47 ud af 47 tidsskrifter valgt, søgeord (dengue) valgt, emner højest 180 dage gamle, sorteret efter nyeste først.
67 emner vises.
1
The influence of gender and temephos exposure on community participation in dengue prevention: a compartmental mathematical model
BMC Infectious Diseases, 3.05.2024
Tilføjet 3.05.2024
Abstract Background The use of temephos, the most common intervention for the chemical control of Aedes aegypti over the last half century, has disappointing results in control of the infection. The footprint of Aedes and the diseases it carries have spread relentlessly despite massive volumes of temephos. Recent advances in community participation show this might be more effective and sustainable for the control of the dengue vector. Methods Using data from the Camino Verde cluster randomized controlled trial, a compartmental mathematical model examines the dynamics of dengue infection with different levels of community participation, taking account of gender of respondent and exposure to temephos. Results Simulation of dengue endemicity showed community participation affected the basic reproductive number of infected people. The greatest short-term effect, in terms of people infected with the virus, was the combination of temephos intervention and community participation. There was no evidence of a protective effect of temephos 220 days after the onset of the spread of dengue. Conclusions Male responses about community participation did not significantly affect modelled numbers of infected people and infectious mosquitoes. Our model suggests that, in the long term, community participation alone may have the best results. Adding temephos to community participation does not improve the effect of community participation alone.
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2
Correction: Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients
Ikkoh Yasuda, Nobuo Saito, Motoi Suzuki, Dorcas Valencia Umipig, Rontgene M. Solante, Ferdinand De Guzman, Ana Ria Sayo, Michio Yasunami, Nobuo Koizumi, Emi Kitashoji, Kentaro Sakashita, Chris Fook Sheng Ng, Chris Smith, Koya Ariyoshi
PLoS One Infectious Diseases, 3.05.2024
Tilføjet 3.05.2024
by Ikkoh Yasuda, Nobuo Saito, Motoi Suzuki, Dorcas Valencia Umipig, Rontgene M. Solante, Ferdinand De Guzman, Ana Ria Sayo, Michio Yasunami, Nobuo Koizumi, Emi Kitashoji, Kentaro Sakashita, Chris Fook Sheng Ng, Chris Smith, Koya Ariyoshi
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3
Efficacy and Safety of a Tetravalent Dengue Vaccine (TAK-003) in Children With Prior Japanese Encephalitis or Yellow Fever Vaccination
Journal of Infectious Diseases, 2.05.2024
Tilføjet 2.05.2024
Abstract Background We explored the impact of prior Yellow fever (YF) or Japanese encephalitis (JE) vaccination on the efficacy of Takeda’s dengue vaccine candidate, TAK-003 (NCT02747927).Methods Children 4–16 years of age were randomized 2:1 to receive TAK-003 or placebo and were under active febrile surveillance. Symptomatic dengue was confirmed by serotype-specific RT-PCR. YF and JE vaccination history was recorded.Results Of the 20,071 children who received TAK-003 or placebo, 21.1% had a YF and 23.9% had a JE vaccination history at randomization. Fifty-seven months after vaccination, vaccine efficacy was 55.7% (95% CI, 39.7%-67.5%) in those with YF vaccination, 77.8% (70.8%-83.1%) for JE vaccination, and 53.5% (45.4%-60.4%) for no prior YF/JE vaccination. Regional differences in serotype distribution confound these results. The apparent higher vaccine efficacy in the JE vaccination subgroup could be largely explained by serotype-specific efficacy of TAK-003. Within 28 days of any vaccination, the proportions of participants with serious adverse events in the YF/JE prior vaccination population were comparable between the TAK-003 and placebo groups.Conclusions The available data do not suggest a clinically relevant impact of prior JE or YF vaccination on TAK-003 performance. Overall, TAK-003 was well-tolerated and efficacious in different epidemiological settings.
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4
Cross Talk between MicroRNAs and Dengue Virus
American Journal of Tropical Medicine and Hygiene, 2.05.2024
Tilføjet 2.05.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 5 Pages: 856-867
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5
Clinical Manifestations of Dengue in Children and Adults in a Hyperendemic Region of Colombia
American Journal of Tropical Medicine and Hygiene, 2.05.2024
Tilføjet 2.05.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 5 Pages: 971-978
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6
Effectiveness of the Integrated Dengue Education and Learning (iDEAL) module in improving the knowledge, attitude, practice, environmental cleanliness index, and dengue index among schoolchildren: A randomised controlled trial protocol
Rahmat Dapari, Kalaivani Muniandy, Ahmad Zaid Fattah Azman, Suhaili Abu Bakar, Mohd Nasir Mohd Desa, Lim Chee Hwa, Sukhvinder Singh Sandhu, Nooreen Farzana Mustapha, Norazman Mohd Rosli, Mohd ‘Ammar Ihsan Ahmad Zamzuri, Mohd Rohaizat Hassan, Nazri Che Dom, Syed Sharizman Syed Abdul Rahim, Balvinder Singh Gill, Nurulhusna Ab Hamid
PLoS One Infectious Diseases, 30.04.2024
Tilføjet 30.04.2024
by Rahmat Dapari, Kalaivani Muniandy, Ahmad Zaid Fattah Azman, Suhaili Abu Bakar, Mohd Nasir Mohd Desa, Lim Chee Hwa, Sukhvinder Singh Sandhu, Nooreen Farzana Mustapha, Norazman Mohd Rosli, Mohd ‘Ammar Ihsan Ahmad Zamzuri, Mohd Rohaizat Hassan, Nazri Che Dom, Syed Sharizman Syed Abdul Rahim, Balvinder Singh Gill, Nurulhusna Ab Hamid Background Dengue is a mosquito-borne disease caused by four distinct, closely related dengue viruses (DENV). Global dengue incidence has markedly increased in the past decades. The World Health Organization reported that cases increased from 505,430 in 2000 to 5.2 million in 2019. Similarly, the total dengue cases in Malaysia increased from 7,103 in 2000 to a peak of 130,101 in 2019. Knowledge, attitude, and practice (KAP) remain the most effective dengue prevention and control tools. Furthermore, school-based health education is key to enhancing knowledge and raising awareness of the seriousness of dengue among schoolchildren and transferring knowledge and practice from classrooms to homes. Thus, it is necessary to plan an integrated module for the primary prevention of dengue infection, specifically among schoolchildren. Aims The present study intends to develop, implement, and evaluate the effectiveness of a theory-based integrated dengue education and learning (iDEAL) module in improving the KAP, environmental cleanliness index, and dengue index among schoolchildren in Selangor and Kuala Lumpur. Methods This study is a single-blinded, cluster randomised controlled trial to be conducted from 1 September 2023 to 31 August 2025. The study will involve 20 primary and 20 secondary schools in Selangor and Kuala Lumpur. The 1600 participants will be randomly allocated to intervention and control groups based on selected clusters to avoid contamination. A cluster is a comparable school that fulfils the inclusion and exclusion criteria. The intervention group will receive the iDEAL module, while the control group will receive standard education. The iDEAL module will be developed following a systematic procedure and delivered in-person by trained researchers to the participants. The outcome will be measured using validated, self-administered questionnaires at baseline (T0), immediately (T1), one month (T2), and three months (T3) post-intervention to measure the intervention module effectiveness. The data will be analysed using IBM Statistical Package for Social Science (SPSS) version 28 and descriptive and inferential statistics. Within-group changes over time will be compared using one-way repeated measure analysis of variance for continuous and normally distributed variables. Within-group analysis of categorical data will use Cochran’s Q test. The main effect and interaction between and within the intervention and control groups at T0, T1, T2, and T3 will be tested using the generalised linear mixed model (GLMM). Hypothetically, the KAP, environmental cleanliness index, and dengue index among the intervention group will be significantly improved compared to the control group. The hypothesis will be tested using a significance level with a p-value of 0.05 and a confidence interval of 95%. Conclusions The study protocol outlines developing and testing an iDEAL module for schoolchildren in Selangor and Kuala Lumpur, with no socio-demographic differences expected. The intervention aims to improve KAP, environmental cleanliness index, and dengue index, potentially reducing dengue risk. Results could inform public health policies, emphasizing school-based interventions’ importance in combating diseases like dengue.
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7
Genotype of dengue virus serotype 1 in relation to severe dengue in Guangzhou, China
Xing‐Yu Leng, Ling‐Zhai Zhao, Lu Liao, Kang‐Hong Jin, Jia‐Min Feng, Fu‐Chun Zhang
Journal of Medical Virology, 30.04.2024
Tilføjet 30.04.2024
8
Revealing the microbiome diversity and biocontrol potential of field Aedes ssp.: Implications for disease vector management
Apolinar M. Hernández, Luis D. Alcaraz, Cristóbal Hernández-Álvarez, Miguel F. Romero, Angélica Jara-Servín, Hugo Barajas, Carlos M. . Ramírez, Mariana Peimbert
PLoS One Infectious Diseases, 29.04.2024
Tilføjet 29.04.2024
by Apolinar M. Hernández, Luis D. Alcaraz, Cristóbal Hernández-Álvarez, Miguel F. Romero, Angélica Jara-Servín, Hugo Barajas, Carlos M. . Ramírez, Mariana Peimbert The mosquito Aedes spp. holds important relevance for human and animal health, as it serves as a vector for transmitting multiple diseases, including dengue and Zika virus. The microbiome’s impact on its host’s health and fitness is well known. However, most studies on mosquito microbiomes have been conducted in laboratory settings. We explored the mixed microbial communities within Aedes spp., utilizing the 16S rRNA gene for diversity analysis and shotgun metagenomics for functional genomics. Our samples, which included Ae. aegypti and Ae. albopictus, spanned various developmental stages—eggs, larvae, and adults—gathered from five semiurban areas in Mexico. Our findings revealed a substantial diversity of 8,346 operational taxonomic units (OTUs), representing 967 bacterial genera and 126,366 annotated proteins. The host developmental stage was identified as the primary factor associated with variations in the microbiome composition. Subsequently, we searched for genes and species involved in mosquito biocontrol. Wolbachia accounted for 9.6% of the 16S gene sequences. We observed a high diversity (203 OTUs) of Wolbachia strains commonly associated with mosquitoes, such as wAlb, with a noticeable increase in abundance during the adult stages. Notably, we detected the presence of the cifA and cifB genes, which are associated with Wolbachia’s cytoplasmic incompatibility, a biocontrol mechanism. Additionally, we identified 221 OTUs related to Bacillus, including strains linked to B. thuringiensis. Furthermore, we discovered multiple genes encoding insecticidal toxins, such as Cry, Mcf, Vip, and Vpp. Overall, our study contributes to the understanding of mosquito microbiome biodiversity and metabolic capabilities, which are essential for developing effective biocontrol strategies against this disease vector.
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9
[Articles] Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial
Kirsten E Lyke, Joel V Chua, Michael Koren, Heather Friberg, Gregory D Gromowski, Rekha R Rapaka, Adam T Waickman, Sudhaunshu Joshi, Kathleen Strauss, Michael K McCracken, Hernando Gutierrez-Barbosa, Biraj Shrestha, Christopher Culbertson, Paula Bernal, Rafael A De La Barrera, Jeffrey R Currier, Richard G Jarman, Robert Edelman
Lancet Infectious Diseases, 26.04.2024
Tilføjet 26.04.2024
Participants who had tetravalent dengue purified inactivated vaccine prime and live-attenuated vaccine boost were unprotected against dengue virus-1 infection and further showed increased clinical, immunological, and transcriptomic evidence for inflammation potentially mediated by pre-existing infection-enhancing antibodies. This study highlights the impact of small cohort, human challenge models studying dengue pathogenesis and downstream vaccine development.
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10
Central nervous system infections in the tropics
T, Angel Miraclin; Singh, Bhagteshwar; Rupali, Priscilla
Current Opinion in Infectious Diseases, 24.04.2024
Tilføjet 24.04.2024
Purpose of review Emerging and re-emerging central nervous system (CNS) infections are a major public health concern in the tropics. The reasons for this are myriad; climate change, rainfall, deforestation, increased vector density combined with poverty, poor sanitation and hygiene. This review focuses on pathogens, which have emerged and re-emerged, with the potential for significant morbidity and mortality. Recent findings In recent years, multiple acute encephalitis outbreaks have been caused by Nipah virus, which carries a high case fatality. Arboviral infections, predominantly dengue, chikungunya and Zika are re-emerging increasingly especially in urban areas due to changing human habitats, vector behaviour and viral evolution. Scrub typhus, another vector borne disease caused by the bacterium Orientia tsutsugamushi, is being established as a leading cause of CNS infections in the tropics. Summary A syndromic and epidemiological approach to CNS infections in the tropics is essential to plan appropriate diagnostic tests and management. Rapid diagnostic tests facilitate early diagnosis and thus help prompt initiation and focusing of therapy to prevent adverse outcomes. Vector control, cautious urbanization and deforestation, and reducing disturbance of ecosystems can help prevent spread of vector-borne diseases. Regional diagnostic and treatment approaches and specific vaccines are required to avert morbidity and mortality.
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11
Gut microbe blocks dengue and Zika viruses in mosquitoes
Catherine Offord
Science, 18.04.2024
Tilføjet 18.04.2024
12
Epidemiological investigation of dengue fever outbreak and its socioeconomic determinants in Banadir region, Somalia
BMC Infectious Diseases, 12.04.2024
Tilføjet 12.04.2024
Abstract Background Dengue has become an alarming global problem and is endemic in many countries, particularly in tropical and subtropical countries. The aim of this study was to investigate dengue fever outbreak in Banadir Region, Somalia, to understand the risk factors (time, place, personal characteristics). Methods A descriptive cross-sectional study was undertaken to determine the levels of circulating anti-dengue virus antibodies and DENV NS1 antigen among Banadir Region residents, while a questionnaire survey was conducted to understand the clinical and demographic characteristics of the patients. Results A total of 735 febrile patients were studied, with 55.6% men and 44.3% women. The majority of the participants were children aged 14 years and younger. Among them, 10.8% tested positive for IgM antibodies against dengue virus (DENV), while the prevalence of DENV NS1 antigen was 11.8%. Fever and myalgia were the most common symptoms observed in the DENV-positive patients. Conclusions A dengue fever outbreak has been confirmed in Banadir region, Somalia. This study provides information on the most affected districts and identifies risk factors contributing to DF outbreaks. The study recommends improving outbreak readiness and response, particularly in surveillance and laboratory diagnostics, by fostering intersectoral collaboration and establishing regulatory frameworks for financial and operational participation.
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13
Molecular identification and phylogenetic analysis of chikungunya virus among dengue-negative patients in Kolkata, India
Rajendra Prasad Chatterjee, Aroni Chatterjee, Sabbir Ansari, Shilpa Chatterjee, Shyamalendu Chatterjee, Nilanjan Chakraborty
PLoS One Infectious Diseases, 4.04.2024
Tilføjet 4.04.2024
by Rajendra Prasad Chatterjee, Aroni Chatterjee, Sabbir Ansari, Shilpa Chatterjee, Shyamalendu Chatterjee, Nilanjan Chakraborty Dengue and chikungunya are co-circulating vector-borne diseases that share a significant number of clinical symptoms. To identify variables to aid physicians in making rapid and effective diagnostic decisions, we performed molecular diagnosis of the chikungunya virus and examined the clinical manifestations of chikungunya cases to identify the prevalence among dengue-negative individuals in Kolkata. Dengue suspected patients’ samples were collected during January 2020—December 2021 and Enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR) methods have been performed to confirm the prevalence of chikungunya infection among dengue-negative patients. By performing phylogenetic analysis, comparing clinical classifications, identifying disease aetiology using clinical and laboratory factors, and evaluating the time course of several clinical variables, we have evaluated the clinical manifestations linked to dengue and chikungunya virus infections. Chikungunya infection was found in 15.1% and 6.3% of the 635 dengue-negative patients, as determined by ELISA and RT-PCR, respectively. Arthritis and myalgia were more common in chikungunya-infected patients at the time of hospital admission while conjunctivitis, photosensitivity, arthralgia, Anorexia, fatigue, retro-orbital pain, vomiting, dermatitis, or swollen glands were significantly presented as an overlapping symptom. Although dengue and chikungunya infections have significant clinical overlap, basic clinical and laboratory criteria can predict these diseases at presentation for proper management. Effective management enables doctors to treat and care for patients properly and contributes to the development of control measures for these infections in a medical setting.
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14
Historical Hot Spots of Dengue and Zika Viruses to Guide Targeted Vector Control in San Juan, Puerto Rico (2010–2022)
American Journal of Tropical Medicine and Hygiene, 3.04.2024
Tilføjet 3.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4 Pages: 731-737
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15
Low Rate of Asymptomatic Dengue Infection Detected in Coastal Kenya Using Pooled Polymerase Chain Reaction Testing
American Journal of Tropical Medicine and Hygiene, 3.04.2024
Tilføjet 3.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4 Pages: 738-740
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16
First-in-human trial evaluating safety and pharmacokinetics of AT-752, a novel nucleotide prodrug with pan-serotype activity against dengue virus
Xiao-Jian ZhouJason LickliterMaureen MontrondLaura IshakKeith PietropaoloDayle JamesBruce BelangerArantxa HorgaJanet Hammond1Atea Pharmaceuticals Inc, Boston, Massachusetts, USA2Nucleus Network, Melbourne, Australia, Miguel Angel Martinez
Antimicrobial Agents And Chemotherapy, 26.03.2024
Tilføjet 26.03.2024
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[Articles] Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study
Michelle Ylade, Maria Vinna Crisostomo, Jedas Veronica Daag, Kristal An Agrupis, Anna Maureen Cuachin, Ava Kristy Sy, Deok Ryun Kim, Hyeon Seon Ahn, Ana Coello Escoto, Leah C Katzelnick, Cameron Adams, Laura White, Aravinda M de Silva, Jacqueline Deen, Anna Lena Lopez
Lancet Infectious Diseases, 23.03.2024
Tilføjet 23.03.2024
The risk of developing virologically confirmed dengue after a single dose of CYD-TDV varied by baseline DENV serostatus. Since the study assessed the effect of only a single dose, the findings cannot inform decisions on vaccination by public health officers. However, the findings have implications for children who receive an incomplete vaccination regimen and these results should prompt more detailed analyses in future trials on dengue vaccines.
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18
Improving dengue fever predictions in Taiwan based on feature selection and random forests
BMC Infectious Diseases, 20.03.2024
Tilføjet 20.03.2024
Abstract Background Dengue fever is a well-studied vector-borne disease in tropical and subtropical areas of the world. Several methods for predicting the occurrence of dengue fever in Taiwan have been proposed. However, to the best of our knowledge, no study has investigated the relationship between air quality indices (AQIs) and dengue fever in Taiwan. Results This study aimed to develop a dengue fever prediction model in which meteorological factors, a vector index, and AQIs were incorporated into different machine learning algorithms. A total of 805 meteorological records from 2013 to 2015 were collected from government open-source data after preprocessing. In addition to well-known dengue-related factors, we investigated the effects of novel variables, including particulate matter with an aerodynamic diameter
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19
Dengue encephalopathy in an adult due to dengue virus type 1 infection
BMC Infectious Diseases, 15.03.2024
Tilføjet 15.03.2024
Abstract Background Dengue is an important public health problem, which caused by the dengue virus (DENV), a single-stranded RNA virus consisted of four serotypes. Central nervus system (CNS) impairment in dengue usually results from DENV-2 or DENV-3 infection, which lead to life-threatening outcomes. Furthermore, neurological complications due to DENV-1 was rare especially in adult patients. Case presentation A 44-year-old man without comorbidities had lethargy after hyperpyrexia and a positive DENV NS1 antigen was detected for confirming the diagnosis of dengue on day 8 of onset. Then logagnosia, decreased muscle strength, delirium and irritability were occurred even radiographic examination were normal. He was treated with low-dose hormone, sedatives and gamma goblin with a short duration of 6 days. The cerebrospinal fluid (CSF) tests were persistent normal. However, presence of DENV-1 RNA was confirmed both in CSF and serum. Furthermore, the complete sequence of the DENV isolated from the patient’s serum was performed (GenBank No.: MW261838). The cytokines as IL-6, IL-10 and sVCAM-1 were increased in critical phase of disease. Finally, the patient was discharged on day 24 of onset without any neurological sequelae. Conclusion Encephalopathy caused by a direct CNS invasion due to DENV-1 during viremia was described in an adult patient. Treatment with low-dose hormone and gamma goblin was helpful for admission.
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20
Exploring community behaviours and stakeholder challenges in engaging communities with dengue prevention behaviour in Malaysia: implementation research for a qualitative study with a community-based participatory research design
Samsudin, N. A., Karim, N., Othman, H., Naserrudin, N. A., Sahani, M., Hod, R., Siau, C. S., Harif, M. N., Abd. Samad, B. H., Zaini, Z.-I. I.
BMJ Open, 13.03.2024
Tilføjet 13.03.2024
ObjectivesTo use a community-based participatory research (CBPR) design to explore local community behaviours and stakeholders’ challenges in engaging communities in dengue prevention behaviours in Hulu Langat, Selangor, Malaysia. DesignThis CBPR design in implementation comprised in-depth interviews (IDIs) and focus group discussions (FGDs). Themes were identified from the data with inductive and deductive thematic analysis. SettingFGDs were conducted in local community areas and IDIs were conducted in the local authority (LA) office and the Hulu Langat district health office. ParticipantsAll FGD and IDI participants consented to the study, and included health authorities (n=4), LAs (n=7), community leader (n=1), faith leader (n=1), patients diagnosed with dengue (IDIs, n=2) and permanent residents of Hulu Langat who had been exposed to dengue infectious disease (FGDs, n=27). ResultsThe main themes were categorised into community behaviour and stakeholder challenges. The community behaviour-related themes were awareness of dengue disease and Aedes mosquitoes, perception of risk and severity, and involvement of authorities. The themes related to stakeholder challenges were resource constraints and capacity issues, jurisdictional constraints and coordination, and educational dissemination and vandalism. ConclusionsThe actions of the authorities shape community and stakeholder behaviours. Effective communication, including clear and aesthetically pleasing messages, motivates individuals to take appropriate actions. It is crucial for the authorities to engage in inclusive communication and consider diverse perspectives, such as those of residents and individuals exposed to dengue infection. Authorities that provide accurate and unbiased information foster transparency and enable informed decision-making by all stakeholders.
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21
Forecasting weekly dengue incidence in Sri Lanka: Modified Autoregressive Integrated Moving Average modeling approach
Nilantha Karasinghe, Sarath Peiris, Ruwan Jayathilaka, Thanuja Dharmasena
PLoS One Infectious Diseases, 8.03.2024
Tilføjet 8.03.2024
by Nilantha Karasinghe, Sarath Peiris, Ruwan Jayathilaka, Thanuja Dharmasena Dengue poses a significant and multifaceted public health challenge in Sri Lanka, encompassing both preventive and curative aspects. Accurate dengue incidence forecasting is pivotal for effective surveillance and disease control. To address this, we developed an Autoregressive Integrated Moving Average (ARIMA) model tailored for predicting weekly dengue cases in the Colombo district. The modeling process drew on comprehensive weekly dengue fever data from the Weekly Epidemiological Reports (WER), spanning January 2015 to August 2020. Following rigorous model selection, the ARIMA (2,1,0) model, augmented with an autoregressive component (AR) of order 16, emerged as the best-fitted model. It underwent initial calibration and fine-tuning using data from January 2015 to August 2020, and was validated against independent 2000 data. Selection criteria included parameter significance, the Akaike Information Criterion (AIC), and Schwarz Bayesian Information Criterion (SBIC). Importantly, the residuals of the ARIMA model conformed to the assumptions of randomness, constant variance, and normality affirming its suitability. The forecasts closely matched observed dengue incidence, offering a valuable tool for public health decision-makers. However, an increased percentage error was noted in late 2020, likely attributed to factors including potential underreporting due to COVID-19-related disruptions amid rising dengue cases. This research contributes to the critical task of managing dengue outbreaks and underscores the dynamic challenges posed by external influences on disease surveillance.
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22
A dengue virus infection in Ethiopia: a systematic review and meta-analysis
BMC Infectious Diseases, 8.03.2024
Tilføjet 8.03.2024
Abstract Background Dengue is caused by a positive-stranded RNA virus called dengue virus, which is spread by Aedes mosquito species. It is a fast-growing acute febrile disease with potentially lethal consequences that is a global public health problem, mostly in tropical and subtropical countries. In Ethiopia, dengue fever is understudied, although the virus is still being transmitted and viral infection rates are rising. This systematic review and meta-analysis was aimed at estimating the pooled prevalence of DENV infection in Ethiopia. Methods A literature search was done on the PubMed, Hinari and Google Scholar databases to identify studies published before July, 2023. Random effects and fixed effects models were used to estimate the pooled prevalence of all three markers. The Inconsistency Index was used to assess the level of heterogeneity. Results A total of 11 studies conducted on suspected individuals with dengue fever and acutely febrile participants were included in this review. The majority of the studies had a moderate risk of bias and no study had a high risk of bias. A meta-analysis estimated a pooled IgG prevalence of 21% (95% CI: 19–23), a pooled IgM prevalence of 9% (95%CI: 4–13) and a pooled DENV-RNA prevalence of 48% (95% CI: 33–62). There is evidence of possible publication bias in IgG but not in the rest of the markers. Conclusion Dengue is prevalent among the dengue fever suspected and febrile population in Ethiopia. Healthcare providers, researchers and policymakers should give more attention to dengue fever.
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23
Brazil is hoping and waiting for a new vaccine as dengue rages
Marcia Triunfol
Science, 8.03.2024
Tilføjet 8.03.2024
24
A dengue virus infection in Ethiopia: a systematic review and meta-analysis
BMC Infectious Diseases, 7.03.2024
Tilføjet 7.03.2024
Abstract Background Dengue is caused by a positive-stranded RNA virus called dengue virus, which is spread by Aedes mosquito species. It is a fast-growing acute febrile disease with potentially lethal consequences that is a global public health problem, mostly in tropical and subtropical countries. In Ethiopia, dengue fever is understudied, although the virus is still being transmitted and viral infection rates are rising. This systematic review and meta-analysis was aimed at estimating the pooled prevalence of DENV infection in Ethiopia. Methods A literature search was done on the PubMed, Hinari and Google Scholar databases to identify studies published before July, 2023. Random effects and fixed effects models were used to estimate the pooled prevalence of all three markers. The Inconsistency Index was used to assess the level of heterogeneity. Results A total of 11 studies conducted on suspected individuals with dengue fever and acutely febrile participants were included in this review. The majority of the studies had a moderate risk of bias and no study had a high risk of bias. A meta-analysis estimated a pooled IgG prevalence of 21% (95% CI: 19–23), a pooled IgM prevalence of 9% (95%CI: 4–13) and a pooled DENV-RNA prevalence of 48% (95% CI: 33–62). There is evidence of possible publication bias in IgG but not in the rest of the markers. Conclusion Dengue is prevalent among the dengue fever suspected and febrile population in Ethiopia. Healthcare providers, researchers and policymakers should give more attention to dengue fever.
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25
Preferences and Demand for Mosquito Control among Dengue-Endemic Communities in Peñuelas, Puerto Rico: An Application of the Best-Worst Choice Model
American Journal of Tropical Medicine and Hygiene, 6.03.2024
Tilføjet 6.03.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 3 Pages: 540-548
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26
Use of Household Insecticides against Mosquitoes in Dengue-Endemic Areas in Sri Lanka
American Journal of Tropical Medicine and Hygiene, 6.03.2024
Tilføjet 6.03.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 3 Pages: 549-556
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27
Arbovirus impact on mosquito behavior: the jury is still out
Théo Maire, Louis Lambrechts, Felix J.H. Hol
Trends in Parasitology, 29.02.2024
Tilføjet 29.02.2024
Parasites can manipulate host behavior to enhance transmission, but our understanding of arbovirus-induced changes in mosquito behavior is limited. Here, we explore current knowledge on such behavioral alterations in mosquito vectors, focusing on host-seeking and blood-feeding behaviors. Reviewing studies on dengue, Zika, La Crosse, Sindbis, and West Nile viruses in Aedes or Culex mosquitoes reveals subtle yet potentially significant effects. However, assay heterogeneity and limited sample sizes challenge definitive conclusions. To enhance robustness, we propose using deep-learning tools for automated behavior quantification and stress the need for standardized assays. Additionally, conducting longitudinal studies across the extrinsic incubation period and integrating diverse traits into modeling frameworks are crucial for understanding the nuanced implications of arbovirus-induced behavioral changes for virus transmission dynamics.
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28
[Articles] An observer-blind, randomised, placebo-controlled, phase 1, single ascending dose study of dengue monoclonal antibody in healthy adults in Australia
Bhagwat Gunale, Nicholas Farinola, Chandrashekhar D Kamat, Cyrus S Poonawalla, Sambhaji S Pisal, Rajeev M Dhere, Claire Miller, Prasad S Kulkarni
Lancet Infectious Diseases, 24.02.2024
Tilføjet 24.02.2024
Dengue monoclonal antibody was safe and well tolerated. It showed a dose-proportionate increase in pharmacokinetic exposure. These data support further evaluation of dengue monoclonal antibody in patients with dengue for safety and efficacy.
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29
Dominant epitopes of cross‐reactive anti‐domain III human antibody response change from early to late convalescence of infection with dengue virus
Luis Gabriel González‐Lodeiro, Alejandro Martín Dunn, Dayron Martín Prieto, Danya Medina‐Carrasco, Lisandra E. García de Castro, Daniela Maldonado Bauzá, Glay Chinea Santiago, Vivian Huerta Galindo
Journal of Medical Virology, 20.02.2024
Tilføjet 20.02.2024
30
Initiatives and Challenges of Dengue Incidence in the Philippines
Journal of Infectious Diseases, 20.02.2024
Tilføjet 20.02.2024
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Integration of population-level data sources into an individual-level clinical prediction model for dengue virus test positivity
Robert J. Williams, Ben J. Brintz, Gabriel Ribeiro Dos Santos, Angkana T. Huang, Darunee Buddhari, Surachai Kaewhiran, Sopon Iamsirithaworn, Alan L. Rothman, Stephen Thomas, Aaron Farmer, Stefan Fernandez, Derek A. T. Cummings, Kathryn B. Anderson, Henrik Salje, Daniel T. Leung
Science Advances, 17.02.2024
Tilføjet 17.02.2024
32
[Seminar] Dengue
Gabriela Paz-Bailey, Laura E Adams, Jacqueline Deen, Kathryn B Anderson, Leah C Katzelnick
Lancet, 16.02.2024
Tilføjet 16.02.2024
Dengue, caused by four closely related viruses, is a growing global public health concern, with outbreaks capable of overwhelming health-care systems and disrupting economies. Dengue is endemic in more than 100 countries across tropical and subtropical regions worldwide, and the expanding range of the mosquito vector, affected in part by climate change, increases risk in new areas such as Spain, Portugal, and the southern USA, while emerging evidence points to silent epidemics in Africa. Substantial advances in our understanding of the virus, immune responses, and disease progression have been made within the past decade.
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33
Within-host models unravelling the dynamics of dengue reinfections
Infectious Disease Modelling, 7.02.2024
Tilføjet 7.02.2024
Publication date: Available online 7 February 2024 Source: Infectious Disease Modelling Author(s): Vizda Anam, Bruno V. Guerrero, Akhil Kumar Srivastav, Nico Stollenwerk, Maíra Aguiar
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34
Chronic and neurotropic: A paradigm-challenging case of dengue virus encephalitis in patient with advanced human immunodeficiency virus infection
Clinical Infectious Diseases, 7.02.2024
Tilføjet 7.02.2024
Abstract A 32-year-old female with advanced HIV infection presented to an Australian hospital with subacute but worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining of brain tissue confirmed active Dengue virus (DENV) encephalitis. The most recent possible DENV exposure was months prior in West Africa, indicating chronicity.
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35
Severe disease during both primary and secondary dengue virus infections in pediatric populations
Charu Aggarwal, Hasan Ahmed, Pragati Sharma, Elluri Seetharami Reddy, Kaustuv Nayak, Mohit Singla, Deepti Maheshwari, Yadya M. Chawla, Harekrushna Panda, Ramesh Chandra Rai, Sivaram Gunisetty, Lalita Priyamvada, Siddhartha Kumar Bhaumik, Syed Fazil Ahamed, Rosario Vivek, Priya Bhatnagar, Prabhat Singh, Manpreet Kaur, Kritika Dixit, Sanjeev Kumar, Kamal Gottimukkala, Keshav Saini, Prashant Bajpai, Gopinathan Pillai Sreekanth, Shobha Mammen, Anand Rajan, Valsan Philip Verghese, Asha Mary Abraham, Paresh Shah, Kalichamy Alagarasu, Tianwei Yu, Carl W. Davis, Jens Wrammert, Aftab Ansari, Rustom Antia, Sushil Kumar Kabra, Guruprasad R. Medigeshi, Rafi Ahmed, Rakesh Lodha, Anita Shet, Anmol Chandele, Kaja Murali-Krishna
Nature, 6.02.2024
Tilføjet 6.02.2024
36
Assessing the basic knowledge and awareness of dengue fever prevention among migrant workers in Klang Valley, Malaysia
Maryam N. Chaudhary, Voon-Ching Lim, Erwin Martinez Faller, Pramod Regmi, Nirmal Aryal, Siti Nursheena Mohd Zain, Adzzie Shazleen Azman, Norhidayu Sahimin
PLoS One Infectious Diseases, 1.02.2024
Tilføjet 1.02.2024
by Maryam N. Chaudhary, Voon-Ching Lim, Erwin Martinez Faller, Pramod Regmi, Nirmal Aryal, Siti Nursheena Mohd Zain, Adzzie Shazleen Azman, Norhidayu Sahimin Background Globally, 390 million dengue virus infections occur per year. In Malaysia, migrant workers are particularly vulnerable to dengue fever (DF) due to mosquito breeding sites exposure and poor health literacy. Therefore, this study aimed to (i) assess the current DF knowledge, attitudes and practices (KAP), and (ii) identify strategies to promote DF awareness, among migrant workers in Klang Valley. Method A survey was conducted with 403 Nepali, Filipino and Indonesian migrant workers through phone interviews and online self-administered questionnaires. Piecewise structural equation modelling was applied to identify predictor variables for DF KAP. Results Most respondents were male, working in the services industry, had completed high school, aged between 30–39 years and with less than ten years work experience in Malaysia. Overall, respondents’ knowledge was positively correlated with attitude but negatively with practices. Older respondents, who had completed higher education, obtained higher knowledge scores. Similarly, those with working experience of >20 years in Malaysia obtained higher attitude scores. Respondents with a previous history of DF strongly considered the removal of mosquito breeding sites as their own responsibility, hence tended to frequently practise DF preventive measures. Respondents’ knowledge was also positively correlated to their understanding of DF information sourced from social media platforms. Conclusion These findings highlighted: (i) the need for targeted DF educational intervention among younger and newly arrived workers with lower levels of education and (ii) maximising the usage of social media platforms to improve DF public awareness.
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37
Live, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults
Esper G. Kallás, Monica A.T. Cintra, José A. Moreira, Elizabeth G. Patiño, Patricia Emilia Braga, Juliana C.V. Tenório, Vanessa Infante, Ricardo Palacios, Marcus Vínicius Guimarães de Lacerda, Dhelio Batista Pereira, Allex Jardim da Fonseca, Ricardo Queiroz Gurgel, Ivo Castelo-Branco Coelho, Cor Jesus Fernandes Fontes, Ernesto T.A. Marques, Gustavo Adolfo Sierra Romero, Mauro Martins Teixeira, André M. Siqueira, Aldina Maria Prado Barral, Viviane Sampaio Boaventura, Fabiano Ramos, Erivaldo Elias Júnior, José Cassio de Moraes, Dimas T. Covas, Jorge Kalil, Alexander Roberto Precioso, Stephen S. Whitehead, Alejandra Esteves-Jaramillo, Tulin Shekar, Jung-Jin Lee, Julieta Macey, Sabrina Gozlan Kelner, Beth-Ann G. Coller, Fernanda Castro Boulos, Mauricio L. Nogueira
New England Journal of Medicine, 1.02.2024
Tilføjet 1.02.2024
38
Three Dengue Vaccines — What Now?
Scott B. Halstead
New England Journal of Medicine, 1.02.2024
Tilføjet 1.02.2024
39
Whole genome sequencing unravels cryptic circulation of divergent dengue virus lineages in the rainforest region of Nigeria
Bernard Anyebe OnojaJudith Uche OguzieUwem Etop GeorgeKaego Emmanuel AsohPhilip AjayiToluwanimi Faithful OmofayeImafidon Oluwatoyin IgelekePhilomena EromonSoumare HarounaEdyth ParkerAdekunle Johnson AdenijiChristian T. Happia Department of Virology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeriab Department of Biological Sciences, Faculty of Natural Sciences, Redeemer’s University, Ede, Osun State, Nigeriac African Center of Excellence for Genomics of Infectious Diseases, Redeemer’s University, Ede, Osun State, Nigeriad Department of Medical Laboratory Science, College of Medicine, University of Ibadan, Ibadan, State Nigeriae Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USAf Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA
Emerg Microbes Infect, 31.01.2024
Tilføjet 31.01.2024
40
Risk factors associated with severe dengue in Latin America: A systematic review and meta‐analysis
Victoria Cruz Paraná, Caroline Alves Feitosa, Greice Carolina Santos da Silva, Luana Leandro Gois, Luciane Amorim Santos
Tropical Medicine & International Health, 24.01.2024
Tilføjet 24.01.2024
41
Detection of anti-premembrane antibody as a specific marker of four flavivirus serocomplexes and its application to serosurveillance in endemic regions
Guan-Hua ChenYu-Ching DaiSzu-Chia HsiehJih-Jin TsaiAva Kristy SyMario JizCelia PedrosoCarlos BritesEduardo Martins NettoPhyllis J. KankiDanielle R. D. SaundersDana L. VanlandinghamStephen HiggsYan-Jang S. HuangWei-Kung Wanga Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USAb Tropical Medicine Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwanc Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwand School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwane National Reference Laboratory for Dengue and Other Arbovirus, Virology Department, Research Institute for Tropical Medicine, Muntinlupa City, Philippinesf Immunology Department, Research Institute for Tropical Medicine, Muntinlupa City, Philippinesg LAPI-Laboratório de Pesquisa em Infectologia-School of Medicine, Federal University of Bahia, Salvador, Brazilh Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USAi Department of Biology, United States Air Force Academy, Colorado Springs, CO, USAj Biosecurity Research Institute and Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA
Emerg Microbes Infect, 23.01.2024
Tilføjet 23.01.2024
42
The burden of dengue in children and risk factors of transmission in nine districts in Sri Lanka
Chandima Jeewandara, Maneshka Vindesh Karunananda, Suranga Fernando, Saubhagya Danasekara, Gamini Jayakody, Segarajasingam Arulkumaran, Nayana Yasindu Samaraweera, Sarathchandra Kumarawansha, Subramaniyam Sivaganesh, Priyadarshanie Geethika Amarasinghe, Chintha Jayasinghe, Dilini Wijesekara, Manonath Bandara Marasinghe, Udari Mambulage, Helanka Wijayatilake, Kasun Senevirathne, Aththidayage Don Priyantha Bandara, Chandana Pushpalal Gallage, Nilu Ranmali Colambage, Ampe Arachchige Thilak Udayasiri, Tharaka Lokumarambage, Yasanayakalage Upasena, Wickramasinghe Pathiranalage Kasun Paramee Weerasooriya, Seroprevalence Study Group, Lahiru Perera, Pradeep Pushpakumara, Laksiri Gomes, Jeewantha Jayamali, Inoka Sepali Aberathna, Thashmi Nimasha, Madushika Dissanayake, Shyrar Ramu, Deneshan Peranantharajah, Hashini Colambage, Rivindu Wickramanayake, Harshani Chathurangika, Farha Bary, Sathsara Yatiwelle, Michael Harvie, Maheli Deheragoda, Tibutius Jayadas, Shashini Ishara, Dinuka Ariyaratne, Shashika Dayarathna, Ruwanthi Wijekulasuriya, Chathura Ranathunga, Graham S. Ogg, Gathsaurie N. Malavige
Journal of Medical Virology, 19.01.2024
Tilføjet 19.01.2024
43
[World Report] Brazil to start widespread dengue vaccinations
Lise Alves
Lancet, 12.01.2024
Tilføjet 12.01.2024
Millions will be eligible as Brazil becomes the first country to include Qdenga in its public health system. Lise Alves reports from São Paulo.
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44
The mosquito core virome: beyond the buzz
Lander De Coninck, Jelle Matthijnssens
Trends in Parasitology, 7.01.2024
Tilføjet 7.01.2024
Mosquito-specific viruses (MSVs), and mosquito viromes in general, have been a hot topic in research for the past few years. The general belief is that MSVs could have an influence on the vector competence of mosquitoes and thereby reduce the burden of disease of arboviruses. This idea is strengthened by studies that have shown an influence of MSVs on arbovirus infection in mosquitoes [1–3], and additionally by the recent success of release programs involving Aedes aegypti infected with the endobacterium Wolbachia, which result in a reduction of dengue cases up to 97% [4,5].
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45
Dengue in Cebu City, Philippines: A Pilot Study of Predictive Models and Visualizations for Public Health
American Journal of Tropical Medicine and Hygiene, 3.01.2024
Tilføjet 3.01.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 1 Pages: 179-187
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46
Dengue in Cebu City, Philippines: A Pilot Study of Predictive Models and Visualizations for Public Health
American Journal of Tropical Medicine and Hygiene, 3.01.2024
Tilføjet 3.01.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 1 Pages: 179-187
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47
Expanding the roles of community health workers to sustain programmes during malaria elimination: a meeting report on operational research in Southeast Asia
Malaria Journal, 2.01.2024
Tilføjet 2.01.2024
Abstract In Southeast Asia malaria elimination is targeted by 2030. Cambodia aims to achieve this by 2025, driven in large part by the urgent need to control the spread of artemisinin-resistant falciparum malaria infections. Rapid elimination depends on sustaining early access to diagnosis and effective treatment. In much of Cambodia, rapid elimination will rely on a village malaria worker (VMW) network. Yet as malaria declines and is no longer a common cause of febrile illness, VMWs may become less popular with febrile patients, as VMWs do not diagnose or treat other conditions at present. There is a risk that VMWs become inactive and malaria rebounds before the complete interruption of transmission is achieved. During 2021–23 a large-scale operational research study was conducted in western Cambodia to explore how a VMW network could be sustained by including health activities that cover non-malarial illnesses to encourage febrile patients to continue to attend. 105 VMWs received new rapid diagnostic tests (including dengue antigen–antibody and combined malaria/C-reactive protein tests), were trained in electronic data collection, and attended health education packages on hygiene and sanitation, disease surveillance and first aid, management of mild illness, and vaccination and antenatal care. In August 2023 the National Malaria Control Programme of Cambodia convened a stakeholder meeting in Battambang, Cambodia. Findings from the study were reviewed in the context of current malaria elimination strategies. The discussions informed policy options to sustain the relevance of the VMW network in Cambodia, and the potential for its integration with other health worker networks. This expansion could ensure VMWs remain active and relevant until malaria elimination is accomplished.
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48
Wastewater-based surveillance of vector-borne pathogens: a cautionary note
Farah Ishtiaq
Trends in Parasitology, 30.12.2023
Tilføjet 30.12.2023
Diamond et al. recently identified malaria and dengue as high-priority diseases in wastewater surveillance for climate-change-driven shifts in pathogen dynamics. When employing wastewater surveillance for vector-borne pathogens it is essential to take into account the geographical context, pathogen biology, and the availability of sewage networks for meaningful interventions.
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49
Spatial analysis of Dengue through the reproduction numbers relating to socioeconomic features: Case studies on two Brazilian urban centers
Infectious Disease Modelling, 23.12.2023
Tilføjet 23.12.2023
Publication date: Available online 22 December 2023 Source: Infectious Disease Modelling Author(s): Ana T.C. Silva, Rejane C. Dorn, Lívia R. Tomás, Leonardo B.L. Santos, Lacita M. Skalinski, Suani T.R. Pinho
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50
Downscaling epidemiological time series data for improving forecasting accuracy: An algorithmic approach
Mahadee Al Mobin, Md. Kamrujjaman
PLoS One Infectious Diseases, 15.12.2023
Tilføjet 15.12.2023
by Mahadee Al Mobin, Md. Kamrujjaman Data scarcity and discontinuity are common occurrences in the healthcare and epidemiological dataset and often is needed to form an educative decision and forecast the upcoming scenario. Often to avoid these problems, these data are processed as monthly/yearly aggregate where the prevalent forecasting tools like Autoregressive Integrated Moving Average (ARIMA), Seasonal Autoregressive Integrated Moving Average (SARIMA), and TBATS often fail to provide satisfactory results. Artificial data synthesis methods have been proven to be a powerful tool for tackling these challenges. The paper aims to propose a novel algorithm named Stochastic Bayesian Downscaling (SBD) algorithm based on the Bayesian approach that can regenerate downscaled time series of varying time lengths from aggregated data, preserving most of the statistical characteristics and the aggregated sum of the original data. The paper presents two epidemiological time series case studies of Bangladesh (Dengue, Covid-19) to showcase the workflow of the algorithm. The case studies illustrate that the synthesized data agrees with the original data regarding its statistical properties, trend, seasonality, and residuals. In the case of forecasting performance, using the last 12 years data of Dengue infection data in Bangladesh, we were able to decrease error terms up to 72.76% using synthetic data over actual aggregated data.
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