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1
Vaccine Against Urinary Tract Infections in Development
Medscape Infectious Diseases, 1.05.2024
Tilføjet 1.05.2024
A randomized study published in 2022 showed the vaccine\'s efficacy in preventing urinary tract infections over 9 months. Medscape Medical News
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2
FDA Approves New Antibiotic for Uncomplicated UTIs
Medscape Infectious Diseases, 27.04.2024
Tilføjet 27.04.2024
The US Food and Drug Administration has approved pivmecillinam (Pivya) tablets to treat uncomplicated urinary tract infections in women. Medscape Medical News
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3
Contact tracing management of a measles case in a paediatric hospital: experience of the local public health unit, Portugal, January 2024
Daniel Saldanha Resendes, António Tomás, Mariana Pinção Cardoso, Sebastian von Schreeb, Rita Miranda Ferrão, Paula Vasconcelos, Maria Helena Almeida, Bruno Novo Castro, Vasco Ricoca Peixoto, Renato Lourenço Silva and Margarida de Morais
Eurosurveillance latest updates, 26.04.2024
Tilføjet 26.04.2024
In January 2024, a child was diagnosed with measles in a paediatric hospital in Lisbon. Of 123 contacts, 39 (32%) were not fully immunised, presenting a risk for a potential outbreak. The public health unit initiated control measures and identified challenges during the response, such as the lack of interoperability between information systems and accessing vaccination records. The lessons learned prompted changes to national contact tracing procedures for measles, further strengthening Portugal’s preparedness.
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4
Can D-Mannose Prevent Recurrent Urinary Tract Infection?
Medscape Infectious Diseases, 24.04.2024
Tilføjet 24.04.2024
The global rise in antibiotic resistance has complicated the therapeutic choices for urinary tract infections. Medscape Medical News
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5
Multiple introductions of monkeypox virus to Ireland during the international mpox outbreak, May 2022 to October 2023
Gabriel Gonzalez, Michael Carr, Tomás M Kelleher, Emer O’Byrne, Weronika Banka, Brian Keogan, Charlene Bennett, Geraldine Franzoni, Patrice Keane, Cliona Kenna, Luke W Meredith, Nicola Fletcher, Jose Maria Urtasun-Elizari, Jonathan Dean, Ciaran Browne, Fiona Lyons, Brendan Crowley, Derval Igoe, Eve Robinson, Greg Martin, Jeff Connell, Cillian F De Gascun and Daniel Hare
Eurosurveillance latest updates, 19.04.2024
Tilføjet 19.04.2024
BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when a global epidemic of cases in non-endemic countries led to the declaration of a Public Health Emergency of International Concern. Cases of mpox in Ireland, a country without previous mpox reports, could reflect extended local transmission or multiple epidemiological introductions. AimTo elucidate the origins and molecular characteristics of MPXV circulating in Ireland between May 2022 and October 2023. MethodsWhole genome sequencing of MPXV from 75% of all Irish mpox cases (182/242) was performed and compared to sequences retrieved from public databases (n = 3,362). Bayesian approaches were used to infer divergence time between sequences from different subclades and evaluate putative importation events from other countries. ResultsOf 242 detected mpox cases, 99% were males (median age: 35 years; range: 15–60). All 182 analysed genomes were assigned to Clade IIb and, presence of 12 distinguishable subclades suggests multiple introductions into Ireland. Estimation of time to divergence of subclades further supports the hypothesis for multiple importation events from numerous countries, indicative of extended and sustained international spread of mpox. Further analysis of sequences revealed that 92% of nucleotide mutations were from cytosine to thymine (or from guanine to adenine), leading to a high number of non-synonymous mutations across subclades; mutations associated with tecovirimat resistance were not observed. ConclusionWe provide insights into the international transmission dynamics supporting multiple introductions of MPXV into Ireland. Such information supported the implementation of evidence-informed public health control measures.
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6
Increased reports of measles in the Metropolitan City of Milan, northern Italy, September 2023 to March 2024
Maria Gori, Clara Fappani, Silvia Bianchi, Sabrina Senatore, Daniela Colzani, Priscilla Pasutto, Melissa Baggieri, Silvia Gioacchini, Antonella Marchi, Paola Bucci, Emilio D’Ugo, Marino Faccini, Danilo Cereda, Luigi Vezzosi, Elisabetta Tanzi, Fabio Magurano and Antonella Amendola
Eurosurveillance latest updates, 19.04.2024
Tilføjet 19.04.2024
Since late 2023, the Metropolitan City of Milan and surrounding areas (northern Italy) have been experiencing a resurgence of measles, with most cases detected starting from January 2024. During this brief period, we observed measles in travellers from endemic areas, participants in international events, vaccinees and healthcare workers. Indigenous cases have also been identified. Even though we have not yet identified large and disruptive outbreaks, strengthening surveillance and vaccination activities is pivotal to help limit the impact of measles spread.
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7
How Can Doctors Best Assess Worsening Dengue Cases?
Medscape Infectious Diseases, 18.04.2024
Tilføjet 18.04.2024
It is important to inform patients about warning signs such as abdominal pain, repeated vomiting, decreased urine output, or dizziness when standing, says an epidemiologist. Medscape Infectious Diseases
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