohua Deng and Hualan Chen
Eurosurveillance latest updates, 13.10.2023
Tilføjet 13.10.2023
BackgroundTwo human cases of avian influenza A (H3N8) virus infection were reported in China in 2022. AimTo characterise H3N8 viruses circulating in China in September 2021−May 2022. MethodsWe sampled poultry and poultry-related environments in 25 Chinese provinces. After isolating H3N8 viruses, whole genome sequences were obtained for molecular and phylogenetic analyses. The specificity of H3N8 viruses towards human or avian receptors was assessed in vitro. Their ability to replicate in chicken and mice, and to transmit between guinea pigs was also investigated. ResultsIn total, 98 H3N8 avian influenza virus isolates were retrieved from 38,639 samples; genetic analysis of 31 representative isolates revealed 17 genotypes. Viruses belonging to 10 of these genotypes had six internal genes originating from influenza A (H9N2) viruses. These reassorted viruses could be found in live poultry markets and comprised the strains responsible for the two human infections. A subset of nine H3N8 viruses (including six reassorted) that replicated efficiently in mice bound to both avian-type and human-type receptors in vitro. Three reassorted viruses were shed by chickens for up to 9 days, replicating efficiently in their upper respiratory tract. Five reassorted viruses tested on guinea pigs were transmissible among these by respiratory droplets. ConclusionAvian H3N8 viruses with H9N2 virus internal genes, causing two human infections, occurred in live poultry markets in China. The low pathogenicity of H3N8 viruses in poultry allows their continuous circulation with potential for reassortment. Careful monitoring of spill-over infections in humans is important to strengthen early-warning systems and maintain influenza pandemic preparedness.
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13
PCPs Prep for 'Less Predictable' Respiratory Virus Season
Medscape Infectious Diseases, 15.09.2023
Tilføjet 15.09.2023
On the cusp of respiratory virus season, experts offer their guidance to primary care physicians about how to advise patients about vaccines for COVID-19, influenza, and RSV. Medscape Medical News
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14
New Moderna Vaccine to Work Against Recent COVID Variant
Medscape Infectious Diseases, 8.09.2023
Tilføjet 8.09.2023
\'We think this is news people will want to hear as they prepare to go out and get their fall boosters.\' WebMD Health News
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15
Developing evidence-informed indicators to monitor HIV pre-exposure prophylaxis programmes across EU/EEA countries: a multi-stakeholder consensus
Jef Vanhamel, Eline Wijstma, Jessika Deblonde, Marie Laga, Bea Vuylsteke, Christiana Nöstlinger and Teymur Noori
Eurosurveillance latest updates, 9.06.2023
Tilføjet 9.06.2023
Several countries in the European Union (EU) and European Economic Area (EEA) established and/or scaled up HIV pre-exposure prophylaxis (PrEP) programmes between 2016 and 2023. Data on PrEP programmes’ performance and effectiveness in reaching those most in need will be needed to assess regional progress in the roll-out of PrEP. However, there is a lack of commonly defined indicators for routine monitoring to allow for minimum comparability. We propose a harmonised PrEP monitoring approach for the EU/EEA, based on a systematic and evidence-informed consensus-building process involving a broad and multidisciplinary expert panel. We present a set of indicators, structured along relevant steps of an adapted PrEP care continuum, and offer a prioritisation based on the degree of consensus among the expert panel. We distinguish between ‘core’ indicators deemed essential for any PrEP programme in the EU/EEA, vs ‘supplementary’ and ‘optional’ indicators that provide meaningful data, yet where experts evaluated their feasibility for data collection and reporting as very context-dependent. By combining a standardised approach with strategic opportunities for adaptation and complementary research, this monitoring framework will contribute to assess the impact of PrEP on the HIV epidemic in Europe.
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16
PRO/EDR> Foodborne illness - Singapore: preschool, salmonellosis susp
ProMED, 2.06.2023
Tilføjet 2.06.2023
Salmonella -- SingaporeAs many as 6 people have been hospitalized following outbreaks of gastroenteritis at MindChamps pre-schools in Changi Airport, Tanglin, and Bishan.A total of 89 people - 79 children and 10 staff - reported having gastroenteritis symptoms after eating food prepared by Nosh Cuisine between [17 May 2023] and [29 May 2023], according to a joint statement by the Ministry of Health, Singapore Food Agency (SFA) and Early Childhood Development Agency on [Tue 30 May 2023] evening. Those
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17
PRO/EDR> Botulism - Belarus: (BR) home-prepared food
ProMED, 27.05.2023
Tilføjet 27.05.2023
Botulism -- Belarus1. Hughes JM, Hatheway CL, Ostroff SM. Botulism. In: Infections of the Central Nervous System. Scheld WM, Whitley RJ, Durack DT, eds., 2nd ed. Philadelphia: Lippincott-Raven, 1997, 615-28.- Mod.LLProMED map:Brest Region, Belarus: ][See Also:2022----Botulism - Ukraine (03): (KK) dried fish http://promedmail.org/post/20221002.8705918Botulism - Ukraine (02) http://promedmail.org/post/20220619.8703951Botulism - Kyrgyzstan http://promedmail.org/post/20220605.8703692Botulism -
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