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This report describes sepsis-related date rates among adults 65 years and older.

Medscape spoke with CDC contributors Raymund Dantes, MD, MPH, and Hallie Prescott, MD, MSc, about the new Hospital Sepsis Program Core Elements to help clinicians improve outcomes from sepsis. CDC Expert Commentary…

Since autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1UK sublineage (26/55) and more diverse emm12 isolates (12/55). …

While 73% of US hospitals have sepsis teams, only 55% of them report that their team leaders get dedicated time to manage the programs for a medical emergency that affects at least 1.7 million people. Medscape Medical News…

This report describes sepsis programs in hospitals and identifies areas of opportunities to improve sepsis programs.

Compared with influenza and sepsis, severe COVID-19 infections resulted in similar risk for neurological and cardiovascular conditions, suggesting a common need for long-term support. Medscape Medical News…

A new review provides insights into intravenous fluid therapy for sepsis, including how much to give at each stage of treatment. Medscape Medical News…

We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3–5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted. …

Enterovirus -- FranceSituation at a glance---------------------On [5 May 2023], France reported an increase in cases of severe neonatal sepsis associated with Enterovirus (Echovirus-11 (E-11)). A total of 9 cases of neonatal sepsis with hepatic impairment and multi-organ failure were reported between [July 2022] and [April 2023] from 4 hospitals in 3 regions of France. As of [5 May 2023], 7 cases have died and 2 were still hospitalized in neonatal unit. The current increase in incidence and severity in…

BackgroundMeningococcus (Neisseria meningitidis) is the causative bacteria of invasive meningococcal disease (IMD), a major cause of meningitis and sepsis. In 2015–16, an outbreak caused by serogroup C meningococci (MenC), belonging to the hyperinvasive strain ST-11(cc-11), resulted in 62 IMD cases in the region of Tuscany, Italy. AimWe aimed to estimate the key outbreak parameters and assess the impact of interventions used in the outbreak response. MethodsWe developed a susceptible-carrier-susceptible individual-based model of MenC transmission, accounting for transmission in households, schools, discos/clubs and the general community, which was informed by detailed data on the 2015–16 outbreak (derived from epidemiological investigations) and on the implemented control measures. ResultsThe outbreak reproduction number (Re) was 1.35 (95% prediction interval: 1.13–1.47) and the IMD probability was 4.6 for every 1,000 new MenC carriage episodes (95% confidence interval: 1.8–12.2). The interventions, i.e. chemoprophylaxis and vaccination of close contacts of IMD cases as well as age-targeted vaccination, were effective in reducing Re and ending the outbreak. Case-based interventions (including ring vaccination) alone would have been insufficient to achieve outbreak control. The definition of age groups to prioritise vaccination had a critical impact on the effectiveness and efficiency of control measures. ConclusionsOur findings suggest that there are no effective alternatives to widespread reactive vaccination during outbreaks of highly transmissible MenC strains. Age-targeted campaigns can increase the effectiveness of vaccination campaigns. These results can be instrumental to define effective guidelines for the control of future meningococcal outbreaks caused by hypervirulent strains. …

Other Human Disease -- United States_Cronobacter sakazakii_, a species of Gram-negative bacteria belonging to the Enterobacteriaceae family, is known to cause severe and often fatal meningitis and sepsis in young infants. _C. sakazakii_ is ubiquitous in the environment, and most reported infant cases have been attributed to contaminated powdered infant formula (powdered formula) or breast milk that was expressed using contaminated breast pump equipment (1-3). Previous investigations of cases and outbreaks have identified _C.

Experts expressed hope that, with additional research, the new testing method could eventually cut the time for sepsis detection from days to hours, potentially saving lives. …

The potentially fatal parechovirus is now circulating in multiple states, causing fevers, seizures, and sepsis-like symptoms, including confusion and extreme pain, according to the CDC. …

Sepsis -- Cambodia…

Rates of resistance to ampicillin-gentamicin are extremely high in low- and middle-income countries. …

Vibrio vulnificus -- United StatesA popular Texas fisherman has died at the age of 61 after being infected with bacteria described as "flesh-eating". He passed away on 30 Jul 2021 at a medical center in Brownsville, Texas, due to complications from vibriosis -- a disease caused by about a dozen species of bacteria from the genus _Vibrio_ -- according to an obituary posted by the McCaleb Funeral Home in Weslaco.

He eventually succumbed to the infection after experiencing organ failure and sepsis -- a life-threatening…

A sepsis-prediction model used widely by hospitals and health systems in the United States performed poorly in predicting sepsis onset in an external validation study. …