Søgeord (dengue) valgt.
30 emner vises.
1
[Articles] Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial
Kirsten E Lyke, Joel V Chua, Michael Koren, Heather Friberg, Gregory D Gromowski, Rekha R Rapaka, Adam T Waickman, Sudhaunshu Joshi, Kathleen Strauss, Michael K McCracken, Hernando Gutierrez-Barbosa, Biraj Shrestha, Christopher Culbertson, Paula Bernal, Rafael A De La Barrera, Jeffrey R Currier, Richard G Jarman, Robert Edelman
Lancet Infectious Diseases, 26.04.2024
Tilføjet 26.04.2024
Participants who had tetravalent dengue purified inactivated vaccine prime and live-attenuated vaccine boost were unprotected against dengue virus-1 infection and further showed increased clinical, immunological, and transcriptomic evidence for inflammation potentially mediated by pre-existing infection-enhancing antibodies. This study highlights the impact of small cohort, human challenge models studying dengue pathogenesis and downstream vaccine development.
Læs mere
Tjek på PubMed
2
Central nervous system infections in the tropics
T, Angel Miraclin; Singh, Bhagteshwar; Rupali, Priscilla
Current Opinion in Infectious Diseases, 24.04.2024
Tilføjet 24.04.2024
Purpose of review Emerging and re-emerging central nervous system (CNS) infections are a major public health concern in the tropics. The reasons for this are myriad; climate change, rainfall, deforestation, increased vector density combined with poverty, poor sanitation and hygiene. This review focuses on pathogens, which have emerged and re-emerged, with the potential for significant morbidity and mortality. Recent findings In recent years, multiple acute encephalitis outbreaks have been caused by Nipah virus, which carries a high case fatality. Arboviral infections, predominantly dengue, chikungunya and Zika are re-emerging increasingly especially in urban areas due to changing human habitats, vector behaviour and viral evolution. Scrub typhus, another vector borne disease caused by the bacterium Orientia tsutsugamushi, is being established as a leading cause of CNS infections in the tropics. Summary A syndromic and epidemiological approach to CNS infections in the tropics is essential to plan appropriate diagnostic tests and management. Rapid diagnostic tests facilitate early diagnosis and thus help prompt initiation and focusing of therapy to prevent adverse outcomes. Vector control, cautious urbanization and deforestation, and reducing disturbance of ecosystems can help prevent spread of vector-borne diseases. Regional diagnostic and treatment approaches and specific vaccines are required to avert morbidity and mortality.
Læs mere
Tjek på PubMed
3
Gut microbe blocks dengue and Zika viruses in mosquitoes
Catherine Offord
Science, 18.04.2024
Tilføjet 18.04.2024
4
Epidemiological investigation of dengue fever outbreak and its socioeconomic determinants in Banadir region, Somalia
BMC Infectious Diseases, 12.04.2024
Tilføjet 12.04.2024
Abstract Background Dengue has become an alarming global problem and is endemic in many countries, particularly in tropical and subtropical countries. The aim of this study was to investigate dengue fever outbreak in Banadir Region, Somalia, to understand the risk factors (time, place, personal characteristics). Methods A descriptive cross-sectional study was undertaken to determine the levels of circulating anti-dengue virus antibodies and DENV NS1 antigen among Banadir Region residents, while a questionnaire survey was conducted to understand the clinical and demographic characteristics of the patients. Results A total of 735 febrile patients were studied, with 55.6% men and 44.3% women. The majority of the participants were children aged 14 years and younger. Among them, 10.8% tested positive for IgM antibodies against dengue virus (DENV), while the prevalence of DENV NS1 antigen was 11.8%. Fever and myalgia were the most common symptoms observed in the DENV-positive patients. Conclusions A dengue fever outbreak has been confirmed in Banadir region, Somalia. This study provides information on the most affected districts and identifies risk factors contributing to DF outbreaks. The study recommends improving outbreak readiness and response, particularly in surveillance and laboratory diagnostics, by fostering intersectoral collaboration and establishing regulatory frameworks for financial and operational participation.
Læs mere
Tjek på PubMed
5
Molecular identification and phylogenetic analysis of chikungunya virus among dengue-negative patients in Kolkata, India
Rajendra Prasad Chatterjee, Aroni Chatterjee, Sabbir Ansari, Shilpa Chatterjee, Shyamalendu Chatterjee, Nilanjan Chakraborty
PLoS One Infectious Diseases, 4.04.2024
Tilføjet 4.04.2024
by Rajendra Prasad Chatterjee, Aroni Chatterjee, Sabbir Ansari, Shilpa Chatterjee, Shyamalendu Chatterjee, Nilanjan Chakraborty Dengue and chikungunya are co-circulating vector-borne diseases that share a significant number of clinical symptoms. To identify variables to aid physicians in making rapid and effective diagnostic decisions, we performed molecular diagnosis of the chikungunya virus and examined the clinical manifestations of chikungunya cases to identify the prevalence among dengue-negative individuals in Kolkata. Dengue suspected patients’ samples were collected during January 2020—December 2021 and Enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR) methods have been performed to confirm the prevalence of chikungunya infection among dengue-negative patients. By performing phylogenetic analysis, comparing clinical classifications, identifying disease aetiology using clinical and laboratory factors, and evaluating the time course of several clinical variables, we have evaluated the clinical manifestations linked to dengue and chikungunya virus infections. Chikungunya infection was found in 15.1% and 6.3% of the 635 dengue-negative patients, as determined by ELISA and RT-PCR, respectively. Arthritis and myalgia were more common in chikungunya-infected patients at the time of hospital admission while conjunctivitis, photosensitivity, arthralgia, Anorexia, fatigue, retro-orbital pain, vomiting, dermatitis, or swollen glands were significantly presented as an overlapping symptom. Although dengue and chikungunya infections have significant clinical overlap, basic clinical and laboratory criteria can predict these diseases at presentation for proper management. Effective management enables doctors to treat and care for patients properly and contributes to the development of control measures for these infections in a medical setting.
Læs mere
Tjek på PubMed
6
Historical Hot Spots of Dengue and Zika Viruses to Guide Targeted Vector Control in San Juan, Puerto Rico (2010–2022)
American Journal of Tropical Medicine and Hygiene, 3.04.2024
Tilføjet 3.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4 Pages: 731-737
Læs mere
Tjek på PubMed
7
Low Rate of Asymptomatic Dengue Infection Detected in Coastal Kenya Using Pooled Polymerase Chain Reaction Testing
American Journal of Tropical Medicine and Hygiene, 3.04.2024
Tilføjet 3.04.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 4 Pages: 738-740
Læs mere
Tjek på PubMed
8
First-in-human trial evaluating safety and pharmacokinetics of AT-752, a novel nucleotide prodrug with pan-serotype activity against dengue virus
Xiao-Jian ZhouJason LickliterMaureen MontrondLaura IshakKeith PietropaoloDayle JamesBruce BelangerArantxa HorgaJanet Hammond1Atea Pharmaceuticals Inc, Boston, Massachusetts, USA2Nucleus Network, Melbourne, Australia, Miguel Angel Martinez
Antimicrobial Agents And Chemotherapy, 26.03.2024
Tilføjet 26.03.2024
9
[Articles] Effect of single-dose, live, attenuated dengue vaccine in children with or without previous dengue on risk of subsequent, virologically confirmed dengue in Cebu, the Philippines: a longitudinal, prospective, population-based cohort study
Michelle Ylade, Maria Vinna Crisostomo, Jedas Veronica Daag, Kristal An Agrupis, Anna Maureen Cuachin, Ava Kristy Sy, Deok Ryun Kim, Hyeon Seon Ahn, Ana Coello Escoto, Leah C Katzelnick, Cameron Adams, Laura White, Aravinda M de Silva, Jacqueline Deen, Anna Lena Lopez
Lancet Infectious Diseases, 23.03.2024
Tilføjet 23.03.2024
The risk of developing virologically confirmed dengue after a single dose of CYD-TDV varied by baseline DENV serostatus. Since the study assessed the effect of only a single dose, the findings cannot inform decisions on vaccination by public health officers. However, the findings have implications for children who receive an incomplete vaccination regimen and these results should prompt more detailed analyses in future trials on dengue vaccines.
Læs mere
Tjek på PubMed
10
Improving dengue fever predictions in Taiwan based on feature selection and random forests
BMC Infectious Diseases, 20.03.2024
Tilføjet 20.03.2024
Abstract Background Dengue fever is a well-studied vector-borne disease in tropical and subtropical areas of the world. Several methods for predicting the occurrence of dengue fever in Taiwan have been proposed. However, to the best of our knowledge, no study has investigated the relationship between air quality indices (AQIs) and dengue fever in Taiwan. Results This study aimed to develop a dengue fever prediction model in which meteorological factors, a vector index, and AQIs were incorporated into different machine learning algorithms. A total of 805 meteorological records from 2013 to 2015 were collected from government open-source data after preprocessing. In addition to well-known dengue-related factors, we investigated the effects of novel variables, including particulate matter with an aerodynamic diameter
Læs mere
Tjek på PubMed
11
Dengue encephalopathy in an adult due to dengue virus type 1 infection
BMC Infectious Diseases, 15.03.2024
Tilføjet 15.03.2024
Abstract Background Dengue is an important public health problem, which caused by the dengue virus (DENV), a single-stranded RNA virus consisted of four serotypes. Central nervus system (CNS) impairment in dengue usually results from DENV-2 or DENV-3 infection, which lead to life-threatening outcomes. Furthermore, neurological complications due to DENV-1 was rare especially in adult patients. Case presentation A 44-year-old man without comorbidities had lethargy after hyperpyrexia and a positive DENV NS1 antigen was detected for confirming the diagnosis of dengue on day 8 of onset. Then logagnosia, decreased muscle strength, delirium and irritability were occurred even radiographic examination were normal. He was treated with low-dose hormone, sedatives and gamma goblin with a short duration of 6 days. The cerebrospinal fluid (CSF) tests were persistent normal. However, presence of DENV-1 RNA was confirmed both in CSF and serum. Furthermore, the complete sequence of the DENV isolated from the patient’s serum was performed (GenBank No.: MW261838). The cytokines as IL-6, IL-10 and sVCAM-1 were increased in critical phase of disease. Finally, the patient was discharged on day 24 of onset without any neurological sequelae. Conclusion Encephalopathy caused by a direct CNS invasion due to DENV-1 during viremia was described in an adult patient. Treatment with low-dose hormone and gamma goblin was helpful for admission.
Læs mere
Tjek på PubMed
12
Exploring community behaviours and stakeholder challenges in engaging communities with dengue prevention behaviour in Malaysia: implementation research for a qualitative study with a community-based participatory research design
Samsudin, N. A., Karim, N., Othman, H., Naserrudin, N. A., Sahani, M., Hod, R., Siau, C. S., Harif, M. N., Abd. Samad, B. H., Zaini, Z.-I. I.
BMJ Open, 13.03.2024
Tilføjet 13.03.2024
ObjectivesTo use a community-based participatory research (CBPR) design to explore local community behaviours and stakeholders’ challenges in engaging communities in dengue prevention behaviours in Hulu Langat, Selangor, Malaysia. DesignThis CBPR design in implementation comprised in-depth interviews (IDIs) and focus group discussions (FGDs). Themes were identified from the data with inductive and deductive thematic analysis. SettingFGDs were conducted in local community areas and IDIs were conducted in the local authority (LA) office and the Hulu Langat district health office. ParticipantsAll FGD and IDI participants consented to the study, and included health authorities (n=4), LAs (n=7), community leader (n=1), faith leader (n=1), patients diagnosed with dengue (IDIs, n=2) and permanent residents of Hulu Langat who had been exposed to dengue infectious disease (FGDs, n=27). ResultsThe main themes were categorised into community behaviour and stakeholder challenges. The community behaviour-related themes were awareness of dengue disease and Aedes mosquitoes, perception of risk and severity, and involvement of authorities. The themes related to stakeholder challenges were resource constraints and capacity issues, jurisdictional constraints and coordination, and educational dissemination and vandalism. ConclusionsThe actions of the authorities shape community and stakeholder behaviours. Effective communication, including clear and aesthetically pleasing messages, motivates individuals to take appropriate actions. It is crucial for the authorities to engage in inclusive communication and consider diverse perspectives, such as those of residents and individuals exposed to dengue infection. Authorities that provide accurate and unbiased information foster transparency and enable informed decision-making by all stakeholders.
Læs mere
Tjek på PubMed
13
Forecasting weekly dengue incidence in Sri Lanka: Modified Autoregressive Integrated Moving Average modeling approach
Nilantha Karasinghe, Sarath Peiris, Ruwan Jayathilaka, Thanuja Dharmasena
PLoS One Infectious Diseases, 8.03.2024
Tilføjet 8.03.2024
by Nilantha Karasinghe, Sarath Peiris, Ruwan Jayathilaka, Thanuja Dharmasena Dengue poses a significant and multifaceted public health challenge in Sri Lanka, encompassing both preventive and curative aspects. Accurate dengue incidence forecasting is pivotal for effective surveillance and disease control. To address this, we developed an Autoregressive Integrated Moving Average (ARIMA) model tailored for predicting weekly dengue cases in the Colombo district. The modeling process drew on comprehensive weekly dengue fever data from the Weekly Epidemiological Reports (WER), spanning January 2015 to August 2020. Following rigorous model selection, the ARIMA (2,1,0) model, augmented with an autoregressive component (AR) of order 16, emerged as the best-fitted model. It underwent initial calibration and fine-tuning using data from January 2015 to August 2020, and was validated against independent 2000 data. Selection criteria included parameter significance, the Akaike Information Criterion (AIC), and Schwarz Bayesian Information Criterion (SBIC). Importantly, the residuals of the ARIMA model conformed to the assumptions of randomness, constant variance, and normality affirming its suitability. The forecasts closely matched observed dengue incidence, offering a valuable tool for public health decision-makers. However, an increased percentage error was noted in late 2020, likely attributed to factors including potential underreporting due to COVID-19-related disruptions amid rising dengue cases. This research contributes to the critical task of managing dengue outbreaks and underscores the dynamic challenges posed by external influences on disease surveillance.
Læs mere
Tjek på PubMed
14
A dengue virus infection in Ethiopia: a systematic review and meta-analysis
BMC Infectious Diseases, 8.03.2024
Tilføjet 8.03.2024
Abstract Background Dengue is caused by a positive-stranded RNA virus called dengue virus, which is spread by Aedes mosquito species. It is a fast-growing acute febrile disease with potentially lethal consequences that is a global public health problem, mostly in tropical and subtropical countries. In Ethiopia, dengue fever is understudied, although the virus is still being transmitted and viral infection rates are rising. This systematic review and meta-analysis was aimed at estimating the pooled prevalence of DENV infection in Ethiopia. Methods A literature search was done on the PubMed, Hinari and Google Scholar databases to identify studies published before July, 2023. Random effects and fixed effects models were used to estimate the pooled prevalence of all three markers. The Inconsistency Index was used to assess the level of heterogeneity. Results A total of 11 studies conducted on suspected individuals with dengue fever and acutely febrile participants were included in this review. The majority of the studies had a moderate risk of bias and no study had a high risk of bias. A meta-analysis estimated a pooled IgG prevalence of 21% (95% CI: 19–23), a pooled IgM prevalence of 9% (95%CI: 4–13) and a pooled DENV-RNA prevalence of 48% (95% CI: 33–62). There is evidence of possible publication bias in IgG but not in the rest of the markers. Conclusion Dengue is prevalent among the dengue fever suspected and febrile population in Ethiopia. Healthcare providers, researchers and policymakers should give more attention to dengue fever.
Læs mere
Tjek på PubMed
15
Brazil is hoping and waiting for a new vaccine as dengue rages
Marcia Triunfol
Science, 8.03.2024
Tilføjet 8.03.2024
16
A dengue virus infection in Ethiopia: a systematic review and meta-analysis
BMC Infectious Diseases, 7.03.2024
Tilføjet 7.03.2024
Abstract Background Dengue is caused by a positive-stranded RNA virus called dengue virus, which is spread by Aedes mosquito species. It is a fast-growing acute febrile disease with potentially lethal consequences that is a global public health problem, mostly in tropical and subtropical countries. In Ethiopia, dengue fever is understudied, although the virus is still being transmitted and viral infection rates are rising. This systematic review and meta-analysis was aimed at estimating the pooled prevalence of DENV infection in Ethiopia. Methods A literature search was done on the PubMed, Hinari and Google Scholar databases to identify studies published before July, 2023. Random effects and fixed effects models were used to estimate the pooled prevalence of all three markers. The Inconsistency Index was used to assess the level of heterogeneity. Results A total of 11 studies conducted on suspected individuals with dengue fever and acutely febrile participants were included in this review. The majority of the studies had a moderate risk of bias and no study had a high risk of bias. A meta-analysis estimated a pooled IgG prevalence of 21% (95% CI: 19–23), a pooled IgM prevalence of 9% (95%CI: 4–13) and a pooled DENV-RNA prevalence of 48% (95% CI: 33–62). There is evidence of possible publication bias in IgG but not in the rest of the markers. Conclusion Dengue is prevalent among the dengue fever suspected and febrile population in Ethiopia. Healthcare providers, researchers and policymakers should give more attention to dengue fever.
Læs mere
Tjek på PubMed
17
Preferences and Demand for Mosquito Control among Dengue-Endemic Communities in Peñuelas, Puerto Rico: An Application of the Best-Worst Choice Model
American Journal of Tropical Medicine and Hygiene, 6.03.2024
Tilføjet 6.03.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 3 Pages: 540-548
Læs mere
Tjek på PubMed
18
Use of Household Insecticides against Mosquitoes in Dengue-Endemic Areas in Sri Lanka
American Journal of Tropical Medicine and Hygiene, 6.03.2024
Tilføjet 6.03.2024
Journal Name: The American Journal of Tropical Medicine and Hygiene Volume: 110 Issue: 3 Pages: 549-556
Læs mere
Tjek på PubMed
19
Arbovirus impact on mosquito behavior: the jury is still out
Théo Maire, Louis Lambrechts, Felix J.H. Hol
Trends in Parasitology, 29.02.2024
Tilføjet 29.02.2024
Parasites can manipulate host behavior to enhance transmission, but our understanding of arbovirus-induced changes in mosquito behavior is limited. Here, we explore current knowledge on such behavioral alterations in mosquito vectors, focusing on host-seeking and blood-feeding behaviors. Reviewing studies on dengue, Zika, La Crosse, Sindbis, and West Nile viruses in Aedes or Culex mosquitoes reveals subtle yet potentially significant effects. However, assay heterogeneity and limited sample sizes challenge definitive conclusions. To enhance robustness, we propose using deep-learning tools for automated behavior quantification and stress the need for standardized assays. Additionally, conducting longitudinal studies across the extrinsic incubation period and integrating diverse traits into modeling frameworks are crucial for understanding the nuanced implications of arbovirus-induced behavioral changes for virus transmission dynamics.
Læs mere
Tjek på PubMed
20
[Articles] An observer-blind, randomised, placebo-controlled, phase 1, single ascending dose study of dengue monoclonal antibody in healthy adults in Australia
Bhagwat Gunale, Nicholas Farinola, Chandrashekhar D Kamat, Cyrus S Poonawalla, Sambhaji S Pisal, Rajeev M Dhere, Claire Miller, Prasad S Kulkarni
Lancet Infectious Diseases, 24.02.2024
Tilføjet 24.02.2024
Dengue monoclonal antibody was safe and well tolerated. It showed a dose-proportionate increase in pharmacokinetic exposure. These data support further evaluation of dengue monoclonal antibody in patients with dengue for safety and efficacy.
Læs mere
Tjek på PubMed
21
Dominant epitopes of cross‐reactive anti‐domain III human antibody response change from early to late convalescence of infection with dengue virus
Luis Gabriel González‐Lodeiro, Alejandro Martín Dunn, Dayron Martín Prieto, Danya Medina‐Carrasco, Lisandra E. García de Castro, Daniela Maldonado Bauzá, Glay Chinea Santiago, Vivian Huerta Galindo
Journal of Medical Virology, 20.02.2024
Tilføjet 20.02.2024
22
Initiatives and Challenges of Dengue Incidence in the Philippines
Journal of Infectious Diseases, 20.02.2024
Tilføjet 20.02.2024
23
Integration of population-level data sources into an individual-level clinical prediction model for dengue virus test positivity
Robert J. Williams, Ben J. Brintz, Gabriel Ribeiro Dos Santos, Angkana T. Huang, Darunee Buddhari, Surachai Kaewhiran, Sopon Iamsirithaworn, Alan L. Rothman, Stephen Thomas, Aaron Farmer, Stefan Fernandez, Derek A. T. Cummings, Kathryn B. Anderson, Henrik Salje, Daniel T. Leung
Science Advances, 17.02.2024
Tilføjet 17.02.2024
24
[Seminar] Dengue
Gabriela Paz-Bailey, Laura E Adams, Jacqueline Deen, Kathryn B Anderson, Leah C Katzelnick
Lancet, 16.02.2024
Tilføjet 16.02.2024
Dengue, caused by four closely related viruses, is a growing global public health concern, with outbreaks capable of overwhelming health-care systems and disrupting economies. Dengue is endemic in more than 100 countries across tropical and subtropical regions worldwide, and the expanding range of the mosquito vector, affected in part by climate change, increases risk in new areas such as Spain, Portugal, and the southern USA, while emerging evidence points to silent epidemics in Africa. Substantial advances in our understanding of the virus, immune responses, and disease progression have been made within the past decade.
Læs mere
Tjek på PubMed
25
Within-host models unravelling the dynamics of dengue reinfections
Infectious Disease Modelling, 7.02.2024
Tilføjet 7.02.2024
Publication date: Available online 7 February 2024 Source: Infectious Disease Modelling Author(s): Vizda Anam, Bruno V. Guerrero, Akhil Kumar Srivastav, Nico Stollenwerk, Maíra Aguiar
Læs mere
Tjek på PubMed
26
Chronic and neurotropic: A paradigm-challenging case of dengue virus encephalitis in patient with advanced human immunodeficiency virus infection
Clinical Infectious Diseases, 7.02.2024
Tilføjet 7.02.2024
Abstract A 32-year-old female with advanced HIV infection presented to an Australian hospital with subacute but worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining of brain tissue confirmed active Dengue virus (DENV) encephalitis. The most recent possible DENV exposure was months prior in West Africa, indicating chronicity.
Læs mere
Tjek på PubMed
27
Severe disease during both primary and secondary dengue virus infections in pediatric populations
Charu Aggarwal, Hasan Ahmed, Pragati Sharma, Elluri Seetharami Reddy, Kaustuv Nayak, Mohit Singla, Deepti Maheshwari, Yadya M. Chawla, Harekrushna Panda, Ramesh Chandra Rai, Sivaram Gunisetty, Lalita Priyamvada, Siddhartha Kumar Bhaumik, Syed Fazil Ahamed, Rosario Vivek, Priya Bhatnagar, Prabhat Singh, Manpreet Kaur, Kritika Dixit, Sanjeev Kumar, Kamal Gottimukkala, Keshav Saini, Prashant Bajpai, Gopinathan Pillai Sreekanth, Shobha Mammen, Anand Rajan, Valsan Philip Verghese, Asha Mary Abraham, Paresh Shah, Kalichamy Alagarasu, Tianwei Yu, Carl W. Davis, Jens Wrammert, Aftab Ansari, Rustom Antia, Sushil Kumar Kabra, Guruprasad R. Medigeshi, Rafi Ahmed, Rakesh Lodha, Anita Shet, Anmol Chandele, Kaja Murali-Krishna
Nature, 6.02.2024
Tilføjet 6.02.2024
28
Assessing the basic knowledge and awareness of dengue fever prevention among migrant workers in Klang Valley, Malaysia
Maryam N. Chaudhary, Voon-Ching Lim, Erwin Martinez Faller, Pramod Regmi, Nirmal Aryal, Siti Nursheena Mohd Zain, Adzzie Shazleen Azman, Norhidayu Sahimin
PLoS One Infectious Diseases, 1.02.2024
Tilføjet 1.02.2024
by Maryam N. Chaudhary, Voon-Ching Lim, Erwin Martinez Faller, Pramod Regmi, Nirmal Aryal, Siti Nursheena Mohd Zain, Adzzie Shazleen Azman, Norhidayu Sahimin Background Globally, 390 million dengue virus infections occur per year. In Malaysia, migrant workers are particularly vulnerable to dengue fever (DF) due to mosquito breeding sites exposure and poor health literacy. Therefore, this study aimed to (i) assess the current DF knowledge, attitudes and practices (KAP), and (ii) identify strategies to promote DF awareness, among migrant workers in Klang Valley. Method A survey was conducted with 403 Nepali, Filipino and Indonesian migrant workers through phone interviews and online self-administered questionnaires. Piecewise structural equation modelling was applied to identify predictor variables for DF KAP. Results Most respondents were male, working in the services industry, had completed high school, aged between 30–39 years and with less than ten years work experience in Malaysia. Overall, respondents’ knowledge was positively correlated with attitude but negatively with practices. Older respondents, who had completed higher education, obtained higher knowledge scores. Similarly, those with working experience of >20 years in Malaysia obtained higher attitude scores. Respondents with a previous history of DF strongly considered the removal of mosquito breeding sites as their own responsibility, hence tended to frequently practise DF preventive measures. Respondents’ knowledge was also positively correlated to their understanding of DF information sourced from social media platforms. Conclusion These findings highlighted: (i) the need for targeted DF educational intervention among younger and newly arrived workers with lower levels of education and (ii) maximising the usage of social media platforms to improve DF public awareness.
Læs mere
Tjek på PubMed
29
Live, Attenuated, Tetravalent Butantan–Dengue Vaccine in Children and Adults
Esper G. Kallás, Monica A.T. Cintra, José A. Moreira, Elizabeth G. Patiño, Patricia Emilia Braga, Juliana C.V. Tenório, Vanessa Infante, Ricardo Palacios, Marcus Vínicius Guimarães de Lacerda, Dhelio Batista Pereira, Allex Jardim da Fonseca, Ricardo Queiroz Gurgel, Ivo Castelo-Branco Coelho, Cor Jesus Fernandes Fontes, Ernesto T.A. Marques, Gustavo Adolfo Sierra Romero, Mauro Martins Teixeira, André M. Siqueira, Aldina Maria Prado Barral, Viviane Sampaio Boaventura, Fabiano Ramos, Erivaldo Elias Júnior, José Cassio de Moraes, Dimas T. Covas, Jorge Kalil, Alexander Roberto Precioso, Stephen S. Whitehead, Alejandra Esteves-Jaramillo, Tulin Shekar, Jung-Jin Lee, Julieta Macey, Sabrina Gozlan Kelner, Beth-Ann G. Coller, Fernanda Castro Boulos, Mauricio L. Nogueira
New England Journal of Medicine, 1.02.2024
Tilføjet 1.02.2024
30
Three Dengue Vaccines — What Now?
Scott B. Halstead
New England Journal of Medicine, 1.02.2024
Tilføjet 1.02.2024